by admin | Jul 16, 2015 | Uncategorized
If you’re looking for natural ways to fight the aches, stiffness and inflammation of fibromyalgia, supplements can be a powerful weapon against symptoms. From vitamin D to brown seaweed extract, an arsenal of tools can help reduce pain. Here, experts reveal what works and why…
If you’re not including fibromyalgia-fighting supplements as part of your pain-management regimen, you could be missing out.
“The right supplements can help muscles relax, which leads to pain reduction, or even prevent pain altogether,” says fibromyalgia expert Jacob Teitelbaum, M.D., director of the Fatigue & Fibromyalgia Practitioners Network and author The Fatigue and Fibromyalgia Solution (Avery).
But when you’re standing in the supplement aisle, it’s hard to figure out which live up to their hype.
Read on for expert advice on the top 6 supplements for relieving fibro pain and other symptoms.
1. Vitamin D
The “sunshine vitamin” isn’t only good for building bones.
It can help fight fibro pain and fatigue, too, according to a 2014 study published in the journal Pain.
For the study, 30 women with fibromyalgia – who were also deficient in vitamin D – were divided into two groups. The treatment group received oral vitamin D supplements for 20 weeks. The control group received a placebo.
Starting after just one week, the treatment group showed improved physical functioning, had less morning fatigue than the placebo group and reported a marked reduction in pain.
The body produces vitamin D when skin is directly exposed to the sun – our best source. But some people don’t produce enough of the nutrient, according to the National Institutes of Health. These include women who are older, dark-skinned or obese.
People with certain disorders, including celiac or Crohn’s disease – as well as those who aren’t exposed to ample sunlight (or who wear sunscreen) – are also likely to be deficient. (Read about 11 natural remedies for Crohn’s management.)
Because few foods contain vitamin D, swallowing supplements is the easiest way to ensure you get enough.
The government’s daily recommendation of vitamin D is 600 international units (IU) for anyone 1 to 70 years old, and 800 IU for people 71 and up – to a maximum of 4,000 IU per day, according to the National Institutes of Health.
But ask your doctor how much you should take to combat your fibro symptoms.
2. Fish Oil
Thanks to its omega-3 fatty acids, fish oil has terrific anti-inflammatory properties, which can help reduce fibro pain.
It reduces the body’s production of inflammatory hormones (prostaglandins), says Nehad Soloman, M.D., a board-certified rheumatologist for Valley Arthritis Care in Arizona. And that may mean less stiffness or fewer tender joints.
Dr. Soloman suggests choosing a mercury-free brand (check the label), although fish oil supplements are considered safe.
Take 1 or 2 capsules (or 1 or 2 tablespoons) daily to reduce inflammation and boost your immunity, recommends the University of Maryland Medical Center. But check with your doctor first – especially if you take blood-thinning medications, such as aspirin or warfarin (Coumadin).
3. SAMe
S-Adenosyl methionine, more commonly known as SAMe, is a synthetic form of a compound the body naturally produces.
We need it for proper immune function, and it plays a role in forming cartilage and our DNA, Dr. Soloman says.
As we age, our bodies produce less of it, which may explain the increased aches after your 40th birthday. Taking a SAMe supplement not only lessens chronic pain, it also can boost your spirits. These 5 other natural mood-lifters help too.
“SAMe assists in the production and breakdown of neurotransmitters, such as serotonin, norepinephrine and dopamine – brain hormones that influence and regulate moods,” Dr. Soloman says.
In fibro studies, the recommended dosing is 400 mg twice a day for six weeks, starting with a lower dose (about 200 mg daily) and increasing gradually to avoid stomach upset, according to the University of Maryland Medical Center. But dosing varies by patient, so ask your doctor.
4. Ribose
Tight muscles are a common cause of fibro pain. To relax and release, muscles need energy, Dr. Teitelbaum says. And that’s where ribose supplements come in.
Ribose, a simple sugar, can increase energy by an average of 61% – and cut the pain experienced by fibromyalgia sufferers by an average of 15.6%, according to a 2012 study Dr. Teitelbaum led, published in The Open Pain Journal.
“The energy-building benefit of ribose directly improved the debilitating symptoms of this condition,” Dr. Teitelbaum says.
Dr. Teitelbaum recommends a 5 g dose three times a day.
5. Magnesium
This mineral is a major player in every body part.
Not only is it credited with keeping the heart, kidneys and bones strong, it also helps us avoid muscle spasms, weakness and back pain, Dr. Teitelbaum says.
Women with fibromyalgia may be deficient in magnesium, studies suggest. And magnesium may help relieve fibro pain and other symptoms.
For example, researchers from Ajou University School of Medicine in Korea analyzed hair samples from 166 women – including 44 with fibromyalgia. The hair from the fibromyalgia group contained significantly lower amounts of magnesium than that of the healthy women, according to the 2011 study.
Researchers at Acıbadem University Medical School in Istanbul, Turkey, also found that women diagnosed with fibromyalgia were likely to have “significantly lower” magnesium levels than women who didn’t have the disorder. But those who then took 300 mg/day of magnesium citrate for 8 weeks reported a reduction of “tender points” and other fibromyalgia symptoms, according to their 2013 study.
Magnesium is found in green leafy vegetables, pumpkin and sunflower seeds, 100% wheat bran cereal and raw spinach.
But these foods are a good source only if you eat them raw. Half of the minerals’ benefits are lost when cooked.
