Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
One of the most fascinating drugs in the anesthesiologist’s armament is ketamine, an N-
methyl-D-aspartate receptor antagonist with a myriad of uses. The drug is a dissociative
anesthetic and has been used more often as an analgesic in numerous hospital units, …
G Unal, G Terzioglu, C Sahin, GY Demirel, F Aricioglu – Bulletin of Clinical …, 2015
Objective: Major depression is a complex and devastating disease which one-third of
patients still do not respond to current treatments. It has been demonstrated that there is a
correlation between high levels of plasma cytokines such as IL-1β, IL-6, IL-18 and TNF-α …
GS Aylan, N Sarper, U Demirsoy, E Zengin, E Çakmak – Turkish journal of …, 2015
OBJECTIVE: The aim of this study is to investigate the efficacy and safety of sedoanalgesia
performed outside the operating room by pediatricians trained in advanced airway
management and life support. MATERIALS AND METHODS: Midazolam and ketamine …
GS Vasconcelos, NC Ximenes, CNS de Sousa… – Schizophrenia Research, 2015
Abstract Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid
(ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied
the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of …
Low Dose Ketamine Infusion For Managing Acute Pain
M Yetim, S Tekindur, Y Emrah Eyi – The American Journal of Emergency Medicine, 2015
Dear Editor, We read with great interest the article “Short (low-dose) ketamine infusion for
managing acute pain in the ED: case-report series” written by Goltser et al (1). We believe
that this original study provides a new and insightful approach to pain management in …
[PDF] Symptomatic remission and hippocampus volume in schizophrenia
PT Chang, JF Lirng, YH Chou – Bulletin of Clinical Psychopharmacology, 2015
… 1):S146-S7 [Abstract:0577] Neuroimaging in psychiatry Alterations in resting state electrocortical
network oscillations, schizophrenia-like symptoms and their relationships induced with the
administration of the NMDA receptor antagonist ketamine in human volunteers …
MA Webster, C Haines, J Fraser – Archives of Disease in Childhood, 2015
… www.midstaffspublicinquiry.com/report (accessed 28 Nov 2014) G536(P) THE CHALLENGES
OF SETTING UP A KETAMINE SEDATION SERVICE IN THE PAEDIATRIC ED – LEARNING
LESSONS AND EFFECTING CHANGE 1E Dewhirst, 1C Whitehouse, 2T Waterfield. …
[PDF] Eyes tell the psychopathology: preliminary findings
H Balibey, C Basoglu, A Ates, A Algul, R Tutuncu… – Bulletin of Clinical …, 2015
… On the other hand, the behavioral and pharmacological effects of the noncompetitive
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine have been used to study
important aspects of psychotomimetic action in humans. …
S Oriaifo, N Oriaifo, M Oriaifo, E Okogbenin, E Omogbai – Journal of Biology, …, 2015
… immune globulin. Control of spasms was mainly by the use of the GABAergic-
enhancing drugs diazepam and sodium valproate combined with the use of the
anti-excitotoxics magnesium sulphate and ketamine. The introduction …
PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines
T Arai, K Tsuchiya, E Matsumura – Organic Letters, 2015
… adduct (27%, 80% ee). The formation of the chiral N,O-acetal inspired us to optimize
the reaction conditions for the addition of methanol to an isatin-derived
N-Boc-ketamine (1a), as shown in Table 1. Table 1. Optimization of …
Radiofrequency Ablation (RFA)
MR Reynolds, AD Kugelmass, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
Abstract Introduction: The objective of this analysis was to report four year trends among
Medicare beneficiaries (MB) undergoing Radiofrequency Ablation (RFA) to treat Atrial
Fibrillation (AF). Methods: This retrospective study examined both the Medicare Provider …
K Gaerty, RM Greer, S Kumar – American Journal of Obstetrics and Gynecology, 2015
Objective The aim of this study was to analyse perinatal outcomes following selective
reduction in monochorionic pregnancies using either radiofrequency ablation (RFA) or
bipolar cord occlusion (BCO). Study Design This was a systematic review and meta- …
Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer
S Safi, G Rauch, J Kunz, T Schneider, M Bischof… – Respiration, 2015
Background: The best therapy for patients with stage I non-small cell lung cancer (NSCLC)
who are medically unfit for lobectomy or prefer not to undergo surgery has not yet been
demonstrated. Objectives: We analyzed data from our prospective database to evaluate …
Y Naya, T Nakamura, M Oishi, T Ueda, H Nakanishi… – International Journal of …, 2015
… Okuma et al. [14] reported that tumors under 20 mm in size can be completely ablated in lung
