by admin | May 5, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
One of the most fascinating drugs in the anesthesiologist’s armament is ketamine, an N-
methyl-D-aspartate receptor antagonist with a myriad of uses. The drug is a dissociative
anesthetic and has been used more often as an analgesic in numerous hospital units, …
Acute administration of ketamine inhibited stress induced pro-inflammatory cytokines in hippocampus of rats
G Unal, G Terzioglu, C Sahin, GY Demirel, F Aricioglu – Bulletin of Clinical …, 2015
Objective: Major depression is a complex and devastating disease which one-third of
patients still do not respond to current treatments. It has been demonstrated that there is a
correlation between high levels of plasma cytokines such as IL-1β, IL-6, IL-18 and TNF-α …
The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.
GS Aylan, N Sarper, U Demirsoy, E Zengin, E Çakmak – Turkish journal of …, 2015
OBJECTIVE: The aim of this study is to investigate the efficacy and safety of sedoanalgesia
performed outside the operating room by pediatricians trained in advanced airway
management and life support. MATERIALS AND METHODS: Midazolam and ketamine …
[HTML] Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and …
GS Vasconcelos, NC Ximenes, CNS de Sousa… – Schizophrenia Research, 2015
Abstract Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid
(ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied
the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of …
Low Dose Ketamine Infusion For Managing Acute Pain
M Yetim, S Tekindur, Y Emrah Eyi – The American Journal of Emergency Medicine, 2015
Dear Editor, We read with great interest the article “Short (low-dose) ketamine infusion for
managing acute pain in the ED: case-report series” written by Goltser et al (1). We believe
that this original study provides a new and insightful approach to pain management in …
[PDF] Symptomatic remission and hippocampus volume in schizophrenia
PT Chang, JF Lirng, YH Chou – Bulletin of Clinical Psychopharmacology, 2015
… 1):S146-S7 [Abstract:0577] Neuroimaging in psychiatry Alterations in resting state electrocortical
network oscillations, schizophrenia-like symptoms and their relationships induced with the
administration of the NMDA receptor antagonist ketamine in human volunteers …
G535 (P) The development and implementation of a policy promoting parental (patient) involvement in escalation of clinical care
MA Webster, C Haines, J Fraser – Archives of Disease in Childhood, 2015
… www.midstaffspublicinquiry.com/report (accessed 28 Nov 2014) G536(P) THE CHALLENGES
OF SETTING UP A KETAMINE SEDATION SERVICE IN THE PAEDIATRIC ED – LEARNING
LESSONS AND EFFECTING CHANGE 1E Dewhirst, 1C Whitehouse, 2T Waterfield. …
[PDF] Eyes tell the psychopathology: preliminary findings
H Balibey, C Basoglu, A Ates, A Algul, R Tutuncu… – Bulletin of Clinical …, 2015
… On the other hand, the behavioral and pharmacological effects of the noncompetitive
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine have been used to study
important aspects of psychotomimetic action in humans. …
Adjunctive Use of Ceftriaxone and Sodium Valproate in the Management of Tetanus: A Case Report and Literature Review
S Oriaifo, N Oriaifo, M Oriaifo, E Okogbenin, E Omogbai – Journal of Biology, …, 2015
… immune globulin. Control of spasms was mainly by the use of the GABAergic-
enhancing drugs diazepam and sodium valproate combined with the use of the
anti-excitotoxics magnesium sulphate and ketamine. The introduction …
PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines
T Arai, K Tsuchiya, E Matsumura – Organic Letters, 2015
… adduct (27%, 80% ee). The formation of the chiral N,O-acetal inspired us to optimize
the reaction conditions for the addition of methanol to an isatin-derived
N-Boc-ketamine (1a), as shown in Table 1. Table 1. Optimization of …
Radiofrequency Ablation (RFA)
Radiofrequency Ablation for Atrial Fibrillation: Trends in Patients, Clinical Outcomes, and Resources Among Medicare Beneficiaries from Fiscal Year 2010 to Fiscal …
MR Reynolds, AD Kugelmass, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
Abstract Introduction: The objective of this analysis was to report four year trends among
Medicare beneficiaries (MB) undergoing Radiofrequency Ablation (RFA) to treat Atrial
Fibrillation (AF). Methods: This retrospective study examined both the Medicare Provider …
Systematic review and meta-analysis of perinatal outcomes following radiofrequency ablation and bipolar cord occlusion in monochorionic pregnancies
K Gaerty, RM Greer, S Kumar – American Journal of Obstetrics and Gynecology, 2015
Objective The aim of this study was to analyse perinatal outcomes following selective
reduction in monochorionic pregnancies using either radiofrequency ablation (RFA) or
bipolar cord occlusion (BCO). Study Design This was a systematic review and meta- …
Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer
S Safi, G Rauch, J Kunz, T Schneider, M Bischof… – Respiration, 2015
Background: The best therapy for patients with stage I non-small cell lung cancer (NSCLC)
who are medically unfit for lobectomy or prefer not to undergo surgery has not yet been
demonstrated. Objectives: We analyzed data from our prospective database to evaluate …
The efficacy of radio-frequency ablation for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage …
Y Naya, T Nakamura, M Oishi, T Ueda, H Nakanishi… – International Journal of …, 2015
… Okuma et al. [14] reported that tumors under 20 mm in size can be completely ablated in lung
tumor. … Cancer 3:1409–1419 7. Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation
of unresectable primary and metastatic hepatic malignancies. Results in 123 patients. …
Metastastectomy for metachronous pulmonary and hepatic metastases from nasopharyngeal carcinoma: Report of 6 cases and review of the literature
SJM Lim, NG Iyer, LL Ooi, HN Koong, A Chung, HK Tan… – Head & Neck, 2015
… not prevent disease progression in the long term. Surgery and radiofrequency ablation have … ten
patients who underwent radiofrequency ablation +/- adjuvant chemotherapy had a median survival
period of 77.1 months compared to 32.4 months in another ten patients who only …
[HTML] Lobulated Enhancement Evaluation in the Follow-Up of Liver Metastases Treated by Stereotactic Body Radiation Therapy
H Jarraya, P Borde, X Mirabel, O Ernst, T Boulanger… – International Journal of …, 2015
… have limitations for the evaluation of targeted therapies; for example, imatinib for gastrointestinal
stromal tumors (GIST) and bevacizumab for colorectal liver metastasis 8, 9 and 10 or other local
treatments, such as lung tumor SBRT (11), liver radiofrequency ablation (12), and …
Percutaneous microwave ablation of thyroid nodules: effects on thyroid function and antibodies
K Heck, C Happel, F Grünwald, H Korkusuz – International Journal of Hyperthermia, 2015
… The results demonstrated that in all 30 sessions the complete volume of the 34
nodules could be ablated. The treatment … al. Radiofrequency ablation of benign thyroid
nodules: Safety and imaging follow-up in 236 patients. Eur …
Current state of the treatment of perforating veins
ED Dillavou, M Harlander-Locke, N Labropoulos… – Journal of Vascular Surgery: …, 2015
… Table II. Technical success of radiofrequency ablation (RFA), endovenous laser ablation (EVLA),
and ultrasound-guided foam sclerotherapy (UGFS). Primary author (year), Perforator treatment
modality, No. … 14, 15, 18 and 26. Radiofrequency ablation (RFA). …
Irreversible Electroporation of the Pancreas Is Feasible and Safe in a Porcine Survival Model.
