Latest Pain Research News!

Latest Pain Research News!

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.



[HTML] Upper urinary tract damage caused by ketamine snorting—A report of nine cases

HY Lee, YC Hsu, CY Hsu, ECL Chou, CC Li, YS Juan… – Urological Science, 2015

Objective The toxicity of ketamine to genitourinary system not only involved in lower urinary

tract, which include urinary frequency, urgency, suprapubic pain, dysuria and hematuria, but

also upper urinary tracts. However, the reports of ketmaine-induced upper urinary tract


Inconsistency of allometric scaling for dissociative anesthesia of wild felids

AB Carregaro, GC Freitas, SP Bisetto, NV Xavier… – Veterinary anaesthesia and …, 2015

Keywords: allometric scaling; dissociative anesthesia; ketamine; metabolic rate; xylazine.

Abstract. Objective. To evaluate allometric scaling for ketamine–xylazine (KX) anesthesia

in wild felids using domestic cats for reference. Study design.


[PDF] The ERα-PI3K Cascade in Pro-opiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice

L Zhu, P Xu, X Cao, Y Yang, AO Hinton Jr, Y Xia… – Endocrinology, 2015

Hypothalamic ER -p85 interaction and phosphorylation of AKT in response to icv PPT

Female C57Bl6 mice (12 weeks) were anesthetized with ip injections of

ketamine/xylazine cocktail (100 mg/kg ketamine and 10 mg/kg xylazine).


[HTML] Effects of leptin on sympathetic nerve activity in conscious mice

DA Morgan, F Despas, K Rahmouni – Physiological Reports, 2015

Here, we examined the sympathetic responses evoked by leptin in conscious mice. Mice

were instrumented, under ketamine/xylazine anesthesia, with renal or lumbar SNA

recordings using a thin (40 gauge) bipolar platinum–iridium wire.


[PDF] Treatment of Pain with Antidepressants

B Kerr, C Benson, K Mifflin, SJB Jesudasan, S Dursun… – Klinik Psikofarmakoloji …, 2015

depression43-45. There has been a great deal of interest in the NMDA receptor antagonist

ketamine and its rapid acting antidepressant action when infused46,47, and it is interesting that

this drug has also been used in treatment of therapy-resistant chronic pain48.


Use of LigaSure on bile duct in rats. An experimental study.

A Marte, L Pintozzi – Minerva pediatrica, 2015

in rats. MATERIALS AND METHODS: Thirty Wistar rats weighing 70 to 120gr were

employed for this study. The animals were all anaesthetized with intraperitoneal

Ketamine and then divided into three groups. The first group


[HTML] Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats

RA Maheshwari, F Dhakwala, R Balaraman, AK Seth… – Indian Journal of …, 2015

Standard drug Calcium Sandoz (cholecalciferol), ketamine hydrochloride, diazepam, povidone,

and ampicillin were purchased from commercial market. The rats were anesthetized with injection

of ketamine hydrochloride (40 mg/kg. ip) and diazepam (5 mg/kg, im).


Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala

K László, A Kovács, O Zagoracz, T Ollmann, L Péczely… – Behavioural Brain Research, 2015

00 h. 2.2. Surgery. Rats were anesthetized ip by ketamine supplemented with

diazepam (Calypsol and Seduxen, Richter Gedeon, Hungary, ketamine: 80

mg/kg body weight, diazepam: 20 mg/kg body weight). Animals were


Minocycline Attenuates Depressive‐like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway

SSS Saravi, SE Mousavi, SSS Saravi, AR Dehpour – Basic & Clinical Pharmacology & …, 2015

Testicular Torsion/Detorsion Animals were anaesthetized with intraperitoneal injection of ketamine

HCl (50 mg/kg) and chlorpromazine (25 mg/kg). 30 days. Testosterone assay At day 30, the rats

were anaesthetized with intraperitoneal injection of ketamine HCl (50 mg/kg)


Spinal Reflexes and Windup In Vitro: Effects of Analgesics and Anesthetics

I Rivera‐Arconada, C Roza, JA Lopez‐Garcia – CNS Neuroscience & Therapeutics, 2015

Spinal cord mechanisms may contribute toward analgesia and akinesia. Ketamine.

The general anesthetic ketamine is a noncompetitive blocker of NMDA receptors

that also shows activity on several ionic channels. As expected


Augmentation Therapy With Serial Intravenous Ketamine Over 18 Months in a Patient With Treatment Resistant Depression.

S Hassamal, M Spivey, AK Pandurangi – Clinical Neuropharmacology, 2015

Abstract Major depressive disorder is a severe illness that affects 3% to 7% of adults

annually in the United States. About 30% of these individuals are refractory to multiple

treatment trials. Recent reports have found a significant and almost immediate


Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells Via a GSK‐3β‐Dependent Mechanism

HY Shyu, CJ Ko, YC Luo, HY Lin, SR Wu, SW Lan… – Journal of Cellular …, 2015

Abstract Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal

recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous

effects, including renal failure; however, the underlying mechanism is poorly understood.


More effective induction of anesthesia using midazolam-butorphanol-ketamine-sevoflurane compared with ketamine-sevoflurane in the common marmoset monkey ( …

H ISHIBASHI – Journal of Veterinary Medical Science, 2015

The common marmoset has been increasingly used for research in the biomedical field;

however, there is little information available regarding effective methods of anesthesia in this

species. This study retrospectively analyzed 2 regimens of anesthesia induction:


[HTML] Comparison of Ketamine–Medetomidine-butorphanol and Ketamine–dexmedetomidine-butorphanol Anesthesia in Rats

R Costea, D Lastofka, M Mehedinţu – Agriculture and Agricultural Science Procedia, 2015

Abstract We evaluated the effect of ketamine-dexmedetomidine-butorphanol (K, 80 mg/kg;

D, 0.25 mg/kg, B, 0.5 mg/kg) and ketamine-medetomidine-butorphanol (K, 80 mg/kg; M, 0.25

mg/kg, B, 0.5 mg/kg) administered intraperitoneally, during anesthesia and immediate


Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increased survival after pneumococcal superinfection

K Reppe, P Radünzel, K Dietert, T Tschernig, T Wolff… – Infection and Immunity, 2015

Five days after IAV infection, 114 the mice were anesthetized intraperitoneally

(ip) with ketamine (80 mg/kg, Ketavet®, Pfizer, 115 re-suspended in sterile PBS.

Mice were anesthetized ip with ketamine and xylazine and 123


Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load

S Choudhury, K Kannan, BS Maruti, MP Addison… – European Journal of …, 2015

ad libitum. The animals were anesthetized by injection of xylazine (10 µg/g body

weight, intraperitoneally) and ketamine (80 µg/g body weight, intraperitoneally) and

a 2-cm ventral midline incision was performed. The cecum


[HTML] Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

YJ Lai, GJ Chang, YH Yeh, JHS Pang, CC Huang… – PLOS ONE, 2015

All the surgery was performed under ketamine and xylazine ip anesthesia, and all efforts were

made to minimize suffering. Housing and maintenance was provided by Chang Gung University,

All animals were fed a standard chow diet with free access to water.


[HTML] Serotonin 5-HT 7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg 2+-ATPase imbalances in spinal cord-injured male rats

A Norouzi-Javidan, J Javanbakht, F Barati, N Fakhraei… – Diagnostic Pathology, 2015

Animals were anesthetized by intraperitoneal injection of a mixture of ketamine hydrochloride

(75 mg/kg) and xylazine hydrochloride (5 mg/kg). All animals were anesthetized (ketamine

hydrochloride 10 % + xylazine 2 %, in 80 and 5 mg/kg doses, respectively).


[HTML] Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis

M Ishizuka, Y Miyazaki, M Masuo, K Suhara, T Tateishi… – PLOS ONE, 2015

They were then placed under light anesthesia with 100 mg/kg ketamine and 10 mg/kg xylazine,

and 5 μg of PDE in 25 μl of 0.9% saline was sprayed into each mouse’s trachea using an

intratracheal MycroSprayer® aerosolizer (Penn-century, Wyndmoor, PA, USA).


Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model

Z Tang, S Li, P Han, J Yin, Y Gan, Q Liu, J Wang… – Journal of Neurochemistry, 2015

blinded to the randomization. Permanent Middle Cerebral Artery Occlusion (pMCAO) Mice were

under Ketamine/Xylazine anesthesia (80 mg/kg Ketamine and 10mg/kg Xylazine, injected ip).

Standard aseptic surgical procedures were used throughout the procedure. The


Radiofrequency Ablation (RFA)


Effectiveness and safety of computed tomography-guided radiofrequency ablation of renal cancer: a 14-year single institution experience in 203 patients

JD Iannuccilli, DE Dupuy, MD Beland, JT Machan… – European Radiology, 2015

Objectives To define effectiveness and safety of CT-guided radiofrequency ablation (RFA) of

renal tumours and prognostic indicators for treatment success. Methods Patients with a

single treatment of a solitary, biopsy-proven renal tumour with intent to cure over a 14-year


Outcomes associated with ablation compared to combined ablation and transilluminated powered phlebectomy in the treatment of venous varicosities.

AT Obi, BN Reames, TJ Rook, SO Mouch, A Zarinsefat… – Phlebology/Venous Forum …, 2015

RESULT: Venous clinical severity scores improved more with radiofrequency ablation +

transilluminated powered phlebectomy as compared to radiofrequency ablation alone

(3.8 ± 3.4 vs. 3.2 ± 3.1, p = 0.018). radiofrequency ablation alone.


Minimally invasive procedures for the management of vertebral bone pain due to cancer: The EAPC recommendations

S Mercadante, P Klepstad, G Paula Kurita, P Sjøgren… – Acta Oncologica, 2015

Radiofrequency ablation (RFA). RFA resulted more effective than radiotherapy and surgical

stabilization [99. Di Francesco A, Flamini S, Zugaro L, Zoccali C. Preoperative

radiofrequency ablation in painful osteolytic long bone metastases.


[HTML] Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis: A single-center retrospective cohort study

F Zhang, J Yan, XB Feng, F Xia, XW Li, KS Ma, P Bie – World J Gastroenterol, 2015

These procedures include liver transplantation, resection, and radiofrequency ablation[ 5 ]. Liver

transplantation may be the best treatment option for cirrhotic patients with HCC because it involves

the simultaneous removal of both the cirrhotic liver and HCC[ 6 ]. However, the


Ethanol ablation in post-biopsy liver hemorrhage following two failed Embolizations

MC Pope, DH Ballard, AL Sticker, C Ahuja… – Clinical Imaging, 2015

C. The feeding vessels were identified and ablated with an additional 10 mL ethanol injection.

to ultrasound-guided percutaneous ethanol injection for achieving hemostasis include techniques

such as cryoablation, radiofrequency (RF)-ablation, and cyanoacrylate glue


[PDF] Catheter Ablation of Fascicular Ventricular Tachycardia: Long Term Clinical Outcomes and Mechanisms of Recurrence

Y Liu, Z Fang, B Yang, P Kojodjojo, H Chen, W Ju… – Circulation: Arrhythmia and …, 2015

ablated. Arrhythmia recurrences after an initially successful ablation were caused by recurrent

FVT involving the Key words: ventricular tachycardia, radiofrequency, idiopathic left ventricular

tachycardia, fascicular ventricular tachycardia, outcomes, radiofrequency ablation


Liver metastases from adenocarcinomas of unknown primary site: management and prognosis in 68 consecutive patients

E Algin, A Ozet, O Gumusay, G Yilmaz, S Buyukberber… – Wiener klinische …, 2015

shown in Fig. 1. Among 39 patients who were managed with chemo- therapy, 12

patients received additional locoregional therapies including radiofrequency ablation

or transar- terial chemoembolization. Median OS was 9.4


[HTML] The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Q Pang, K Qu, JY Zhang, SD Song, SS Liu, MH Tai… – Medicine, 2015

Abbreviations: HBV = hepatitis B virus, HCC = hepatocellular carcinoma, HCV = hepatitis C virus,

HR = hazard ratio, MPV = mean platelet volume, OS = overall survival, PLT = platelet count, RFA =

radiofrequency ablation, RFS = recurrence-free survival, TACE = transcatheter


Safety and Feasibility of Open Chest Epicardial Mapping and Ablation of Ventricular Tachycardia During the Period of Left Ventricular Assist Device Implantation

M Patel, F Rojas, FR Shabari, L Simpson, W Cohn… – Journal of Cardiovascular …, 2015

Endocardial and epicardial radiofrequency ablation of ventricular tachycardia associated with

dilated cardiomyopathy: The importance of low-voltage scars. Comparison of epicardial

cryoablation and irrigated radiofrequency ablation in a swine infarct model.


Contact Force Variability during Catheter Ablation of Atrial Fibrillation: The Role of Atrial Rhythm and Ventricular Contractions: Co-Force AF Study

A Sarkozy, D Shah, J Saenen, J Sieira, T Phlips… – Circulation: Arrhythmia and …, 2015

3 Background Lesion formation by using radiofrequency (RF) current depends on the power

delivered, duration of energy application, temperature, tip size, and tip orientation. given RF power1.

Irrigated tip ablation catheters capable of real-time CF measurement have


[HTML] Pulmonary vein isolation using the visually guided laser balloon: a prospective, multicenter, and randomized comparison to standard radiofrequency ablation

SR Dukkipati, F Cuoco, I Kutinsky, A Aryana… – Journal of the American …, 2015

Background Balloon catheters have been designed to facilitate pulmonary vein (PV)

isolation in patients with paroxysmal atrial fibrillation (AF). The visually guided laser balloon

(VGLB) employs laser energy to ablate tissue under direct visual guidance. Objectives


Optimal Temperature for Radiofrequency Ablation of Lumbar Medial Branches for Treatment of Facet‐Mediated Back Pain

S Costandi, M Garcia‐Jacques, T Dews, M Kot, K Wong… – Pain Practice, 2015

Background Radiofrequency ablation (RFA) of the medial branch nerves that innervate the

facet joints is a well-established treatment modality; however, studies to determine the

optimal radiofrequency ablation temperature are lacking. A wide range (70 to 90 C) has


[HTML] Catheter Ablation of Atrial Fibrillation: Advent of Second-Generation Technologies

E Buch, K Shivkumar – Journal of the American College of Cardiology, 2015

and wide-area isolation (5), with or without additional lesion sets targeting non-PV

foci (6) or modifying atrial substrate. All of these techniques initially used

point-by-point ablation with radiofrequency (RF) ablation catheters.


[HTML] Computed tomography-guided percutaneous trephine removal of the nidus in osteoid osteoma patients: experience of a single center in Brazil

M Petrilli, AA Senerchia, AS Petrilli, HM Lederman… – Radiologia Brasileira, 2015

Osteoid osteoma: CTguided percutaneous radiofrequency ablation and follow-up in 47 patients.

J Vasc Interv Radiol. 2001;12:717–722. Peyser A, Applbaum Y, Khoury A, et al. Osteoid osteoma:

CT-guided radiofrequency ablation using a water-cooled probe. Ann Surg Oncol.


Proton beam therapy for metastatic liver tumors

N Fukumitsu, T Okumura, D Takizawa, H Makishima… – Radiotherapy and Oncology, 2015

The maximal diameter of the lesions was 1–18 cm (median, 4 cm). Of the 140 patients, 87

had received another form of treatment before PBT, such as chemotherapy, radiofrequency

ablation, transcatheter arterial chemoembolization, and surgery.


Accuracy of Late Gadolinium Enhancement-Magnetic Resonance Imaging in the Measurement of Left Atrial Substrate Remodeling in Patients With Rheumatic Mitral …

D Zhu, Z Wu, RJ van der Geest, Y Luo, J Sun, J Jiang… – International Heart Journal, 2015

We enrolled adult patients with rheumatic mitral valve disease and persistent AF who un-

derwent open-heart surgery for mitral valve replacement with concurrent radiofrequency

ablation for AF at our institution between February 2013 and March 2014.


Predictive value of nodule size and differentiation in HCC recurrence after liver transplantation

GG Piero, P Domenico, F Di Benedetto, M Elena… – Surgical Oncology, 2015

Generally, radiofrequency ablation (RFA) was proposed in cases of a single tumor less than 3

cm, whereas a single tumor > 3 cm or multifocal lesions in patients with impaired liver function

were directed instead to treatment with trans-arterial chemoembolization (TACE).


Radiofrequency ablation or stripping of large-diameter incompetent great saphenous varicose veins with C2 or C3 disease

EV Shaidakov, AG Grigoryan, EA Ilyukhin, VL Bulatov… – Journal of Vascular Surgery: …, 2015

Objective The objectives of this study were to compare the results of radiofrequency ablation

(RFA) and stripping for large-diameter varicose target veins for the period of 1 year, based

on a composite end point; to analyze the pain severity on a digital rating scale for 7 days


Clinical outcomes and risk factors of hepatocellular carcinoma treated by liver transplantation: A multi-centre comparison of living donor and deceased donor …

Z Hu, Z Qian, J Wu, J Zhou, M Zhang, L Zhou, S Zheng – Clinics and Research in …, 2015

HCC: hepatocellular carcinoma; LDLT: living donor liver transplantation; DDLT: deceased donor

liver transplantation; GWRW: graft weight/recipient weight; TACE: transcatheter arterial

chemoembolisation; RFA: radiofrequency ablation; PEI: percutaneous ethanol injection; ICU


[PDF] Hepatocellular carcinoma treatment strategies–a case-based review

R Alves, MT Gomes, CS Macedo, HP Miranda, F Nery – Journal of Solid Tumors, 2015

Resection techniques have been refined, from the use of new radiofrequency ablation resection

devices to laparoscopic approaches, both showing to diminished blood loss [1, 2]. A recent

meta-analysis showed that laparoscopic approach decreases blood loss, transfusion


Complex Regional Pain Syndrome (CRPS/RSD)


Skin sympathetic function in complex regional pain syndrome type 1

A Poudel, M Asahina, Y Fujinuma, Y Yamanaka… – Clinical Autonomic …, 2015

10.1007/s10286-015-0314-x. Copyright information. Abstract. Purpose. Cutaneous

sympathetic pathophysiology in complex regional pain syndrome type 1 (CRPS-1) is

not yet completely understood. To evaluate cutaneous sympathetic


Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

WW Li, TZ Guo, X Shi, Y Sun, T Wei, DJ Clark… – Neuroscience, 2015

hypersensitivity. Abstract. Tibia fracture in rodents induces substance P

(SP)-dependent keratinocyte activation and inflammatory changes in the hindlimb,

similar to those seen in complex regional pain syndrome (CRPS). In


Economic impact of mgnregp on rural livelihood security in tumkur district, karnataka–a sam analysis

CHR Gowda – 2015

Item Type: Thesis (Masters). Divisions: RP-Market Institutions and Policies. CRPS: CGIAR

Research Program on Policies, Institutions, and Markets. Uncontrolled Keywords: Economic

Impact, MGNREGP, Rural Livelihood Security, Karnataka, SAM analysis.


[PDF] DMSA-coated Iron Oxide Nanoparticle Greatly Affect the Expression of Genes Coding Cysteine-rich Proteins by its DMSA Coating

L Zhang, X Wang, J Zou, Y Liu, J Wang – Chemical Research in Toxicology, 2015

times. The results revealed that about one fourth of DEGs coded cysteine-rich proteins

(CRPs) in all cells under each treatment, indicating that the nanoparticles greatly

affected the expressions of CRP-coding genes. Additionally


Changing appearance using visual illusions improves ownership of the painful hand in complex regional pain syndrome

J Lewis, C McCabe, R Newport – 2015

Abstract. Background and aims People with Complex Regional Pain Syndrome (CRPS)

experience a diminished sense of ownership of their painful limb. Thirty nine patients with CRPS

of one arm were randomly allocated to either a control or experimental group.


The role of genetically‐engineered pigs in xenotransplantation research

DKC Cooper, B Ekser, J Ramsoondar, C Phelps… – The Journal of Pathology, 2015

This is because of the expression of human complement-regulatory proteins (CRPs) on the

surface of vascular endothelial cells. Pigs have similar CRPs, but these are relatively inefficient

at protecting the pig cells from human complement-mediated injury [13].


Individuality: How knowledge of body perception disturbance can inform treatment

J Lewis – 2015

Lewis, J. (2015) Individuality: How knowledge of body perception disturbance can inform

treatment. In: International Association of the Study of Pain (IASP) CRPS SIG, Zurich, Switzerland,

31 August – 1 September 2015. [img] Preview. PDF 1MB. Abstract.


Spinal Cord Stimulation (SCS) and Functional Magnetic Resonance Imaging (fMRI): Modulation of Cortical Connectivity With Therapeutic SCS

M Deogaonkar, M Sharma, C Oluigbo, DM Nielson… – … : Technology at the Neural …, 2015

Methods. Ten patients with complex regional pain syndrome (CRPS) or neuropathic leg pain

underwent thoracic epidural spinal cord stimulator implantation. Stimulation parameters associated

with “optimal” pain reduction were evaluated prior to imaging studies.


[PDF] Similarity-based semi-local estimation of EMOS models

S Lerch, S Baran – arXiv preprint arXiv:1509.03521, 2015

The most popular scoring rules providing summary measures of predictive performance are the

logarithmic score, ie, the negative logarithm of the predictive PDF evaluated at the verifying

observation, and the continuous ranked probability score (CRPS; Gneiting and Raftery


Review of Plastic Surgery

DW Buck II – 2015


[PDF] Independent CRP-Commissioned External Evaluation of the CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)

J Compton, D McLean, B Emmens, M Balagamwala – 2015

development partners (IFPRI, 2011). CRPs are not legal entities and therefore legal

and financial responsibility for A4NH ultimately rests with the lead CGIAR Center

and its Board of Trustees (IFPRI- BOT). 2. IFPRI is legally


[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis

C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015

Different diseases could lead to neuro- pathic pain including postsurgical pain, post-herpetic

neuralgia (PHN), spinal cord stenosis (SCS), Complex Regional Pain Syndrome (CRPS), Diabetic

peripheral neuropathy (DPN), and chemotherapy induced pe- ripheral neuropathy.


Traumatic Life Events and Psychopathology in a High Risk, Ethnically Diverse Sample of Young Children: A Person-Centered Approach

MJ Hagan, MJ Sulik, AF Lieberman – Journal of abnormal child psychology, 2015

Conditional response probabilities (CRPs) are defined as the probability that an

individual from a specific latent class will endorse an item. CRPs provide across

classes. CRPs for the exploratory LCA model are shown in Fig.


Two placebo-controlled, randomized withdrawal studies to evaluate the fentanyl 1-day patch in opioid-naïve patients with chronic pain

T Arai, Y Kashimoto, Y Ukyo, Y Tominaga, K Imanaka – Current Medical Research …, 2015

study]) and the other study included opioid-naïve subjects with neuropathic pain (post- herpetic

neuralgia, complex regional pain syndrome [CRPS], or chronic postoperative pain; included: had

osteoarthritis, low back pain, post-herpetic neuralgia, CRPS, or chronic


[PDF] Challenges of Peripheral Nerve Stimulator Implantation in a Patient with New Onset Thrombocytopenia

S Thompson

We present a patient with complex regional pain syndrome (CRPS)-like symptoms of the lateral

femoral cutaneous nerve after laparoscopic hysterectomy who underwent successful

ultrasound-guided PNS trial using SCS leads and unfortunate delayed implantation due to


Improving student learning via mobile phone video content: Evidence from the BridgeIT India project

M Wennersten, ZB Quraishy, M Velamuri – International Review of Education


[PDF] The Association Between Soft Tissue Releases and Bony Resections Performed During Total Knee Arthroplasty and Patients’ Pain and Satisfaction Postoperatively

M Carter – 2015

Page 1. Western University Scholarship@Western Electronic Thesis and Dissertation Repository

September 2015 The Association Between Soft Tissue Releases and Bony Resections Performed

During Total Knee Arthroplasty and Patients’ Pain and Satisfaction


[PDF] Parthasarathy Rao and Cynthia Bantilan. 2015. Grain Legumes Production, Consumption and Trade Trends in Developing Countries

S Nedumaran, P Abinaya, P Jyosthnaa, B Shraavya

Markets (PIM). Financial support by CRPs Grain Legumes and Policies, Institutions

and Markets are gratefully acknowledged. This working paper has gone through

the standard peer-review procedure of ICRISAT. The authors



AR Rezai, M Deogaonkar – US Patent 20,150,251,008, 2015

In subjects with fibromyalgia as well as other conditions (eg, hot flashes, CRPS, etc.),

clinicians have used pharmacological blockade of the sympathetic nervous system, and

in particular the stellate ganglion, to achieve some clinical benefit.




Psychiatric Disorders in Young Adults Diagnosed with Juvenile Fibromyalgia in Adolescence.

NR Cunningham, ST Tran, AM Lynch-Jordan, TV Ting… – The Journal of …, 2015

OBJECTIVE: Adolescents with juvenile-onset fibromyalgia (JFM) have increased rates of

psychiatric disorders, but to our knowledge no studies have examined psychiatric disorders

in adolescents with JFM when they enter young adulthood. This study examined the


Fibromyalgia beyond reductionism. Heart rhythm fractal analysis to assess autonomic nervous system resilience

C Lerma, LA Martinez-Martinez, N Ruiz, A Vargas… – Scandinavian Journal of …, 2015

Objectives: The prevailing linear reductionist medical model seems unable to explain

complex multisymptomatic illnesses such as fibromyalgia (FM) and similar maladies.

Paradigms derived from the complexity theory may provide a coherent framework for


Exploring the role of peripheral mechanisms: An evaluation of a theory-based approach to reducing symptoms of fibromyalgia

K Mooney – 2015

Abstract: This mixed method study presented an integrative approach for the treatment of

fibromyalgia, the rationale that justifies the approach, and an evaluation of two integrated

components of this protocol designed to mitigate symptoms of fibromyalgia. Considering


Chronic Widespread Back Pain is Distinct from Chronic Local Back Pain: Evidence from Quantitative Sensory Testing, Pain Drawings, and Psychometrics.

A Gerhardt, W Eich, S Janke, S Leisner, RD Treede… – The Clinical journal of pain, 2015

Therefore, this study compared quantitative-sensory-testing (QST) profiles of

non-specific chronic back pain patients with CLP (n=48) and CWP (n=29) with

pain-free controls (PCs, n=40) and Fibromyalgia patients (FMS, n=90).


Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation.

LM Tracy, L Ioannou, KS Baker, SJ Gibson… – PAIN, 2015

frequency HRV in chronic pain, implicating a decrease in parasympathetic activation.

These effects were heavily influenced by fibromyalgia studies. Future research would

benefit from wider use of standardised definitions of


[HTML] Analgesic effect of cathodal transcranial current stimulation over right dorsolateral prefrontal cortex in subjects with muscular temporomandibular disorders: study …

RA Brandão Filho, AF Baptista, RAFS Brandão… – Trials, 2015

In a fibromyalgia study using transcranial magnetic stimulation (TMS), the authors found higher

thresholds in both sides of the resting motor cortex with lower up regulation responses.

Furthermore, they found lower intracortical facilitation and inhibition.


Clinical Research Methodology 1: Study Designs and Methodologic Sources of Error

DI Sessler, PB Imrey – Anesthesia & Analgesia, 2015

The distinction can be nonobvious. For example, consider a study in which investigators compared

anesthetic requirement in patients with and without fibromyalgia. But, in fact, fibromyalgia is the

exposure in this study and anesthetic requirement is the outcome.


[HTML] Economic evaluation in chronic pain: a systematic review and de novo flexible economic model

W Sullivan, M Hirst, S Beard, D Gladwell, F Fagnani… – The European Journal of …, 2015

While the attributes and management of specific diseases associated with chronic pain, such

as fibromyalgia and osteoarthritis, and different analgesic requirements for neuropathic versus

other chronic pain may have justifiably led to modelling heterogeneity, clinical


[PDF] Evaluation of the Immediate Effect of Auricular Acupuncture on Pain and Electromyographic Activity of the Upper Trapezius Muscle in Patients with Nonspecific Neck …

ACO Silva, DA Biasotto-Gonzalez, DM Santos… – … -Based Complementary and …, 2015

NS-NP could contribute to the following: (i) a standardization of the points to be used as stimuli

for the treatment of abnormalities caused in this muscle by mechanical injuries, myofacial tension

(with or without trigger-points), and systemic diseases such as fibromyalgia; (ii) an


Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic

AD Nelson, MA Mouchli, N Valentin, D Deyle… – Neurogastroenterology & …, 2015

hernia,[7] rectal evacuation disorder,[8] diverticulosis, gastritis,[9] constipation, diarrhea, nausea,

vomiting, abdominal pain, and reflux disease.[10] Several non-musculoskeletal symptoms often

found in patients with functional GI disorders such as fibromyalgia, fatigue, cognitive


[HTML] Real-life assessment of the validity of patient global impression of change in fibromyalgia

E Rampakakis, PA Ste-Marie, JS Sampalis, A Karellis… – RMD Open, 2015

Objectives Patient Global Rating of Change (GRC) scales are commonly used in routine

clinical care given their ease of use, availability and short completion time. This analysis

aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC


[HTML] Increased Risk of Coronary Heart Disease in Patients with Primary Fibromyalgia and Those with Concomitant Comorbidity—A Taiwanese Population-Based Cohort …

CH Su, JH Chen, JL Lan, YC Wang, CH Tseng, CY Hsu… – PLOS ONE, 2015

Objectives Fibromyalgia has seldom been associated with coronary heart disease (CHD).

The aim of this study was to evaluate the risk of CHD in patients with fibromyalgia. Methods

We used a dataset of one million participants, systemically scrambled from the Taiwanese


[HTML] Group cognitive-behavioral therapy for chronic pain adults: review of Brazilian trials

LF Kirchner, CC Jorge, MJD Reis – Revista Dor, 2015

26 . With regard to studied population, table 1 shows predominance of females in all studies,

being fibromyalgia (FM) the most frequent diagnosis. Nevertheless, literature assertiveness,

3. (6 to 8), Fibromyalgia (100%), VAS. LSSI. RAS. Lorençatto


[HTML] Chronic Pain Pharmacological Treatment in Patients with Depressive Disorders

C Aurilio, MC Pace, MB Passavanti, V Pota, P Sansone… – Journal of Psychiatry, 2015

Patients with fibromyalgia present a reduced dopamine presynaptic activity in great many

brain regions, included hippocampus. Neurocircuits and neurochemistry. [50] published

a review on amitriptyline for neuropathic pain and fibromyalgia.


Medical Marijuana Patient Counseling Points for Healthcare Professionals Based on Trends in the Medical Uses, Efficacy, and Adverse Effects of Cannabis-Based …

JR Parmar, BD Forrest, RA Freeman – Research in Social and Administrative …, 2015

All three medications have similarly been used in improving sleep, fibromyalgia, rheumatoid

arthritis associated pain, and spasticity in MS. A complete list of medical uses and included

publications can be reviewed in Table 5. Table 5. Fibromyalgia, 1 16, 16,


Identification and description of controlled clinical trials published in Physiotherapy journals in Spain

M Turrillas, M Sitjà‐Rabert, H Pardo… – Journal of Evaluation in …, 2015

16.7% of the identified studies were multicentric. Traumatology and orthopaedics was the most

studied field (33.3%) followed by neurology (15.4%). The most researched health problems were

back pain (17.24%) fibromyalgia, arthrosis and stroke (6.8% each).


[HTML] Serum calprotectin (S100A8/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis

J Hurnakova, J Zavada, P Hanova, H Hulejova, M Klein… – Arthritis Research & …, 2015

which is obtained by using several composite indexes [4–7]. Nevertheless, a clinical examination

might lack sensitivity in patients with mild synovitis, be limited in patients with established

deformities, and be overestimated in patients with concomitant fibromyalgia or other


[HTML] Systematic review of the measurement properties of self-report physical activity questionnaires in healthy adult populations

Z Silsbury, R Goldsmith, A Rushton – BMJ Open, 2015

6 The review found strong evidence for effectiveness within cardiovascular disease, type 2

diabetes and obesity; and strong evidence for improved symptom management and quality of

life for patients with cancer, osteoarthritis, osteoporosis, fibromyalgia and depression.


[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis

C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015

JOP 2003; 4 (1): 1-10. 4. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Ami- triptyline for

neuropathic pain and fibromyalgia in adults. Review. 5. Moore RA, Wiffen PJ, Derry S, Toelle

T, Rice AS. Gabapen- tin for chronic neuropathic pain and fibromyalgia in adults.


Illness deception

SB Nimmo – Occupational Medicine, 2015

In a survey of US neuropsychologists, prevalence of malingering and symptom exaggeration

was found to be minor head injury 39%, fibromyalgia/chronic fatigue syndrome 35%, chronic

pain 31%, personal injury cases 29%, disability or workers compensation 30% and

Stay Up to Date With the Latest Pain Research News!

Stay Up to Date With the Latest Pain Research News!

Weekly Breaking Research Updates


Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.




Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine

VCM Borella, MV Seeman, RC Cordeiro… – Developmental …, 2015

Abstract Neonatal NMDA receptor blockade in rodents triggers schizophrenia-like

alterations during adult life. Schizophrenia is influenced by gender in age of onset,

premorbid functioning and course. Estrogen, the hormone potentially driving the gender


Hypothalamic, thalamic and hippocampal lesions in the mouse MCAO model: potential involvement of deep cerebral arteries?

M El Amki, T Clavier, N Perzo, R Bernard, PO Guichet… – Journal of Neuroscience …, 2015

Anesthetic methods in rodent models of cerebral ischemia impact the infarct volume. In

experimental models developed in rodents, the most used anesthetics are the volatile ones such

as isoflurane or halothane and intraperitoneal (ip) ketamine or barbiturates.


Targeting the CD80/CD86 costimulatory pathway with CTLA4‐Ig directs microglia toward a repair phenotype and promotes axonal outgrowth

A Louveau, V Nerrière‐Daguin, B Vanhove… – Glia, 2015

Male LEWIS 1A rats were anesthetized by intramuscular injection of 2% Rompun and 50mg/mL

ketamine (1.6 mL/kg) (PanPharma). Twenty-eight days after transplantation, grafted-male Lewis

1A rats were deeply anesthetized with Rompun-ketamine (1:4) at 1 mg/kg (ip).


[PDF] Anti-nociceptive effects of taurine and caffeine in sciatic nerve ligated wistar rats: involvement of autonomic receptors

W Abdulmajeed, BV Owoyele – Journal of African Association of Physiological …, 2015

(St. Louis MO, USA) while propranolol and prazosin were products of Namco

Chemicals, Amritsr, India. Normal saline and ketamine were purchased from Momrota

pharmacy, opposite University of Ilorin Teaching Hospital’s gate.


Two Cellular Hypotheses Explaining Ketamine’s Antidepressant Actions: Direct Inhibition and Disinhibition

OH Miller, JT Moran, BJ Hall – Neuropharmacology, 2015

Abstract A single, low dose of ketamine has antidepressant actions in depressed patients

and in patients with treatment-resistant depression (TRD). Unlike classic antidepressants,

which regulate monoamine neurotransmitter systems, ketamine is an antagonist of the N-


Effect of Piperine on Liver Function of CF-1 albino Mice.

JR Peela, SD Kolla, F Elshaari, F Elshaari, H El Awamy… – Infectious disorders drug …, 2015

with high fat diet. These mice were anaesthetized with ketamine and halothane and

blood was drawn from each mouse before the study and after three weeks by

cardiocentesis. Serum transaminases (alanine aminotransferase


[PDF] Correlation between anti-HBs and immunostimulatory cytokines following hepatitis B vaccination in mice

OU Peter, PO OKONKWO, OO John, A Dorathy – 2015

AM daily. All mice were acclimatized for two weeks. Diazepam injection (Valium,

Roche, USA), and ketamine injection (Ketalar, Popular Pharmaceuticals, Bangladesh)

were procured from Pax Pharmacy, Onitsha. Hepatitis B


Phosphodiesterase‐4D: an enzyme to remember

R Ricciarelli, E Fedele – British Journal of Pharmacology, 2015

enzyme isoform is localized in brain regions associated with emesis (eg area postrema and

nucleus of the solitary tract; Cherry and Davis, 1999; Lamontagne et al, 2001; Mori et al, 2010)

and its deletion in transgenic mice reduced the xylazine/ketamine-induced anaesthesia, a


The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia–reperfusion induced injury

UV Ustundag, S Sahin, K Ak, I Keskin… – Reproductive Biology, 2015

the ovaries. The rats were anesthetized with a combination of ketamine hydrochloride

(60 mg/kg ip.) and xylazine (5 mg/kg ip.). Supplementary injections of ketamine

hydrochloride were given when needed. After anesthesia


Novel Rat Model for Neurocysticercosis Using Taenia solium

MR Verastegui, A Mejia, T Clark, CM Gavidia… – The American Journal of …, 2015

Before intracranial inoculation, the rats were anesthetized with 70 mg/kg of ketamine plus

11 mg/kg of xylazine. Animals were euthanized after being anesthetized with a mixture of

100 mg/kg of ketamine, 10 mg/kg of xylazine, and 3 mg/kg of tramadol.


Photo of the Day: Low-dose Ketamine Infusions

A Katz – Emergency Medicine News, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. This blog serves as a bulletin board for


[HTML] Impact of Anesthesia Protocols on In Vivo Bioluminescent Bacteria Imaging Results

T Chuzel, V Sanchez, M Vandamme, S Martin, O Flety… – PLOS ONE, 2015

S. aureus Xen36 strain. Bioluminescence imaging was performed on mice

anesthetized by either ketamine/xylazine (with or without oxygen supplementation),

or isoflurane carried with air or oxygen. Total flux emission was


Sedative and Anxiolytic Agents

SI Ganzberg, S Wilson – Oral Sedation for Dental Procedures in Children, 2015

The salient fea- tures of nitrous oxide, chloral hydrate, meperidine, midazolam, antihista- mines,

and ketamine are discussed in relation to sedating children for dental procedures. Studies

using ketamine administered orally have resulted in mixed results.


[HTML] Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1

MAS Kumar, M Peluso, P Chaudhary, J Dhawan… – PLOS ONE, 2015

Ethics Statement. All exposures to radiation were done under ip anesthesia of xylazine/ ketamine

mixture- 4.3–5 ml per rat (male, Wistar strain) for an average weight of 540–600 gms (80 mg/kg

body weight of ketamine and 8 mg/ kg body weight of xylazine in PBS).


Combinations of dexmedetomidine and alfaxalone with butorphanol in cats: application of an innovative stepwise optimisation method to identify optimal clinical doses …

C Adami, T Imboden, AE Giovannini, C Spadavecchia – Journal of Feline Medicine …, 2015

anaesthesia. Commonly used protocols often include an a 2 -adrenoreceptor agonist

to produce reliable sedation, an opioid derivative to provide some analgesia, and

ketamine owing to its anaesthetic and analgesic effects.


[HTML] Development of Animal Models of Local Retinal DegenerationAnimal Models of Local Retinal Degeneration

H Lorach, J Kung, C Beier, Y Mandel, R Dalal, P Huie… – … Ophthalmology & Visual …, 2015

Animal facility. For surgeries, animals (P35–P50) were anesthetized with ketamine

(75 mg/kg) and Xylazine (5 mg/kg), delivered by intramuscular injection. Subretinal

implantations were performed as previously described. 31


[HTML] Following specific podocyte injury captopril protects against progressive long term renal damage

YS Zhou, IA Ihmoda, RG Phelps, COS Bellamy… – F1000Research, 2015

VD DOM02, made by Orion Pharma, supplied by Henry Schein Medical) and 100mg/ml

ketamine (Vetalar) (Ref. Terminal blood samples were collected at week 8 from intraperitoneally

anaesthetised animals (injected with medetomidine and ketamine).


Clinical Sedation Regimens

S Wilson – Oral Sedation for Dental Procedures in Children, 2015

Page 74. Clinical Sedation Regimens Stephen Wilson S. Wilson, DMD, MA, PhD

Division of Pediatric Dentistry, Department of Pediatrics, Cincinnati Children’s Hospital

Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229


Electrocardiogram reference intervals for clinically normal wild-born chimpanzees (Pan troglodytes)

R Atencia, L Revuelta, JD Somauroo, RE Shave – American Journal of Veterinary …, 2015

Immediately before the examination procedures, body weight was estimated.

Chimpanzees were anesthetized by administration of a combination of ketamine

hydrochloride a (5 mg/kg) and medetomidine b (50 μg/kg). Anesthetic


Deep Sedation and GA

SI Ganzberg – Oral Sedation for Dental Procedures in Children, 2015

When an anesthesia machine capable of delivering sevoflurane is not available, as is typical

is most dental offices,“induction” is most commonly provided with an intramuscular injection of

ketamine and midazolam with or without an anticholinergic, ie, such as glycopyr- rolate or


Radiofrequency Ablation (RFA)


In-utero radiofrequency ablation in fetal piglets: lessons learned

OO Olutoye, AN Gay, F Sheikh, AC Akinkuotu… – Journal of Pediatric Surgery, 2015

Methods 90 day gestation Yorkshire piglets (term 115 days) were subjected to RFA of the

chest and abdominal viscera under various temperatures and wattages. The extent of tissue

damage was determined by NADPH diaphorase histochemistry. Results Tyne


Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation

SI Sarvari, KH Haugaa, TM Stokke, HZ Ansari, IS Leren… – Eur Heart J Cardiovasc …, 2015

Of these, 30 had not while 31 had recurrence of AF after radiofrequency ablation (RFA). Twenty

healthy individuals were included for comparison. For patients with symptomatic drug-refractory

AF, radiofrequency ablation (RFA) has become an important therapy option.


[HTML] Current management of patients with hepatocellular carcinoma

T Kanda, S Ogasawara, T Chiba, Y Haga, M Omata… – World J Hepatol, 2015

of HCC. Many HCC patients are treated with surgical resection and radiofrequency

ablation (RFA), although these modalities should be considered in only selected

cases with a certain HCC number and size. Although there



T Chakalaa-Yancheva, S Tisheva, A Qnakieva… – Journal of Hypertension, 2015

In all patients MRA excluded new or progression of pre- existing low grade renal artery stenosis

as well as focal aneurysms at the sites of radiofrequency ablation. In none of the patients new

segmental perfusion deficits in either kidney were detected on MRI.


Multiscale Tetrahedral Meshes for FEM Simulations of Esophageal Injury

LA Neves, E Pavarino, MP Souza, CR Valencio… – Computer-Based Medical …, 2015

[3] OJ Eick and D. Bierbaum, “Tissue temperature- controlled radiofrequency ablation,” Pacing

and clinical electrophysiology, vol. [4] MO Siegel, DM Parenti, and GL Simon, “Atrialesophageal

fistula after atrial radiofrequency catheter ablation,” Clinical infectious diseases, vol.


The meaning of gross tumor type in the aspects of cytokeratin 19 expression and resection margin in patients with hepatocellular carcinoma

SC Gong, MY Cho, SW Lee, SH Kim, MY Kim, SK Baik – Journal of Gastroenterology …, 2015

From March 2012 to December 2014, 87 patients with HCC underwent surgical treatment including

intraoperative radiofrequency ablation at Wonju Severance Christian Hospital, Wonju, Korea.

Among them, 75 patients who underwent only hepatectomy were enrolled in


Impact of catheter ablation with remote magnetic navigation on procedural outcomes in patients with persistent and long-standing persistent atrial fibrillation

Q Jin, S Pehrson, PK Jacobsen, X Chen – Journal of Interventional Cardiac …, 2015

venous anatomy, left atrial (LA) volume, procedure time, mapping plus ablation time,

radiofrequency (RF) abla CFAEs at the right atrium were not mapped and ablated in this study.

Although PVAI and CFAE ablation time were calculat- ed separately, CFAE ablation time did


The role of AEG-1 in the development of liver cancer

CL Robertson, J Srivastava, D Rajasekaran, R Gredler… – Hepatic Oncology, 2015

by rapid growth and early vascular invasion and thus the incidence and mortality of the disease

run in parallel [1,3]. Standard treatment options for patients afflicted with localized forms of the

disease include surgical resection, radiofrequency ablation or liver transplantation [4–7


Unexpected Findings in the Left Atrium of a Patient with a Paravalvular Mitral Leak

FS Silva, CA Barreiros, MC Antunes, ÂL Nobre – Journal of Cardiothoracic and …, 2015

described including catheter-based cardiac interventions (eg valvular procedures, coronary

intervention, radiofrequency ablation), endocarditis, myocardial infarction and blunt cardiac

trauma.1 There are also cases of spontaneous dissection 2,10-11 occurring in patients with


[PDF] Typical chest pain and precordial leads ST-elevation in patients with pacemakers-are we always looking at an acute myocardial infarction?

MM Ostojić, TS Potpara, MM Polovina, MM Ostojić… – Vojnosanitetski pregled, 2015

ECG changes occurred due to pericardial re- action following two interventions: pacemaker

implantation a month before and radiofrequency catheter ablation of AV junction two weeks

before presentation in Emergency De- partment. Conclusion.


[PDF] AB10-06

RC ABLATION – Heart Rhythm, 2015

Methods: The clinical features including freedom from AF/atrial tachycardia (AT) recurrence

as outcome after RFCA were compared between women and men in 1: 1 age, AF type,

duration of AF (±1 year) matched manner. Subgroup analysis was performed in categories



S Chen – US Patent 20,150,201,988, 2015

Abstract: A multi-pole synchronous pulmonary artery radiofrequency ablation catheter may

comprise a control handle, a catheter body and an annular ring. One end of the catheter

body may be flexible, and the flexible end of the catheter body may be connected to the


Diagnostic and Interventional Endoscopy

Y Tomizawa, I Waxman – Atlas of Esophageal Surgery, 2015

previous ablation zone. Ablation is repeated until the entire length of disease has

received radiofrequency energy (Fig. 3.15). After the entire lesion is ablated, the

guidewire, ablation catheter, and endoscope are removed. For focal


[HTML] Osteoid osteoma masquerading tubercular arthritis or osteomyelitis on MRI: Case series and review of literature

JP Singh, S Srivastava, D Singh – Indian Journal of Radiology and Imaging, 2015

periostitis. The patient underwent CT-guided biopsy and radiofrequency ablation. The

effusion. A CT-guided radiofrequency ablation (RFA) [Figure 10]C was performed and

the patient remained symptom-free at 20 months follow-up. Figure


Hybrid Transthoracic Esophagectomy

B Borraez, MG Patti – Atlas of Esophageal Surgery, 2015

hernia, 11, 12 Schatzki’s ring, 12, 13 sliding hiatal hernia, 10, 11, 46 squamous cell cancer, 19

Zenker’s diverticulum, 15, 97 Barrett’s esophagus esophagectomy, 151, 152 focal nodular lesion,

25, 27 proximal resection margin, 141, 147 radiofrequency ablation, 23, 29 salmon



J Ribeiro, A Correia, R Ferreira, P Morgado, JM Bastos… – Journal of Hypertension, 2015

In all patients MRA excluded new or progression of pre- existing low grade renal artery stenosis

as well as focal aneurysms at the sites of radiofrequency ablation. In none of the patients new

segmental perfusion deficits in either kidney were detected on MRI.


Perspectives on the modern management of non-valvularatrial fibrillation: non-valvular af

R Gopal, MH Tayebjee – SA Heart, 2015

catheters and the development of balloon based or circular ablation catheters with multiple

ablation electrodes that can be applied to the pulmonary vein antrum to isolate pulmonary veins

and ablate left atrial substrate(44,17) (Figures 1 a,b,c). Both radiofrequency catheter and



BB Hill, J Hong, W Qi – US Patent 20,150,201,947, 2015

The following is a list of one or more advantages that may be achieved using the apparatus and

methods described herein, eg, as compared to endovenous laser, radiofrequency ablation

technologies, and other methods that destroy the vein by applying chemicals or applying


Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan)

T Ishizawa, N Kokudo – Fluorescence Imaging for Surgeons: Concepts and …, 2015


Hepatocellular Carcinoma Precursor Lesions

ML Smith – Surgical Pathology of Liver Tumors, 2015


Chronic Regional Pain Syndrome (CRPS/RSD)


A scoring rule-based truthful demand response mechanism

K Hara, T Ito – Computer and Information Science (ICIS), 2015 IEEE/ …, 2015

Therefore, conventional scoring rule with single item, such as Brier score [5] is of no use for this

mode. In order to rightfully incentivize the CA to make their prediction of device shifting for multiple

items rightfully; the continuous ranked probability score (CRPS) is applied [13].


[PDF] Why Attackers Win: On the Learnability of XOR Arbiter PUFs

F Ganji, S Tajik, JP Seifert – 2015

These attacks, as cost-effective approaches, can clone the challenge-response behavior of an

arbiter PUF by collecting a subset of challenge-response pairs (CRPs). Moreover, when applying

current ML attacks, the maximum number of CRPs required for Page 3.


[PDF] A Multivariate Modeling Approach for Generating Ensemble Climatology Forcing for Hydrologic Applications

S Khajehei – 2015

Page 1. Portland State University PDXScholar Dissertations and Theses Dissertations and Theses

Spring 7-21-2015 A Multivariate Modeling Approach for Generating Ensemble Climatology Forcing

for Hydrologic Applications Sepideh Khajehei Portland State University


[HTML] Oil Palm Leaf and Corn Stalk–Mechanical Properties and Surface Characterization

Z Daud, MZM Hatta, H Awang – Procedia-Social and Behavioral Sciences, 2015

Bhaduri et al., 1995; BK Bhaduri, A. Day, SB Mondal, .SK Sen; Ramie hemicelluloses as beater

additive in a paper making from jute-stick kraft pulp. Industrial Crps and Products, 4 (1995), pp.

79–84. Daud et al., 2013; Z. Daud, MZM Hatta, ASM Kassim, AM Aripin, H. Awang;


[HTML] Nerve injury and neuropathic pain–a question of age

M Fitzgerald, R McKelvey – Experimental Neurology, 2015

Furthermore several complex pain syndromes (eg CRPS) that emerge in older children are

associated with little or no measurable disease activity or inflammation at the time of presentation

and are clinically defined as ‘functional’ or ‘medically unexplained’ (Bromberg et al


Acute acalculous cholecystitis and cardiovascular disease: a land of confusion

M Tana, C Tana, G Cocco, G Iannetti, M Romano… – Journal of Ultrasound, 2015

Most common clinical onset was represented by fever (70 %) in opposite to abdominal pain

which occurred in 20 % of patients. 8/10 patients were male. Elevated CRPs, leukocytosis

(60 %), and elevated aminotransferase (30 %) occurred frequently.


[PDF] Characterizing the Stability of Okun’s Law during Economic Recessions by cross-Recurrence Plot and Rolling Regression

J Gao, Y Cao

2 n xx x , , , and 1 2 n yy y , , , , which, for concreteness, may be equated to unemployment and

production data, one obtains CRPs (Marwan & Kurths 2002; Marwan, et al. 2007). 4, No. 3 ~ 5 ~

Figure 2. Cross recurrence plots (CRPs); notice the correspondence of vertical


[PDF] Use of Hidden Markov Mobility Model for Location Prediction and Biclustering for Cache Replacement in MANET

BD Shelar, MDK Chitre

But these policies give satisfactory performance for stable user and prove inefficient for mobile

user which free to change his direction. Direction and Distance Based CRPs think for the mobile

nature of user. Prediction Based CRPs analyze the history of users’ movements.


Field Deployable Chemical Redox Probe for Quantitative Characterization of Carboxymethylcellulose Modified Nano Zerovalent Iron

D Fan, S Chen, RL Johnson, PG Tratnyek – 2015

Page 1. 1 2 Field Deployable Chemical Redox Probe for Quantitative Characterization of 3

Carboxymethylcellulose Modified Nano Zerovalent Iron 4 5 6 Dimin Fan, Shengwen Chen, Richard

L. Johnson, and Paul G. Tratnyek* 7 8 Institute of Environmental Health 9


Technical innovations for small-scale producers and households to process wet cassava peels into high quality animal feed ingredients and aflasafe™ substrate

I Okike, A Samireddypalle, L Kaptoge, C Fauquet… – Food Chain, 2015

Headache and Pain

R Baron, A May – 2015


Molecular Biology of Retinoblastoma

SD Walter, JW Harbour – Recent Advances in Retinoblastoma Treatment, 2015

Rb directly inhibits E2Fs by binding and masking the transactivation domain, and it also recruits

chromatin remodeling proteins (CRPs) that alter local chromatin structure into a confirmation

that is not permis- sive for transcription.(b) When Rb is hyperphosphory- lated, it does


[PDF] Guidelines for Neuromusculoskeletal Infrared Thermography Sympathetic Skin Response (SSR) Studies

DO Getson, S Govindan, J Uricchio, T Bernton…

Assessment of patients with presumptive Complex Regional Pain Syndrome (CRPS) Type I or

II – formally known as Reflex Sympathetic Dystrophy (RSD), Thoracic Outlet Syndrome,

Vaso-motor Headache and Barre’-Leiou Syndrome. CRPS: Current Diagnosis and Therapy.


[HTML] Thread: Advances in treatment of post-amputation phantom limb pain

W Young, J Date

reviewed fifteen papers reporting mirror therapy to treat upper limb function and concluded that

most of the studies were weak methodologically and that the results suggest possible benefit

in patients after stroke and complex regional pain syndrome (CRPS) but the


[PDF] Guidelines For Dental-Oral And Systemic Health Infrared Thermography

M Brioschi, H Usuki, BSN Jan Crawford, P Steed…

c. Relevant risk factors for inflammation or vasomotor instability: prior history of RSD

or CRPS, trauma, fracture, repetitive use, vibration syndrome, peripheral neuropathy,

spinal pathology, radiculopathy, vasomotor headache, Page 4.


[HTML] Chronic Pain Medication & Treatment Guide

AR Guide

cord injuries. It may develop months or years after injury or damage to the CNS.

This also includes conditions such as chronic headaches, fibromyalgia, and Complex

Regional Pain Syndrome (CRPS). Tailoring selection of



F Place, P Hazell



THE CGIAR. Frank Place and Peter Hazell. WORKSHOP ON


CRPS A contingent hypothesis with prostaglandins as crucial conversion factor

PHE van der Veen – Medical Hypotheses, 2015

Abstract CRPS is an acute pain disease expressed as chronic pain with a severe loss of

tissue and function. CRPS usually occurs after minor injuries and then progresses in a way

that is scarcely controllable, or completely uncontrollable. This article addresses the


Vitamin C to Prevent Complex Regional Pain Syndrome in Patients With Distal Radius Fractures: A Meta-Analysis of Randomized Controlled Trials

N Evaniew, C McCarthy, YV Kleinlugtenbelt, M Ghert… – Journal of orthopaedic …, 2015

Collapse Box Abstract. Objective: To determine whether vitamin C is effective in preventing

complex regional pain syndrome (CRPS) in patients with distal radius fractures. 2 CRPS has been

previously referred to as causalgia, reflex sympathetic dystrophy, and algodystrophy. 3.


Injury of the corticoreticular pathway in patients with mild traumatic brain injury: A diffusion tensor tractography study

HD Lee, SH Jang – Brain Injury, 2015

Figure 1. Diffusion tensor tractography for the corticoreticular pathway (CRP): a normal control

subject (44 year-old, female), type A = the CRPs showed narrowing, although integrity was

preserved from the premotor cortex to the reticular formation of the medulla, type B = the


[PDF] Plasma Exchange Therapy in Patients with Complex Regional Pain Syndrome

E Aradillas, RJ Schwartzman, JR Grothusen, A Goebel – Pain Physician, 2015

Page 1. Background: Complex regional pain syndrome (CRPS) is a severe chronic

pain condition that most often develops following trauma. These patients were then

placed on Complex regional pain syndrome (CRPS) is a


Controversial Pain Syndromes of the Arm: Pathogenesis and Surgical Treatment of Resistant Cases

A Wilhelm – 2015


[PDF] Mixture EMOS model for calibrating ensemble forecasts of wind speed

S Baran, S Lerch – arXiv preprint arXiv:1507.06517, 2015

The most popular scoring rules are the logarithmic score, that is the negative logarithm of the

predictive PDF evaluated at the verifying observation and the continuous ranked probability score

(CRPS; Gneiting and Raftery, 2007; Wilks, 2011). CRPS(F, x) := ∫ ∞


[PDF] Targeted Ultrasound-Guided Double Catheters (Infraclavicular-Brachial Plexus, Median Nerve) Facilitate Hand Rehabilitation with Superb Analgesia and Motor …

AE Holman, B Sharma, VE Modest – Open Journal of Anesthesiology, 2015 Abstract A 44-year-old male who suffered a

crush-degloving hand injury complicated by Complex Regional Pain Syndrome (CRPS) type

I was scheduled for operative hand manipulation and inpatient physi- otherapy.


Leads for neurostimulation and methods of assembling same

A Raines – US Patent 9,084,882, 2015

As used herein the term “complex regional pain syndrome” or “CRPS” refers to painful

conditions that usually affect the distal part of an upper or lower extremity and are

associated with characteristic clinical phenomena. CRPS


[PDF] Identification and characterization of a novel family of cysteine-rich peptides (MgCRP-I) from Mytilus galloprovincialis

M Gerdol, N Puillandre, G De Moro, C Guarnaccia… – Genome Biology and …, 2015

encoding peptides with unique chemico-physical properties and/or sequence patterns. Actually,

cysteine-rich peptides (CRPs) encompass a large and widespread group of secreted plants

(Gruber, et al. 2007; Marshall, et al. 2011; Taylor, et al. 2008). Invertebrate CRPs are


Peri‐infarct reorganization of an injured corticoreticulospinal tract in a patient with cerebral infarct

SH Jang, J Lee, HD Lee – International Journal of Stroke, 2015

(c) The CRPs are descended through the subcortical white matter in two age-matched normal

control subjects. Letter to the editor © 2015 World Stroke Organization E62 Vol 10, August 2015,

E62–E63 Page 2. References 1 Yeo SS, Chang MC, Kwon YH, Jung YJ, Jang SH.




Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats

A Blasco-Serra, F Escrihuela-Vidal, EM González-Soler… – Physiology & Behavior, 2015

Abstract Since the pathogenesis of fibromyalgia is unknown, treatment options are limited,

ineffective and in fact based on symptom relief. A recently proposed rat model of

fibromyalgia is based on central depletion of monamines caused by reserpine


Is there any link between joint hypermobility and mitral valve prolapse in patients with fibromyalgia syndrome?

E Kozanoglu, IC Benlidayi, RE Akilli, A Tasal – Clinical Rheumatology, 2015

Abstract The objective of the present study is to determine whether benign joint

hypermobility syndrome (BJHS) modifies the risk of mitral valve prolapse (MVP) in patients

with fibromyalgia (FM). Female patients fulfilling the 1990 American College of


[HTML] Calibration and Validation of the Dutch-Flemish PROMIS Pain Interference Item Bank in Patients with Chronic Pain

MHP Crins, LD Roorda, N Smits, HCW de Vet… – PLOS ONE, 2015

as pain that persists beyond the normal tissue healing time, in which the most prevalent pain

is musculoskeletal pain, with prevalence varying from 30–40% for low back pain, 15–20% for

shoulder- and neck pain, 10–15% for chronic widespread pain and 2% for fibromyalgia [3,4


Assessment of response bias in neurocognitive evaluations

DA Carone – NeuroRehabilitation, 2015

survey data of neuropsychologists show that the base rates of malingering or symptom

exaggeration are much higher (29% to 41%) in settings where patients are seeking financial

compensation or disability and in patient groups (ie, concussion, fibromyalgia, chronic fatigue



S Lopez-Pousa, GB Pagès, S Monserrat-Vila

ABSTRACT Background and objective: Most patients with fibromyalgia benefit from different

forms of physical exercise. Studies show that exercise can help restore the body’s

neurochemical balance and that it triggers a positive emotional state. So, regular exercise


[HTML] Miller Chiropractic & Laser Treatment Center

D Emery

Acta Medica Academica 2013;42(1):46-54. doi: 10.5644/ama2006-124.70. Study Finds

Chiropractic Beneficial for Fibromyalgia. A new study from Egypt reports that chiropractic care

can be an effective treatment strategy for fibromyalgia treatment with chiropractic care.


[PDF] Cost-effectiveness of 40-hour versus 100-hour vocational rehabilitation on work participation for workers on sick leave due to subacute or chronic musculoskeletal …

TT Beemster, JM van Velzen, CAM van Bennekom… – Trials, 2015

as follows: 1) individuals of working age (18 to 65 years); 2) suffering from subacute (6 to 12 weeks)

or chronic (>12 weeks) nonspecific musculoskeletal pain such as back, neck, shoulder,

widespread pain, Whiplash Associated Disorder (WAD I or II), or fibromyalgia; 3) having


Peer-Reviewed Abstracts

D Avans – Research Quarterly for Exercise and Sport, 2015

Fine motor control knowingly declines with age and certain diseases such as fibromyalgia and

cerebral palsy (Perez-de-Heredia-Torres, 2013). Research of this nature could also be translated

to diseased populations such as those with fibromyalgia or diabetes.


Gastro-protective and Anti-stress Efficacies of Monomethyl Fumarate and a Fumaria indica Extract in Chronically Stressed Rats

A Shakya, UK Soni, G Rai, SS Chatterjee, V Kumar – Cellular and Molecular …, 2015

are some of the major symptoms of numerous, if not all, chronic inflammatory diseases

accompanying central sensitivity syndromes (Yunus 2008 ), and it is now well recognized that

cytokine and immune system abnormalities are the root cause of fibromyalgia and other central


[PDF] Mechanisms of action of balneotherapy in rheumatic diseases

A Fioravanti, S Cheleschi – IV CIBAP BOÍ 2015

Anti-inflammatory aspects Recent studies have shown a reduction of circulating levels of

Prostaglandin E2 (PGE2) and Leukotriene B4 (LTB4), important mediators of inflammation and

pain, in patients suffering from OA or fibromyalgia who undergo mud-packs or


Determinants of Patient Satisfaction in an Academic Rheumatology Practice.

JH Ku, A Danve, H Pang, D Choi, JT Rosenbaum – Journal of clinical rheumatology: …, 2015

95% CI, -15.25 to -3.25), arthralgia (β = -8.67; 95% CI, -16.60 to -0.74), myalgia (β = -8.67; 95%

CI, -16.60 to -0.74), gout (β = -7.5; 95% CI, -14.13 to -0.89), ankylosing spondylitis (β = -5.20;

95% CI, -9.65 to -0.75), pain (β = -4.62; 95% CI, -8.43 to -0.81), fibromyalgia (β = -4.62; 95


Method and Apparatus for Diagnosing and Assessing Centralized Pain

JB Hargrove – US Patent 20,150,201,879, 2015

Because of this emerging understanding, the role of CS is increasingly being shown to be

pathological in seemingly unrelated chronic pain conditions and syndromes including fibromyalgia,

complex regional pain syndrome, phantom pain, and migraine headaches.



E Berry, Y Avraham, J Katzhendler, J Mograbi… – US Patent 20,150,202,179, 2015

Abstract: The invention provides fatty acid derivatives for use in a method of treatment of at least

one disease, disorder or condition selected from anxiety, depression, conditions associated

menopause, stress, bipolar disorder, neuropathic pain and fibromyalgia.



A Rajpal, MN Devalaraja, K Toy, L Yang, H Huang… – US Patent 20,150,203,574, 2015

The term “fibromyalgia” is also known as fibromyalgia syndrome. The American College

of Rheumatology (ACR) 1990 classification criteria for fibromyalgia include a history

of chronic, widespread pain for more than three months


Impact of Gender-Based Aggression on Women’s Mental Health in Portugal

M Reis, L Ramiro, MG de Matos – … Mental Health: Resistance and Resilience in …, 2015

The rate was even higher for women who had experienced non-partner sexual violence (WHO,

2013). Health effects can also include headaches, back pain, abdominal pain, fibromyalgia,

gastrointestinal disorders, limited mobility, and poor overall health (WHO, 2013).


Pain 2014 Refresher Courses: 15th World Congress on Pain

SN Raja, CL Sommer – 2015


Restless Legs Syndrome: The Devil Is in the Details

PJ Sampognaro, RE Salas, A Kalloo, C Gamaldo – Sleepy or Sleepless: Clinical …, 2015

medical conditions Restless legs syndrome (Willis-Ekbom disease) Renal failure Periodic limb

movement disorder Anemia REM sleep behavior disorder (RBD) Peripheral neuropathy

Obstructive sleep apnea syndrome (OSAS) Rheumatoid arthritis Fibromyalgia Attention deficit


[PDF] Dermatologic Extrahepatic Manifestations of Hepatitis C

B Dedania, GY Wu – Journal of Clinical and Translational Hepatology, 2015

cutanea tarda23 – Lichen planus33,35,36 – Sicca syndrome – Auto-antibody productions

(rheumatoid factor, cryoglobulins, anti-smooth muscle) – Glomerulonephritis12 C. Possible

association2,16 – Polyarthritis – Pruritus – Fibromyalgia – Chronic polyradiculoneuropathy – Lung



E Skolnik, Z Li, S Srivastava – US Patent 20,150,204,846, 2015

Exemplary IgE-mediated allergic disorders include, without limitation, allergic rhinitis,

allergic or atopic asthma, anaphylaxis, atopic dermatitis, eczema, hay fever,

fibromyalgia, and an immediate type hypersensitivity reaction.


Psychological Interventions for the Management of Chronic Pain: a Review of Current Evidence

RS Kaiser, M Mooreville, K Kannan – Current Pain and Headache Reports, 2015

A few of the many variants of this approach will be highlighted. Currently, cognitive

behavioral therapy (CBT) is a first-line psychological treatment for individuals with chronic

pain, such as back pain, headache, arthritis, and fibromyalgia [ 12 •].

Latest Pain Research News!

Week of July 7, 2015 Breaking Research Updates

Weekly Breaking Research Updates


Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.




Withdrawal from Acute Amphetamine Induces an Amygdala-Driven Attenuation of Dopamine Neuron Activity: Reversal by Ketamine.

P Belujon, NL Jakobowski, HK Dollish, AA Grace – … : official publication of the …, 2015

Drug addiction is a chronic disorder characterized by a cycle composed of drug seeking,

intoxication with drug taking and withdrawal associated with negative affect. Numerous

studies have examined withdrawal/negative affect after chronic use; however, very few


Enantioselective inhibition of D‐serine transport by (S)‐ketamine

NS Singh, M Bernier, S Camandola, MA Khadeer… – British Journal of …, 2015

Background and purpose Patients with major depressive disorder receiving racemic

ketamine,(R, S)-ketamine, experience transient increases in Clinician-Administered

Dissociative States Scale (CADDS) scores and coincident drop in plasma D-serine levels.


Pain Management with Low-Dose Ketamine Infusions

A Katz – Emergency Medicine News, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. The M 2 E Too! Blog by Larry Mellick,


Sedative medications outside the operating room and the pharmacology of sedatives

TG Hansen – Current Opinion in Anesthesiology, 2015

Ketamine. Ketamine is a unique phencyclidine derivate that differs from other sedatives in several

ways. Ketamine seems to induce a dissociative anesthetic state with functional and

electrophysiological separation between the limbic system and hypothalamus.


Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

A Hadhimane, M Shankariah, KV Neswi – Journal of Maxillofacial and Oral Surgery, 2015

Purpose In this study we assessed the clinical efficacy of sub-mucosal injection of ketamine

at sub-anesthetic dose of 0.5 mg/kg on post-operative pain, swelling and trismus following

surgical extraction of impacted mandibular third molars. Methods Forty bilaterally


Fluorescence‐guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti‐CEA dylight 650 for tumor illumination

S Miwa, N De Magalhães, M Toneri, Y Zhang, W Cao… – Journal of Orthopaedic …, 2015

Tumor implantation Six to eight-week-old male mice were anesthetized by a ketamine mixture

(10 µL ketamine HCL, 7.6 Before resection of the metastatic tumor, mice were anesthetized with

the ketamine mixture (described above), and their limbs were sterilized with alcohol.


Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples

J Van Schoors, C Lens, K Maes, Y Michotte, I Smolders… – Journal of Chromatography …, 2015

Diazepam 10 mg/2 mL is purchased as Valium ® from Roche (Cenexi, Fontenay-sous-Bois,

France), ketamine 1000 mg/10 mL as Ketamine 1000 ® from Ceva (Libourne, France), Ketoprofen

1% as Ketofen ® from Merial (Toulouse, France) and NaCl 0.9% from Baxter (Lessines


Ultrasound-induced suppression of visually-evoked potentials: experience in nonhuman primates with a clinical transcranial MRI-guided focused ultrasound system

N McDannold, C Arvanitis, N Vykhodtseva… – Journal of Therapeutic …, 2015

650 kHz. Methods. The animal was deeply anesthetized using ketamine and

dexdormitor. First we targeted the LGN using MR temperature imaging, and then

we relocated the MRI table just outside the MRI. Visually-evoked


Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)

CM Parrula, J Mysore, H Burr, W Freebern, N Neef – Comparative Medicine, 2015

On day 4, a follow-up complete physical exam under ketamine sedation (10 mg/kg IM; ketamine

hydrochloride, Fort Dodge Animal Health, Fort Dodge, IA), showed diffuse, pale-red discoloration

in both inguinal regions, as noted previously, and multifocal pinpoint foci of


Estradiol protects female rats against sepsis induced by Enterococcus faecalis improving leukocyte bactericidal activity

RS Saia, FM Garcia, EC Cárnio – Steroids, 2015

0.5–1 × 10 10 CFU/animal) (time “zero” hour). At 6 and 24 h, rats were deeply

anesthetized (ketamine and xylazine at 55 and 10 mg/kg, respectively, ip) for sample

collection. As detailed in the subsequent sections, the blood


Hot Off the Press: Subdissociative‐dose Ketamine for Acute Pain in the Emergency Department

AB Drake, WK Milne, CR Carpenter – Academic Emergency Medicine, 2015

Social Media. Hot Off the Press: Subdissociative-dose Ketamine for Acute Pain in the Emergency

Department. How to Cite. Drake, AB, Milne, WK, Carpenter, CR (2015), Hot Off the Press:

Subdissociative-dose Ketamine for Acute Pain in the Emergency Department.


Optimization and application of an extraction procedure to determine drugs of abuse in solid environmental matrices of Turia River Basin

MJ Andres, R Alvarez, V Andreu, Y Pico – EGU General Assembly Conference …, 2015

Amphetamine, methamphetamine, ethylamphetamine, ecstasy, ethylone, bk-MMBDB and MBDB

belong to phenylethylamine group; codeine and ketamine belong to opioid and phencyclidine

group, respectively, and benzoylecgonine is the major excreted metabolite of the


Green spaces and cognitive growth in children

C Dieme – PNAS, 2015

AG. Previous Section. Neural mechanism of ketamine. Ketamine can produce rapid and

long-lasting antidepressant effects, but the drug’s potential for side effects and abuse limits its

widespread use, and the cellular mechanisms of ketamine’s effects are not yet known.


Increasing use of ‘party drugs’ in people living with HIV on antiretrovirals: a concern for patient safety

M Bracchi, D Stuart, R Castles, S Khoo, D Back… – AIDS, 2015

These substances are a combination of ‘club drugs’ (methylenedioxy- methamphetamine,

gamma-hydroxybutyrate, ketamine, benzodiazepine) and drugs that are more specifically used

in a sexualized context (methamphetamine, mephe- drone, poppers and erectile Ketamine


Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil …

BA MacDonald, KV Chakravarthy, BA Davidson… – Anesthesiology, 2015

The authors demonstrate that halothane mitigates the risk of SBP postflu through modulation

of the effects of type I interferon (IFN). METHODS: Mice (n = 6 to 15) were exposed to halothane

or ketamine and treated with influenza and Streptococcus pneumoniae.


[HTML]Airtraq® laryngoscope-assisted fiberoptic bronchoscope intubation in a child with Pierre-Robin sequence: a case report

S Zhang, M Yi – International Journal of Clinical and Experimental …, 2015

Sedation was achieved with IV dexmedetomidine 1 μg/kg and ketamine 1 mg/kg. We

opted to use dexmedetomidine and ketamine in this child because they provide

sedation and analgesia without compromising respiratory drive.


[HTML]Transcutaneous electric acupoint stimulation alleviates remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial

Y Chen, Y Yao, Y Wu, D Dai, Q Zhao, L Qiu – International Journal of Clinical and …, 2015

Some medications, including ketamine, methadone, dextromethorphan, COX-2 inhibitors and

α 2 receptor agonists can modulate remifentanil-induced hyperalgesia [7]. Due to drug-related

side effects and longer duration of PACU stay, however, we have found these


Impact of Obesity on Endotoxin-Induced Disseminated Intravascular Coagulation.

T Duburcq, A Tournoys, G Viviane, T Hubert, V Gmyr… – Shock, 2015

animals). For the experiment, animals were premedicated with intramuscular injection of ketamine

(Ketamine 1000, 10 mg/kg of body weight; Virbac, Carros, France) and xylazine (Sedaxylan,

2.5 mg/kg of body weight; CEVA Santé Animale, Libourne, France). Then we


Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro …

RC Almada, CM Roncon, DH Elias-Filho, NC Coimbra – Neuroscience, 2015

The surgeries were performed under deep anesthesia with 100 mg/kg ketamine (Ketamine

Agener, União Química Farmacêutica Nacional, São Paulo, Brazil) and 10 mg/kg xylazine

(Calmiun, União Química Farmacêutica Nacional, São Paulo, Brazil).



MD Dănilă, AI Privistirescu, SN Mirica, A Sturza… – Canadian Journal of …, 2015

Male (body weight 400-450 g) and female (body weight 250-300 g) Wistar rats were anesthetized

with ketamine (Vetased, 30 mg/kg) and xylazine (Xylazin, 10 mg/kg) Page 4 of 23 Page 5. 5

ketamine able to induce anesthesia was chosen in order to not interfere with the IPC-



Radiofrequency Ablation (RFA)


In vitro artefact assessment of a new MR-compatible microwave antenna and a standard MR-compatible radiofrequency ablation electrode for tumour ablation

R Hoffmann, H Rempp, F Eibofner, DE Keßler… – European Radiology, 2015

Objective To evaluate and compare artefact configuration and diameters in a magnetic

resonance (MR)-compatible prototype microwave (MW) applicator and a standard MR-

compatible radiofrequency (RF) applicator for MR-guided tumour ablation. Methods Both


Does Surgical Resection Provide Better Outcomes Than Radiofrequency Ablation in Patients With BCLC Very Early-stage Hepatocellular Carcinoma?.

C Li, TF Wen – Annals of Surgery, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. Skip Navigation Links Home >


Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry.

RJ Haidry, G Lipman, MR Banks, MA Butt, V Sehgal… – Endoscopy, 2015

Background and study aim: Mucosal neoplasia arising in Barrett’s esophagus can be

successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency

ablation (RFA). The aim of the study was to compare clinical outcomes of patients with


Effectiveness of focal vs. balloon radiofrequency ablation devices in the treatment of Barrett’s esophagus

J Brown, B Alsop, N Gupta, DC Buckles, MS Olyaee… – United European …, 2015

Abstract Background and aims The safety and efficacy of radiofrequency ablation (RFA) in

treatment of Barrett’s esophagus (BE)-associated dysplasia has been well established. The

effectiveness of focal and balloon RFA devices has not been compared. Therefore, the


Microwave Ablation: Comparison of Simultaneous and Sequential Activation of Multiple Antennas in Liver Model Systems

CM Harari, M Magagna, M Bedoya, FT Lee Jr… – Radiology, 2015

Although both methods have been used in clinical studies of radiofrequency (RF) and microwave

ablation, an optimal delivery method has not yet been determined (6–9). Comparison studies

of sequential and simultaneous RF ablation techniques have concluded that


Heparin Kinetics: The “Holy Grail” of Periprocedural Anticoagulation for ablation of atrial fibrillation

DF Briceno, A Natale, LD Biase – Pacing and Clinical Electrophysiology, 2015

anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from

a multicenter prospective registry. anticoagulation in patients undergoing radiofrequency ablation

for atrial fibrillation: results from a multicenter prospective registry.


Catheter Ablation of Atrial Fibrillation Should Be Offered as Primary Therapy: What’s Your Hurry?

EF Wedam, MCP Haigney – Cardiac Electrophysiology Clinics, 2015

medications. Radiofrequency ablation/cryoballoon ablation: a cure for atrial fibrillation?

Merriam-Webster’s unknown. Does early radiofrequency ablation/cryoballoon ablation

prevent progression to permanent atrial fibrillation? A major


OC-037 6 year disease durability outcomes on patients treated with endoscopic therapy for barrett’s related neoplasia from the uk registry

R Haidry, G Lipman, A Gupta, J Dunn, H Smart… – Gut, 2015

Introduction Endoscopic therapy with combined Endoscopic mucosal resection (EMR) followed

by Radiofrequency ablation (RFA) is now the recommended first line Thereafter patients underwent

RFA 3 monthly until all visible BE was ablated or cancer developed (endpoints).


[HTML]Hybrid atrial fibrillation ablations and the increasing importance of the hybrid cardiovascular laboratory operating room

WJ Schleifer, JF Beshai, H Ramakrishna – Annals of Cardiac Anaesthesia, 2015

the epicardium. [4] Moreover, endocardial catheters can check for the completeness

of the epicardial lesions and potentially identify gaps, which can then be addressed

with endocardial radiofrequency ablation. A similar approach


[PDF]Effects of Hepatitis B Virus Load on Hepatectomy

M Wang, W Peng, TF Wen, LH He, C Li – Clin Microbiol, 2015

MC: Milan Criteria; HR: Hepatic Resection; AFP: Alpha-Fetoprotein; OS: Overall Survival; RFS:

Recurrence-Free Survival; DNA: Deoxyribonucleic Acid; CT: Computed Tomography; MRI:

Magnetic Resonance Imaging; RFA: Radiofrequency Ablation; PEI: Percutaneous Ethanol



R Valcavi, P Tsamatropoulos – Endocrine practice: official journal of the American …, 2015

OBJECTIVE: We studied the impact of Radiofrequency ablation (RFA) on health-related

quality of life (HRQL) in patients with benign thyroid nodules (TN) in a 2-year follow-up.

