Weekly Breaking Research Updates


Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.




Rapid antidepressant Action and Restoration of Excitatory Synaptic Strength after Chronic Stress by Negative Modulators of alpha5-containing GABAA Receptors.

J Fischell, AM Van Dyke, MD Kvarta, TA LeGates… – … : official publication of the …, 2015

The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but

has troubling side-effects. We hypothesized that negative allosteric modulators of

GABAA receptors would exert similar effects on brain activity


Temporal evoltion on MRI of successful treatment of rabies

A Lu, P Shah, P Shen, P Lee, AE Nidecker… – Clinical Imaging, 2015

Her treatment regimen came to be known as the “Milwaukee protocol” [1]. Briefly, the

protocol consists of using a sedative agent such as ketamine, midazolam, propofol, or

a combination to place the patient in a medically induced coma.


[PDF] A Gelatin-Based Prophylactic Sealant for Bowel Wall Closure, Initial Evaluation in Mid-rectal Anastomosis in a Large Animal Model

Y Kopelman, Y Nir, Y Siman-Tov, B Person, O Zmora – J Gastrointest Dig Syst, 2015

Preemptive analgesia (intramuscular Dipyron 1 gr) was given to all any amounts prior to surgery.

The animals were anesthetized with a combination of Ketamine 22 mg/mL and Xylazine injection

(Apectrum Chemicals and Laboratory Products, Gardena, California) 1 mg/kg IM.


[PDF] The optimal fitting model for aging-related receptive field size curve of macaque V1 neurons

J Cui, H Ding, L Wang, J Qiang – … on Mechatronics, Electronic, Industrial and Control …, 2015

of 28 years. An initial ophthalmological examination was performed under ketamine

(100 mg/kg im, Ketalar, Parke-Davis, Morris Plains, NJ, USA) anesthesia to screen

for monkeys with ocular pathology. B. Visual Stimulation


[PDF] Preventing Testicular Damage in Genital Burns With Cooling: An Experimental Study

AE Abalı, H Özdemir

The sham group (S group) consisted of 10 healthy testes. In this group, rats were anesthetized

with an intraperitoneal injection of 100 mg/kg ketamine hydrochloride (Alfamine 10%, Alfasan,

Holland) and 10 mg/kg Animals were killed by high-dose ketamine HCl.




Page 2. Ketamine & Phencyclidine . . . Dosage, prepared according to levels

recommended by other investigators-fit10:11 was as fol- lows: phencyclidine HCl,

1.5 ngkg. of body weight (intramuscular); ketamine HCI, 25 mgjkg.


Fine-scale genetic structure of the ringtail (Bassariscus astutus) in a Sky Island mountain range

RC Lonsinger, RM Schweizer, JP Pollinger, RK Wayne… – Journal of Mammalogy, 2015

Traps were baited with dry cat food and either loganberry paste or sardines. Captured ringtails

were anesthetized using a mixture of medetomidine hydrochloride (50 µg/kg) and ketamine

hydrochloride (5mg/kg) injected intramuscularly (Orion Corporation, Espoo, Finland).


[PDF] Evaluation of the Effect of Alfalfa Extract on Breast Cancer

F Nabatchian, SMH Aghoosi, A Mordadi, F Khodaverdi – J. Appl. Environ. Biol. Sci, 2015

normal saline. In the solution, the tumor was cut into 3 mm2 pieces. Then, the mice

in the first and second groups were anesthetized with intraperitoneal injection of

ketamine (10 mg/kg) and xylene (5 mg/kg). The tumor pieces


Effects of light pollution on seasonal estrus and daily rhythms in a nocturnal primate