Normal daily recommended dosage for adult women is 280 to 300 mg per day, taken with meals, says the Mayo Clinic.
But if you have kidney disease or are taking medication, talk to your doctor before taking magnesium. Magnesium can interact with certain medications, including high blood pressure medicines and antibiotics, the University of Maryland Medical Center says.
6. Brown Seaweed Extract
You may not be familiar with these capsules, but this supplement is one to look for.
“It’s showing great promise in the fight against chronic pain,” Dr. Soloman says.
In fact, taking 1,000 mg of brown seaweed extract daily can reduce joint pain and stiffness by 52%, according to a 2011 study from Australia’s Centre of Health and Wellbeing, published in the journal Biologics.
Even better: These benefits kicked in after just one week, so you don’t have to wait long to find out if it’s working for you.
Supplement Smarts
Check with your doctor before taking these or other supplements.
“Like prescription drugs, it’s possible to take too much. And many supplements have side effects,” says David Pisetsky M.D., Ph.D., a professor of immunology at Duke University Medical Center in Durham, N.C.
Questions to ask your doctor include:
1. What’s the right dosage for me?
2. Should I take it with food?
3. What time of day should I take it?
4. Will this supplement interact badly with my prescriptions?
5. Does it have side effects that might mimic or aggravate my fibro symptoms (such as depression or sleep difficulties)?
For more expert advice and information, visit Lifescript’s Fibromyalgia Health Center.
Also, visit these other resources for more support:
The National Institutes of Health: Information and resources from the U.S. government’s medical research agency.
The American Fibromyalgia Syndrome Association: This group’s mission is to fund scientific studies on fibromyalgia.
Fibromyalgia Network: A nonprofit that offers information about the disease from top fibromyalgia clinicians and researchers.
by admin | Jul 7, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Withdrawal from Acute Amphetamine Induces an Amygdala-Driven Attenuation of Dopamine Neuron Activity: Reversal by Ketamine.
P Belujon, NL Jakobowski, HK Dollish, AA Grace – … : official publication of the …, 2015
Drug addiction is a chronic disorder characterized by a cycle composed of drug seeking,
intoxication with drug taking and withdrawal associated with negative affect. Numerous
studies have examined withdrawal/negative affect after chronic use; however, very few …
Enantioselective inhibition of D‐serine transport by (S)‐ketamine
NS Singh, M Bernier, S Camandola, MA Khadeer… – British Journal of …, 2015
Background and purpose Patients with major depressive disorder receiving racemic
ketamine,(R, S)-ketamine, experience transient increases in Clinician-Administered
Dissociative States Scale (CADDS) scores and coincident drop in plasma D-serine levels. …
Pain Management with Low-Dose Ketamine Infusions
A Katz – Emergency Medicine News, 2015
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining
your privacy and will not share your personal information without your express consent. For more
information, please refer to our Privacy Policy. … The M 2 E Too! Blog by Larry Mellick, …
Sedative medications outside the operating room and the pharmacology of sedatives
TG Hansen – Current Opinion in Anesthesiology, 2015
… Ketamine. Ketamine is a unique phencyclidine derivate that differs from other sedatives in several
ways. … Ketamine seems to induce a dissociative anesthetic state with functional and
electrophysiological separation between the limbic system and hypothalamus. …
Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars
A Hadhimane, M Shankariah, KV Neswi – Journal of Maxillofacial and Oral Surgery, 2015
Purpose In this study we assessed the clinical efficacy of sub-mucosal injection of ketamine
at sub-anesthetic dose of 0.5 mg/kg on post-operative pain, swelling and trismus following
surgical extraction of impacted mandibular third molars. Methods Forty bilaterally …
Fluorescence‐guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti‐CEA dylight 650 for tumor illumination
S Miwa, N De Magalhães, M Toneri, Y Zhang, W Cao… – Journal of Orthopaedic …, 2015
… Tumor implantation Six to eight-week-old male mice were anesthetized by a ketamine mixture
(10 µL ketamine HCL, 7.6 … Before resection of the metastatic tumor, mice were anesthetized with
the ketamine mixture (described above), and their limbs were sterilized with alcohol. …
Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples
J Van Schoors, C Lens, K Maes, Y Michotte, I Smolders… – Journal of Chromatography …, 2015
… Diazepam 10 mg/2 mL is purchased as Valium ® from Roche (Cenexi, Fontenay-sous-Bois,
France), ketamine 1000 mg/10 mL as Ketamine 1000 ® from Ceva (Libourne, France), Ketoprofen
1% as Ketofen ® from Merial (Toulouse, France) and NaCl 0.9% from Baxter (Lessines …
Ultrasound-induced suppression of visually-evoked potentials: experience in nonhuman primates with a clinical transcranial MRI-guided focused ultrasound system
N McDannold, C Arvanitis, N Vykhodtseva… – Journal of Therapeutic …, 2015
… 650 kHz. Methods. The animal was deeply anesthetized using ketamine and
dexdormitor. First we targeted the LGN using MR temperature imaging, and then
we relocated the MRI table just outside the MRI. Visually-evoked …
Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)
CM Parrula, J Mysore, H Burr, W Freebern, N Neef – Comparative Medicine, 2015
… On day 4, a follow-up complete physical exam under ketamine sedation (10 mg/kg IM; ketamine
hydrochloride, Fort Dodge Animal Health, Fort Dodge, IA), showed diffuse, pale-red discoloration
in both inguinal regions, as noted previously, and multifocal pinpoint foci of …
Estradiol protects female rats against sepsis induced by Enterococcus faecalis improving leukocyte bactericidal activity
RS Saia, FM Garcia, EC Cárnio – Steroids, 2015
… 0.5–1 × 10 10 CFU/animal) (time “zero” hour). At 6 and 24 h, rats were deeply
anesthetized (ketamine and xylazine at 55 and 10 mg/kg, respectively, ip) for sample
collection. As detailed in the subsequent sections, the blood …
Hot Off the Press: Subdissociative‐dose Ketamine for Acute Pain in the Emergency Department
AB Drake, WK Milne, CR Carpenter – Academic Emergency Medicine, 2015
… Social Media. Hot Off the Press: Subdissociative-dose Ketamine for Acute Pain in the Emergency
Department. … How to Cite. Drake, AB, Milne, WK, Carpenter, CR (2015), Hot Off the Press:
Subdissociative-dose Ketamine for Acute Pain in the Emergency Department. …
Optimization and application of an extraction procedure to determine drugs of abuse in solid environmental matrices of Turia River Basin
MJ Andres, R Alvarez, V Andreu, Y Pico – EGU General Assembly Conference …, 2015
… Amphetamine, methamphetamine, ethylamphetamine, ecstasy, ethylone, bk-MMBDB and MBDB
belong to phenylethylamine group; codeine and ketamine belong to opioid and phencyclidine
group, respectively, and benzoylecgonine is the major excreted metabolite of the …
Green spaces and cognitive growth in children
C Dieme – PNAS, 2015
… AG. Previous Section. Neural mechanism of ketamine. … Ketamine can produce rapid and
long-lasting antidepressant effects, but the drug’s potential for side effects and abuse limits its
widespread use, and the cellular mechanisms of ketamine’s effects are not yet known. …
Increasing use of ‘party drugs’ in people living with HIV on antiretrovirals: a concern for patient safety
M Bracchi, D Stuart, R Castles, S Khoo, D Back… – AIDS, 2015
… These substances are a combination of ‘club drugs’ (methylenedioxy- methamphetamine,
gamma-hydroxybutyrate, ketamine, benzodiazepine) and drugs that are more specifically used
in a sexualized context (methamphetamine, mephe- drone, poppers and erectile … Ketamine …
Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil …
BA MacDonald, KV Chakravarthy, BA Davidson… – Anesthesiology, 2015
… The authors demonstrate that halothane mitigates the risk of SBP postflu through modulation
of the effects of type I interferon (IFN). METHODS: Mice (n = 6 to 15) were exposed to halothane
or ketamine and treated with influenza and Streptococcus pneumoniae. …
[HTML]Airtraq® laryngoscope-assisted fiberoptic bronchoscope intubation in a child with Pierre-Robin sequence: a case report
S Zhang, M Yi – International Journal of Clinical and Experimental …, 2015
… Sedation was achieved with IV dexmedetomidine 1 μg/kg and ketamine 1 mg/kg. … We
opted to use dexmedetomidine and ketamine in this child because they provide
sedation and analgesia without compromising respiratory drive. …
[HTML]Transcutaneous electric acupoint stimulation alleviates remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial
Y Chen, Y Yao, Y Wu, D Dai, Q Zhao, L Qiu – International Journal of Clinical and …, 2015
… Some medications, including ketamine, methadone, dextromethorphan, COX-2 inhibitors and
α 2 receptor agonists can modulate remifentanil-induced hyperalgesia [7]. Due to drug-related
side effects and longer duration of PACU stay, however, we have found these …
Impact of Obesity on Endotoxin-Induced Disseminated Intravascular Coagulation.
T Duburcq, A Tournoys, G Viviane, T Hubert, V Gmyr… – Shock, 2015
… animals). For the experiment, animals were premedicated with intramuscular injection of ketamine
(Ketamine 1000, 10 mg/kg of body weight; Virbac, Carros, France) and xylazine (Sedaxylan,
2.5 mg/kg of body weight; CEVA Santé Animale, Libourne, France). Then we …
Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro …
RC Almada, CM Roncon, DH Elias-Filho, NC Coimbra – Neuroscience, 2015
… The surgeries were performed under deep anesthesia with 100 mg/kg ketamine (Ketamine
Agener, União Química Farmacêutica Nacional, São Paulo, Brazil) and 10 mg/kg xylazine
(Calmiun, União Química Farmacêutica Nacional, São Paulo, Brazil). …
ACUTE INHIBITION OF MONOAMINE OXIDASE AND ISCHEMIC PRECONDITIONING IN ISOLATED RAT HEARTS: INTERFERENCE WITH POSTISCHEMIC …
MD Dănilă, AI Privistirescu, SN Mirica, A Sturza… – Canadian Journal of …, 2015
… Male (body weight 400-450 g) and female (body weight 250-300 g) Wistar rats were anesthetized
with ketamine (Vetased, 30 mg/kg) and xylazine (Xylazin, 10 mg/kg) … Page 4 of 23 Page 5. 5
ketamine able to induce anesthesia was chosen in order to not interfere with the IPC- …
Radiofrequency Ablation (RFA)
In vitro artefact assessment of a new MR-compatible microwave antenna and a standard MR-compatible radiofrequency ablation electrode for tumour ablation
R Hoffmann, H Rempp, F Eibofner, DE Keßler… – European Radiology, 2015
Objective To evaluate and compare artefact configuration and diameters in a magnetic
resonance (MR)-compatible prototype microwave (MW) applicator and a standard MR-
compatible radiofrequency (RF) applicator for MR-guided tumour ablation. Methods Both …
Does Surgical Resection Provide Better Outcomes Than Radiofrequency Ablation in Patients With BCLC Very Early-stage Hepatocellular Carcinoma?.
C Li, TF Wen – Annals of Surgery, 2015
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining
your privacy and will not share your personal information without your express consent. For more
information, please refer to our Privacy Policy. … Skip Navigation Links Home > …
Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry.
RJ Haidry, G Lipman, MR Banks, MA Butt, V Sehgal… – Endoscopy, 2015
Background and study aim: Mucosal neoplasia arising in Barrett’s esophagus can be
successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency
ablation (RFA). The aim of the study was to compare clinical outcomes of patients with …
Effectiveness of focal vs. balloon radiofrequency ablation devices in the treatment of Barrett’s esophagus
J Brown, B Alsop, N Gupta, DC Buckles, MS Olyaee… – United European …, 2015
Abstract Background and aims The safety and efficacy of radiofrequency ablation (RFA) in
treatment of Barrett’s esophagus (BE)-associated dysplasia has been well established. The
effectiveness of focal and balloon RFA devices has not been compared. Therefore, the …
Microwave Ablation: Comparison of Simultaneous and Sequential Activation of Multiple Antennas in Liver Model Systems
CM Harari, M Magagna, M Bedoya, FT Lee Jr… – Radiology, 2015
… Although both methods have been used in clinical studies of radiofrequency (RF) and microwave
ablation, an optimal delivery method has not yet been determined (6–9). Comparison studies
of sequential and simultaneous RF ablation techniques have concluded that …
Heparin Kinetics: The “Holy Grail” of Periprocedural Anticoagulation for ablation of atrial fibrillation
DF Briceno, A Natale, LD Biase – Pacing and Clinical Electrophysiology, 2015
… anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from
a multicenter prospective registry. … anticoagulation in patients undergoing radiofrequency ablation
for atrial fibrillation: results from a multicenter prospective registry. …
Catheter Ablation of Atrial Fibrillation Should Be Offered as Primary Therapy: What’s Your Hurry?
EF Wedam, MCP Haigney – Cardiac Electrophysiology Clinics, 2015
… medications. Radiofrequency ablation/cryoballoon ablation: a cure for atrial fibrillation?
Merriam-Webster’s … unknown. Does early radiofrequency ablation/cryoballoon ablation
prevent progression to permanent atrial fibrillation? A major …
OC-037 6 year disease durability outcomes on patients treated with endoscopic therapy for barrett’s related neoplasia from the uk registry
R Haidry, G Lipman, A Gupta, J Dunn, H Smart… – Gut, 2015
… Introduction Endoscopic therapy with combined Endoscopic mucosal resection (EMR) followed
by Radiofrequency ablation (RFA) is now the recommended first line … Thereafter patients underwent
RFA 3 monthly until all visible BE was ablated or cancer developed (endpoints). …
[HTML]Hybrid atrial fibrillation ablations and the increasing importance of the hybrid cardiovascular laboratory operating room
WJ Schleifer, JF Beshai, H Ramakrishna – Annals of Cardiac Anaesthesia, 2015
… the epicardium. [4] Moreover, endocardial catheters can check for the completeness
of the epicardial lesions and potentially identify gaps, which can then be addressed
with endocardial radiofrequency ablation. A similar approach …
[PDF]Effects of Hepatitis B Virus Load on Hepatectomy
M Wang, W Peng, TF Wen, LH He, C Li – Clin Microbiol, 2015
… MC: Milan Criteria; HR: Hepatic Resection; AFP: Alpha-Fetoprotein; OS: Overall Survival; RFS:
Recurrence-Free Survival; DNA: Deoxyribonucleic Acid; CT: Computed Tomography; MRI:
Magnetic Resonance Imaging; RFA: Radiofrequency Ablation; PEI: Percutaneous Ethanol …
HEALTH-RELATED QUALITY OF LIFE AFTER PERCUTANEOUS RADIOFREQUENCY ABLATION OF COLD SOLID BENIGN THYROID NODULES: A 2-YEAR …
R Valcavi, P Tsamatropoulos – Endocrine practice: official journal of the American …, 2015
OBJECTIVE: We studied the impact of Radiofrequency ablation (RFA) on health-related
quality of life (HRQL) in patients with benign thyroid nodules (TN) in a 2-year follow-up.