METHODS: Forty patients (35 female and 5 men; age 54.9±14.3 years) with cold thyroid


Comparison of laparoscopic radiofrequency ablation versus open resection in the treatment of symptomatic-enlarging hepatic hemangiomas: a prospective study

X Zhang, L Yan, B Li, T Wen, W Wang, M Xu, Y Wei… – Surgical Endoscopy, 2015

Background Radiofrequency ablation (RFA) has been demonstrated to be a promising

therapy for symptomatic large hepatic hemangioma. However, there is a lack of studies to

demonstrate the benefits and disadvantages of RFA as compared with surgical resection


… mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett’s esophagus: results from the United States Radiofrequency Ablation

N Li, S Pasricha, WJ Bulsiewicz, RE Pruitt… – Diseases of the Esophagus, 2015

Summary The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and

safety of radiofrequency ablation (RFA) for treatment of nodular Barrett’s esophagus (BE) is

poorly understood. Prior studies have been limited to case series from individual tertiary


… MicroRNA-122 Expression is a Poor Prognostic Marker in Patients with Hepatitis B Virus-related Hepatocellular Carcinoma who undergo Radiofrequency Ablation

HJ Cho, JK Kim, JS Nam, HJ Wang, J hee Lee, SS Kim… – Clinical Biochemistry, 2015

Objectives: Aim of this study was to investigate the prognostic potential of plasma microRNA-

122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after

hepatic resection or radiofrequency ablation (RFA).


[HTML]… efficacy enough to prevent stroke in atrial fibrillation patient with high CHADS2 score during peri-procedural catheter radiofrequency ablation? A case report with …

XM Shi, FK Chen, Z Liang, J Li, K Lin, JP Guo, ZL Shan – International Journal of …, 2015

Abstract Atrial fibrillation (AF) is a major cause of thromboembolic (TE) events including

stroke and transient ischemic attacks, catheter radiofrequency ablation (CA) has been

demonstrated to effectively eliminate AF in majority of patients. During the peri-procedural


Right upper lobe lung cancer: Resection through left anterior mediastinotomy

M Sirois, WA Arab, E Turcotte, Y Poulin – Asian Cardiovascular and Thoracic Annals, 2015

evaluation revealed a forced expiratory volume in 1 s of 1.8 L with carbon dioxide diffusion

capacity of 48% and maximal uptake of oxygen 14 mL min −1 kg −1 . Treatment including

stereotactic body radiation therapy, radiofrequency ablation, and surgery were discussed.


Magnetic guidance versus manual control: comparison of radiofrequency lesion dimensions and evaluation of the effect of heart wall motion in a myocardial phantom

A Bhaskaran, MAT Barry, SI Al Raisi, W Chik… – Journal of Interventional …, 2015

Abbreviations MNS Magnetic navigation system MC Manual control 1 Introduction Magnetic

navigation system (MNS) allows remote guidance of ablation catheters during radiofrequency

ablation for cardi- ac arrhythmias. Page 3. 2.2 MNS versus MC radiofrequency ablation


Thermal necrosis induced by electrocauterization as a local adjuvant therapy in local aggressive bone tumors, what is the safe limit for surgical margins? An …

M Aydin, K Basarir, M Armangil, HY Yildiz, Y Saglik… – Archives of Orthopaedic and …, 2015

Majno PE, Mentha G, Mazzaferro V (2010) Partial hepatectomy versus radiofrequency ablation

for hepatocellular carcinoma: confirming the trial that will never be, and some comments on the

indications for liver resection. Hepatology 51(4):1116–1118PubMedView Article; 23.


Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation

K Hayashi, T Konno, H Tada, S Tani, L Liu, N Fujino… – Circulation: Arrhythmia and …, 2015


Endoscopic Management of Early Esophageal Cancer.

JA Barnes, FF Willingham – Journal of Clinical Gastroenterology, 2015

proportionately. In the past decade, radiofrequency ablation has become the standard

first-line therapy for high-grade dysplasia when found in the precursor lesion to

esophageal adenocarcinoma, Barrett’s esophagus. Success


Chronic Regional Pain Syndrome (CRPS/RSD)


V33. Functional imaging of somatosensory finger representation and intracortical inhibition modulation in complex regional pain syndrome

S Strauss, M Grothe, T Usichenko, W Byblow, M Lotze – Clinical Neurophysiology, 2015

Neurophysiological pathology in CRPS type I is characterized by somatosensory and motor deficits.

Transcranial magnetic stimulation (TMS) and functional MRI rev. Neurophysiological pathology

in CRPS type I is characterized by somatosensory and motor deficits.


Exploiting resistive cross-point array for compact design of physical unclonable function

PY Chen, R Fang, R Liu, C Chakrabarti, Y Cao, S Yu – Hardware Oriented Security …, 2015

primitive that leverages the inherent randomness in the physical systems (eg the semiconductor

manufacturing process) to produce a unique response (output) for a given challenge (input)

[1]. Depending on the number of possible challenge-response pairs (CRPs), PuFs can


Do psychological factors influence recovery from Complex Regional Pain Syndrome Type-1? A Prospective Study.

DJ Bean, MH Johnson, W Heiss-Dunlop, AC Leed… – PAIN, 2015

Conflicts of Interest: none declared. Running Head: “Psychological factors in the recovery from

CRPS-1” Number of Pages: 19 Number of Tables: 3 Number of Figures: 1 Summary: Amongst

patients with recently-onset CRPS-1, those with higher levels of pain-related


A comparison of linear and non-linear data assimilation methods using the NEMO ocean model

P Kirchgessner, J Tödter, L Nerger – EGU General Assembly Conference Abstracts, 2015, which ensures identical experimental conditions for both filters. To

account for the nonlinearity, the assimilation skill of the two methods is assessed

by using different statistical metrics, like CRPS and Histograms.


The total probabilities from high-resolution ensemble forecasting of floods

J Olav Skøien, K Bogner, P Salamon, P Smith… – EGU General Assembly …, 2015

Weather Rev., 135(4), 1386-1402, doi:10.1175/MWR3341.1, 2007. Gneiting, T., Raftery,

AE, Westveld, AH and Goldman, T.: Calibrated Probabilistic Forecasting Using Ensemble

Model Output Statistics and Minimum CRPS Estimation, Mon.


Efficacy of combined physical and occupational therapy in patients with conservatively treated distal radius fracture: randomized controlled trial

V Filipova, D Lonzarić, BJ Papež – Wiener klinische Wochenschrift, 2015

Two participants from group A and two from group B were suspected of having complex

regional pain syndrome (CRPS) type I yet were not excluded from the trial since there

was no significant deviation regarding the observed variables.


Combining Graph Analysis and Recurrence Plot on fMRI data

A Lombardi, P Guccione, L Mascolo, P Taurisano… – Medical Measurements and …, 2015

Even if a visual inspection of CRPs can reveal valuable information about the relationship between

the two systems, the quantification of the structures in CRPs through CRQA has been used for

making more objective the comparison between the time series. Page 3.


Improving Precipitation Forecasts by Generating Ensembles through Postprocessing

DL Shrestha, DE Robertson, JC Bennett, QJ Wang – Monthly Weather Review, 2015

In this study, the forecast 3 performance is characterized by evaluating the bias, the Continuous

Ranked Probability Score 4 (CRPS), reliability and Relative Operating Characteristics (ROC)

to assess different aspects of 5 forecast quality. 6 The mean CRPS (hereafter 16


The Forecast Skill Horizon

R Buizza, M Leutbecher – Quarterly Journal of the Royal Meteorological Society, 2015

theoretical tools are deemed to be impractical to use. We select the continuous ranked probability

score (CRPS, Brown 1974, Hersbach 2000) as metric to decide when the closer to the observed

CDF (bottom panel). The CRPS is equal to the mean squared error


Functional Outcomes Following Bridge Plate Fixation for Distal Radius Fractures

A Lauder, S Agnew, K Bakri, CH Allan, DP Hanel… – The Journal of Hand …, 2015

2/134 deep infection. 2/134 extensor tendon adhesions. 1/134 EPL rupture. DASH: N/A. Hanel

et al 13, IV: retrospective chart review, 62 pts via chart review, second metacarpal, No CRPS,

1/62 ECRL rupture, 1/62 hardware failure, 0/62 postoperative digit stiffness. DASH: N/A.


New findings implicated in Coronary calcification in Chronic phase Kawasaki disease

T Yahata, K Ikeda, A Hamaoka, C Suzuki, A Yoshioka… – Circulation, 2015

tomography. We measured %FMD as an endothelial function marker and hs-CRPs

as an inflammatory marker, serum hydroperoxide and urinary 8-OHdG as oxidative

stress markers, and the bone mineral density (BMD). Patients


[PDF]Evaluation of the Red Sea State Food Security Status 2007-2009

AAA Ahmed – 2015

nutrition monitoring using MUAC Since 2006 no nutrition survey conducted. However, EWS

started collecting the nutrition information using the Community Resource Persons (CRPs)

to follow up the nutrition situation in sentinel sites in RPS and Tokar.


Spatio-temporal circular models with non-separable covariance structure

G Mastrantonio, GJ Lasinio, AE Gelfand – TEST, 2015

Page 1. TEST DOI 10.1007/s11749-015-0458-y ORIGINAL PAPER Spatio-temporal

circular models with non-separable covariance structure Gianluca Mastrantonio1 ·

Giovanna Jona Lasinio2 · Alan E. Gelfand3 Received: 7


Predictors of Spinal Cord Stimulation Success

P De La Cruz, C Fama, S Roth, J Haller, M Wilock… – … : Technology at the Neural …, 2015

Failure, Success. CRPS, Complex Regional Pain Syndrome; FBSS, Failed Back Surgery

Syndrome. Age, Mean + Range, 47.8 + 25.0, 51.2 + 53. Gender, Male : Female, 3:7, 20:27. Hybrid

(%), 0, 8.1. Indication, FBSS (%), 60, 37.8. CRPS (%), 20, 37.8. Neuritis (%), 20, 24.3.


Physical Therapy Examination and Assessment

JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015

Why Are My Nerves So Sensitive? Neuroscience Education for Patients With CRPS

or RSD. Authors: Ariana Brutico, MSPT, PhD. AFFILIATION: Body Dynamic: Outpatient

Physical Therapy, Pilates, and Yoga Clarks Summit, PA.


Improved model output statistics of numerical weather prediction based irradiance forecasts for solar power applications

RA Verzijlbergh, PW Heijnen, SR de Roode, A Los… – Solar Energy, 2015

irradiance is zero. The evaluation of the probabilistic forecasts is carried out using

two metrics. The first is the continuous ranked probability score (CRPS): equation(9).

CRPS ( k ) = 1 T ∑ t = 1 T ∫ x F ̂ t + k | t ( x ) – H ( x – y t + k ) 2.


Thoracic sympathectomy: a review of current indications

M Hashmonai, AEP Cameron, PB Licht, C Hensman… – Surgical Endoscopy, 2015

However, because the role of the autonomous nervous system is obscure in the pathogenesis

of these disorders, the term “Complex regional pain syndrome” (CRPS) is preferred. There is

very little good evidence in the literature to guide treatment of CRPS.


NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.

CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015

image (contralateral) side [21]. This symptom has been observed in many clinical

pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid

arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror


Process Documentation Research and Impact of Community-Driven Development Grants Research in Rural India, Socioeconomics Discussion Paper Series 34

M Bhattarai, Y Mohan Rao, BL Varalakshmi, VD Duche… – 2015

Item Type: Socioeconomics Discussion Paper Series. Divisions: RP-Market Institutions

and Policies. CRPS: CGIAR Research Program on Policies, Institutions, and Markets.

Series Name: Socioeconomics Discussion Paper Series.


SCAMP: A new tool for an old problem

RH Rathod – Journal of Hospital Medicine, 2015

BWH, Brigham and Women’s Hospital; CRPS, complex regional pain syndrome; EPL, extensor

pollicis longus; PFL, Flexor pollicis longus; MRN, medical record number; N/A, not applicable;

OT, occupational therpay; PA, physician’s assistant. Download figure to PowerPoint.




Results of an active neurodynamic mobilization program in patients with fibromyalgia syndrome: a randomized controlled clinical trial

JR Torres, IC Martos, IT Sánchez, AO Rubio… – Archives of Physical …, 2015

To examine the effects of an active neurodynamic mobilization program on pain, neurodynamics,

perceived health state and fatigue in patients with fibromyalgia s. Setting. A local Fibromyalgia

Association. Participants. 48 patients with fibromyalgia syndrome. Interventions.


The evaluation in terms of sarcopenia of patients with fibromyalgia syndrome

I Koca, E Savas, ZA Ozturk, A Boyaci, A Tutoglu… – Wiener klinische …, 2015

Background Fibromyalgia syndrome (FMS) is an extra-articular rheumatic illness,

characterized by widespread body pain and decreased muscle function. Generalized loss of

muscle mass and strength is named as sarcopenia. The objective of this study was to


Stigma, Unspeakable Dilemmas, and Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia

J Griffith, N Ryan – Meanings of ME: Interpersonal and Social Dimensions …, 2015

Chronic fatigue syndrome (CFS) and fibromyalgia are both illnesses for which suffering is

amplified by stigmatisation. People with these illnesses often feel judged, devalued,

marginalised, or discriminated against by employers, family members, friends and, most of


[PDF]Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia

DH Choi, HS Kim – Korean Journal of Internal Medicine, 2015

Background/Aims: Nailfold capillaroscopy (NFC) has been used to examine morphological

and functional microcirculation changes in connective tissue diseases. It has been

demonstrated that NFC patterns reflect abnormal microvascular dynamics, which may play


Fibromyalgia incidence among patients with hepatitis B infection

L Yazmalar, Ö Deveci, İ Batmaz, D İpek, T Çelepkolu… – International Journal of …, 2015

Aim The purpose of our investigation was to evaluate the incidence of fibromyalgia

syndrome (FMS) and identify FMS-related clinical symptoms in hepatitis B virus (HBV)

patients. Methods One hundred and eighteen HBV surface antigen (HbsAg)-positive


[PDF]Rheumatology: Current Research

EÖ Bulduk, B Biral – 2015

Page 1. Treatment Approaches of Juvenile Fibromyalgia Syndrome Abstract Juvenile

fibromyalgia syndrome (JFMS) is an idiopathic long-term health condition characterized

by widespread musculoskeletal pain in children and adolescents.


Meanings of ME: Interpersonal and Social Dimensions of Chronic Fatigue

CD Ward – 2015

10 11 12 13 14 The Challenge of CFS/ME in Primary Care Laura Saunders The Said and the

Unsaid: Ambivalence in CFS/ME Christopher D. Ward Stigma, Unspeakable Dilemmas, and

Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia James Griffith and


AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome

P Bullon, E Alcocer-Gómez, AM Carrión… – Antioxidants and Redox …, 2015

Deficient AMPK activation and over-activation of NLRP3-inflammasome axis was also observed

in blood cells from patients with Fibromyalgia (FM), a prevalent human some pain conditions as

neuropathic pain, fibromyalgia (FM), and complex regional pain syndrome (6,15,16).


Is Chronic Pain a Disease in Its Own Right? Discussions from a Pre-OMERACT 2014 Workshop on Chronic Pain

AM Taylor, K Phillips, JO Taylor, JA Singh… – The Journal of …, 2015

In a review of functional disorders36, various mechanisms were proposed to explain the cause

of conditions such as irritable bowel syndrome, fibromyalgia, temporomandibular joint disorder,

and inter- stitial cystitis, including enhanced pain perception, altered brain activation


Compendium for the Antenatal Care of High-Risk Pregnancies

H Narayan – 2015

AB1222-HPR Hypervigilance to Emotional Subliminal Images in Patients with Fibromyalgia

I Peláez, F Mercado, P Barjola, S Cardoso – Annals of the Rheumatic Diseases, 2015

Background Fibromyalgia (FM) is a chronic condition characterized by the presence of pain,

fatigue and cognitive dysfunction, among other symptoms. Previous research (Duschek et

al., 2014) also indicated that patients show an hypervigilance pattern to pain and negative


[HTML]Temporal analysis of pain responders and common adverse events: when do these first appear following treatment with pregabalin

J Fink, B Emir, B Parsons, A Clair – Journal of Pain Research, 2015

Clair Pfizer, New York, NY, USA Background: Pregabalin is an α2δ ligand indicated in the USA

for treatment of a number of chronic pain conditions, including diabetic peripheral neuropathy,

postherpetic neuralgia, pain associated with spinal cord injury, and fibromyalgia.


SP0133 Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Diseases

T Avcin – Annals of the Rheumatic Diseases, 2015

The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.

Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12

JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford.


Neuropathic pain as part of chronic widespread pain: environmental and genetic influences.

SK Momi, SM Fabiane, G Lachance, G Livshits… – Pain, 2015; +44 (0) 20 7188 6765 Keywords: chronic widespread pain;

neuropathic pain; genetic; fibromyalgia; twin ACCEPTED ABSTRACT Chronic widespread pain

(CWP) has complex aetiology and forms part of the fibromyalgia syndrome.


SP0130 C5A and its Receptor in Anca-Associated Vasculitis

MH Zhao – Annals of the Rheumatic Diseases, 2015

The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.

Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12

JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford.


The spectrum of noncoeliac gluten sensitivity

I Aziz, M Hadjivassiliou, DS Sanders – Nature Reviews Gastroenterology & …, 2015

with NCGS is described as well as the symptom manifestations commonly reported after gluten

exposure, which include intestinal symptoms consistent with IBS, and extraintestinal symptoms

such as neurological dysfunction, psychological disturbances, fibromyalgia and skin


Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

M Schedlowski, P Enck, W Rief, U Bingel – Pharmacological Reviews, 2015


Health-related quality of life improvements among women with chronic pain: comparison of two multidisciplinary interventions

SV Björnsdóttir, M Arnljótsdóttir, G Tómasson, J Triebel… – Disability & Rehabilitation, 2015

18,19]. Recently published systematic reviews on multidisciplinary programs for

people with chronic pain [19], chronic low back pain [20] or fibromyalgia syndrome

[21] agree on recommended content in such programs. This


NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.

CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015

image (contralateral) side [21]. This symptom has been observed in many clinical

pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid

arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror


Physical Therapy Examination and Assessment

JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015

and nerve sensitivity. It is one of several manuals written by the primary author, all

of which discuss concurrent topics involving pain and recovery from injury, including

whiplash, headaches, and fibromyalgia. The manual begins

Weekly Breaking Research Updates, June 22, 2015

Weekly Breaking Research Updates, June 22, 2015

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.




Ketamine and Phencyclidine: the good, the bad and the unexpected

D Lodge, MS Mercier – British Journal of Pharmacology, 2015

ABSTRACT: The history of ketamine and phencyclidine from their development as potential

clinical anaesthetics, through drugs of abuse and animal models of schizophrenia to

potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA


Intra‐and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

R Minoshima, S Kosugi, D Nishimura, N Ihara, H Seki… – Acta Anaesthesiologica …, 2015

Background In this randomized controlled trial, we examined whether intra-and

postoperative infusion of low-dose ketamine decreased postoperative morphine

requirement and morphine-related adverse effects as nausea and vomiting after scoliosis


Period Prevalence of Ketamine-Propofol Admixture “Ketofol” in the Operating Room among Anesthesia Providers at an Academic Medical Center

AN Olson, WR Rao, ME Marienau, NJ Smischney – Medical Science Monitor, 2015

BACKGROUND: The primary aim of this study was to determine the period prevalence of the

single-syringe ketamine-propofol admixture used for sedation and induction among

anesthesia providers during a 5-year period before and after educational sessions


Electrochemiluminescence immunosensor for ketamine detection based on polyamidoamine-coated carbon dot film

Q Li, W Tang, Y Wang, J Di, J Yang, Y Wu – Journal of Solid State Electrochemistry, 2015

Abstract In this work, we reported the synthesis of water-soluble carbon dots (CDs) by a one-

step hydrothermal synthetic route using polyamidoamine (PAMAM) as platform and

passivant, where the formation of CDs capped with PAMAM and the surface passivation


Letter to the editor: When what you see might not be what you get: prudent considerations of anesthetics for murine echocardiography

J Wu, J You, S Wang, Y Ye, X Wang, J Jia, Y Zou – American Journal of Physiology- …, 2015

In their well- designed experiments, the authors compared four popular an- esthetic regimens

(ketamine-xylazine, ketamine alone, avertin, and isoflurane) used in mice during

echocardiographic mea- surement, with conscious state as a reference.


Ketamine promotes inflammation through increasing TLR4 expression in RAW264. 7 cells

C Meng, Z Liu, G Liu, L Fu, M Zhang, Z Zhang, H Xia… – Journal of Huazhong …, 2015

Summery Ketamine (KTM), a N-methyl-D-aspartate (NMDA) receptor antagonist, was found

to has an anti-inflammatory effect, but some patients suffered from exacerbated pro-

inflammatory reactions after anesthesia with KTM. The present study was aimed to


The effect of NMDA receptor antagonists and antidepressants on resting state in major depressive disorder

A Dutta – 2015

fMRI ; major depressive disorder ; resting state ; antidepressant ; lanicemine ; ketamine ; citalopram

; anterior cingulate cortex ; NMDA ; glutamate. Ketamine and other NMDA antagonists have

improved MDD symptoms within 24 hours though the effects are short lasting.


Assessing Measures of Suicidal Ideation in Clinical Trials with a Rapid-Acting Antidepressant

ED Ballard, DA Luckenbaugh, EM Richards, TL Walls… – Journal of Psychiatric …, 2015

Received 22 April 2015, Revised 21 May 2015, Accepted 5 June 2015, Available online 16 June

2015. Highlights. • Clinical trials of ketamine and suicide will require appropriate measurement. •

We compared several suicide assessment measures in ketamine clinical trials. •



AR Durrant, U Heresco-Levy – Encyclopedia of Psychopharmacology, 2015

of this concept became evident during the last decade when robust antidepressant effects

emerging within 2–4 h and lasting up to more than 2 weeks were obtained and replicated fol-

lowing intravenous administration of single sub-anesthetic doses of ketamine (Krystal et al.


Depression: Response and Remission

SD Østergaard, GI Papakostas, M Fava – Encyclopedia of Psychopharmacology, 2015

of this concept became evident during the last decade when robust antidepressant effects

emerging within 2–4 h and lasting up to more than 2 weeks were obtained and replicated fol-

lowing intravenous administration of single sub-anesthetic doses of ketamine (Krystal et al.


Is pre-emptive administration of ketamine a significant adjunction to intravenous morphine analgesia for controlling postoperative pain? A randomized, double-blind, …

A Fiorelli, A Mazzella, B Passavanti, P Sansone… – … and Thoracic Surgery, 2015

OBJECTIVES To evaluate if the pre-emptive administration of ketamine would potentiate the

effect of intravenous morphine analgesia in the management of post-thoracotomy pain.

METHODS This was a unicentre, double-blind, placebo-controlled, parallel-group,


Kappa-Opioid Agonists

E Opioid – 2015

It is considered a precancerous condition. Ketamine Synonyms Ketalar; Ketaset Definition

Ketamine is an FDA-approved medication for induction and maintenance of anesthesia

in adults. It is a phencyclidine derivative first synthetized in 1962.


Investigation of the effects of stress on some liver enzymes (AST, ALT, ALP) in rats.

YG Gencer, A Çınar, B Comba – Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2015

was applied intraperitoneally (ip) to the experimental group. After 3 h, blood samples

were collected from both groups under ketamine anaesthesia, using appropriate

techniques. The control group serum AST, ALT, ALP values


Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy?

RM Hoffman – Gene Therapy of Solid Cancers, 2015

7. Anesthetic reagents (ketamine, xylazine, acepromazine maleate). 8. Kanamycin. 9. Nair. 10.

1. Four-week-old female mice were anesthetized by a ketamine mixture (10 μl ketamine HCL,

7.6 μl xylazine, 2.4 μl acepromazine maleate, and 10 μl H 2 O) via sc injection.


[PDF] The Protective Effect of Melatonin vs. Vitamin E in the Ischemic/Reperfused Skeletal Muscle in the Adult Male Rat Model

EA Mohamed – J Cytol Histol S, 2015

All surgical procedures were performed under anesthesia with IP injection of

Ketamine hydrochloride (Ketame, Egyptian Int. Co. After 2 hours of reperfusion, the

rats were sacrificed by Ketamine hydrochloride (100 mg/kg) [10].


[PDF] CORM2 protects from myocardial ischemia reperfusion injury via modulation of the inflammatory response and apoptosis

NR Hadi, FG Al-Amran, KA Muhsin, A Taher – Journal of Advanced Pharmacy …, 2015

2% vials (RompunTM, Bayer AG, Leverkusen, Germany), ketamine (Hikma, Jordan), ethanol

(Fluka, Switzerland) and normal saline (KSA). Rat (IL-1β), (IL- Surgical LAD ligation The rats were

anesthetized by intraperitoneal injection with a mixture of ketamine and xylazine in a


[HTML] Long-term correlation of the electrocorticogram as a bioindicator of brain exposure to ionizing radiation

LAA Aguiar, IMS Silva, TS Fernandes, RA Nogueira – Brazilian Journal of Medical and …, 2015

The irradiation was carried out with the animals anesthetized with 10 mg/kg xylazine and 75

mg/kg ketamine administered intraperitoneally. To record the ECoG, animals were anesthetized

with 10 mg/kg xylazine and 75 mg/kg ketamine administered intraperitoneally.


[HTML] The Anti-Tumor Effects of Adipose Tissue Mesenchymal Stem Cell Transduced with HSV-Tk Gene on U-87-Driven Brain Tumor

SM de Melo, S Bittencourt, EG Ferrazoli, CS da Silva… – PLOS ONE, 2015

The animals were anesthetized via the ip injection of a ketamine (100 mg/kg) and xylazine

(10 mg/kg) solution (Syntec, 1356009 and 1720407) and fastened to a stereotaxic

instrument (David Kopf) equipped with a mouse adapter (Enlaup).


[HTML] Intrarectal Lidocaine-Diltiazem-Meperidine Gel for Transrectal Ultrasound Guided Prostate Biopsy

F Imani, Y Moghaddam, RS Moharari, F Etezadi… – Anesthesiology and Pain …, 2015

4, 6) or bupivacaine as a single agent (7). These latter studies have suggested that rectal

administration of lidocaine gel is a safe, simple modality, without any discomfort for patients (8).

Not only local anesthetic agents but also intravenous anesthetic drugs (ketamine) (9) or


[PDF] Alcohol Withdrawal Syndrome: Improving Outcomes Through Early Identification And Aggressive Treatment Strategies

AF Pizon – 2015

Page 1. June 2015 Volume 17, Number 6 Authors Joseph H. Yanta, MD Medical

Toxicology Fellow, Division of Medical Toxicology, Dept. of Emer- gency Medicine,

University of Pittsburgh Medical Center, Pittsburgh, PA Greg


Radiofrequency Ablation (RFA)


Use of Contact Force Sensing Technology During Radiofrequency Ablation Reduces Recurrence of Atrial Fibrillation: A Systematic Review and Meta-Analysis

MR Afzal, J Chatta, A Samanta, S Waheed… – Heart Rhythm, 2015

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use a different browser: Firefox or Chrome. For additional information please see the


Comparison of Surgical Resection and Radiofrequency Ablation for Hepatocellular Carcinoma: Take Care Not to Neglect Radiofrequency Technic and Device.

A Hocquelet, M Montaudon, P Balageas, N Frulio… – Annals of Surgery, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. Skip Navigation Links Home >


Effect of different ablation settings on acute complications using the novel irrigated multipolar radiofrequency ablation catheter (nMARQ)

T Deneke, P Müller, P Halbfaß, A Szöllösi, M Roos… – Journal of Cardiovascular …, 2015

Background: Single-shot ablation devices for pulmonary vein isolation (PVI) in patients with

symptomatic atrial fibrillation (AF) have been increasingly used in clinical practice. Objective:

A novel mapping-system integrated irrigated multipolar circular ablation catheter (nMARQ)


Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and Neuron Remodeling in Target Atrial Tissues in a Canine Model

X Wang, M Zhang, Y Zhang, X Xie, W Wang, Z Li… – Circulation: Arrhythmia and …, 2015

Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and

Neuron Remodeling in Target Atrial Tissues in a Canine Model. Atrial electrophysiological

characteristics were examined before ablation, immediately and continuously after ablation.


… to Letter From Bisbal et al Regarding,“Repeat Left Atrial Catheter Ablation: Cardiac Magnetic Resonance Prediction of Endocardial Voltage and Gaps in Ablation

JL Harrison, C Sohns, NW Linton, R Karim, SE Williams… – Circulation: Arrhythmia and …, 2015

Tolosana JM,; Arbelo E,; de Caralt TM,; Perea RJ,; Brugada J,; Mont L. CMR-guided

approach to localize and ablate gaps in repeat AF ablation procedure. JACC Cardiovasc

Imaging . 2014;7:653–663. doi: 10.1016/j.jcmg.2014.01.014.


Pulmonary vein stenosis after pulmonary vein isolation using duty-cycled unipolar/bipolar radiofrequency ablation guided by intracardiac echocardiography

S Asbach, F Schluermann, L Trolese, M Langer… – Journal of Interventional …, 2015

Purpose Concerning rates of pulmonary vein (PV) stenosis were reported following PV

isolation (PVI) with a circular pulmonary vein ablation catheter (PVAC). As this may depend

on intraprocedural imaging, we evaluated the incidence of PV stenosis in patients


Atrioventricular Block During Slow Pathway Ablation Entirely Preventable?

H Chen, M Shehata, W Ma, J Xu, J Cao, E Cingolani… – Circulation: Arrhythmia and …, 2015

In a small percentage of cases of AVNRT, it may be necessary to ablate within the CS

with larger atrial potentials, however, ablation at the roof of the proximal CS carries

a high risk of AV nodal block during radiofrequency application.


Is There Still a Role for CFAE Ablation in Addition to Pulmonary Vein Isolation in Patients with Paroxysmal and Persistent Atrial Fibrillation? A Meta-Analysis of 1,415 …

R Providência, PD Lambiase, N Srinivasan, GG Babu… – Circulation: Arrhythmia and …, 2015

Is There Still a Role for CFAE Ablation in Addition to Pulmonary Vein Isolation in Patients with

Paroxysmal and Persistent Atrial Fibrillation? We aimed to assess the impact of CFAE ablation

in addition to pulmonary vein isolation (PVI) in patients undergoing ablation for AF.


Real-Time Contact Force Measurement A Key Parameter for Controlling Lesion Creation With Radiofrequency Energy

DC Shah, M Namdar – Circulation: Arrhythmia and Electrophysiology, 2015

Low CF values are also advisable in the vicinity of already ablated sites, where the for the

acquisition of reliable mapping information and achievement of stable ablation lesions 183 gs)

as area under curve (red hatched zone) during short duration of radiofrequency (RF) energy


Atrioventricular Nodal Block With Atrioventricular Nodal Reentrant Tachycardia Ablation

SJ Asirvatham, WG Stevenson – Circulation: Arrhythmia and Electrophysiology, 2015

a relatively slow stable, junctional rhythm with consistent stable retrograde atrial conduction during

radiofrequency application. of energy delivery, junctional rhythm may not be seen despite adequate

slow pathway ablation, and the operator may be inclined to ablate at more


[HTML] Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial …

RP Singh-Moon, CC Marboe, CP Hendon – Biomedical Optics Express, 2015

Abstract Effects of radiofrequency ablation (RFA) treatment of atrial fibrillation can be limited

by the ability to characterize the tissue in contact. Parameters obtained by conventional

catheters, such as impedance and temperature can be insufficient in providing


A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular …

CJ Breitbach, A Moon, J Burke, TH Hwang, DH Kirn – Gene Therapy of Solid Cancers, 2015

Download Protocol (725 KB). Abstract. Primary liver cancer (hepatocellular carcinoma; HCC)

in patients not eligible for surgery or transplant is currently treated by locoregional therapeutic

approaches, including trans-arterial chemoembolization and radiofrequency ablation.


[PDF] Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

CM Huang, MY Huang, JY Tang, SC Chen, LY Wang… – World Journal of Surgical …, 2015

Several other treatment modalities for patients with unresectable HCC, including percutaneous

ethanol injection (PEI), radiofrequency ablation (RFA), and transcatheter arterial

chemoembolization (TACE), seem to be more effective in smaller tumors and are contraindicated


The Wolf-Parkinson-White ECG Pattern-Assessing the Mortality Risk

E Posan – Journal of Insurance Medicine, 2015

32. MANAGEMENT. Radiofrequency Ablation Therapy With pacing maneuvers, the accessory

pathway properties are defined, potential tachycardias are induced, accurate mapping (localization)

of the accessory pathway is achieved and radiofrequency ablation is employed.


[HTML] Congenital (in growing) osteoma skull in 20-day-old neonate

PG Devi, TS Venkatachalam, YV Sharma, MP Kumar – CHRISMED Journal of …, 2015

6. 7. Virayavanich W, Singh R, O’Donnell RJ, Horvai AE, Goldsby RE, Link TM. Osteoid osteoma

of the femur in a 7-month-old infant treated with radiofrequency ablation. Skeletal Radiol

2010;39:1145-9. Back to cited text no. 7. 8. McHugh JB, Mukherji SK, Lucas DR.


[PDF] Simulating and Optimizing the Response of a Sine Wave Finite state Machine with Timestamp Simulation Using Simulink

M Kalpna, MA Varma – International Journal of Research, 2015

[5.] Dagmara M. Dołęga, Jerzy Barglik, (2012) “Computer modeling and simulation of

radiofrequency thermal ablation“, COMPEL – The international journal for computation and

mathematics in electrical and electronic engineering, Vol. 31 Iss: 4, pp.1087 – 1095


[PDF] Coexistence of permanent junctional reciprocating tachycardia with rheumatic valvular disease; a case sucessfully treated with radiofrequency ablation

M Aydın, A Yıldız, M Yüksel, Y İslamoğlu

Abstract A seventeen years old female had presented with palpitation. On the

electrocardiography (ECG), long RP, narrow QRS tachycardia, inverted P waves in leads

D2, D3 and aVF were noticed. On transthoracic echocardiography, rheumatic mitral


[PDF] Macrophage Inflammatory Protein Derivative ECI301

T Radiotherapy

inhibition by ECI301 was not attributable to radiation alone but also shown to other factors such

as the heat generated from high-frequency alter- nating current, namely radiofrequency ablation

(RFA; ref. 5B), significant differences were ablated by the anti- HMGB1 antibody.


[PDF] Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. J Stem Cells Res

D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015

back or neck pain refractory to physical therapy, trigger point injections, medial branch blocks,

or radio- frequency ablation. There is scarce evidence supporting less commonly performed

non-surgical treatments for lumbar radiculopathy including pulsed radiofrequency to the


[HTML] Modern medicine-morcellation

SC Olmstead

abandoned as a surgical procedure? What about noninvasive treatment options that

leave the presumed fibroid inside the body, such as uterine artery embolization,

MRI-guided focused ultrasound, and radiofrequency ablation?


Chronic Regional Pain Syndrome (CRPS/RSD)


What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature

S Grieve, L Jones, N Walsh, C McCabe – European Journal of Pain, 2015

Background and objective. Complex Regional Pain Syndrome (CRPS) is a chronic pain condition,

often triggered by trauma to a limb and characterized by sensory, motor, autonomic and trophic

changes within the affected limb. 2.4 Classification of CRPS clinical trials.



A Najiha, J Alagesan, VJ Rathod, P Paranthaman – Int J Physiother Res, 2015

Three particular conditions that have been studied the most are stroke, CRPS and phantom

limb pain. MT was used in conditions like stroke, cerebral palsy (CP), complex regional pain

syndrome (CRPS), phantom limb pain (PL) and fracture rehabilitation.


Physical Therapy Treatment for Patients Diagnosed with Complex Regional Pain Syndrome

J Connole – 2015

Abstract. This case study and evidence-based research analyzes the effects of physical

therapy interventions on a patient diagnosed with type 1 complex regional pain

syndrome (CRPS) to determine the most beneficial treatments.


Hybrid short-term freeway speed prediction methods based on periodic analysis

Y Zou, X Hua, Y Zhang, Y Wang – Canadian Journal of Civil Engineering, 2015

Page 1. Hybrid short-term freeway speed prediction methods based on periodic

analysis By Yajie Zou, Ph.D. Research associate 133B More Hall, Box 352700

Department of Civil and Environmental Engineering University of


[HTML] Japanese MD Develops Nutritional Protocols for Gardasil/Cervarix HPV Vaccine Injury

LC Botha – 2015

subacute sclerosing panencephalitis; CRPS: Complex regional pain syndrome; POTS:

Postural orthostatic tachycardia syndrome; Anti-phospholipid antibody syndrome;

SLE: systemic lupus erythematosus; Rheumatoid arthritis;


The social behavior of children adopted from Russian Federation: a controlled study

C Caprin, L Ballarin, L Benedan, A Castelli – Psicologia clinica dello sviluppo, 2015

Nonostante nella ricerca si sia utilizzata la forma estesa per genitori dello strumento

(CRPS-R:L; Conners, validazione Italiana a cura di Nobile, Alberti e Zuddas, 2007), composta

da 80 item (valori di a com- presi fra 0.57 e 0.91 per i maschi e 0.58 e 0.89 per le femmine), in


A Review of the Use of Stellate Ganglion Block in the Treatment of PTSD

E Lipov, EC Ritchie – Current Psychiatry Reports, 2015

14. Lipov EG, Joshi JR, et al. A unifying theory linking the prolonged efficacy of the stellate

ganglion block for the treatment of chronic regional pain syndrome (CRPS), hot flashes,

and posttraumatic stress disorder (PTSD). Med Hypotheses.


Addiction Recovery in Services and Policy: An International Overview

A Laudet, D Best – Textbook of Addiction Treatment: International …, 2015

model is growing in popularity nationwide: in the past decade, growing concerns about substance

use on campus and federal agencies’ focus on building a community-based continuum of care

system for youths have fueled a fivefold increase in the number of CRPs, from four


[HTML] Related Products

R Frank

43. Canalith Repositioning Procedures. The recommended treatment for BPPV is a canalith

repositioning procedure (CRP). There are several CRPs described in the literature; the most

studied and used in the United States was first described by Epley in 1992.


Central habituation and distraction alter C‐fibre‐mediated laser‐evoked potential amplitudes

P Hüllemann, YQ Shao, G Manthey, A Binder, R Baron – European Journal of Pain, 2015

Skip to Main Content. Wiley Online Library. Log in / Register. Log In E-Mail

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Nuclear Medicine Imaging of Sport Injuries of the Wrist, Hand and Fingers

M Sathekge, FE Suleman, MD Velleman, R Clauss – Nuclear Medicine and …, 2015

Abductor pollicis longus. CRPS: Chronic regional pain syndrome. 1997 ). 24.7 Complex Regional

Pain Syndrome (Reflex Sympathetic Dystrophy, Sudeck’s Dystrophy). Complex regional pain

syndrome (CRPS) is one of the most challenging chronic pain conditions of the limbs.


The Child with a Painful Limp

J Robb – Paediatric Orthopaedic Diagnosis, 2015

There may be symptoms of psychological distress and further specialist evaluation may

reveal an underlying cause. Complex Regional Pain Syndrome (CRPS). Children with

CRPS type 1 affecting the lower limb often limp (Wilder et al. 1992 ).