S Fritz, CM Sommer, D Vollherbst, MF Wachter… – Pancreas, 2015
… From a histopathological point of view, the ablated area was character- ized by cellular eosinophila …
The ability of IRE to ablate undesirable tissue near large blood vessels and damageable … of the
electric field to which the tissue is exposed.13 Radiofrequency ablation has been …
An Analysis of Patients Transferred to a Tertiary Oncological Intensive Care Unit for Defined Procedures
S Kamat, S Chawla, P Rajendram, SM Pastores… – American Journal of Critical …, 2015
Skip to main page content. …
Complex Regional Pain Syndrome (CRPS/RSD)
Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS
AS Won, CA Tataru, CM Cojocaru, EJ Krane… – Pain Medicine, 2015
… Letter to the Editor. Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. … How
to Cite. Won, AS, Tataru, CA, Cojocaru, CM, Krane, EJ, Bailenson, JN, Niswonger, S. and Golianu,
B. (2015), Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. …
A dynamic PUF anti-aging authentication system based on restrict race code
B Li, S Chen – Science China Information Sciences, 2015
… Based on the CRP mechanism, the PUF circuit can produce chip-unique responses when
challenges are applied to it and stored in the database by the way of CRPs. (2) Authentication. …
The expected data in the database are called CRPs in paper. …
Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?
RG Boles, EA Zaki, JR Kerr, K Das, S Biswas… – Mitochondrion, 2015
… Herein, we tested for these variants in chronic fatigue, CRPS, SIDS and depression. … CVS = cyclic
vomiting syndrome, Fxn abd pain = functional abdominal pain (a common pediatric functional
syndrome), IBS = irritable bowel syndrome, CRPS = complex regional pain syndrome. …
[HTML] TURAN and EVAN Mediate Pollen Tube Reception in Arabidopsis Synergids through Protein Glycosylation
H Lindner, SA Kessler, LM Müller, H Shimosato-Asano… – 2015
… Abbreviations:: ConA, Concanavalin A; CRPs, cysteine-rich polypeptides; CrRLK1L, Catharanthus
roseus receptor-like kinase 1-like subfamily; DAE, days after emasculation; DAP, days after
pollination; DAPI, 4′,6-diamidino-2-phenylindole; DEFL, defensin-like protein; Dol-P …
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to post-fracture nociceptive sensitization.
X Shi, T Guo, T Wei, W Li, DJ Clark, WS Kingery – PAIN, 2015
… neuropeptide-dependent nociceptive and inflammatory changes in the hindlimbs of rats similar
to those seen in complex regional pain syndrome (CRPS). Inflammatory changes … inflammatory
mediators contributing to nociceptive sensitization in a rodent fracture model of CRPS. …
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
… pain clinics, and in the prehospital realm. It has been used to treat postoperative pain, chronic
pain, complex regional pain syndrome (CRPS), phantom limb pain (PLP), and other neuropathic
conditions requiring anal- gesia. … CRPS has remained a difficult-to-treat entity. …
Trends in Coronary Revascularization Procedures among Medicare Beneficiaries between Fiscal Years 2010 and 2013
A Kugelmass, MR Reynolds, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
… Mortality rates were highest and increasing for MBs presenting with STEMI across all procedures.
Conclusions: The overall volume of CRPs among MBs is declining and more MBs are presenting
with an AMI, and overall mortality rates are increasing year over year. …
CORD STIMULATIONS IN PATIENTS WITH COMPLEX REGIONAL PAIN SYNDROME: A RANDOMIZED PLACEBO CONTROLLED TRIAL
N Kriek, J Groeneweg, D Stronks, F Huygen
… N. Kriek, J. Groeneweg, D. Stronks, F. Huygen Center for pain management, Erasmus MC,
Rotterdam, The Netherlands Objectives: Spinal cord stimulation (SCS) is an effective invasive
therapy to treat neuropathic pain states including complex regional pain syndrome (CRPS). …
[HTML] Diagnostic value of C-reactive protein to rule out infectious complications after major abdominal surgery: a systematic review and meta-analysis
SL Gans, JJ Atema, S van Dieren, BG Koerkamp… – International Journal of …, 2015
… The posttest odds were calculated by multiplying the pretest odds with the positive and
negative LR. Posttest probabilities for a high and a low CRPs were calculated and presented
in a graph for pretest probabilities across the range of 0 to 100 %. …
[HTML] World congress comes to you 7: Yes we can (control chronic pain)
V Bellan
… If you want more information on CRPS you might find what we know about CRPS helpful as
well as these resources by the Royal College of Physicians. You can also read recent research
published by the team and browse through our CRPS blog articles. …
Fibromyalgia
Factors Associated With Time to Diagnosis in Fibromyalgia
G Chodick, D Weitzman, Y Bar-On, V Shalev, H Amital – Journal of Patient-Centered …, 2015
Background/Aims: The diagnosis of fibromyalgia, a chronic debilitating disorder, is
complicated and affected by various factors of the patient and the caregiver. The objectives
of this study were to investigate the time passing from initial complaints to diagnosis and to …
[PDF] Central Sensitization Syndrome and the Initial Evaluation of a Patient with Fibromyalgia: A Review
KC Fleming, MM Volcheck – Rambam Maimonides Med J, 2015
ABSTRACT In both primary care and consultative practices, patients presenting with
fibromyalgia (FM) often have other medically unexplained somatic symptoms and are
ultimately diagnosed as having central sensitization (CS). Central sensitization …
Does low bone density influence symptoms and functional status in patients with fibromyalgia? Observations from rural South India
AS Babu, FM Ikbal, MS Noone, AN Joseph, D Danda – International Journal of …, 2015
Results Low BMD was seen in 81.6%(129/158) of the persons screened. FMS was seen in
37/158 persons, of which 31/37 (83.7%) had low BMD. Conclusion FMS with low bone
density leads to higher levels of pain and a poorer QoL compared to those without FMS. …
[PDF] Walking as physical exercise in Fibromyalgia: An elicitation study from the Theory of Planned Behavior
MÁ Pastor, S López-Roig, Y Sanz, C Peñacoba – anales de psicología, 2015
Abstract: This study is the first phase of the formative research recommended in the Theory
of Planned Behavior for the development of an intervention. Our aims are to identify modal
beliefs about the performance of an exercise pattern in people with fibromyalgia, to test …
… advances in spinal cord and brainstem fMRI provide an unprecedented view of human pain processing and alterations to pain mechanisms in fibromyalgia
R Bosma – 2015
Abstract: Functional MRI of the human spinal cord and brainstem has tremendous potential
to enhance our basic understanding of healthy subcortical function, and impact our ability to
accurately diagnose and treat injury and disease. Despite this potential, there are many …
Understanding High Blood Pressure
S Aziz – 2015
Overcoming Low Self-Esteem with Mindfulness
D Ward – 2015
[HTML] Efficacy and processes of change in acceptance and commitment therapy for chronic pain
M Kemani – 2015
… The first trial utilized a wait-list control condition and included women with fibromyalgia (Study
I). Assessments were done pre- and post-treatment and at 3-month follow-up. … Acceptance and
commitment therapy for fibromyalgia: A randomized controlled trial. …
[PDF] Evaluation of psychiatry consultations requested for inpatients in a university hospital
H Mayda, HI Guzel, Y Gorucu, E Bagcioglu – Bulletin of Clinical Psychopharmacology, 2015
… [Abstract:0282] Psychosomatic disorders Metacognitive evaluation in patients with fibromyalgia
syndrome … In this study, we tested the assumption that patients with Fibromyalgia Syndrome (FMS)
experience more metacognitive thoughts compared to healthy individuals. …
[PDF] Investigation of state and trait anxiety levels among pharmacy students in TRNC
YH Balcıoglu, E Duran – Bulletin of Clinical Psychopharmacology, 2015
… Bulletin of Clinical Psychopharmacology 2015;25(Suppl. 1):S93-S4 [Abstract:0452] Anxiety,
stress, and adjustment disorders Angiotensin-converting enzyme and
methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome …
by admin | Apr 30, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Rapid antidepressant Action and Restoration of Excitatory Synaptic Strength after Chronic Stress by Negative Modulators of alpha5-containing GABAA Receptors.
J Fischell, AM Van Dyke, MD Kvarta, TA LeGates… – … : official publication of the …, 2015
… The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but
has troubling side-effects. We hypothesized that negative allosteric modulators of
GABAA receptors would exert similar effects on brain activity …
Temporal evoltion on MRI of successful treatment of rabies
A Lu, P Shah, P Shen, P Lee, AE Nidecker… – Clinical Imaging, 2015
… Her treatment regimen came to be known as the “Milwaukee protocol” [1]. Briefly, the
protocol consists of using a sedative agent such as ketamine, midazolam, propofol, or
a combination to place the patient in a medically induced coma. …
[PDF] A Gelatin-Based Prophylactic Sealant for Bowel Wall Closure, Initial Evaluation in Mid-rectal Anastomosis in a Large Animal Model
Y Kopelman, Y Nir, Y Siman-Tov, B Person, O Zmora – J Gastrointest Dig Syst, 2015
… Preemptive analgesia (intramuscular Dipyron 1 gr) was given to all any amounts prior to surgery.
The animals were anesthetized with a combination of Ketamine 22 mg/mL and Xylazine injection
(Apectrum Chemicals and Laboratory Products, Gardena, California) 1 mg/kg IM. …
[PDF] The optimal fitting model for aging-related receptive field size curve of macaque V1 neurons
J Cui, H Ding, L Wang, J Qiang – … on Mechatronics, Electronic, Industrial and Control …, 2015
… of 28 years. An initial ophthalmological examination was performed under ketamine
(100 mg/kg im, Ketalar, Parke-Davis, Morris Plains, NJ, USA) anesthesia to screen
for monkeys with ocular pathology. B. Visual Stimulation …
[PDF] Preventing Testicular Damage in Genital Burns With Cooling: An Experimental Study
AE Abalı, H Özdemir
… The sham group (S group) consisted of 10 healthy testes. In this group, rats were anesthetized
with an intraperitoneal injection of 100 mg/kg ketamine hydrochloride (Alfamine 10%, Alfasan,
Holland) and 10 mg/kg … Animals were killed by high-dose ketamine HCl. …
[PDF] JAMES A. McNAMARA, JR., DDS, Ph. DT
T KURODA
… Page 2. Ketamine & Phencyclidine . . . … Dosage, prepared according to levels
recommended by other investigators-fit10:11 was as fol- lows: phencyclidine HCl,
1.5 ngkg. of body weight (intramuscular); ketamine HCI, 25 mgjkg. …
Fine-scale genetic structure of the ringtail (Bassariscus astutus) in a Sky Island mountain range
RC Lonsinger, RM Schweizer, JP Pollinger, RK Wayne… – Journal of Mammalogy, 2015
… Traps were baited with dry cat food and either loganberry paste or sardines. Captured ringtails
were anesthetized using a mixture of medetomidine hydrochloride (50 µg/kg) and ketamine
hydrochloride (5mg/kg) injected intramuscularly (Orion Corporation, Espoo, Finland). …
[PDF] Evaluation of the Effect of Alfalfa Extract on Breast Cancer
F Nabatchian, SMH Aghoosi, A Mordadi, F Khodaverdi – J. Appl. Environ. Biol. Sci, 2015
… normal saline. In the solution, the tumor was cut into 3 mm2 pieces. Then, the mice
in the first and second groups were anesthetized with intraperitoneal injection of
ketamine (10 mg/kg) and xylene (5 mg/kg). The tumor pieces …
Effects of light pollution on seasonal estrus and daily rhythms in a nocturnal primate
T LeTallec, M Théry, M Perret – Journal of Mammalogy, 2015
… Ltd, Saint-Paul, Minnesota) previously implanted in the visceral cavity under general anesthesia
and under veterinary supervision (Diazepam-Valium: 1mg/100g, subcutaneous injection; Ketamine
hydrochloride-Imalgen: 10mg/100g, intraperitoneal injection; postoperative …
[PDF] Evaluation of Cissampelos pareira root for antifertility activity
J Samanta, S Bhattacharya, AC Rana – Journal of Pharmacy Research Vol, 2015
… from D1 pregnancy. On day 12th day (D12) all the rats of control and treated group
were anaesthetized with normal dose of ketamine-xylazine anaesthesia15 and
laparotomized to count the no. of implants of each rat. 2.3.6. Effectsof …
Radiofrequency Ablation (RFA)
[HTML] Transcatheter embolization therapy in liver cancer: an update of clinical evidences
YXJ Wáng, T De Baere, JM Idée, S Ballet – Chinese Journal of Cancer Research, 2015
… 2-4). For the treatment of early stage HCC, curative therapies including liver transplantation,
hepatic resection, and radiofrequency ablation (RFA) are … coagulative necrosis of both the tumor
and a rim of surrounding parenchymal tissue producing a margin of ablated non-tumoral …
CATHETER WITH ATRAUMATIC TIP
ES Olson, JV Kauphusman, LK Nemec, TT Tegg – US Patent 20,150,112,331, 2015
… According to at least one medical study (See, eg, Ikeda et al., Radiofrequency Ablation Catheter
with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine
Heart, Conference Proceedings of the Hearth Rhythm Society, May 2008 and …
ELECTRICAL STIMULATION OF THE CAROTID ARTERY
I Gillbe – US Patent 20,150,112,359, 2015
… or bodies without heating the tissues to a temperature at which they are ablated such that … the
RF energy delivered is of a non-thermal nature, so that ablation and possible … As previously
described, pulsed radiofrequency is employed for this purpose; comprising short bursts of …
METHOD TO REDUCE SENSE OF TASTE AND FOOD INTAKE
H Li – US Patent 20,150,112,326, 2015
… To ablate the subsurface tissue without ablating the surface tissue of the mouth, a room … During
a heat induced ablation with fluid cooling, ablation head and the tissue surface in … delivered into
it from an energy source such as ultrasound, microwave, and radiofrequency current. …
MODULATION OF NERVES INNERVATING THE LIVER
BR Azamian, JA Coe, SB Vafai – US Patent 20,150,112,332, 2015
… In some embodiments, the neuromodulation catheter is a radiofrequency (RF) ablation catheter
comprising … about substantially 180 degrees of the vessel circumference to ablate in a … In some
embodiments, other patterns of ablation electrode movement (regardless of inherent …
BALLOON CATHETERS WITH FLEXIBLE CONDUCTING WIRES AND RELATED METHODS OF USE AND MANUFACTURE
MR Willard, DC Sutermeister, KR Larson, TA Ostroot… – US Patent 20,150,112,328, 2015
… Sympathetic nerve ablation device 12 may be used to ablate nerves (eg, renal nerves) disposed
adjacent to the kidney K (eg, renal nerves … Sympathetic nerve modulation device 12 may be
configured to deliver ablation energy, for example, radiofrequency energy, to a target …
Current Control Methods and Systems
H Cadouri – US Patent 20,150,112,321, 2015
… an energy field to a target site in the renal artery (eg, via radiofrequency ablation) have been … above
45° C. (or above 60° C. in other cases) may induce thermal ablation of the … In some patients, it
may be desirable to achieve temperatures that thermally ablate the target neural …
DIAPHRAGM ENTRY FOR POSTERIOR SURGICAL ACCESS
SD Fleischman, R Neubert, EW Rogers – US Patent 20,150,112,145, 2015
… Atrial fibrillation surgery involving radiofrequency, DC, microwave, ultrasound, laser or other
modes of thermal … of focusing energy into local areas spaced at known distances from the ablation
device (in … tissue in the ventricles from the diaphragm) are used to ablate the imaged …
[PDF] ASRA/ESRA/INS/AAPM/WIP/NANS guidelines for interventional spine and pain procedures in patients on antiplatelets and anticoagulants
S Narouze, HT Benzon, D Provenzano, A Buvanendran…
… C, cervical; T, thoracic; L, lumbar; S, sacral; MBNB, medial branch nerve block; RFA,
radiofrequency ablation *Patients with high risk for bleeding undergoing low or intermediate
risk procedures should be treated as internmediate or high risk repectively. …
SYSTEM AND METHOD FOR TREATING URINARY TRACT DISORDERS
U Eshel – US Patent 20,150,112,413, 2015
… transurethral microwave thermotherapy (temperatures over 46 degrees Celsius that cause tissue
ablation to exposed … that the higher level of heat in the surrounding non-ablated tissue either … It
includes a catheter with a sheathed radiofrequency antenna, surrounded by a flow of …
Complex Regional Pain Syndrome (CRPS/RSD)
What is the maximum safe tourniquet time in elective upper limb surgery?