tumor. … Cancer 3:1409–1419 7. Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation
of unresectable primary and metastatic hepatic malignancies. Results in 123 patients. …
SJM Lim, NG Iyer, LL Ooi, HN Koong, A Chung, HK Tan… – Head & Neck, 2015
… not prevent disease progression in the long term. Surgery and radiofrequency ablation have … ten
patients who underwent radiofrequency ablation +/- adjuvant chemotherapy had a median survival
period of 77.1 months compared to 32.4 months in another ten patients who only …
H Jarraya, P Borde, X Mirabel, O Ernst, T Boulanger… – International Journal of …, 2015
… have limitations for the evaluation of targeted therapies; for example, imatinib for gastrointestinal
stromal tumors (GIST) and bevacizumab for colorectal liver metastasis 8, 9 and 10 or other local
treatments, such as lung tumor SBRT (11), liver radiofrequency ablation (12), and …
Percutaneous microwave ablation of thyroid nodules: effects on thyroid function and antibodies
K Heck, C Happel, F Grünwald, H Korkusuz – International Journal of Hyperthermia, 2015
… The results demonstrated that in all 30 sessions the complete volume of the 34
nodules could be ablated. The treatment … al. Radiofrequency ablation of benign thyroid
nodules: Safety and imaging follow-up in 236 patients. Eur …
Current state of the treatment of perforating veins
ED Dillavou, M Harlander-Locke, N Labropoulos… – Journal of Vascular Surgery: …, 2015
… Table II. Technical success of radiofrequency ablation (RFA), endovenous laser ablation (EVLA),
and ultrasound-guided foam sclerotherapy (UGFS). Primary author (year), Perforator treatment
modality, No. … 14, 15, 18 and 26. Radiofrequency ablation (RFA). …
Irreversible Electroporation of the Pancreas Is Feasible and Safe in a Porcine Survival Model.
S Fritz, CM Sommer, D Vollherbst, MF Wachter… – Pancreas, 2015
… From a histopathological point of view, the ablated area was character- ized by cellular eosinophila …
The ability of IRE to ablate undesirable tissue near large blood vessels and damageable … of the
electric field to which the tissue is exposed.13 Radiofrequency ablation has been …
S Kamat, S Chawla, P Rajendram, SM Pastores… – American Journal of Critical …, 2015
Skip to main page content. …
Complex Regional Pain Syndrome (CRPS/RSD)
Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS
AS Won, CA Tataru, CM Cojocaru, EJ Krane… – Pain Medicine, 2015
… Letter to the Editor. Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. … How
to Cite. Won, AS, Tataru, CA, Cojocaru, CM, Krane, EJ, Bailenson, JN, Niswonger, S. and Golianu,
B. (2015), Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. …
A dynamic PUF anti-aging authentication system based on restrict race code
B Li, S Chen – Science China Information Sciences, 2015
… Based on the CRP mechanism, the PUF circuit can produce chip-unique responses when
challenges are applied to it and stored in the database by the way of CRPs. (2) Authentication. …
The expected data in the database are called CRPs in paper. …
RG Boles, EA Zaki, JR Kerr, K Das, S Biswas… – Mitochondrion, 2015
… Herein, we tested for these variants in chronic fatigue, CRPS, SIDS and depression. … CVS = cyclic
vomiting syndrome, Fxn abd pain = functional abdominal pain (a common pediatric functional
syndrome), IBS = irritable bowel syndrome, CRPS = complex regional pain syndrome. …
[HTML] TURAN and EVAN Mediate Pollen Tube Reception in Arabidopsis Synergids through Protein Glycosylation
H Lindner, SA Kessler, LM Müller, H Shimosato-Asano… – 2015
… Abbreviations:: ConA, Concanavalin A; CRPs, cysteine-rich polypeptides; CrRLK1L, Catharanthus
roseus receptor-like kinase 1-like subfamily; DAE, days after emasculation; DAP, days after
pollination; DAPI, 4′,6-diamidino-2-phenylindole; DEFL, defensin-like protein; Dol-P …
X Shi, T Guo, T Wei, W Li, DJ Clark, WS Kingery – PAIN, 2015
… neuropeptide-dependent nociceptive and inflammatory changes in the hindlimbs of rats similar
to those seen in complex regional pain syndrome (CRPS). Inflammatory changes … inflammatory
mediators contributing to nociceptive sensitization in a rodent fracture model of CRPS. …
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
… pain clinics, and in the prehospital realm. It has been used to treat postoperative pain, chronic
pain, complex regional pain syndrome (CRPS), phantom limb pain (PLP), and other neuropathic
conditions requiring anal- gesia. … CRPS has remained a difficult-to-treat entity. …
A Kugelmass, MR Reynolds, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
… Mortality rates were highest and increasing for MBs presenting with STEMI across all procedures.