Complex regional pain syndrome type I. An analysis of 7 cases in children

VP Stalla, CM Olaso, VK Almada, GG Rabelino – Neurología (English Edition), 2015

Complex regional pain syndrome (CRPS) is characterised by the presence of pain accompanied

by sensory, autonomic and motor symptoms, usually preceded by a lesio.


Vitamin C, Extremity Trauma and Surgery

N Shibuya, MR Agarwal, DC Jupiter – 2015

987 Abstract Complex regional pain syndrome (CRPS) is a devastating condition often seen

after extrem- ity injury and surgery. Efficacy and safety of vitamin C used to prevent CRPS are

discussed. List of Abbreviations CRPS Complex regional pain syndrome Introduction


Psychological Factors as Outcome Predictors for Spinal Cord Stimulation

T Bendinger, N Plunkett, D Poole, D Turnbull – Neuromodulation: Technology at the …, 2015

SCS trials were offered for the following indications: failed back surgery syndrome (FBSS),

refractory radiculopathy or peripheral neuropathy, complex regional pain syndrome (CRPS),

and refractory angina (at the beginning of observed period—since 2008, this indication is not


[PDF] The Role of Transitional Justice and Access to Justice in Conflict Resolution and Democratic Advancement

MF Moscati – 2015

year mandate. The Community Reconciliation Processes (CRPs) of Timor-Leste were created

with the specific aim of dealing with disputes between perpetrators into their communities. The

possibility of recourse to CRPs was established by the United Nations Transitional


Complex Regional Pain Syndrome in Children: a Multidisciplinary Approach and Invasive Techniques for the Management of Nonresponders

MJ Rodriguez‐Lopez, M Fernandez‐Baena, A Barroso… – Pain Practice, 2015

Complex regional pain syndrome (CRPS) is multifactorial condition with complex

pathogenesis characterized by spontaneous or stimulus-induced pain that is

disproportionate to the inciting event. It is also commonly accompanied


Analgesic response to intravenous ketamine is linked to a circulating microRNA signature in female complex regional pain syndrome patients

SR Douglas, BB Shenoda, RA Qureshi, A Sacan… – The Journal of Pain, 2015

Although ketamine is beneficial in treating complex regional pain syndrome (CRPS), a subset

of patients respond poorly to therapy. We investigated treatment-ind. Highlights. • We studied

ketamine treatment induced miRNA alterations in blood from CRPS patients. •


Peptide signalling during the pollen tube journey and double fertilization

LJ Qu, L Li, Z Lan, T Dresselhaus – Journal of Experimental Botany, 2015

In general, plant peptides can be categorized into two classes: secreted peptides and

non-secreted peptides. Secreted peptides can be further divided into two major classes:

cysteine-rich peptides (CRPs) and non-CRPs (NCRPs). CRPs are significantly larger peptides.


[HTML] Overexpression of the Arabidopsis thaliana signalling peptide TAXIMIN1 affects lateral organ development

J Colling, T Tohge, R De Clercq, G Brunoud, T Vernoux… – Journal of Experimental …, 2015

Two distinct classes of secreted peptides can be distinguished in plants: small post-translationally

modified peptides such as the CLAVATA3/ENDOSPERM SURROUNDING REGION (CLE) family,

and cysteine-rich peptides (CRPs), exemplified by the EPIDERMAL



H Tabuteau – US Patent 20,150,157,582, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type 11 (CRPS-II



H Tabuteau – US Patent 20,150,157,564, 2015

embodiments, an osteoclast inhibitor, such as a nitrogen-containing bisphosphonate, eg

zoledronic acid, ibandronic acid or minodronic acid, may be administered to relieve complex

regional pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex




The Use of Polysymptomatic Distress Categories in the Evaluation of Fibromyalgia (FM) and FM Severity

F Wolfe, BT Walitt, JJ Rasker, RS Katz, W Häuser – The Journal of Rheumatology, 2015

Objective The polysymptomatic distress (PSD) scale is derived from variables used in the

2010 American College of Rheumatology (ACR) fibromyalgia (FM) criteria modified for

survey and clinical research. The scale is useful in measuring the effect of PSD over the


Association of different levels of depressive symptoms with symptomatology, overall disease severity, and quality of life in women with fibromyalgia

A Soriano-Maldonado, K Amris, FB Ortega… – Quality of Life Research, 2015

Purpose This study examined the associations of different levels of depression with pain,

sleep quality, fatigue, functional exercise capacity, overall fibromyalgia (FM) severity, and

health-related quality of life (HRQoL) in women with FM. Methods A total of 451 women


Fibromyalgia: Clinical Guidelines and Treatments

E Lawson, M Wallace – 2015


Major Classes of Medication for Treatment of Fibromyalgia

AM Kelly, K Mauer – Fibromyalgia: Clinical Guidelines and Treatments, 2015


Implications of proposed fibromyalgia criteria across other functional pain syndromes

N Egloff, R von Känel, V Müller, UT Egle… – Scandinavian Journal of …, 2015

Objectives: In 2010, the American College of Rheumatology (ACR) proposed new criteria for

the diagnosis of fibromyalgia (FM) in the context of objections to components of the criteria of

1990. The new criteria consider the Widespread Pain Index (WPI) and the Symptom


Omar I. Halawa and David A. Edwards

DA Edwards – Fibromyalgia: Clinical Guidelines and Treatments, 2015


Psychophysiological Methods

RH McAllister-Williams – Encyclopedia of Psychopharmacology, 2015

potential. Tramadol reduces pain substantially in osteoarthritis and fibromyalgia

(Bennett et al. 2003). Methadone below). There is evidence of a mild degree of benefit

in low back pain, fibromyalgia, and headaches. Anticonvulsant


PTSD and Fibromyalgia Syndrome: Focus on Prevalence, Mechanisms, and Impact

W Häusera, J Ablinb, B Walittc – 2015

Abstract The association between fibromyalgia syndrome (FMS) and posttraumatic stress

disorder (PTSD) is of growing interest in psychosocial research. The mechanisms by which

both disorders are interconnected are not well understood. The article presents an


Conditioned Pain Modulation: Neurophysiological, Cognitive, And Pharmacological Aspects

RR Nir, D Yarnitsky – Topics in Pain Management, 2015

The relevance of modulatory pain mechanisms in the clinical arena is represented through

cumulative research reporting impaired pain inhibition associated with pain disorders, particularly

fibromyalgia, irritable bowel syndrome, migraine, tension-type headache


Ryan D. McConn and Magdalena Anitescu

RD McConn – Fibromyalgia: Clinical Guidelines and Treatments, 2015


[HTML] Another dimension of pain

TH Khan – Anaesth Pain & Intensive Care, 2015

Pain Manag Nurs. 2013 Dec;14(4):368-78. [PubMed] doi: 10.1016/j.pmn.2011.08.001. Menzies

V, Taylor AG, Bourguignon C. Effects of guided imagery on outcomes of pain, functional status,

and self-efficacy in persons diagnosed with fibromyalgia. J Altern Complement Med.


[HTML] Pattern of irritable bowel syndrome and its impact on quality of life: A tertiary hospital based study from Kolkata on newly diagnosed patients of irritable bowel …

U Sinharoy, K Sinharoy, P Mukhopadhyay… – CHRISMED Journal of …, 2015

[6],[7],[8],[9] IBS can coexist with other functional disorders, most notably fibromyalgia, chronic

fatigue syndrome 10. 11. Aaron LA, Burke MM, Buchwald D. Overlapping conditions among

patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.


[PDF] Disability Status, Disability Type, and Training as Predictors of Job Placement

J Stahl – 2015

Deafness Hearing, Communicating Deafness Neurological Memory, Speaking TBI, Multiple

Sclerosis, Fibromyalgia Developmental Reading, Writing, Speaking Autism, Williams Syndrome

Mental Neurological Memory, Speaking TBI, Multiple Sclerosis, Fibromyalgia


[HTML] Pilates for Fibromyalgia

DPT Tom Lavosky, C MDT

By Gabrielle Shirer As originally seen in the Fall 2006 edition of the Pilates Coreterly

According to the National Fibromyalgia Association, Fibromyalgia Syndrome (FMS) is an

increasingly recognized chronic pain illness characterized by widespread


New study by guidelines author dismisses risk of chronic Lyme disease

D Cameron

In addition, these patients were not more prone to developing fibromyalgia and/or chronic fatigue,

according to two additional papers by Dr. Wormser. [1]. And previous studies report there’s a

high risk of developing fibromyalgia after having Lyme disease.


[HTML] Evolution of Skin Temperature after the Application of Compressive Forces on Tendon, Muscle and Myofascial Trigger Point

MF Magalhães, AV Dibai-Filho, EC de Oliveira Guirro… – PLOS ONE, 2015

of musculoskeletal, tendon or nervous injuries in the upper limb, history of fracture in the upper

limb, use of painkillers, anti-inflammatory drugs or muscle relaxants during the previous week,

presence of systemic or neuromuscular diseases, and medical diagnosis of fibromyalgia


[HTML] Rejuvenate With Stem Cells

R Schilling – 2015

literature. This combination (laser activated, intravenous mesenchymal injection) has

the potential for being useful for a multitude of chronic illnesses like fibromyalgia,

MS, generalized arthritis, just to mention a few. Mesenchymal


[PDF] Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. J Stem Cells Res

D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015

Positive results for Prolotherapy have been published for a variety of conditions including lateral

epicondylosis [21], osteoarthritis [22], sacroiliac joint pain [23], chondromalacia patellae [24],

fibromyalgia [25], chronic groin pain [26] and Osgood-Schlatter disease [27].



M Holman – 2015

Page 14. Effect of US and Graston on Muscle Contraction 11 plantar fasciitis,

patellofemoral disorders, fibromyalgia, scar tissue, and trigger finger. 13 The Graston

Technique allows for controlled application of friction massage to the


[HTML] Blueg rass Doctors of Physical Therapy, PLLC Physical Therapy Care Provider in the Louisville, Kentucky We provide EXPERT CARE for YOUR Health!

N Patient, C Forms

There are many symptoms that can lead the person with fibromyalgia syndrome (FMS)

and/or chronic myofascial pain (CMP) to your office. Research indicates that fibromyalgia

may increase the risk of cardiovascular disease (Curtis, O’Keefe Jr 2002).

Weekly Breaking Research Updates, May 22, 2015

Weekly Breaking Research Updates, May 22, 2015

Weekly Breaking Research Updates, May 22, 2015


Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.




[HTML] Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome

X Feng, M Maze, LG Koch, SL Britton, J Hellman – 2015

All procedures were performed under ketamine and xylazine anesthesia, and all efforts

were made to minimize suffering. Animals. The edema. At 48 h, the rats were sacrificed

under deep anesthesia provided by ketamine/xylazine.


Drugs that Target the Glutamate Synapse: Implications for the Glutamate Hypothesis of Schizophrenia

CA MIELNIK, A RAMSEY – Drug Discovery for Schizophrenia, 2015

In addition to the ligand bind- ing domains, NMDA receptors have modulatory sites for

zinc and spermine, and a modulatory site within the channel that binds the

non-competitive inhibitors phencyclidine (PCP), dizocilpine, and ketamine.



TJ Smyser, SR Johnson, MD Stallard, AK McGrew… – Journal of Wildlife Diseases, 2015

lactating were released at the capture location. We anesthe- tized captured raccoons

with ketamine/xyla- zine (10 mg/kg ketamine and 2 mg/kg xylazine, intramuscularly

[Fowler 2009]). Upon induc- tion, animals were weighed


[PDF] Intra-ventral tegmental HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

J Zhu, NM Midde, AM Gomez, W Sun, SB Harrod – Name: Frontiers in Microbiology, 2015

session 29 (Fig 1A). 30 Briefly, rats were anesthetized using a mixture of ketamine

hydrochloride and xylazine 31 by intraperitoneal (IP) injection (7.5 mg ketamine/100

g b.wt. and 30 mg xylazine/100 g b.wt.). 32 Rats were then


Autonomic remodeling: How atrial fibrillation begets atrial

L Zhang, SS Po, HW PhD&, BJ Scherlag, HL PhD&… – 2015

13 Fifty-two male adult New Zealand white rabbits, weighing 2.0–2.5 kg, were 14 premedicated

with ketamine/xylazine ( 35mg/5mg/kg ),and restrained in the 15 supine position. Anesthesia

was also maintained by intra-peritoneal injection of 16 20% urethane 5 ml as needed.


Protein Interactions with Dopamine Receptors as Potential New Drug Targets for Treating Schizophrenia

P SUa, AHC WONG, F LIU – Drug Discovery for Schizophrenia, 2015

Page 222. Chapter 9 208 antagonist, ketamine, or PCP-induced cognitive deficits with an

inverted U-shaped dose response curve. 52 Conversely, there is less ketamine-induced

behavioral activation in D1R knockout mice than in wild-type mice.


Plasma arginine metabolites reflect airway dysfunction

H Grasemann, JA Scott, ML North, M Rafii, H Huang… – J Appl Physiol, 2015

On day 21, 24 h after the final aerosol challenge, mice were anesthetized (ketamine/xylazine)

for tracheal and jugular venous cannulations for ventilator-based measurement of respiratory

function and infusion of the stable L-arginine isotopomer cocktail, respectively.


[PDF] Histological and Histomorphometric Evaluation of Pharmacological Action of the Essential Oil of Melaleuca Alternifolia on Healing of Infected Alveolitis in Experimental …

WS Abdel-fattah, MM Dahaba, AA Ahmed… – J Interdiscipl Med Dent Sci, 2015

Materials and Methods Chemicals Tea tree oil was purchased from (SIGMA-ALDRICH

Chemie GmbH RiedstrasseUSA), vancomycin hydrochloride and ketamine were

obtained from the local pharmaceutical market. Bacterial infection


[PDF] Clinical Evaluation of Caudal Clonidine as an Adjuvant to Bupivacaine in Pediatric Patients Undergoing Sub Umbilical Surgeries

S Dalal – 2015

Prolongation of caudal analgesia using a single-shot technique has been achieved by addition

of various adjuvants, such as epinephrine, opioid, ketamine, and alpha 2 agonists [9]. Clonidine,

an alpha 2 agonist has extensively been used in neuraxial blocks [10- 13] and


The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats

E Taslidere, N Vardi, M Esrefoglu, B Ates, C Taskapan… – Human & Experimental …, 2015

kg body weight for 20 days. At the end of the experiment, rats were killed by ketamine

anesthesia. After blood samples were collected from tail vein, livers were removed

and divided into two portions. One sample was used for


[PDF] Assessment of the effect of ketamine on cytochrome P450 isoforms activity in rats by cocktail method

F Lin, Y He, L Zhang, M Zhang, Y Zhang, C Wen – Int J Clin Exp Med, 2015

Abstract: Cocktail method was used to evaluate the influence of ketamine on the activities of

CYP450 isoforms CYP1A2, CYP2D6, CYP3A4, CYP2C19, CYP2C9 and CYP2B6, which

were reflected by the changes of pharmacokinetic parameters of six specific probe drugs


Ketamine and suicidal ideation in depression: Jumping the gun?

R Rajkumar, J Fam, EYM Yeo, GS Dawe – Pharmacological Research, 2015

Abstract Depression and suicide are known to be intricately entwined but the

neurobiological basis underlying this association is yet to be understood. Ketamine is an N-

methyl D-aspartate (NMDA) receptor antagonist used for induction and maintenance of


Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid- …

X Zhu, P Li, X Hao, K Wei, S Min, J Luo, F Xie, J Jin – Neuroscience Letters, 2015

Abstract Electroconvulsive therapy (ECT) is an effective treatment for depression, but can

result in memory deficits. This study aimed to determine whether ketamine could alleviate

electroconvulsive shock (ECS, an analogue of ECT in animals)-induced memory


D-AMPHETAMINE withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treament with ketamine

JJL Fuller, RC Murray, KA Horner – Neuropharmacology, 2015

Abstract Withdrawal from chronic D-amphetamine (D-AMPH) can induce negative emotional

states, which may contribute to relapse and the maintenance of addiction. Diminished levels

of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus has been


Management of acute pain in patients on treatment with opioids

J De Andres, G Fabregat-Cid, JM Asensio-Samper… – Pain Management, 2015

In fact, the use of NMDA receptor antagonists such as ketamine inhibits the development of

tolerance in test animals [15]. Inhibition of tolerance has been demonstrated in test animals with

the use of noncompetitive antagonists of NMDA receptors such as ketamine [48].



T Ha, L Abbott, J Booth, M Morrow, M Rawlins… – 2015

Emerg Med J 2014; 31: 706–13. Ketamine and Intraocular Pressure in Children This prospective

observational study sought to examine the potential increase in the intraocular pressure following

ketamine administration for paediatric procedural seda- tion.


Multimodal Analgesic Protocol and Postanesthesia Respiratory Depression During Phase I Recovery After Total Joint Arthroplasty.

TN Weingarten, AK Jacob, CW Njathi, GA Wilson… – Regional Anesthesia and …, 2015

Procedural sedation during block placement was with incremental dosing of intravenous midazo-

lam, fentanyl, and ketamine. Use of ketamine as a sedative for nerve blockade or analgesia was

at the discretion of the attending anesthesiologist and not part of the protocol.


Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis

X Ma, J Qin, B Song, C Shi, R Zhang, X Liu, Y Ji, W Ji… – Neurological Sciences, 2015

CAMARADES) [10]: peer- reviewed publication; statement of control of tem- perature; random

allocation to treatment or control; blinded induction; blinded assessment of outcome; use of

anesthetic without significant intrinsic neuroprotec- tive activity (such as ketamine); use of


Anatomical organization of the visual dorsal ventricular ridge in the chick (Gallus Gallus): Layers and columns in the avian pallium

P Ahumada‐Galleguillos, M Fernandez, GJ Marin… – Journal of Comparative …, 2015

Deposits of biocytin in vital slices. Forty chicks (P1-P5) were deeply anesthetized with a mixture

(3:1) of 1% Ketamine and 2% Xylazine, and then decapitated. Deposits of DiI in fixed slices. Ten

chicks were deeply anesthetized using the Ketamine/Xilazine mixture and perfused


[PDF] Alterations in molecular pathways in the retina of early experimental glaucoma eyes

L Cao, L Wang, G Cull, A Zhou – Int J Physiol Pathophysiol Pharmacol, 2015

in one eye of each animal under ketamine and xyla- zine anesthesia. One hundred follow-

up. During each test, IOP was measured by a rebound tonometer (Tonopen XL, Reichert

Inc) under ketamine and xylazine anesthesia. The peripapillary


Radiofrequency Ablation (RFA)


… K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A …

G Santarpia, S De Rosa, A Polimeni, S Giampà… – PloS one, 2015

BACKGROUND: Use of the non-vitamin K antagonist oral anticoagulants (NOACs) is

endorsed by current guidelines for stroke prevention in patients with atrial fibrillation (AF).

However efficacy and safety of NOACs in patients undergoing catheter ablation (RFCA) of


Treatment of Renal Cell Carcinomas

SN Kurukkal, SS Al-Busaidy – Urological Cancer Management, 2015

cavitational ultrasound (PCU). However, only two ablation therapies are recommended

by expert panels for the treatment of renal tumours: cryoablation and radiofrequency

ablation. hilum. 16.3.1 Radiofrequency Ablation (RFA). It is


[PDF] Metastatic Colorectal Cancer: Review of Diagnosis and Treatment Options

M Palaghia, CC Prelipcean, E Cotea, N Vlad… – Journal of Surgery [Jurnalul …, 2015

Liver Metastases: Addition of new, multidisciplinary techniques and therapies like systemic or

local chemotherapy, radiofrequency ablation (RFA), cryotherapy and radiotherapy improves the

rate of liver metastases resectability but currently there is no gold standard concerning


ть е рыв ж ть

H Takeuchi – 2015

transplantation and as a radiofrequency ablation for AF [3]. Sixty-four-slice multidetector CT

(64-MDCT) becomes an option to evaluate coronary artery stenosis. pulmonary venous stenosis

following radiofrequency ablation. Respiratory Care 2004; 49:1525-7.


[PDF] The natural product sulforaphane inhibits breast cancer stem cell targets in triple negative and trastuzumab-resistant breast cancers

J Burnett – 2015

metastasis (1). Substantial progress has been made with respect to the treatment of primary

tumors using surgery, chemotherapy, radiation therapy, and radiofrequency ablation. However,

the advancement of cancer to an invasive or metastatic stage is


[HTML] Multidisciplinary management of advanced lung neuroendocrine tumors

PL Filosso, P Ferolla, F Guerrera, E Ruffini, WD Travis… – Journal of Thoracic Disease, 2015

In the absence of hormonal control, many patients may benefit of SSA or Interferon,

associated with loco-regional therapies (liver palliative surgery, radiofrequency metastasis

ablation or trans arterial chemoembolization). Low-grade NETs.


[PDF] Minimally-invasive Therapy in Thyroid Practice

L Hegedüs

Ethanol ablation (PEI) • Laser ablation (ILP) • Radiofrequency ablation (RFA • Laszlo Hegedüs •

Enrico Papini (Rome, Italy) • Jung Hwan Baek (Seoul) Ford T Maserati Quatroporte Proto Spirra

Radiofrequency Ablation (RFA) Page 21. 5/13/2015 21 P < 0,0001 RFA Obs.


[PDF] 0915-0940 TBD 0940-1000 Coffee break/Poster viewing

M Kudo, G Abou-Alfa, O Baatarkhuu, RN Chien… – Surgery

Prof Ho Yeong Lim (Korea) 1535-1555 Novel techniques: ablation Dr Shuichiro

Shiina (Japan) Circulating biomarkers Dr Wei Tang (Japan) 1555-1615 Surgery

vs. ablation: a new balance in the era of new technologies?


Urological Cancer Management

SA Al-Mamari, SS Al-Busaidy

time PSM Positive surgical margins PTH-rP Parathormone-related peptide pTNM Pathological

TNM QoL Quality of life RALP Robotic assisted laparoscopic radical prostatectomy RC Radical

cystectomy RCC Renal cell carcinoma RFA Radiofrequency ablation RN Radical


[DOC] Deliverable 11

B Plan

Introduction. Ablatech Inc. is a novel company developing a direct current (DC) Ablation device

for the treatment of fibroadenomas and lipomas. Note: The DC Ablation generator is indicated

for use with Ablatech’s A2500 series of delivery needles, which are sold separately.


Radiofrequency ablation for treatment of hereditary hemorrhagic telangiectasia lesions:“How I do it”

B Rotenberg, S Noyek, CJ Chin – American Journal of Rhinology & Allergy, 2015

Introduction: Hereditary hemorrhagic telangiectasia (HHT) can cause significant epistaxis for

those that suffer from it. Traditaional surgical treatments are ablative and can cause thermal

damage. Radiofrequency (RF) energy can potentially be used to ablate HHT plaques at a


Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients

A Facciorusso, V Del Prete, N Crucinio, N Muscatiello… – Journal of Gastroenterology …, 2015

Methods Data on 153 patients were reviewed. The study population was classified into three

groups: 73 (47.8%) patients who received neither angiotensin converting enzyme inhibitors

nor sartans (Group 1), 49 (32%) patients treated with angiotensin converting enzyme


Ablative therapies: Advantages and disadvantages of radiofrequency, cryotherapy, microwave and electroporation methods, or how to choose the right method for an …

O Seror – Diagnostic and Interventional Imaging, 2015

It is important, however, to understand that each of the ablated regions created remains as possible

the functional liver parenchyma which implies to not ablate too large No touch multibipolar

radiofrequency ablation for single liver metastases: a: axial computed tomography at


Pulmonary Vein Stenosis After Minimally Invasive Stand‐alone Surgical Ablation of Atrial Fibrillation

E Abo‐salem, J Munjal, S Kapur – Journal of Cardiac Surgery, 2015

vein. In our case, several rounds of cryoablation alternating with radiofrequency ablation

were also applied to confirm a transmural block. An extensive ablation strategy may

have contributed to the development of stenosis. Aggressive


[PDF] Comparative study between conventional chemo-embolization and chemo-embolization using drug eluting beads as alternative methods for treatment of …

RS Elshahat, HA Ahmed, OI Saleh, EEA Ibrahim… – Life Science Journal, 2015

Although preliminary screening and diagnosis have allowed HCC patients to benefit from radical

resection, transplantation, or radiofrequency ablation, tumors in some patients still progress rapidly

because of local spreading or metastases, particularly in those with background


Treatment of hepatocellular carcinomas by thermal ablation and hepatic transarterial chemoembolization

P Chevallier, G Baudin, R Anty, A Guibal, M Chassang… – … and Interventional Imaging, 2015

It has now been shown for monopolar radiofrequency ablation that this therapy

alone is sufficient to effectively treat single HCCs < 3 cm in diameter provided that

liver micrometastases are not present. If the HCC is >3 cm in


The “Duality” of Idiopathic Ventricular Arrhythmias from the Left Ventricular Ostium

DJ Callans, P Santangeli – Pacing and Clinical Electrophysiology, 2015

LBBB, the other RBBB which were ablated from a single region. These patients were identified

from a series of 247 patients with idiopathic outflow tract PVCs. The methods included

electroanatomic mapping, irrigated radiofrequency ablation and site verification


nonsystemic treAtment of Liver metAstAses from neuroendocrine tumor

D Putzer, G Widmann, D Waitz, W Jaschke, IJ Virgolini – … Analogues: From Research …, 2015

274 NONsYsTEMIC TREATMENT Of LIVER METAsTAsEs RfA radiofrequency ablation RILD

radiation‐induced liver disease sIRT selective internal radiation therapy sPECT single photon

emission computed tomography TACE transarterial chemoembolization Us ultrasound


Interventional oncology for liver and lung metastases from colorectal cancer: The current state of the art

T de Baere, L Tselikas, E Pearson, S Yevitch, V Boige… – … and Interventional Imaging, 2015

tissue causes cooling through convention, which is responsible for the “heat sink effect”, and

causes difficulties in ablating tissue close to The hepatic recurrence rate in 6025 patients

undergoing surgery with or without radiofrequency ablation for malignant liver metastases from


One Year Incidence of Atrial Septal Defect After PV Isolation: A Comparison Between Conventional Radiofrequency and Cryoballoon Ablation

G Mugnai, J Sieira, G Ciconte, MS Hervas, G Irfan… – Pacing and Clinical …, 2015

Background: Transseptal (TS) catheterization is needed to access the left heart during

pulmonary vein isolation (PVI) procedures. In the radiofrequency (RF) ablation procedure,

left atrial access is commonly achieved with a double TS puncture; cryoballoon (CB)



Complex Regional Pain Syndrome (CRPS/RSD)


[PDF] Topics on estimation, prediction and bounding risk for multivariate extremes

RA Yuen – 2015

17 2.3 CRPS M-estimation for max-stable models . . . . . 20 2.4 Simulation . . . . . 141

A.1 Code for fitting max-linear models via CRPS . . . . . 142 A.2 Code for fitting a

Tawn-Molchanov max-stable model . . . . 144 BIBLIOGRAPHY . . . . .



DK Garas, MD Rano Faltas, ER Viscusi

refractory CRPS, and has been found to be particularly efficacious6. • In a study

of 25 patients with refractory CRPS who underwent surgery, IV ketamine

exacerbations or spread of their CRPS at their 3 month evaluation6, 13.


[PDF] Preliminary Port Recovery Plan Schedule 2: Regional Coastal Environment Plan for the Canterbury Region (RCEP) Provisions-Specific Changes Sought (or wording …

L Port, P Page – policy

for by policies, rules and other methods set out in the RCEP. These changes sought are consistent

with the CRPS as set in Schedule 1. These changes sought are consistent with the CRPS as set

out in Schedule 1. Amendments sought to Action 7 are Insert a new policy:


Organisational Complaint Management

S Garding, A Bruns – Complaint Management and Channel Choice, 2015

2013). Garnefeld et al. (2013) even recommend companies to consider “building CRPs

into social media campaigns to take advantage 6 1 Organisational Complaint

Management Page 7. of the increasing social commerce opportunities”.


[PDF] Reverse total shoulder arthroplasty for complex proximal humeral fractures in the elderly: How to improve outcomes and avoid complications

RPDM UCT, F Ortho, UCT MMed Orth, BVM Zim, F Orth… – pain

139 (90–180) – 27 (0–45) 1 (VAS) 10% 1 patient with CRPS, DVT, and GT resorption, 1 patient

with GT malunion, 1 patient with Grade 1 notching ASES 78 T a b le I: R esu lts o RTSA 9

133(±20) 41 (±19) 1 (±1) 1/9 CRPS (recovered) ASES 80 (±11) T a b le II: R esu lts fo r stu


[PDF] Syringomyelia & Spinal Cord Stimulation

RB Pitkanen, DL James

found to be successfully used in the treatment of several neuropathic pain syndromes

such as radiculopathy, failed back surgery syndrome, CRPS, post-herpetic neuralgia,

as well as to a lesser extent for chronic migraine, refractory


[PDF] Neuropsychology of Chronic Pain

EM Desensitization

For example, com- plex regional pain syndrome (CRPS) is caused by a disturbance of the

sympathetic nervous system— the network of nerves located along the spinal cord that controls

bodily functions such as the opening and closing of blood vessels and sweat glands.


Stefan Garding Andrea Bruns


2013). Garnefeld et al. (2013) even recommend companies to consider “building CRPs

into social media campaigns to take advantage 6 1 Organisational Complaint Management

Page 19. of the increasing social commerce opportunities”.


” What I really needed was the truth”. Exploring the information needs of people with Complex Regional Pain Syndrome

S Grieve, C McCabe, J Adams – Musculoskeletal Care, 2015

Download (52Kb) | Request a copy: Description/Abstract. Background United Kingdom

guidelines indicate individuals with Complex Regional Pain Syndrome (CRPS) require

information and education to support self management.


Reprogramming of in situ spinal cord stimulator for covering newly developed postthoracotomy pain

NN Knezevic, MV Rana, P Czarnocki… – Journal of Clinical …, 2015

Postthoracotomy pain; Spinal cord stimulation. 1. Introduction. Spinal cord stimulation has become

increasingly successful in the treatment of pain syndromes, especially neuropathic pain, ranging

from failed back surgery syndrome to complex regional pain syndrome (CRPS).


Late Amputation May Not Reduce Complications or Improve Mental Health in Combat-Related, Lower Extremity Limb Salvage Patients

CA Krueger, JC Rivera, DJ Tennent, AJ Sheean… – Injury, 2015

Table 2. Documented reasons of why the limb salvage patients wanted a late amputation. CRPS:

Chronic Regional Pain Syndrome. Reasons for Desired Late Amputation, (n, %), Lack of joint

motion, 6, 13%. Lack of strength, 4, 9%. Skin coverage or flap failure, 2, 5%. CRPS, 1, 2%


Community-Based Review of Research Across Diverse Community Contexts: Key Characteristics, Critical Issues, and Future Directions

N Shore, A Ford, E Wat, M Brayboy, ML Isaacs, A Park… – American Journal of Public …, 2015

These community-based research review processes (CRPs) can provide individual and

community-level ethics protections, enhance the cul- tural relevance of study de- signs and

competence of re- searchers, build community and academic research capac- ity, and shape


Bayesian Model Averaging with Stratified Sampling for Probabilistic Quantitative Precipitation Forecasting in Northern China during Summer 2010

J Zhu, F Kong, L Ran, H Lei – Monthly Weather Review, 2015

Page 1. Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of

the author-produced manuscript that has been peer-reviewed and accepted for publication.

Since it is being posted so soon after acceptance, it has not yet been



H Tabuteau – US Patent 20,150,133,485, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type II (CRPS-II



H Tabuteau – US Patent 20,150,133,486, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type II (CRPS-II


Osteoclast Inhibitors for Knee Conditions

H Tabuteau, G Jones – US Patent 20,150,133,403, 2015

embodiments, an osteoclast inhibitor, such as a nitrogen-containing bisphosphonate, eg

zoledronic acid, ibandronic acid or minodronic acid, may be administered to relieve complex

regional pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex


Neuroimaging-based biomarker discovery and validation.

CW Woo, TD Wager, CW Woo – PAIN, 2015

Neuroimage 2008;40(2):788-795. [11] Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish

TB, Apkarian AV. The brain in chronic CRPS pain: abnormal gray-white matter interactions

in emotional and autonomic regions. Neuron 2008;60(4):570-581.


[PDF] IASP Interprofessional Pain Curriculum Outline

N Kariuki, J Miró, L Niemi-Murola, G Ochoa…

Primary Lesion Peripheral • degenerative disc disease with radiculopathy in neck and low back •

peripheral neuropathies (diabetes, cancer, alcohol, HIV) • post herpetic neuralgia • acute disc

herniation with radiculopathy • complex regional pain syndrome II (CRPS II) (causalgia




Inflammatory Allied Conditions

MA Oliveira, A Ciechomska – Musculoskeletal Ultrasonography in Rheumatic …, 2015

biopsies. Whereas in fibromyalgia, there are conflicting data about the utility of US,

and if used, it is mainly to exclude other causes of pain. XXXIX. Sonographic assessment

of hip in fibromyalgia patients. Clin Exp Rheumatol 30: pp.


Childhood adversity and illness progression in bipolar disorder

J Bücker, M Kauer-Sant’Anna, LN Yatham – Neuroprogression and Staging in Bipolar …, 2015

BD patients with a history of childhood adversity also seem to report comorbidity with numerous

medical conditions, including allergies, arthritis, asthma, chronic fatigue syndrome, chronic

menstrual irregularities, fibromyalgia, head injury, hypotension, irrit- able bowel syndrome


The Use of Motivational Interviewing in Physical Therapy Education and Practice: Empowering Patients Through Effective Self-Management

RM Pignataro, PT James Huddleston – Journal of Physical Therapy Education, 2015

been successfully employed in promoting adherence to a walking program in patients receiving

chemotherapy for breast cancer,42 in improving health promotion behaviors among people with

coronary risk factors,42 and in promoting exercise in patients with fibromyalgia.39 In


[PDF] Temporomandibular Joint Dysfunction

J Poduval – JMR, 2015

J Craniomandib Disord 1992, 6:301-355. 4. Truta MP, Santucci ET, Donlon WC. Head

and Neck fibromyalgia and temporomandibular arthralgia. In: Jacobson AL, Donlon WC,

(Eds). Headache and Facial Pain. New York: Raven, 1990:141.


From the Desk of Dr. Karl ROS Johnson, DC…..

ROS Karl

Intentional musings of a unique Shelby Township Michigan Chiropractic Physician dedicated

to helping people find solutions to improving their health by rooting out causes to chronic

conditions such as fibromyalgia, thyroid disorder symptoms, balance disorders, migraines


Ankylosing Spondylitis

M Backhaus, Y El Miedany – Musculoskeletal Ultrasonography in Rheumatic …, 2015

Beside spondyloarthritis patients, enthesitis have been reported among athletes

as a consequence of traumatic injuries. Distinguishing fibromyalgia tender points

from enthesitis is another important challenge to be considered.


[HTML] Development of a Learning-Oriented Computer Assisted Instruction Designed to Improve Skills in the Clinical Assessment of the Nutritional Status: A Pilot Evaluation

LG de Diego, M Cuervo, JA Martínez – 2015



[PDF] P1. Community-Clinical Linkages in the WISEWOMAN Program

K Ahmed, I Vaid, D May, D Manheim – JOURNAL OF WOMEN’S HEALTH, 2015

this study. Of the women patients, 361 reported a history of hysterectomy. A

comparison group consisted of 361 patients with a primary diagnosis of headache

or fibromyalgia without history of hysterectomy. Patients completed


[HTML] The Hot Sauce: Peppers and Fat Loss

VR Prisk

Aside from deterrence of muggers and bets between friends, there are many therapeutic

applications of capsaicin. Capsaicin creams, which desensitize nerves over time, are used

to treat neuropathy, shingles, psoriasis, arthritis pain and fibromyalgia.



AG Büyüktür – 2015

al., 2010; Hubbard et al., 2010), motor neuron disease (eg Locock et al., 2009), chronic fatigue

syndrome and fibromyalgia (eg Asbring, 2001), HIV infection (eg Anderson et al., 2010; Wilson,

2007), and multiple sclerosis (eg Green et al., 2007), among others.


34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand?

JN Ablin, D Buskila – Vaccines and Autoimmunity, 2015


Gender and psychosocial context as determinants of fibromyalgia symptoms (fibromyalgia research criteria) in young adults from the general population

S Lourenço, L Costa, AM Rodrigues, F Carnide… – Rheumatology, 2015

Objective. To quantify the prevalence of FM (FM research criteria), to describe its

components—symptom severity score (SSS) and widespread pain index (WPI)—and to

identify biopsychosocial predictors of the severity of SSS as well as WPI using a


Fibromyalgia and the Risk of a Subsequent Motor Vehicle Crash

DA Redelmeier, JD Zung, D Thiruchelvam… – The Journal of …, 2015

Objective Motor vehicle crashes are a widespread contributor to mortality and morbidity,

sometimes related to medically unfit motorists. We tested whether patients diagnosed with

fibromyalgia (FM) have an increased risk of a subsequent serious motor vehicle crash.


Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

J Ahmad, H Blumen, CE Tagoe – Rheumatology International, 2015

Abstract To investigate how autoimmune thyroiditis (ATD) affects the clinical presentation of

established rheumatoid arthritis (RA) with particular reference to fibromyalgia and chronic

widespread pain (CWP). A cohort of 204 patients with RA for whom the presence or


Association between fibromyalgia and thyroid autoimmunity

N Shirzad, S Movassaghi, H Karmostaji, F Esfahanian… – 2015

Fibromyalgia is a disorder characterised by fatigue, generalised body pain and cognitive

symptoms, and the aetiology has not been clearly described. Because similar symptoms are

frequently found in Hashimoto’s thyroiditis and there is not an optimal response to the



M Kandula – US Patent 20,150,133,408, 2015

Abstract: The invention relates to the compounds of formula I or its pharmaceutical

acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates

thereof. The pharmaceutical compositions comprising an effective amount of compounds



SB de Lorena, MCC de Lima, A Ranzolin, ÂLBP Duarte – rev bras reumatol, 2015

Review article Effects of muscle stretching exercises in the treatment of fibromyalgia: a systematic

review articleinfo Article history: Received 16 March 2014 Accepted 17 August 2014 Available

online 6 January 2015 Keywords: Fibromyalgia Stretching Physiotherapy abstract


36 Infections, Vaccinations, and Chronic Fatigue Syndrome

H Mahagna, N Mahroum, H Amital – Vaccines and Autoimmunity, 2015



MP Czech, M Wang – US Patent 20,150,133,520, 2015

12. The method of claim 11, wherein the muscle disorder is selected from the group consisting

of: muscle atrophy, muscle weakness, myopathy, chronic fatigue syndrome, fibromyalgia, muscular

dystrophy, fatigue fibromyalgia, spinal muscle atrophy, distal muscular dystrophy


27 Aluminum Particle Biopersistence, Systemic Transport, and Long-Term Safety: Macrophagic Myofasciitis and Beyond

RK Gherardi, J Cadusseau, FJ Authier – Vaccines and Autoimmunity, 2015