N Sawant, GEB Giddins – Journal of Hand Surgery (European Volume), 2015
… Two patients developed chronic regional pain syndrome type 1 (CRPS 1). In one patient this
was noticed 4 weeks following complex rheumatoid surgery. The tourniquet time was 2 hours
4 minutes and there was no immediate post-operative pain or distal paraesthesia. …
RODENT RUN
MJ Dixon, PM Taylor, B Dixon – US Patent 20,150,107,525, 2015
… [2] Millecamps, Laferrière, Ragavendran, Stone, Coderre: “Role of peripheral endothelin receptors
in an animal model of complex regional pain syndrome type 1 (CRPS-I)” J Pain, volume 151
(2010) pages 174-183; [3] Ugo Basile Leaflet for Von Frey Hairs (with grid) Cat. No. …
Using Computing with Words for Managing Non-cooperative Behaviors in Large Scale Group Decision Making
FJ Quesada, I Palomares, L Martínez – Granular Computing and Decision-Making, 2015
… sufficiently to reach the solution made. In order to overcome this drawback, Consensus
Reaching Processes (CRPs) were introduced as an additional phase in the resolution
process for GDM problems [17]. In a CRP, experts try …
The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature
AC Young, TR Lubenow, A Buvanendran – Regional Anesthesia and Pain Medicine, 2015
… Complex regional pain syndrome (CRPS) is neuropathic pain syndrome that is more common
in women, with some studies showing a higher prevalence among women aged 25 to 50
years. … Patient 3 suffered from CRPS of the right upper extremity. …
Decision Makers’ Opinions Changing Attitude-Driven Consensus Model under Linguistic Environment and Its Application in Dynamic MAGDM Problems
B Dutta, D Guha – Granular Computing and Decision-Making, 2015
… Based on the concept of soft consensus, vari- ous consensus reaching processes
(CRPs) have been designed in the literature [22]. The existing CRPs for solving GDM
problems can be classified in two categories: static consensus …
Peripheral Nerve Stimulationperipheral nerve stimulation
AS Hanna – Anatomy and Exposures of Spinal Nerves, 2015
… Download Chapter (482 KB). Abstract. Peripheral nerve stimulation is an off-label use of spinal
cord stimulators. It is used for intractable pain in a peripheral nerve distribution, refractory to
medical management, especially with complex regional pain syndrome (CRPS ). …
[HTML] External Fixation and Adjuvant Pins Versus Volar Locking Plate Fixation in Unstable Distal Radius Fractures: A Randomized, Controlled Study With a 5-Year Follow- …
JH Williksen, T Husby, JC Hellund, HD Kvernmo… – The Journal of Hand …, 2015
… At the 5-year follow-up, 3 patients had died, 1 (with an extensor pollicis longus rupture) had moved
abroad, and 2 (1 patient with complex regional pain syndrome [CRPS]) withdrew from the study. …
Carpal tunnel syndrome, 2, 1. CRPS, 0, 1. Extensor tendon synovitis, 0, 5. …
Complex regional pain syndrome type I: a comprehensive review
M Bussa, D Guttilla, M Lucia, A Mascaro, S Rinaldi – Acta Anaesthesiologica …, 2015
… Background. Complex regional pain syndrome type I (CRPS I), formerly known as reflex
sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a
minor injury to a limb. … Pathophysiological mechanisms of CRPS I. …
Phenotype-Specific Diagnosis of Functional (Psychogenic) Movement Disorders
AJ Espay, AE Lang – Current Neurology and Neuroscience Reports, 2015
Page 1. MOVEMENT DISORDERS (M OKUN, SECTION EDITOR) Phenotype-Specific
Diagnosis of Functional (Psychogenic) Movement Disorders Alberto J. Espay1,3 & Anthony
E. Lang2 © Springer Science+Business Media New York 2015 …
[PDF] Time-consistent calibration of short-term regional wind power ensemble forecasts
S SPäTH, L VON BREMEN, C JUNk, D HEINEMANN – 2015
… For minimum score esti- mation, we use the continuous ranked probability score (crps). … For
a forecast cumulative distribution function (cdf) Fp(x) and the verifying obser- vation y, the crps
can be calculated as: crps(Fp,y) = ∞ ∫ − Fp(x) − Θ(x − y) ]2 dx (4.4) …
Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization
S Tomisawa, Y Sato, M Kamiya, Y Kumaki, T Kikukawa… – Protein Expression and …, 2015
… The mouse Paneth cell α-defensins, termed cryptdins (Crps) 1 , are secreted into the lumen of
the small intestinal crypts in response to exposure to bacteria or bacterial antigens [6]. Among
the known isoforms, cryptdin-4 (Crp4) has the most potent antimicrobial activity [7 …
[PDF] Erythrocyte Sedimentation Rate, C-Reactive Protein and Procalcitonin in Infections of the Spine and Infections in Spinal Cord Injury Patients
JAL Buensalido, MP Reyes – Open Infectious Diseases Journal, 2015
… One study reported a mean CRP of 3 mg/L in paraplegics, while a mixed paraplegia/tetraplegia
study that excluded patients with CRPs >10 mg/L, also showed a mean of 3 mg/L. Another group
noted that mean CRP level was 38 mg/L, or 27% higher, in SCI versus non-SCI …
Fibromyalgia
The role of sleep in pain and fibromyalgia.
EH Choy – Nature reviews. Rheumatology, 2015
Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced
pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common
symptoms include nonrestorative sleep, fatigue, cognitive dysfunction, stiffness and mood …
Nonpharmacological Treatments of Insomnia for Long-Term Painful Conditions: A Systematic Review and Meta-analysis of Patient-Reported Outcomes in …
NK Tang, ST Lereya, H Boulton, MA Miller, D Wolke… – Sleep, 2015
… This study evaluated the effect of nonpharmacological sleep treatments on
patient-reported sleep quality, pain, and well-being in people with long-term cancer
and non-cancer (eg, back pain, arthritis, fibromyalgia) pain conditions. …
COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY
S Hoffman – US Patent 20,150,111,878, 2015
… Abstract: The present invention provides methods, compositions, and kits for treating intestinal
hyperpermeability in a subject in need thereof, including underlying diseases such as diabetes,
autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease …
American College of Lifestyle Medicine Expert Panel Discussion Treat the Cause: Evidence-Based Practice*
JM Rippe, M Greger, DL Katz, JH Kelly, M Moore… – American Journal of …, 2015
… Following this strategy, I am fostering clinical evaluation of coaching for fibromyalgia,
for which there is no good treatment other than exercise. However, it has taken 10
years to get to the place where we have enough coaches …
Whole body vibration training in patients with COPD A systematic review
R Gloeckl, I Heinzelmann, K Kenn – Chronic Respiratory Disease, 2015
… Abstract. In recent years, several studies have shown that whole body vibration training (WBVT)
may be a beneficial training mode in a variety of chronic diseases and conditions such as
osteoporosis, fibromyalgia, multiple sclerosis, or chronic low back pain. …
[PDF] Fibromyalgia Syndrome AmongIraqi Patients with Systemic Lupus Erythematosus: A Case Control Study
ZS Al-Rawi, HAJ Badran, FI Gorial
Abstract: Objective: To determine the prevalence of fibromyalgia syndrome (FMS) among
Iraqi patients with systemic lupus erythematosus (SLE) and its association with disease
activity. Patients and methods: This case control study included 100 patients with SLE and …
[PDF] Quality of life, sense of coherence and experiences with three different treatments in patients with psychological distress in primary care: a mixed-methods study
T Arvidsdotter, C Taft, B Marklund, S Kylén – BMC Complementary and Alternative …, 2015
… More detailed data on the procedure are reported elsewhere [48]. The patients had a primary
diagnosis of depression, anxiety or panic disorders, severe stress, somatic symptoms/pain
(including irritable bowel syndrome, fibromyalgia, migraine, fatigue) or sleep disorders. …
SULFUR-CONTAINING BICYCLIC COMPOUND
N Shiraishi, H Hoshii, W Hamaguchi, E Honjo… – US Patent 20,150,111,876, 2015
… containing bicyclic compound having a PAM action of GABA B , and it use for preventing
and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum
disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot …
TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY
R Aung-din – US Patent 20,150,111,930, 2015
… respective receptors. They are indicated for such diverse and seemingly different
conditions as: focal onset seizures, post-herpetic neuralgia, diabetic peripheral
neuropathy, fibromyalgia, anxiety, and drug withdrawal syndromes. The …
Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis
YH Lee, SC Bae, SJ Choi, JD Ji, GG Song – Lupus, 2015
[HTML] Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia
B Regland, S Forsmark, L Halaouate, M Matousek… – 2015
Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue
syndrome) may respond most favorably to frequent vitamin B12 injections, in vital
combination with oral folic acid. However, there is no established algorithm for …
Cardiovascular control in women with fibromyalgia syndrome: do casual methods provide non redundant information compared to more traditional approaches?
AR Zamunér, A Porta, CP Andrade, A Marchi, M Forti… – American Journal of …, 2015
Abstract The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have
been widely studied in FMS patients through the computation of linear indices of
spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However, …
Aberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia
CM Brummett, AG Lohse, A Tsodikov, SE Moser… – Regional Anesthesia and …, 2015
Abstract Background and Objectives: Facet interventions for spine pain have high failure
rates, and preprocedural prediction of response is nearly impossible. A potential explanation
may be aberrant central pain processing as that existing in conditions like fibromyalgia. To …
[HTML] Effects of Whole-Body Vibration Therapy in Patients with Fibromyalgia: A Systematic Literature Review
D Collado-Mateo, JC Adsuar, PR Olivares… – … -Based Complementary and …, 2015
Objective. To review the literature on the effects of whole-body vibration therapy in patients
with fibromyalgia. Design. Systematic literature review. Patients. Patients with fibromyalgia.
Methods. An electronic search of the literature in four medical databases was performed to …
Six Syndromes with Surprising Psychotherapy Solutions
T Rodriguez, V Stern – Scientific American Mind, 2015
… These links to content published by NPG are automatically generated. Cognitive behavioral
therapy for fibromyalgia. … Utility of cognitive behavioral therapy as a treatment for insomnia in
patients with fibromyalgia. Nature Clinical Practice Rheumatology (01 Apr 2006). …
Comorbid Conditions Do Not Differ in Children and Young Adults with Functional Disorders with or without Postural Tachycardia Syndrome
G Chelimsky, K Kovacic, M Nugent, A Mueller… – The Journal of Pediatrics, 2015
… All patients underwent formal autonomic testing, Beighton scores assessment for joint
hypermobility (0-9), and fibromyalgia tender points (0-18) (43 subjects). Results. … All subjects with
fibromyalgia by tender point-examination had a Beighton score ≥4 (P = .002). Conclusions. …
Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias
S Regauer, B Eberz, C Beham‐Schmid – APMIS, 2015
… Similar to other chronic pain syndromes among which are chronic pelvic and bladder pain,
fibromyalgia, and atopic dermatitis morphological correlates are hyperinnervation and increased
infiltrates of mast cells [3-5]. Activated mast cells release pre-stored or rapidly produced …
Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study
E Generaal, N Vogelzangs, GJ Macfarlane, R Geenen… – Annals of the Rheumatic …, 2015
… Previous studies mostly defined chronic widespread pain, a cardinal symptom of the fibromyalgia
syndrome, as axial and bilateral pain above and below the waist.41 With this somewhat ‘less
stringent’ definition, we may have included some patients with milder pain. …
Speed, science and optimal pain relief
RA Moore – International Journal of Clinical Practice, 2015
… For example, a retrospective analysis of patients with chronic back pain or fibromyalgia revealed
that patients rated their treatment as successful if their pain was reduced by 50–70%, from a level
of 5–10 on a visual analogue scale (total score 10) to below three (no more than …
[PDF] An Insight of D 鄄 Ribose Metabolic Imbalance in Type 2 Diabetes Mellitus
T SU, RQ HE – Progress in Biochemistry and Biophysics, 2015
… 14-15]. Ribose is often marked as a supplement for bodybuilders with a common
recommended daily dose of 5g or more and has also been used to reduce fatigue
in fibromyalgia and chronic fatigue syndrome [2,16]. Ribose …
by admin | Apr 13, 2015 | Uncategorized
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates (below).
If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Wastewater analysis to monitor spatial and temporal patterns of use of two synthetic recreational drugs, ketamine and mephedrone, in Italy
S Castiglioni, A Borsotti, I Senta, E Zuccato – Environmental Science & Technology, 2015
Wastewater analysis was applied in a four-year monitoring study to assess temporal and
spatial patterns of ketamine and mephedrone use in the general population in Italy.