Conclusions: The overall volume of CRPs among MBs is declining and more MBs are presenting
with an AMI, and overall mortality rates are increasing year over year. …
N Kriek, J Groeneweg, D Stronks, F Huygen
… N. Kriek, J. Groeneweg, D. Stronks, F. Huygen Center for pain management, Erasmus MC,
Rotterdam, The Netherlands Objectives: Spinal cord stimulation (SCS) is an effective invasive
therapy to treat neuropathic pain states including complex regional pain syndrome (CRPS). …
SL Gans, JJ Atema, S van Dieren, BG Koerkamp… – International Journal of …, 2015
… The posttest odds were calculated by multiplying the pretest odds with the positive and
negative LR. Posttest probabilities for a high and a low CRPs were calculated and presented
in a graph for pretest probabilities across the range of 0 to 100 %. …
[HTML] World congress comes to you 7: Yes we can (control chronic pain)
V Bellan
… If you want more information on CRPS you might find what we know about CRPS helpful as
well as these resources by the Royal College of Physicians. You can also read recent research
published by the team and browse through our CRPS blog articles. …
Fibromyalgia
Factors Associated With Time to Diagnosis in Fibromyalgia
G Chodick, D Weitzman, Y Bar-On, V Shalev, H Amital – Journal of Patient-Centered …, 2015
Background/Aims: The diagnosis of fibromyalgia, a chronic debilitating disorder, is
complicated and affected by various factors of the patient and the caregiver. The objectives
of this study were to investigate the time passing from initial complaints to diagnosis and to …
[PDF] Central Sensitization Syndrome and the Initial Evaluation of a Patient with Fibromyalgia: A Review
KC Fleming, MM Volcheck – Rambam Maimonides Med J, 2015
ABSTRACT In both primary care and consultative practices, patients presenting with
fibromyalgia (FM) often have other medically unexplained somatic symptoms and are
ultimately diagnosed as having central sensitization (CS). Central sensitization …
AS Babu, FM Ikbal, MS Noone, AN Joseph, D Danda – International Journal of …, 2015
Results Low BMD was seen in 81.6%(129/158) of the persons screened. FMS was seen in
37/158 persons, of which 31/37 (83.7%) had low BMD. Conclusion FMS with low bone
density leads to higher levels of pain and a poorer QoL compared to those without FMS. …
MÁ Pastor, S López-Roig, Y Sanz, C Peñacoba – anales de psicología, 2015
Abstract: This study is the first phase of the formative research recommended in the Theory
of Planned Behavior for the development of an intervention. Our aims are to identify modal
beliefs about the performance of an exercise pattern in people with fibromyalgia, to test …
R Bosma – 2015
Abstract: Functional MRI of the human spinal cord and brainstem has tremendous potential
to enhance our basic understanding of healthy subcortical function, and impact our ability to
accurately diagnose and treat injury and disease. Despite this potential, there are many …
Understanding High Blood Pressure
S Aziz – 2015
Overcoming Low Self-Esteem with Mindfulness
D Ward – 2015
[HTML] Efficacy and processes of change in acceptance and commitment therapy for chronic pain
M Kemani – 2015
… The first trial utilized a wait-list control condition and included women with fibromyalgia (Study
I). Assessments were done pre- and post-treatment and at 3-month follow-up. … Acceptance and
commitment therapy for fibromyalgia: A randomized controlled trial. …
[PDF] Evaluation of psychiatry consultations requested for inpatients in a university hospital
H Mayda, HI Guzel, Y Gorucu, E Bagcioglu – Bulletin of Clinical Psychopharmacology, 2015
… [Abstract:0282] Psychosomatic disorders Metacognitive evaluation in patients with fibromyalgia
syndrome … In this study, we tested the assumption that patients with Fibromyalgia Syndrome (FMS)
experience more metacognitive thoughts compared to healthy individuals. …
[PDF] Investigation of state and trait anxiety levels among pharmacy students in TRNC
YH Balcıoglu, E Duran – Bulletin of Clinical Psychopharmacology, 2015
… Bulletin of Clinical Psychopharmacology 2015;25(Suppl. 1):S93-S4 [Abstract:0452] Anxiety,
stress, and adjustment disorders Angiotensin-converting enzyme and
methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome …