Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
J Fischell, AM Van Dyke, MD Kvarta, TA LeGates… – … : official publication of the …, 2015
… The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but
has troubling side-effects. We hypothesized that negative allosteric modulators of
GABAA receptors would exert similar effects on brain activity …
Temporal evoltion on MRI of successful treatment of rabies
A Lu, P Shah, P Shen, P Lee, AE Nidecker… – Clinical Imaging, 2015
… Her treatment regimen came to be known as the “Milwaukee protocol” [1]. Briefly, the
protocol consists of using a sedative agent such as ketamine, midazolam, propofol, or
a combination to place the patient in a medically induced coma. …
Y Kopelman, Y Nir, Y Siman-Tov, B Person, O Zmora – J Gastrointest Dig Syst, 2015
… Preemptive analgesia (intramuscular Dipyron 1 gr) was given to all any amounts prior to surgery.
The animals were anesthetized with a combination of Ketamine 22 mg/mL and Xylazine injection
(Apectrum Chemicals and Laboratory Products, Gardena, California) 1 mg/kg IM. …
[PDF] The optimal fitting model for aging-related receptive field size curve of macaque V1 neurons
J Cui, H Ding, L Wang, J Qiang – … on Mechatronics, Electronic, Industrial and Control …, 2015
… of 28 years. An initial ophthalmological examination was performed under ketamine
(100 mg/kg im, Ketalar, Parke-Davis, Morris Plains, NJ, USA) anesthesia to screen
for monkeys with ocular pathology. B. Visual Stimulation …
[PDF] Preventing Testicular Damage in Genital Burns With Cooling: An Experimental Study
AE Abalı, H Özdemir
… The sham group (S group) consisted of 10 healthy testes. In this group, rats were anesthetized
with an intraperitoneal injection of 100 mg/kg ketamine hydrochloride (Alfamine 10%, Alfasan,
Holland) and 10 mg/kg … Animals were killed by high-dose ketamine HCl. …
[PDF] JAMES A. McNAMARA, JR., DDS, Ph. DT
T KURODA
… Page 2. Ketamine & Phencyclidine . . . … Dosage, prepared according to levels
recommended by other investigators-fit10:11 was as fol- lows: phencyclidine HCl,
1.5 ngkg. of body weight (intramuscular); ketamine HCI, 25 mgjkg. …
Fine-scale genetic structure of the ringtail (Bassariscus astutus) in a Sky Island mountain range
RC Lonsinger, RM Schweizer, JP Pollinger, RK Wayne… – Journal of Mammalogy, 2015
… Traps were baited with dry cat food and either loganberry paste or sardines. Captured ringtails
were anesthetized using a mixture of medetomidine hydrochloride (50 µg/kg) and ketamine
hydrochloride (5mg/kg) injected intramuscularly (Orion Corporation, Espoo, Finland). …
[PDF] Evaluation of the Effect of Alfalfa Extract on Breast Cancer
F Nabatchian, SMH Aghoosi, A Mordadi, F Khodaverdi – J. Appl. Environ. Biol. Sci, 2015
… normal saline. In the solution, the tumor was cut into 3 mm2 pieces. Then, the mice
in the first and second groups were anesthetized with intraperitoneal injection of
ketamine (10 mg/kg) and xylene (5 mg/kg). The tumor pieces …
Effects of light pollution on seasonal estrus and daily rhythms in a nocturnal primate
T LeTallec, M Théry, M Perret – Journal of Mammalogy, 2015
… Ltd, Saint-Paul, Minnesota) previously implanted in the visceral cavity under general anesthesia
and under veterinary supervision (Diazepam-Valium: 1mg/100g, subcutaneous injection; Ketamine
hydrochloride-Imalgen: 10mg/100g, intraperitoneal injection; postoperative …
[PDF] Evaluation of Cissampelos pareira root for antifertility activity
J Samanta, S Bhattacharya, AC Rana – Journal of Pharmacy Research Vol, 2015
… from D1 pregnancy. On day 12th day (D12) all the rats of control and treated group
were anaesthetized with normal dose of ketamine-xylazine anaesthesia15 and
laparotomized to count the no. of implants of each rat. 2.3.6. Effectsof …
Radiofrequency Ablation (RFA)
[HTML] Transcatheter embolization therapy in liver cancer: an update of clinical evidences