T LeTallec, M Théry, M Perret – Journal of Mammalogy, 2015

Ltd, Saint-Paul, Minnesota) previously implanted in the visceral cavity under general anesthesia

and under veterinary supervision (Diazepam-Valium: 1mg/100g, subcutaneous injection; Ketamine

hydrochloride-Imalgen: 10mg/100g, intraperitoneal injection; postoperative


[PDF] Evaluation of Cissampelos pareira root for antifertility activity

J Samanta, S Bhattacharya, AC Rana – Journal of Pharmacy Research Vol, 2015

from D1 pregnancy. On day 12th day (D12) all the rats of control and treated group

were anaesthetized with normal dose of ketamine-xylazine anaesthesia15 and

laparotomized to count the no. of implants of each rat. 2.3.6. Effectsof



Radiofrequency Ablation (RFA)


[HTML] Transcatheter embolization therapy in liver cancer: an update of clinical evidences

YXJ Wáng, T De Baere, JM Idée, S Ballet – Chinese Journal of Cancer Research, 2015

2-4). For the treatment of early stage HCC, curative therapies including liver transplantation,

hepatic resection, and radiofrequency ablation (RFA) are coagulative necrosis of both the tumor

and a rim of surrounding parenchymal tissue producing a margin of ablated non-tumoral



ES Olson, JV Kauphusman, LK Nemec, TT Tegg – US Patent 20,150,112,331, 2015

According to at least one medical study (See, eg, Ikeda et al., Radiofrequency Ablation Catheter

with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine

Heart, Conference Proceedings of the Hearth Rhythm Society, May 2008 and



I Gillbe – US Patent 20,150,112,359, 2015

or bodies without heating the tissues to a temperature at which they are ablated such that the

RF energy delivered is of a non-thermal nature, so that ablation and possible As previously

described, pulsed radiofrequency is employed for this purpose; comprising short bursts of



H Li – US Patent 20,150,112,326, 2015

To ablate the subsurface tissue without ablating the surface tissue of the mouth, a room During

a heat induced ablation with fluid cooling, ablation head and the tissue surface in delivered into

it from an energy source such as ultrasound, microwave, and radiofrequency current.



BR Azamian, JA Coe, SB Vafai – US Patent 20,150,112,332, 2015

In some embodiments, the neuromodulation catheter is a radiofrequency (RF) ablation catheter

comprising about substantially 180 degrees of the vessel circumference to ablate in a In some

embodiments, other patterns of ablation electrode movement (regardless of inherent



MR Willard, DC Sutermeister, KR Larson, TA Ostroot… – US Patent 20,150,112,328, 2015

Sympathetic nerve ablation device 12 may be used to ablate nerves (eg, renal nerves) disposed

adjacent to the kidney K (eg, renal nerves Sympathetic nerve modulation device 12 may be

configured to deliver ablation energy, for example, radiofrequency energy, to a target


Current Control Methods and Systems

H Cadouri – US Patent 20,150,112,321, 2015

an energy field to a target site in the renal artery (eg, via radiofrequency ablation) have been above

45° C. (or above 60° C. in other cases) may induce thermal ablation of the In some patients, it

may be desirable to achieve temperatures that thermally ablate the target neural



SD Fleischman, R Neubert, EW Rogers – US Patent 20,150,112,145, 2015

Atrial fibrillation surgery involving radiofrequency, DC, microwave, ultrasound, laser or other

modes of thermal of focusing energy into local areas spaced at known distances from the ablation

device (in tissue in the ventricles from the diaphragm) are used to ablate the imaged


[PDF] ASRA/ESRA/INS/AAPM/WIP/NANS guidelines for interventional spine and pain procedures in patients on antiplatelets and anticoagulants

S Narouze, HT Benzon, D Provenzano, A Buvanendran…

C, cervical; T, thoracic; L, lumbar; S, sacral; MBNB, medial branch nerve block; RFA,

radiofrequency ablation *Patients with high risk for bleeding undergoing low or intermediate

risk procedures should be treated as internmediate or high risk repectively.



U Eshel – US Patent 20,150,112,413, 2015

transurethral microwave thermotherapy (temperatures over 46 degrees Celsius that cause tissue

ablation to exposed that the higher level of heat in the surrounding non-ablated tissue either It

includes a catheter with a sheathed radiofrequency antenna, surrounded by a flow of


Complex Regional Pain Syndrome (CRPS/RSD)


What is the maximum safe tourniquet time in elective upper limb surgery?

N Sawant, GEB Giddins – Journal of Hand Surgery (European Volume), 2015

Two patients developed chronic regional pain syndrome type 1 (CRPS 1). In one patient this

was noticed 4 weeks following complex rheumatoid surgery. The tourniquet time was 2 hours

4 minutes and there was no immediate post-operative pain or distal paraesthesia.



MJ Dixon, PM Taylor, B Dixon – US Patent 20,150,107,525, 2015

[2] Millecamps, Laferrière, Ragavendran, Stone, Coderre: “Role of peripheral endothelin receptors

in an animal model of complex regional pain syndrome type 1 (CRPS-I)” J Pain, volume 151

(2010) pages 174-183; [3] Ugo Basile Leaflet for Von Frey Hairs (with grid) Cat. No.


Using Computing with Words for Managing Non-cooperative Behaviors in Large Scale Group Decision Making

FJ Quesada, I Palomares, L Martínez – Granular Computing and Decision-Making, 2015

sufficiently to reach the solution made. In order to overcome this drawback, Consensus

Reaching Processes (CRPs) were introduced as an additional phase in the resolution

process for GDM problems [17]. In a CRP, experts try


The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature

AC Young, TR Lubenow, A Buvanendran – Regional Anesthesia and Pain Medicine, 2015

Complex regional pain syndrome (CRPS) is neuropathic pain syndrome that is more common

in women, with some studies showing a higher prevalence among women aged 25 to 50

years. Patient 3 suffered from CRPS of the right upper extremity.


Decision Makers’ Opinions Changing Attitude-Driven Consensus Model under Linguistic Environment and Its Application in Dynamic MAGDM Problems

B Dutta, D Guha – Granular Computing and Decision-Making, 2015

Based on the concept of soft consensus, vari- ous consensus reaching processes

(CRPs) have been designed in the literature [22]. The existing CRPs for solving GDM

problems can be classified in two categories: static consensus


Peripheral Nerve Stimulationperipheral nerve stimulation

AS Hanna – Anatomy and Exposures of Spinal Nerves, 2015

Download Chapter (482 KB). Abstract. Peripheral nerve stimulation is an off-label use of spinal

cord stimulators. It is used for intractable pain in a peripheral nerve distribution, refractory to

medical management, especially with complex regional pain syndrome (CRPS ).


[HTML] External Fixation and Adjuvant Pins Versus Volar Locking Plate Fixation in Unstable Distal Radius Fractures: A Randomized, Controlled Study With a 5-Year Follow- …

JH Williksen, T Husby, JC Hellund, HD Kvernmo… – The Journal of Hand …, 2015

At the 5-year follow-up, 3 patients had died, 1 (with an extensor pollicis longus rupture) had moved

abroad, and 2 (1 patient with complex regional pain syndrome [CRPS]) withdrew from the study.

Carpal tunnel syndrome, 2, 1. CRPS, 0, 1. Extensor tendon synovitis, 0, 5.


Complex regional pain syndrome type I: a comprehensive review

M Bussa, D Guttilla, M Lucia, A Mascaro, S Rinaldi – Acta Anaesthesiologica …, 2015

Background. Complex regional pain syndrome type I (CRPS I), formerly known as reflex

sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a

minor injury to a limb. Pathophysiological mechanisms of CRPS I.


Phenotype-Specific Diagnosis of Functional (Psychogenic) Movement Disorders

AJ Espay, AE Lang – Current Neurology and Neuroscience Reports, 2015


Diagnosis of Functional (Psychogenic) Movement Disorders Alberto J. Espay1,3 & Anthony

E. Lang2 © Springer Science+Business Media New York 2015


[PDF] Time-consistent calibration of short-term regional wind power ensemble forecasts


For minimum score esti- mation, we use the continuous ranked probability score (crps). For

a forecast cumulative distribution function (cdf) Fp(x) and the verifying obser- vation y, the crps

can be calculated as: crps(Fp,y) = ∞ ∫ − Fp(x) − Θ(x − y) ]2 dx (4.4)


Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization

S Tomisawa, Y Sato, M Kamiya, Y Kumaki, T Kikukawa… – Protein Expression and …, 2015

The mouse Paneth cell α-defensins, termed cryptdins (Crps) 1 , are secreted into the lumen of

the small intestinal crypts in response to exposure to bacteria or bacterial antigens [6]. Among

the known isoforms, cryptdin-4 (Crp4) has the most potent antimicrobial activity [7


[PDF] Erythrocyte Sedimentation Rate, C-Reactive Protein and Procalcitonin in Infections of the Spine and Infections in Spinal Cord Injury Patients

JAL Buensalido, MP Reyes – Open Infectious Diseases Journal, 2015

One study reported a mean CRP of 3 mg/L in paraplegics, while a mixed paraplegia/tetraplegia

study that excluded patients with CRPs >10 mg/L, also showed a mean of 3 mg/L. Another group

noted that mean CRP level was 38 mg/L, or 27% higher, in SCI versus non-SCI




The role of sleep in pain and fibromyalgia.

EH Choy – Nature reviews. Rheumatology, 2015

Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced

pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common

symptoms include nonrestorative sleep, fatigue, cognitive dysfunction, stiffness and mood


Nonpharmacological Treatments of Insomnia for Long-Term Painful Conditions: A Systematic Review and Meta-analysis of Patient-Reported Outcomes in …

NK Tang, ST Lereya, H Boulton, MA Miller, D Wolke… – Sleep, 2015

This study evaluated the effect of nonpharmacological sleep treatments on

patient-reported sleep quality, pain, and well-being in people with long-term cancer

and non-cancer (eg, back pain, arthritis, fibromyalgia) pain conditions.



S Hoffman – US Patent 20,150,111,878, 2015

Abstract: The present invention provides methods, compositions, and kits for treating intestinal

hyperpermeability in a subject in need thereof, including underlying diseases such as diabetes,

autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease


American College of Lifestyle Medicine Expert Panel Discussion Treat the Cause: Evidence-Based Practice*

JM Rippe, M Greger, DL Katz, JH Kelly, M Moore… – American Journal of …, 2015

Following this strategy, I am fostering clinical evaluation of coaching for fibromyalgia,

for which there is no good treatment other than exercise. However, it has taken 10

years to get to the place where we have enough coaches


Whole body vibration training in patients with COPD A systematic review

R Gloeckl, I Heinzelmann, K Kenn – Chronic Respiratory Disease, 2015

Abstract. In recent years, several studies have shown that whole body vibration training (WBVT)

may be a beneficial training mode in a variety of chronic diseases and conditions such as

osteoporosis, fibromyalgia, multiple sclerosis, or chronic low back pain.


[PDF] Fibromyalgia Syndrome AmongIraqi Patients with Systemic Lupus Erythematosus: A Case Control Study

ZS Al-Rawi, HAJ Badran, FI Gorial

Abstract: Objective: To determine the prevalence of fibromyalgia syndrome (FMS) among

Iraqi patients with systemic lupus erythematosus (SLE) and its association with disease

activity. Patients and methods: This case control study included 100 patients with SLE and


[PDF] Quality of life, sense of coherence and experiences with three different treatments in patients with psychological distress in primary care: a mixed-methods study

T Arvidsdotter, C Taft, B Marklund, S Kylén – BMC Complementary and Alternative …, 2015

More detailed data on the procedure are reported elsewhere [48]. The patients had a primary

diagnosis of depression, anxiety or panic disorders, severe stress, somatic symptoms/pain

(including irritable bowel syndrome, fibromyalgia, migraine, fatigue) or sleep disorders.



N Shiraishi, H Hoshii, W Hamaguchi, E Honjo… – US Patent 20,150,111,876, 2015

containing bicyclic compound having a PAM action of GABA B , and it use for preventing

and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum

disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot



R Aung-din – US Patent 20,150,111,930, 2015

respective receptors. They are indicated for such diverse and seemingly different

conditions as: focal onset seizures, post-herpetic neuralgia, diabetic peripheral

neuropathy, fibromyalgia, anxiety, and drug withdrawal syndromes. The


Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

YH Lee, SC Bae, SJ Choi, JD Ji, GG Song – Lupus, 2015


[HTML] Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia

B Regland, S Forsmark, L Halaouate, M Matousek… – 2015

Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue

syndrome) may respond most favorably to frequent vitamin B12 injections, in vital

combination with oral folic acid. However, there is no established algorithm for


Cardiovascular control in women with fibromyalgia syndrome: do casual methods provide non redundant information compared to more traditional approaches?

AR Zamunér, A Porta, CP Andrade, A Marchi, M Forti… – American Journal of …, 2015

Abstract The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have

been widely studied in FMS patients through the computation of linear indices of

spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However,


Aberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia

CM Brummett, AG Lohse, A Tsodikov, SE Moser… – Regional Anesthesia and …, 2015

Abstract Background and Objectives: Facet interventions for spine pain have high failure

rates, and preprocedural prediction of response is nearly impossible. A potential explanation

may be aberrant central pain processing as that existing in conditions like fibromyalgia. To


[HTML] Effects of Whole-Body Vibration Therapy in Patients with Fibromyalgia: A Systematic Literature Review

D Collado-Mateo, JC Adsuar, PR Olivares… – … -Based Complementary and …, 2015

Objective. To review the literature on the effects of whole-body vibration therapy in patients

with fibromyalgia. Design. Systematic literature review. Patients. Patients with fibromyalgia.

Methods. An electronic search of the literature in four medical databases was performed to


Six Syndromes with Surprising Psychotherapy Solutions

T Rodriguez, V Stern – Scientific American Mind, 2015

These links to content published by NPG are automatically generated. Cognitive behavioral

therapy for fibromyalgia. Utility of cognitive behavioral therapy as a treatment for insomnia in

patients with fibromyalgia. Nature Clinical Practice Rheumatology (01 Apr 2006).


Comorbid Conditions Do Not Differ in Children and Young Adults with Functional Disorders with or without Postural Tachycardia Syndrome

G Chelimsky, K Kovacic, M Nugent, A Mueller… – The Journal of Pediatrics, 2015

All patients underwent formal autonomic testing, Beighton scores assessment for joint

hypermobility (0-9), and fibromyalgia tender points (0-18) (43 subjects). Results. All subjects with

fibromyalgia by tender point-examination had a Beighton score ≥4 (P = .002). Conclusions.


Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias

S Regauer, B Eberz, C Beham‐Schmid – APMIS, 2015

Similar to other chronic pain syndromes among which are chronic pelvic and bladder pain,

fibromyalgia, and atopic dermatitis morphological correlates are hyperinnervation and increased

infiltrates of mast cells [3-5]. Activated mast cells release pre-stored or rapidly produced


Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study

E Generaal, N Vogelzangs, GJ Macfarlane, R Geenen… – Annals of the Rheumatic …, 2015

Previous studies mostly defined chronic widespread pain, a cardinal symptom of the fibromyalgia

syndrome, as axial and bilateral pain above and below the waist.41 With this somewhat ‘less

stringent’ definition, we may have included some patients with milder pain.


Speed, science and optimal pain relief

RA Moore – International Journal of Clinical Practice, 2015

For example, a retrospective analysis of patients with chronic back pain or fibromyalgia revealed

that patients rated their treatment as successful if their pain was reduced by 50–70%, from a level

of 5–10 on a visual analogue scale (total score 10) to below three (no more than


[PDF] An Insight of D 鄄 Ribose Metabolic Imbalance in Type 2 Diabetes Mellitus

T SU, RQ HE – Progress in Biochemistry and Biophysics, 2015

14-15]. Ribose is often marked as a supplement for bodybuilders with a common

recommended daily dose of 5g or more and has also been used to reduce fatigue

in fibromyalgia and chronic fatigue syndrome [2,16]. Ribose