METHODS: Forty patients (35 female and 5 men; age 54.9±14.3 years) with cold thyroid …
Comparison of laparoscopic radiofrequency ablation versus open resection in the treatment of symptomatic-enlarging hepatic hemangiomas: a prospective study
X Zhang, L Yan, B Li, T Wen, W Wang, M Xu, Y Wei… – Surgical Endoscopy, 2015
Background Radiofrequency ablation (RFA) has been demonstrated to be a promising
therapy for symptomatic large hepatic hemangioma. However, there is a lack of studies to
demonstrate the benefits and disadvantages of RFA as compared with surgical resection …
… mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett’s esophagus: results from the United States Radiofrequency Ablation …
N Li, S Pasricha, WJ Bulsiewicz, RE Pruitt… – Diseases of the Esophagus, 2015
Summary The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and
safety of radiofrequency ablation (RFA) for treatment of nodular Barrett’s esophagus (BE) is
poorly understood. Prior studies have been limited to case series from individual tertiary …
… MicroRNA-122 Expression is a Poor Prognostic Marker in Patients with Hepatitis B Virus-related Hepatocellular Carcinoma who undergo Radiofrequency Ablation
HJ Cho, JK Kim, JS Nam, HJ Wang, J hee Lee, SS Kim… – Clinical Biochemistry, 2015
Objectives: Aim of this study was to investigate the prognostic potential of plasma microRNA-
122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after
hepatic resection or radiofrequency ablation (RFA).
[HTML]… efficacy enough to prevent stroke in atrial fibrillation patient with high CHADS2 score during peri-procedural catheter radiofrequency ablation? A case report with …
XM Shi, FK Chen, Z Liang, J Li, K Lin, JP Guo, ZL Shan – International Journal of …, 2015
Abstract Atrial fibrillation (AF) is a major cause of thromboembolic (TE) events including
stroke and transient ischemic attacks, catheter radiofrequency ablation (CA) has been
demonstrated to effectively eliminate AF in majority of patients. During the peri-procedural …
Right upper lobe lung cancer: Resection through left anterior mediastinotomy
M Sirois, WA Arab, E Turcotte, Y Poulin – Asian Cardiovascular and Thoracic Annals, 2015
… evaluation revealed a forced expiratory volume in 1 s of 1.8 L with carbon dioxide diffusion
capacity of 48% and maximal uptake of oxygen 14 mL min −1 kg −1 . Treatment including
stereotactic body radiation therapy, radiofrequency ablation, and surgery were discussed. …
Magnetic guidance versus manual control: comparison of radiofrequency lesion dimensions and evaluation of the effect of heart wall motion in a myocardial phantom
A Bhaskaran, MAT Barry, SI Al Raisi, W Chik… – Journal of Interventional …, 2015
… Abbreviations MNS Magnetic navigation system MC Manual control 1 Introduction Magnetic
navigation system (MNS) allows remote guidance of ablation catheters during radiofrequency
ablation for cardi- ac arrhythmias. … Page 3. 2.2 MNS versus MC radiofrequency ablation …
Thermal necrosis induced by electrocauterization as a local adjuvant therapy in local aggressive bone tumors, what is the safe limit for surgical margins? An …
M Aydin, K Basarir, M Armangil, HY Yildiz, Y Saglik… – Archives of Orthopaedic and …, 2015
… Majno PE, Mentha G, Mazzaferro V (2010) Partial hepatectomy versus radiofrequency ablation
for hepatocellular carcinoma: confirming the trial that will never be, and some comments on the
indications for liver resection. Hepatology 51(4):1116–1118PubMedView Article; 23. …
Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation
K Hayashi, T Konno, H Tada, S Tani, L Liu, N Fujino… – Circulation: Arrhythmia and …, 2015
Endoscopic Management of Early Esophageal Cancer.
JA Barnes, FF Willingham – Journal of Clinical Gastroenterology, 2015
… proportionately. In the past decade, radiofrequency ablation has become the standard
first-line therapy for high-grade dysplasia when found in the precursor lesion to
esophageal adenocarcinoma, Barrett’s esophagus. Success …
Chronic Regional Pain Syndrome (CRPS/RSD)
V33. Functional imaging of somatosensory finger representation and intracortical inhibition modulation in complex regional pain syndrome
S Strauss, M Grothe, T Usichenko, W Byblow, M Lotze – Clinical Neurophysiology, 2015
Neurophysiological pathology in CRPS type I is characterized by somatosensory and motor deficits.
Transcranial magnetic stimulation (TMS) and functional MRI rev. … Neurophysiological pathology
in CRPS type I is characterized by somatosensory and motor deficits. …
Exploiting resistive cross-point array for compact design of physical unclonable function
PY Chen, R Fang, R Liu, C Chakrabarti, Y Cao, S Yu – Hardware Oriented Security …, 2015
… primitive that leverages the inherent randomness in the physical systems (eg the semiconductor
manufacturing process) to produce a unique response (output) for a given challenge (input)
[1]. Depending on the number of possible challenge-response pairs (CRPs), PuFs can …
Do psychological factors influence recovery from Complex Regional Pain Syndrome Type-1? A Prospective Study.
DJ Bean, MH Johnson, W Heiss-Dunlop, AC Leed… – PAIN, 2015
… Conflicts of Interest: none declared. Running Head: “Psychological factors in the recovery from
CRPS-1” Number of Pages: 19 Number of Tables: 3 Number of Figures: 1 Summary: Amongst
patients with recently-onset CRPS-1, those with higher levels of pain-related …
A comparison of linear and non-linear data assimilation methods using the NEMO ocean model
P Kirchgessner, J Tödter, L Nerger – EGU General Assembly Conference Abstracts, 2015
…pdaf.awi.de), which ensures identical experimental conditions for both filters. To
account for the nonlinearity, the assimilation skill of the two methods is assessed
by using different statistical metrics, like CRPS and Histograms.