YXJ Wáng, T De Baere, JM Idée, S Ballet – Chinese Journal of Cancer Research, 2015
… 2-4). For the treatment of early stage HCC, curative therapies including liver transplantation,
hepatic resection, and radiofrequency ablation (RFA) are … coagulative necrosis of both the tumor
and a rim of surrounding parenchymal tissue producing a margin of ablated non-tumoral …
ES Olson, JV Kauphusman, LK Nemec, TT Tegg – US Patent 20,150,112,331, 2015
… According to at least one medical study (See, eg, Ikeda et al., Radiofrequency Ablation Catheter
with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine
Heart, Conference Proceedings of the Hearth Rhythm Society, May 2008 and …
ELECTRICAL STIMULATION OF THE CAROTID ARTERY
I Gillbe – US Patent 20,150,112,359, 2015
… or bodies without heating the tissues to a temperature at which they are ablated such that … the
RF energy delivered is of a non-thermal nature, so that ablation and possible … As previously
described, pulsed radiofrequency is employed for this purpose; comprising short bursts of …
METHOD TO REDUCE SENSE OF TASTE AND FOOD INTAKE
H Li – US Patent 20,150,112,326, 2015
… To ablate the subsurface tissue without ablating the surface tissue of the mouth, a room … During
a heat induced ablation with fluid cooling, ablation head and the tissue surface in … delivered into
it from an energy source such as ultrasound, microwave, and radiofrequency current. …
MODULATION OF NERVES INNERVATING THE LIVER
BR Azamian, JA Coe, SB Vafai – US Patent 20,150,112,332, 2015
… In some embodiments, the neuromodulation catheter is a radiofrequency (RF) ablation catheter
comprising … about substantially 180 degrees of the vessel circumference to ablate in a … In some
embodiments, other patterns of ablation electrode movement (regardless of inherent …
BALLOON CATHETERS WITH FLEXIBLE CONDUCTING WIRES AND RELATED METHODS OF USE AND MANUFACTURE
MR Willard, DC Sutermeister, KR Larson, TA Ostroot… – US Patent 20,150,112,328, 2015
… Sympathetic nerve ablation device 12 may be used to ablate nerves (eg, renal nerves) disposed
adjacent to the kidney K (eg, renal nerves … Sympathetic nerve modulation device 12 may be
configured to deliver ablation energy, for example, radiofrequency energy, to a target …
Current Control Methods and Systems
H Cadouri – US Patent 20,150,112,321, 2015
… an energy field to a target site in the renal artery (eg, via radiofrequency ablation) have been … above
45° C. (or above 60° C. in other cases) may induce thermal ablation of the … In some patients, it
may be desirable to achieve temperatures that thermally ablate the target neural …
DIAPHRAGM ENTRY FOR POSTERIOR SURGICAL ACCESS
SD Fleischman, R Neubert, EW Rogers – US Patent 20,150,112,145, 2015
… Atrial fibrillation surgery involving radiofrequency, DC, microwave, ultrasound, laser or other
modes of thermal … of focusing energy into local areas spaced at known distances from the ablation
device (in … tissue in the ventricles from the diaphragm) are used to ablate the imaged …
S Narouze, HT Benzon, D Provenzano, A Buvanendran…
… C, cervical; T, thoracic; L, lumbar; S, sacral; MBNB, medial branch nerve block; RFA,
radiofrequency ablation *Patients with high risk for bleeding undergoing low or intermediate
risk procedures should be treated as internmediate or high risk repectively. …
SYSTEM AND METHOD FOR TREATING URINARY TRACT DISORDERS
U Eshel – US Patent 20,150,112,413, 2015
… transurethral microwave thermotherapy (temperatures over 46 degrees Celsius that cause tissue
ablation to exposed … that the higher level of heat in the surrounding non-ablated tissue either … It
includes a catheter with a sheathed radiofrequency antenna, surrounded by a flow of …
Complex Regional Pain Syndrome (CRPS/RSD)
What is the maximum safe tourniquet time in elective upper limb surgery?