Composite raw wastewater samples were collected from sewage treatment plants (STPs) …
The use of ketamine as an antidepressant: a systematic review and meta‐analysis
CM Coyle, KR Laws – Human Psychopharmacology: Clinical and …, 2015
Objective The current meta-analysis examines the effects of ketamine infusion on
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder
(BD). Methods Following a systematic review of the literature, data were extracted from 21 …
Intravenous Ketamine to Facilitate Non-Invasive Ventilation in a Patient with a Severe Asthma Exacerbation
E Kiureghian, JM Kowalski – The American Journal of Emergency Medicine, 2015
Background Despite advances in outpatient treatment and an improved understanding of
the pathophysiology, asthma continues to be a significant source of morbidity and mortality
in the United States. While there is certainly a component of chronic inflammation, the …
Perioperative low-dose ketamine improves postoperative analgesia following Cesarean delivery with general anesthesia
M Haliloglu, M Ozdemir, N Uzture, PO Cenksoy… – The Journal of Maternal- …, 2015
Abstract Objective: In this study, the effect of perioperative uses of low dose ketamine on
post-operative wound pain and analgesic consumption in patients undergoing elective
Cesarean section was evaluated. Methods: In randomized, double blind clinical trial, 52 …
The Clinical Effect of Fentanyl in Comparison with Ketamine in Analgesic Effect for Oncology Procedures in Children: A Randomized, Double-Blinded, Crossover Trial
C Monsereenusorn, P Rujkijyanont, C Traivaree – JOURNAL OF THE MEDICAL …, 2015
Material and Method: A randomized, double-blinded, crossover trial was conducted with 55 children
undergoing painful procedures (intrathecal chemotherapy and/or bone marrow
aspiration/biopsy). Patients were randomly assigned in a double-blinded fashion to …
Dexmedetomidine, Ketamine, and Midazolam for Oral Rehabilitation: A Case Report
BWS Kim, RM Peskin – Anesthesia Progress, 2015
Abstract Intravenous sedation is frequently provided by anesthesiologists for phobic patients
undergoing elective dental treatment in outpatient settings. Propofol is one of the most
commonly used anesthetic agents that can result in apnea and respiratory depression, …
Ketamine May Be Related to Minor Troponin Elevations in Children Undergoing Minor Procedures in Emergency Department
M Serinken, C Eken – The American Journal of Emergency Medicine, 2015
Objective Ketamine is a dissociative anesthetic agent that has an increased frequency of
usage in the last years particularly in emergency departments. In the present study, we
aimed to determine whether ketamine is related to myocardial injury in children …
Anesthesia and neuromonitoring
EN Menga, GJ Spessot, JA Bendo – Seminars in Spine Surgery, 2015
… Commonly used intravenous anesthetics include propofol, dexmedetomidine, etomidate,
barbiturates, ketamine, and benzodiazepines. … Using a canine model, Glassman et al. 13 reported
consistent and reproducible TcMEPs with ketamine and etomidate. …
Inflammatory Biomarkers as Differential Predictors of Antidepressant Response
K Hashimoto – International Journal of Molecular Sciences, 2015
… situation. This article discusses inflammatory molecules as predictive biomarkers
for antidepressant responses to several classes of antidepressants, including the
N-methyl-d-aspartate (NMDA) receptor antagonist ketamine. …
Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury
CC Liao, GE DiCarlo, OA Gharbawie, HX Qi, JH Kaas – Journal of Comparative …, 2015
… tranquilized with an intramuscular injection (IM) of ketamine hydrochloride (10-25 mg/ kg, IM)
and Page 4 of 55 John Wiley & Sons Journal of Comparative Neurology … In preparation for the
injection, each monkey was tranquilized with ketamine hydrochloride (10mg/kg, …
Radiofrequency Ablation (RFA)
[PDF] Comparison of amiodarone and propafenone for maintenance of stable sinus rhythm after bipolar radiofrequency ablation combined with a mitral valve procedure in …
Y Beşir, O Gökalp, U Yetkin, E Çelik, H İner, B Lafçı… – Türk Göğüs Kalp Damar …, 2015
ABSTRACT Background: This study aims to examine the effects of amiodarone versus
propafenone for maintenance of stable sinus rhythm after left atrial bipolar radiofrequency
ablation combined with a mitral valve procedure in patients with mitral valve disease and …
New Technologies and Approaches to Endoscopic Control of Gastrointestinal Bleeding
LL Fujii-Lau, LMWK Song, MJ Levy – Gastrointestinal Endoscopy Clinics of North …, 2015
… Radiofrequency Ablation. Technique. Focal radiofrequency ablation (RFA) catheters
(Barrx; Covidien, Mansfield, MA) have been used to treat GI bleeding in the setting of
gastric antral vascular ectasia (GAVE) (Fig. 3) and radiation proctitis. …
Dichorionic triplet pregnancies: risk of miscarriage and severe preterm delivery with fetal reduction versus expectant management. Outcomes of a cohort study and …
M Morlando, L Ferrara, F D’Antonio, A Lawin‐O’Brien… – BJOG: An International …, 2015
… Ultrasound-guided laser ablation or radiofrequency ablation of the pelvic vessels of one
of the monochorionic fetuses was used in all cases of reduction from three to two fetuses
for selective reduction of one of the two monochorionic fetuses. …
Interventional MR elastography for MRI‐guided percutaneous procedures
N Corbin, J Vappou, E Breton, Q Boehler, L Barbé… – Magnetic Resonance in …, 2015
… [27] showed that the Young’s modulus of the treated liver tumor in swine increases from 6 to 40
kPa approximately during a 5 min-long radiofrequency ablation by providing elastographic
information every 30 s. The monitoring of thermal ablations with MRE is limited by the …
[HTML] Editorials & Opinions
JP Tasto – Am J Orthop, 2015
… Published December 2014. Accessed March 6, 2015. « Back To: Editorials & Opinions. Did
you miss this content? Cutaneous Burn Caused by Radiofrequency Ablation Probe During
Shoulder Arthroscopy. More From The American Journal of Orthopedics …
Hysteroscopy and heavy menstrual bleeding (to cover TCRE and second generation endometrial ablation)
M Bongers – Best Practice & Research Clinical Obstetrics & …, 2015
… cryo-ablation (HerOption™, Cooper Surgical, Trumbull, CT) [14], and bipolar radiofrequency
(Novasure™, Hologic … The difference between the first and the second-generation endometrial
ablation are several. … Under direct vision the total endometrium can be resected or ablated. …
Atrioesophageal fistula and pneumocephalus after pulmonary vein isolation
BD Wilson, JH Morshedzadeh – European Heart Journal-Cardiovascular Imaging, 2015
… Catheter radiofrequency ablation of atrial fibrillation is an increasingly common procedure,
and atrioesophageal fistula is a rare and often fatal complication. High clinical suspicion,
rapid diagnosis, and surgical therapy may prevent death. …
Gastroparesis as a Complication of Atrial Fibrillation Ablation
T Aksu, S Golcuk, TE Guler, K Yalin, I Erden – The American Journal of Cardiology, 2015
… ventricular ejection fraction, M=male; N=normal; PIN=patient identification number; R=
radiofrequency. … more reasonable avoiding cryo-energy at lower temperatures while ablating
inferior PVs … The most possible mechanism of gastroparesis related with AF ablation is collateral …
The impact of left atrial surface area and the second generation cryoballoon on clinical outcome of atrial fibrillation cryoablation
H Greiss, A Berkowitsch, M Wojcik, S Zaltsberg… – Pacing and Clinical …, 2015
… 16 Impact of LA area on outcome In our previous studies performed on patients ablated with CB,
we found NLA area to be predictive for outcome, but absolute LA area was not predictive. … Raviele
A, Themistoclakis S, Rossillo A, Bonso A, Natale A. Radiofrequency ablation …
Persistence of Phrenic Nerve Palsy Following 28 mm Cryoballoon Ablation: A Four Year Single Center Experience
Y Saitoh, G Irfan, G Ciconte, G Mugnai, J Sieira… – Pacing and Clinical …, 2015
… Great attention must be paid when ablating with the large 28 mm CB2 due to the … large cryoballoon
for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and
non-randomised comparison with pulmonary venous isolation by radiofrequency ablation. …
Complex Regional Pain Syndrome (CRPS/RSD)
Hydromorphone for neuropathic pain in adults
D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015
… Types of participants Studies will include adults aged 18 years and above with one or more chronic
neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central
neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human …
Fentanyl for neuropathic pain in adults
S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015
… Types of participants Studies will include adults aged 18 years and above with one or more chronic
neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central
neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human …
The role of glia in the spinal cord in neuropathic and inflammatory pain
EA Old, AK Clark, M Malcangio – Pain Control, 2015
… microglia pool. Nat Neurosci 14: pp. 1142-1149; Alexander, GM, Rijn, MA, Hilten,
JJ, Perreault, MJ, Schwartzman, RJ (2005) Changes in cerebrospinal fluid levels
of pro-inflammatory cytokines in CRPS. Pain 116: pp. 213-219; …
[HTML] To study the incidence and risk factors of early onset neonatal sepsis in an out born neonatal intensive care unit of India
M Jajoo, K Kapoor, LK Garg, V Manchanda, SK Mittal – Journal of Clinical …, 2015
… [6] Screening tests such as total and differential leukocyte counts, band cells, absolute neutrophil
counts (ANCs), and rapid immunological techniques like C-reactive proteins (CRPs) assays may
help in the diagnosis of septicemia; however, they lack the capacity to detect …
[PDF] Psychological Aspects of Reflex Sympathetic Dystrophy (RSD) Complex Regional Pain Syndrome (CRPS)
H Hooshmand, EM Phillips, FL Vero Beach
Abstract. Reflex sympathetic dystrophy (RSD) or complex regional pain syndrome (CRPS) is
a complex form of neuropathic pain associated with hyperpathia; neurovascular instability;
neuroinflammation; and limbic system dysfunction. As the condition becomes chronic, the …
[PDF] COMPLEX REGIONAL PAIN SYNDROME (CRPS) REFLEX SYMPATHETIC DYSTROPHY (RSD) DIAGNOSIS AND MANAGEMENT PROTOCOL
H Hooshmand, EM Phillips, FL Vero Beach
Complex Regional Pain Syndrome (CRPS)/Reflex Sympathetic Dystrophy (RSD) is a
disease that usually starts after a relatively minor trauma. In the early stages there is a
sympathetic component in the development of the disease, but with passage of time, quite …
[PDF] Complex Regional Pain Syndrome (CRPS) and Sympathectomy
H Hooshmand, EM Phillips
Abstract. Sympathectomy may provide temporary pain relief, but after a few weeks to months
it loses its effect. Sympathectomy and the application of Chemical Sympathectomy
(neurolytic agents eg, phenol, alcohol, etc.) should be limited to patients with life …
[PDF] REPETITIVE STRAIN INJURY (RSI) DIAGNOSIS AND TREATMENT
H Hooshmand, EM Phillips, FL Vero Beach
… Careful history taking, neurological evaluation, along with such tests as quantitative
sensory testing (QST) and infrared thermal imaging (ITI) is helpful to differentiate RSI
from other causes of complex regional pain syndrome (CRPS). …
Polysomnographic Characteristics in Nonmalignant Chronic Pain Populations: A Review of Controlled Studies
MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015
… Glossary of terms. AHI apnea/hypopnea index. ArI arousal index. BDNF brain-derived neurotrophic
factor. CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic
widespread pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls. …
Fibromyalgia
Validation and cross-cultural adaptation of the ‘Fibromyalgia Participation Questionnaire’to the Spanish population: study protocol
M Gomez-Calvente, I Medina-Porqueres… – Rheumatology International, 2015
Abstract There are few high-quality instruments to evaluate the participation and social
functioning of fibromyalgia patients. The Fibromyalgia Participation Questionnaire (FPQ) is a
questionnaire that evaluates these aspects with high reliability and validity in its German …
What Constitutes Appropriate Treatment of Post-Lyme Disease Symptoms and Other Pain and Fatigue Syndromes?
AC Steere, SL Arvikar – Clinical Infectious Diseases, 2015
… This chronic syndrome, which sometimes meets criteria for fibromyalgia or chronic fatigue
syndrome, is not specific for Lyme disease [8]. Such symptoms may follow other infections or
physical or emotional trauma, or the inciting cause may not be apparent. …
Central sensitization in humans: assessment and pharmacology
L Arendt-Nielsen – Pain Control, 2015
… J Pain 4: pp. 372-380; Balasubramaniam, R, Leeuw, R, Zhu, H, Nickerson, RB, Okeson, JP,
Carlson, CR (2007) Prevalence of temporomandibular disorders in fibromyalgia and failed
back syndrome patients: a blinded prospective comparison study. …
Chronic pain and the adaptive significance of positive emotions.
AD Ong, AJ Zautra, MC Reid – 2015
… Indeed, such in- terventions may prove to be particularly important for patients with specific chronic
pain conditions, such as fibromyalgia, who show a core affective disturbance that is characterized
by an overall deficit in posi- tive emotion (Finan, Zautra, & Davis, 2009). …
Chronic widespread pain: clinical comorbidities and psychological correlates Running title: Genetics of CWP
A Burri, S Ogata, J Vehof, FMK Williams, B Box – 2015
… 3 1. Introduction Chronic widespread pain (CWP) is the cardinal symptom of fibromyalgia. … four
items pertaining to the “pain subscale” were drawn from the London Fibromyalgia Epidemiology
Symptom Screening questionnaire (LFESSQ).[34] The four items ask about pain …
Hydromorphone for neuropathic pain in adults
D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015
… Pharmacological treatment of fibromyalgia. … Journal of Pain 2008;9(2): 105–21. [DOI:
10.1016/j.jpain.2007.09.005] Gaskell 2014 Gaskell H, Moore RA, Derry, S, Stannard
C. Oxycodone for neuropathic pain and fibromyalgia in adults. …
Tarasoff’s catch-22.
SR Huey – 2015
… REFERENCES Davis, MC, & Zautra, AJ (2013). An online mindfulness intervention targeting
socioemo- tional regulation in fibromyalgia: Results of a randomized controlled trial. … Daily affect
relations in fibromyalgia patients reveal positive affective disturbance. …
Fentanyl for neuropathic pain in adults
S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015
… Pharmacological treatment of fibromyalgia. … Durogesic® DTrans. www.medicines.org.uk/EMC/
medicine/17088/ (accessed 16 December 2014). Gaskell 2014 Gaskell H, Moore RA, Derry, S,
Stannard C. Oxycodone for neuropathic pain and fibromyalgia in adults. …
Polysomnographic Characteristics in Nonmalignant Chronic Pain Populations: A Review of Controlled Studies
MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015
… CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic widespread
pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls. IL interleukin. MFP
myofascial pain. NREM non-rapid-eye-movement. NSM non-sleep migraine. OA …
Methods to Measure Peripheral and Central Pain Sensitization Using Quantitative Sensory Testing: A Focus on Individuals with Low Back Pain
AR Starkweather, A Heineman, S Storey, G Rubia… – Applied Nursing Research, 2015
… In order to evaluate and compare centralized mechanisms, the QST protocol of the German
Research Network on Neuropathic Pain was used in a group of 21 patient with fibromyalgia
(mean duration 13.4 years), 23 individuals with chronic back pain (mean duration 15.9 years …
by admin | Jan 9, 2015 | Uncategorized
Introduction
Radiofrequency ablation is a term used when radio waves are used to produce heat to destroy tissue, usually a nerve. It has been used for several years with great success in patients who have abnormally fast heartbeats. More recently, it is being used to destroy tumors. It is a non-surgical option to treat your spine pain.
Spine pain is the second most frequent pain complaint. It occurs in 65 to 80 percent of the population at one time or another, and can be disabling and frightening. Its costs to society are great.
In the case of spinal pain, radiofrequency waves are transmitted through a needle placed into the facet joint under x-ray guidance. This procedure is also known as rhizotomy.
This guide will help you understand
- What parts of the spine are involved
- What is the surgeon is trying to achieve
- What happens during the procedure
- What are the possible complications
Anatomy
What parts make up the spine?
The spine is made up of three general parts. The top portion is the cervical spine and connects with the skull or cranium. The middle portion is the thoracic spine and is identified by the ribs that attach to each of the vertebrae. The lower portion is the lumbar spine. It connects with the pelvis at the sacrum.
The human spine is made up of 24 spinal bones called vertebrae. Vertebrae are stacked on top of one another to form the spinal column. The spinal column is the body’s main upright support.
The vertebrae have discs that serve as cushions in between them. Each vertebra has two sets of bony knobs that meet between each vertebra. These form facet joints. The facet joints are located on the back of the spinal column in the lumbar and thoracic spine. In the neck, or cervical spine, they are located on each side of the vertebra. They are also called zygoaphophyseal or apophyseal joints.
A joint is where two or more bones are joined, allowing motion. Facet joints allow flexion or forward bending, and extension or backward bending, as well as rotation of your spine. The facet joints are synovial joints. This means that a capsule of soft tissue encloses them to help support it. It also makes fluid that lubricates the joint, like oil for the moving parts of a machine.
The surfaces of the joints are lined with cartilage. This allows joints to move or glide smoothly. The articular cartilage surface of the facet joint can become thin due to wear and tear. Bone spurs and enlargement of the joint can occur due to chronic inflammation and arthritis.
Nerves called medial branches supply facet joints. They carry the pain signals to the spinal cord. The signals eventually reach the brain where the pain is registered. Pain is a warning when the joint is irritated.
Rationale
What do surgeons hope to achieve with this procedure?
There are several structures in the spine that can be a source of pain. One of the most common sources is the facet joint. The joints can develop arthritis and cause acute and chronic pain. The pain may come and go depending on activity.
Facet joint pain as the cause of back pain can be determined by a facet joint injection. This is called a diagnostic injection, meaning the doctor uses it to help make a diagnosis. The physician using x-ray guidance will inject the facet joint(s) in question with a small amount of a combination of local anesthetic and cortisone. Relief of the acute or chronic problem while the joint is numb indicates that you will likely have a good response to radiofrequency ablation.
Radiofrequency ablation uses radio waves to produce heat to destroy the nerve(s) carrying the pain signals from the facet joint. Once the nerves carrying pain sensation from the joints are destroyed, your pain should be reduced. This should allow you to do more activity, and decrease your pain medications.
Preparation
How should I prepare for the surgery?
Your surgeon will discuss the preoperative guidelines. Follow your surgeon’s instructions. These instructions may include
- Do not eat or drink for at least six hours before the procedure. You will be able to take your usual medication with a small amount of water. If you have diabetes, do not take your insulin or diabetic pills until after the procedure
- You will need a driver to return home
- Do not take any aspirin or aspirin-containing medication at least eleven days before the procedure. They may prolong bleeding
- Wear loose fitting clothing that is easy to take off and put on
- Take a shower the morning of the procedure, using a bactericidal soap to reduce chances of infection
- Do not wear jewelry
Procedure
What happens during the procedure?
When the procedure is to begin, an IV will be started. This will allow the use of medications to help sedate you and make the procedure more comfortable. It is also important to have IV access for medications if you should have an allergic reaction during the procedure.
You should be awake for the procedure to help the doctor with correct placement of the electrode used for radiofrequency ablation. You will not be given a general anesthetic. The area to be treated will be cleaned and then numbed with a local anesthetic.
Using x-ray guidance, the doctor will place the needle in the proper facet joint. A microelectrode is then placed inside the needle. A small radiofrequency current is then sent to the medial branch nerve of the joint capsule for approximately 60 to 90 seconds. The procedure is done with sterile technique to minimize the risk of infection.
After the procedure, you will be taken to a recovery area. The nurses will monitor you and be sure you do not have an allergic reaction. You will be allowed to leave once you are stable.
Complications
What might go wrong?
This procedure is a safe, non-surgical treatment, and the risks for complications are low. However there are several complications that may occur during or after this procedure. No procedure is 100 percent foolproof. This article doesn’t provide a complete list of all the possible complication, but it does highlight some of the most common problems. Complications are uncommon, but you should know what to watch for if they occur. Some of the most common complications following radiofrequency ablation include
- Neuritis
- Neuroma
- Numbness-nerve damage
- Infection
- Allergic reaction
- Lack of pain relief
Neuritis
Neuritis is an inflammation of the nerve with pain and tenderness that lasts three to six weeks. This can occur in 10 to 15 percent of patients. Neuritis usually goes away by itself. If it doesn’t, the doctor can inject a local anesthetic along with a steroid into the nerve. Pulsed radiofrequency can also be used to help with the pain and inflammation.
Neuroma
A neuroma is a tumor from a nerve made of nerve cells and fibers. It forms around the area destroyed during radiofrequency ablation. The tumor can put pressure on the nerve and nearby tissue causing increased pain.
Numbness
Numbness caused by nerve damage can occur. Permanent numbness is also a possible complication.
Infection
Infections can also happen. Infections can involve the skin, or the joint and surrounding bone.
Allergic Reaction
Allergic reactions can occur since medications and sometimes contrast dye is used during the procedure. Anaphylaxis is an allergic reaction that is serious and can result in death.
Lack of Pain Relief
Even though a test block was beneficial, some patients have no pain relief from the procedure.
After Care
What should I expect after surgery?
Immediately following the procedure, you may have some relief of pain from the numbing medication used during the procedure.
You will not be able to drive or do any physical activity for 24 hours.
You may experience an increase in pain for the first several days following the procedure. Additional pain medications may be necessary to make you comfortable. If these include narcotics, you will need to watch for constipation. Drink lots of fluids and eat foods with plenty of fiber. If constipation should occur you will need to use a laxative, available over-the-counter.
You may also note some swelling and bruising where the needle was inserted. Using a cold pack may ease the discomfort. Occasionally infection or bleeding can occur at the site of the procedure. If you have a fever of 101 degrees or greater, chills, or redness or drainage at the treatment site, call your doctor.
The degree of pain relief varies from person to person. The maximum decrease in pain may take up to three or more weeks to occur. You can eventually expect 50 percent or greater pain relief. Pain relief can last from six to12 months or even longer. The nerves do repair themselves and your pain may return. The procedure may be done again.
Your doctor will arrange a follow-up appointment, or phone consult within three to four weeks after the procedure to see how you are doing.
Rehabilitation
What should I expect during my rehabilitation?
It is important that you start a program of conditioning, strengthening, and range of motion exercises after radiofrequency ablation. Ideally, increased muscle strength around the arthritic joints will make them less painful for several months after radiofrequency ablation.