N Sawant, GEB Giddins – Journal of Hand Surgery (European Volume), 2015
… Two patients developed chronic regional pain syndrome type 1 (CRPS 1). In one patient this
was noticed 4 weeks following complex rheumatoid surgery. The tourniquet time was 2 hours
4 minutes and there was no immediate post-operative pain or distal paraesthesia. …
MJ Dixon, PM Taylor, B Dixon – US Patent 20,150,107,525, 2015
… [2] Millecamps, Laferrière, Ragavendran, Stone, Coderre: “Role of peripheral endothelin receptors
in an animal model of complex regional pain syndrome type 1 (CRPS-I)” J Pain, volume 151
(2010) pages 174-183; [3] Ugo Basile Leaflet for Von Frey Hairs (with grid) Cat. No. …
FJ Quesada, I Palomares, L Martínez – Granular Computing and Decision-Making, 2015
… sufficiently to reach the solution made. In order to overcome this drawback, Consensus
Reaching Processes (CRPs) were introduced as an additional phase in the resolution
process for GDM problems [17]. In a CRP, experts try …
The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature
AC Young, TR Lubenow, A Buvanendran – Regional Anesthesia and Pain Medicine, 2015
… Complex regional pain syndrome (CRPS) is neuropathic pain syndrome that is more common
in women, with some studies showing a higher prevalence among women aged 25 to 50
years. … Patient 3 suffered from CRPS of the right upper extremity. …
B Dutta, D Guha – Granular Computing and Decision-Making, 2015
… Based on the concept of soft consensus, vari- ous consensus reaching processes
(CRPs) have been designed in the literature [22]. The existing CRPs for solving GDM
problems can be classified in two categories: static consensus …
Peripheral Nerve Stimulationperipheral nerve stimulation
AS Hanna – Anatomy and Exposures of Spinal Nerves, 2015
… Download Chapter (482 KB). Abstract. Peripheral nerve stimulation is an off-label use of spinal
cord stimulators. It is used for intractable pain in a peripheral nerve distribution, refractory to
medical management, especially with complex regional pain syndrome (CRPS ). …
JH Williksen, T Husby, JC Hellund, HD Kvernmo… – The Journal of Hand …, 2015
… At the 5-year follow-up, 3 patients had died, 1 (with an extensor pollicis longus rupture) had moved
abroad, and 2 (1 patient with complex regional pain syndrome [CRPS]) withdrew from the study. …
Carpal tunnel syndrome, 2, 1. CRPS, 0, 1. Extensor tendon synovitis, 0, 5. …
Complex regional pain syndrome type I: a comprehensive review
M Bussa, D Guttilla, M Lucia, A Mascaro, S Rinaldi – Acta Anaesthesiologica …, 2015
… Background. Complex regional pain syndrome type I (CRPS I), formerly known as reflex
sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a
minor injury to a limb. … Pathophysiological mechanisms of CRPS I. …
Phenotype-Specific Diagnosis of Functional (Psychogenic) Movement Disorders
AJ Espay, AE Lang – Current Neurology and Neuroscience Reports, 2015
Page 1. MOVEMENT DISORDERS (M OKUN, SECTION EDITOR) Phenotype-Specific
Diagnosis of Functional (Psychogenic) Movement Disorders Alberto J. Espay1,3 & Anthony
E. Lang2 © Springer Science+Business Media New York 2015 …
[PDF] Time-consistent calibration of short-term regional wind power ensemble forecasts
S SPäTH, L VON BREMEN, C JUNk, D HEINEMANN – 2015
… For minimum score esti- mation, we use the continuous ranked probability score (crps). … For
a forecast cumulative distribution function (cdf) Fp(x) and the verifying obser- vation y, the crps
can be calculated as: crps(Fp,y) = ∞ ∫ − Fp(x) − Θ(x − y) ]2 dx (4.4) …
S Tomisawa, Y Sato, M Kamiya, Y Kumaki, T Kikukawa… – Protein Expression and …, 2015
… The mouse Paneth cell α-defensins, termed cryptdins (Crps) 1 , are secreted into the lumen of
the small intestinal crypts in response to exposure to bacteria or bacterial antigens [6]. Among
the known isoforms, cryptdin-4 (Crp4) has the most potent antimicrobial activity [7 …
JAL Buensalido, MP Reyes – Open Infectious Diseases Journal, 2015
… One study reported a mean CRP of 3 mg/L in paraplegics, while a mixed paraplegia/tetraplegia
study that excluded patients with CRPs >10 mg/L, also showed a mean of 3 mg/L. Another group
noted that mean CRP level was 38 mg/L, or 27% higher, in SCI versus non-SCI …
Fibromyalgia
The role of sleep in pain and fibromyalgia.
EH Choy – Nature reviews. Rheumatology, 2015
Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced
pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common
symptoms include nonrestorative sleep, fatigue, cognitive dysfunction, stiffness and mood …
NK Tang, ST Lereya, H Boulton, MA Miller, D Wolke… – Sleep, 2015
… This study evaluated the effect of nonpharmacological sleep treatments on
patient-reported sleep quality, pain, and well-being in people with long-term cancer
and non-cancer (eg, back pain, arthritis, fibromyalgia) pain conditions. …
COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY
S Hoffman – US Patent 20,150,111,878, 2015
… Abstract: The present invention provides methods, compositions, and kits for treating intestinal
hyperpermeability in a subject in need thereof, including underlying diseases such as diabetes,
autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease …
JM Rippe, M Greger, DL Katz, JH Kelly, M Moore… – American Journal of …, 2015
… Following this strategy, I am fostering clinical evaluation of coaching for fibromyalgia,
for which there is no good treatment other than exercise. However, it has taken 10
years to get to the place where we have enough coaches …
Whole body vibration training in patients with COPD A systematic review
R Gloeckl, I Heinzelmann, K Kenn – Chronic Respiratory Disease, 2015
… Abstract. In recent years, several studies have shown that whole body vibration training (WBVT)
may be a beneficial training mode in a variety of chronic diseases and conditions such as
osteoporosis, fibromyalgia, multiple sclerosis, or chronic low back pain. …
[PDF] Fibromyalgia Syndrome AmongIraqi Patients with Systemic Lupus Erythematosus: A Case Control Study
ZS Al-Rawi, HAJ Badran, FI Gorial
Abstract: Objective: To determine the prevalence of fibromyalgia syndrome (FMS) among
Iraqi patients with systemic lupus erythematosus (SLE) and its association with disease
activity. Patients and methods: This case control study included 100 patients with SLE and …
T Arvidsdotter, C Taft, B Marklund, S Kylén – BMC Complementary and Alternative …, 2015
… More detailed data on the procedure are reported elsewhere [48]. The patients had a primary
diagnosis of depression, anxiety or panic disorders, severe stress, somatic symptoms/pain
(including irritable bowel syndrome, fibromyalgia, migraine, fatigue) or sleep disorders. …
SULFUR-CONTAINING BICYCLIC COMPOUND
N Shiraishi, H Hoshii, W Hamaguchi, E Honjo… – US Patent 20,150,111,876, 2015
… containing bicyclic compound having a PAM action of GABA B , and it use for preventing
and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum
disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot …
TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY
R Aung-din – US Patent 20,150,111,930, 2015
… respective receptors. They are indicated for such diverse and seemingly different
conditions as: focal onset seizures, post-herpetic neuralgia, diabetic peripheral
neuropathy, fibromyalgia, anxiety, and drug withdrawal syndromes. The …
YH Lee, SC Bae, SJ Choi, JD Ji, GG Song – Lupus, 2015
[HTML] Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia
B Regland, S Forsmark, L Halaouate, M Matousek… – 2015
Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue
syndrome) may respond most favorably to frequent vitamin B12 injections, in vital
combination with oral folic acid. However, there is no established algorithm for …
AR Zamunér, A Porta, CP Andrade, A Marchi, M Forti… – American Journal of …, 2015
Abstract The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have
been widely studied in FMS patients through the computation of linear indices of
spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However, …
Aberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia
CM Brummett, AG Lohse, A Tsodikov, SE Moser… – Regional Anesthesia and …, 2015
Abstract Background and Objectives: Facet interventions for spine pain have high failure
rates, and preprocedural prediction of response is nearly impossible. A potential explanation
may be aberrant central pain processing as that existing in conditions like fibromyalgia. To …
D Collado-Mateo, JC Adsuar, PR Olivares… – … -Based Complementary and …, 2015
Objective. To review the literature on the effects of whole-body vibration therapy in patients
with fibromyalgia. Design. Systematic literature review. Patients. Patients with fibromyalgia.
Methods. An electronic search of the literature in four medical databases was performed to …
Six Syndromes with Surprising Psychotherapy Solutions
T Rodriguez, V Stern – Scientific American Mind, 2015
… These links to content published by NPG are automatically generated. Cognitive behavioral
therapy for fibromyalgia. … Utility of cognitive behavioral therapy as a treatment for insomnia in
patients with fibromyalgia. Nature Clinical Practice Rheumatology (01 Apr 2006). …
G Chelimsky, K Kovacic, M Nugent, A Mueller… – The Journal of Pediatrics, 2015
… All patients underwent formal autonomic testing, Beighton scores assessment for joint
hypermobility (0-9), and fibromyalgia tender points (0-18) (43 subjects). Results. … All subjects with
fibromyalgia by tender point-examination had a Beighton score ≥4 (P = .002). Conclusions. …
Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias
S Regauer, B Eberz, C Beham‐Schmid – APMIS, 2015
… Similar to other chronic pain syndromes among which are chronic pelvic and bladder pain,
fibromyalgia, and atopic dermatitis morphological correlates are hyperinnervation and increased
infiltrates of mast cells [3-5]. Activated mast cells release pre-stored or rapidly produced …
E Generaal, N Vogelzangs, GJ Macfarlane, R Geenen… – Annals of the Rheumatic …, 2015
… Previous studies mostly defined chronic widespread pain, a cardinal symptom of the fibromyalgia
syndrome, as axial and bilateral pain above and below the waist.41 With this somewhat ‘less
stringent’ definition, we may have included some patients with milder pain. …
Speed, science and optimal pain relief
RA Moore – International Journal of Clinical Practice, 2015
… For example, a retrospective analysis of patients with chronic back pain or fibromyalgia revealed
that patients rated their treatment as successful if their pain was reduced by 50–70%, from a level
of 5–10 on a visual analogue scale (total score 10) to below three (no more than …
[PDF] An Insight of D 鄄 Ribose Metabolic Imbalance in Type 2 Diabetes Mellitus
T SU, RQ HE – Progress in Biochemistry and Biophysics, 2015
… 14-15]. Ribose is often marked as a supplement for bodybuilders with a common
recommended daily dose of 5g or more and has also been used to reduce fatigue
in fibromyalgia and chronic fatigue syndrome [2,16]. Ribose …