The total probabilities from high-resolution ensemble forecasting of floods
J Olav Skøien, K Bogner, P Salamon, P Smith… – EGU General Assembly …, 2015
… Weather Rev., 135(4), 1386-1402, doi:10.1175/MWR3341.1, 2007. Gneiting, T., Raftery,
AE, Westveld, AH and Goldman, T.: Calibrated Probabilistic Forecasting Using Ensemble
Model Output Statistics and Minimum CRPS Estimation, Mon. …
Efficacy of combined physical and occupational therapy in patients with conservatively treated distal radius fracture: randomized controlled trial
V Filipova, D Lonzarić, BJ Papež – Wiener klinische Wochenschrift, 2015
… Two participants from group A and two from group B were suspected of having complex
regional pain syndrome (CRPS) type I yet were not excluded from the trial since there
was no significant deviation regarding the observed variables. …
Combining Graph Analysis and Recurrence Plot on fMRI data
A Lombardi, P Guccione, L Mascolo, P Taurisano… – Medical Measurements and …, 2015
… Even if a visual inspection of CRPs can reveal valuable information about the relationship between
the two systems, the quantification of the structures in CRPs through CRQA has been used for
making more objective the comparison between the time series. Page 3. …
Improving Precipitation Forecasts by Generating Ensembles through Postprocessing
DL Shrestha, DE Robertson, JC Bennett, QJ Wang – Monthly Weather Review, 2015
… In this study, the forecast 3 performance is characterized by evaluating the bias, the Continuous
Ranked Probability Score 4 (CRPS), reliability and Relative Operating Characteristics (ROC)
to assess different aspects of 5 forecast quality. 6 … The mean CRPS (hereafter 16 …
The Forecast Skill Horizon
R Buizza, M Leutbecher – Quarterly Journal of the Royal Meteorological Society, 2015
… theoretical tools are deemed to be impractical to use. We select the continuous ranked probability
score (CRPS, Brown 1974, Hersbach 2000) as metric to decide when the … closer to the observed
CDF (bottom panel). The CRPS is equal to the mean squared error …
Functional Outcomes Following Bridge Plate Fixation for Distal Radius Fractures
A Lauder, S Agnew, K Bakri, CH Allan, DP Hanel… – The Journal of Hand …, 2015
… 2/134 deep infection. 2/134 extensor tendon adhesions. 1/134 EPL rupture. DASH: N/A. Hanel
et al 13, IV: retrospective chart review, 62 pts via chart review, second metacarpal, No CRPS,
1/62 ECRL rupture, 1/62 hardware failure, 0/62 postoperative digit stiffness. DASH: N/A. …
New findings implicated in Coronary calcification in Chronic phase Kawasaki disease
T Yahata, K Ikeda, A Hamaoka, C Suzuki, A Yoshioka… – Circulation, 2015
… tomography. We measured %FMD as an endothelial function marker and hs-CRPs
as an inflammatory marker, serum hydroperoxide and urinary 8-OHdG as oxidative
stress markers, and the bone mineral density (BMD). Patients …
[PDF]Evaluation of the Red Sea State Food Security Status 2007-2009
AAA Ahmed – 2015
… nutrition monitoring using MUAC Since 2006 no nutrition survey conducted. However, EWS
started collecting the nutrition information using the Community Resource Persons (CRPs)
to follow up the nutrition situation in sentinel sites in RPS and Tokar. …
Spatio-temporal circular models with non-separable covariance structure
G Mastrantonio, GJ Lasinio, AE Gelfand – TEST, 2015
Page 1. TEST DOI 10.1007/s11749-015-0458-y ORIGINAL PAPER Spatio-temporal
circular models with non-separable covariance structure Gianluca Mastrantonio1 ·
Giovanna Jona Lasinio2 · Alan E. Gelfand3 Received: 7 …
Predictors of Spinal Cord Stimulation Success
P De La Cruz, C Fama, S Roth, J Haller, M Wilock… – … : Technology at the Neural …, 2015
… Failure, Success. CRPS, Complex Regional Pain Syndrome; FBSS, Failed Back Surgery
Syndrome. Age, Mean + Range, 47.8 + 25.0, 51.2 + 53. Gender, Male : Female, 3:7, 20:27. … Hybrid
(%), 0, 8.1. Indication, FBSS (%), 60, 37.8. CRPS (%), 20, 37.8. Neuritis (%), 20, 24.3. …
Physical Therapy Examination and Assessment
JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015
… Why Are My Nerves So Sensitive? Neuroscience Education for Patients With CRPS
or RSD. Authors: Ariana Brutico, MSPT, PhD. AFFILIATION: Body Dynamic: Outpatient
Physical Therapy, Pilates, and Yoga Clarks Summit, PA. …
Improved model output statistics of numerical weather prediction based irradiance forecasts for solar power applications
RA Verzijlbergh, PW Heijnen, SR de Roode, A Los… – Solar Energy, 2015
… irradiance is zero. The evaluation of the probabilistic forecasts is carried out using
two metrics. The first is the continuous ranked probability score (CRPS): equation(9).
CRPS ( k ) = 1 T ∑ t = 1 T ∫ x F ̂ t + k | t ( x ) – H ( x – y t + k ) 2.
Thoracic sympathectomy: a review of current indications
M Hashmonai, AEP Cameron, PB Licht, C Hensman… – Surgical Endoscopy, 2015
… However, because the role of the autonomous nervous system is obscure in the pathogenesis
of these disorders, the term “Complex regional pain syndrome” (CRPS) is preferred. … There is
very little good evidence in the literature to guide treatment of CRPS. …
NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.
CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015
… image (contralateral) side [21]. This symptom has been observed in many clinical
pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid
arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror …
Process Documentation Research and Impact of Community-Driven Development Grants Research in Rural India, Socioeconomics Discussion Paper Series 34
M Bhattarai, Y Mohan Rao, BL Varalakshmi, VD Duche… – 2015
… Item Type: Socioeconomics Discussion Paper Series. Divisions: RP-Market Institutions
and Policies. CRPS: CGIAR Research Program on Policies, Institutions, and Markets.
Series Name: Socioeconomics Discussion Paper Series. …
SCAMP: A new tool for an old problem
RH Rathod – Journal of Hospital Medicine, 2015
… BWH, Brigham and Women’s Hospital; CRPS, complex regional pain syndrome; EPL, extensor
pollicis longus; PFL, Flexor pollicis longus; MRN, medical record number; N/A, not applicable;
OT, occupational therpay; PA, physician’s assistant. Download figure to PowerPoint. …
Fibromyalgia
Results of an active neurodynamic mobilization program in patients with fibromyalgia syndrome: a randomized controlled clinical trial
JR Torres, IC Martos, IT Sánchez, AO Rubio… – Archives of Physical …, 2015
To examine the effects of an active neurodynamic mobilization program on pain, neurodynamics,
perceived health state and fatigue in patients with fibromyalgia s. … Setting. A local Fibromyalgia
Association. Participants. 48 patients with fibromyalgia syndrome. Interventions. …
The evaluation in terms of sarcopenia of patients with fibromyalgia syndrome
I Koca, E Savas, ZA Ozturk, A Boyaci, A Tutoglu… – Wiener klinische …, 2015
Background Fibromyalgia syndrome (FMS) is an extra-articular rheumatic illness,
characterized by widespread body pain and decreased muscle function. Generalized loss of
muscle mass and strength is named as sarcopenia. The objective of this study was to …
Stigma, Unspeakable Dilemmas, and Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia
J Griffith, N Ryan – Meanings of ME: Interpersonal and Social Dimensions …, 2015
Chronic fatigue syndrome (CFS) and fibromyalgia are both illnesses for which suffering is
amplified by stigmatisation. People with these illnesses often feel judged, devalued,
marginalised, or discriminated against by employers, family members, friends and, most of …
[PDF]Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia
DH Choi, HS Kim – Korean Journal of Internal Medicine, 2015
Background/Aims: Nailfold capillaroscopy (NFC) has been used to examine morphological
and functional microcirculation changes in connective tissue diseases. It has been
demonstrated that NFC patterns reflect abnormal microvascular dynamics, which may play …
Fibromyalgia incidence among patients with hepatitis B infection
L Yazmalar, Ö Deveci, İ Batmaz, D İpek, T Çelepkolu… – International Journal of …, 2015
Aim The purpose of our investigation was to evaluate the incidence of fibromyalgia
syndrome (FMS) and identify FMS-related clinical symptoms in hepatitis B virus (HBV)
patients. Methods One hundred and eighteen HBV surface antigen (HbsAg)-positive …
[PDF]Rheumatology: Current Research
EÖ Bulduk, B Biral – 2015
Page 1. Treatment Approaches of Juvenile Fibromyalgia Syndrome … Abstract Juvenile
fibromyalgia syndrome (JFMS) is an idiopathic long-term health condition characterized
by widespread musculoskeletal pain in children and adolescents. …
Meanings of ME: Interpersonal and Social Dimensions of Chronic Fatigue
CD Ward – 2015
… 10 11 12 13 14 The Challenge of CFS/ME in Primary Care Laura Saunders The Said and the
Unsaid: Ambivalence in CFS/ME Christopher D. Ward Stigma, Unspeakable Dilemmas, and
Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia James Griffith and …
AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome
P Bullon, E Alcocer-Gómez, AM Carrión… – Antioxidants and Redox …, 2015
… Deficient AMPK activation and over-activation of NLRP3-inflammasome axis was also observed
in blood cells from patients with Fibromyalgia (FM), a prevalent human … some pain conditions as
neuropathic pain, fibromyalgia (FM), and complex regional pain syndrome (6,15,16). …
Is Chronic Pain a Disease in Its Own Right? Discussions from a Pre-OMERACT 2014 Workshop on Chronic Pain
AM Taylor, K Phillips, JO Taylor, JA Singh… – The Journal of …, 2015
… In a review of functional disorders36, various mechanisms were proposed to explain the cause
of conditions such as irritable bowel syndrome, fibromyalgia, temporomandibular joint disorder,
and inter- stitial cystitis, including enhanced pain perception, altered brain activation …
Compendium for the Antenatal Care of High-Risk Pregnancies
H Narayan – 2015
AB1222-HPR Hypervigilance to Emotional Subliminal Images in Patients with Fibromyalgia
I Peláez, F Mercado, P Barjola, S Cardoso – Annals of the Rheumatic Diseases, 2015
Background Fibromyalgia (FM) is a chronic condition characterized by the presence of pain,
fatigue and cognitive dysfunction, among other symptoms. Previous research (Duschek et
al., 2014) also indicated that patients show an hypervigilance pattern to pain and negative …
[HTML]Temporal analysis of pain responders and common adverse events: when do these first appear following treatment with pregabalin
J Fink, B Emir, B Parsons, A Clair – Journal of Pain Research, 2015
… Clair Pfizer, New York, NY, USA Background: Pregabalin is an α2δ ligand indicated in the USA
for treatment of a number of chronic pain conditions, including diabetic peripheral neuropathy,
postherpetic neuralgia, pain associated with spinal cord injury, and fibromyalgia. …
SP0133 Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Diseases
T Avcin – Annals of the Rheumatic Diseases, 2015
… The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.
Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12
JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford. …
Neuropathic pain as part of chronic widespread pain: environmental and genetic influences.
SK Momi, SM Fabiane, G Lachance, G Livshits… – Pain, 2015
…frances.williams@kcl.ac.uk; +44 (0) 20 7188 6765 Keywords: chronic widespread pain;
neuropathic pain; genetic; fibromyalgia; twin ACCEPTED … ABSTRACT Chronic widespread pain
(CWP) has complex aetiology and forms part of the fibromyalgia syndrome. …
SP0130 C5A and its Receptor in Anca-Associated Vasculitis
MH Zhao – Annals of the Rheumatic Diseases, 2015
… The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.
Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12
JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford. …
The spectrum of noncoeliac gluten sensitivity
I Aziz, M Hadjivassiliou, DS Sanders – Nature Reviews Gastroenterology & …, 2015
… with NCGS is described as well as the symptom manifestations commonly reported after gluten
exposure, which include intestinal symptoms consistent with IBS, and extraintestinal symptoms
such as neurological dysfunction, psychological disturbances, fibromyalgia and skin …
Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice
M Schedlowski, P Enck, W Rief, U Bingel – Pharmacological Reviews, 2015
Health-related quality of life improvements among women with chronic pain: comparison of two multidisciplinary interventions
SV Björnsdóttir, M Arnljótsdóttir, G Tómasson, J Triebel… – Disability & Rehabilitation, 2015
… 18,19]. Recently published systematic reviews on multidisciplinary programs for
people with chronic pain [19], chronic low back pain [20] or fibromyalgia syndrome
[21] agree on recommended content in such programs. This …
NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.
CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015
… image (contralateral) side [21]. This symptom has been observed in many clinical
pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid
arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror …
Physical Therapy Examination and Assessment
JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015
… and nerve sensitivity. It is one of several manuals written by the primary author, all
of which discuss concurrent topics involving pain and recovery from injury, including
whiplash, headaches, and fibromyalgia. The manual begins …
by admin | Jun 24, 2015 | Uncategorized
Between aching muscles, tender skin, fatigue, headaches, flulike symptoms and difficulties concentrating, you may wonder if you’re a hypochondriac. You could have fibromyalgia. Start by asking your doctor these 15 questions about symptoms of fibromyalgia…One day you have aching muscles, tender skin, fatigue, headaches, flulike symptoms and difficulties concentrating. The next day you feel great.
That’s one reason coping with fibromyalgia symptoms is such a challenge.
But a doctor-approved treatment plan — which may include exercise, psychotherapy, medication and natural remedies — can help.
Here are 15 important questions to ask about your symptoms of fibromyalgia and treatment:
1. Could there be another cause for my symptoms?
Before making a fibromyalgia diagnosis, doctors typically rule out other conditions that cause similar symptoms, such as thyroid disease, arthritis, lupus, infections and some medications (like those used to treat high cholesterol).
Unfortunately, there’s no objective measure — like an X-ray or a blood test — to decisively diagnose fibromyalgia.
2. What’s my long-term outlook?
Early diagnosis of the symptoms of fibromyalgia and treatment is the key to successfully managing symptoms of fibromyalgia, says Leslie Crofford, M.D., chief of rheumatology and director of the Center for the Advancement of Women’s Health at the University of Kentucky in Lexington.
“If you catch it early and develop a good self-management strategy, the condition doesn’t have to dominate your life,” she says.
3. What’s the first-line treatment for symptoms of fibromyalgia?
Your doctor may prescribe one of the following medications, which treat fibromyalgia in two different ways:
- Duloxetine (Cymbalta) and milnacipran (Savella) increase the amount of two neurotransmitters, serotonin and norepinephrine, in the brain. This reduces your sensitivity to pain.
- Pregabalin (Lyrica) blocks overactivity of nerve cells, which also reduces pain.
About half of those who try these drugs see modest improvement, Dr. Crofford says. Some patients respond better to medication than others.
“There may be other pathways involved in pain for which neither of these medications work well,” she says.
4. If these medications don’t help, what’s the next step?
IV Ketamine Infusion therapy has been shown to be very effective in treating Fibromyalgia
Your doctor may prescribe older medications “off-label.”
Although the Food and Drug Administration (FDA) hasn’t approved them for fibromyalgia, it allows physicians to prescribe such drugs to treat the condition.
These include amitriptyline (Elavil), cyclobenzaprine (Flexeril) and venlafaxine (Effexor), which increase neurotransmitters in the brain.
Also, antidepressants that affect only one neurotransmitter — such as fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft) — are sometimes prescribed.
Another older drug, gabapentin (Neurontin), blocks overactivity of nerve cells.
5. Since many drugs used to treat fibromyalgia are antidepressants, is the disease psychological?
No. With fibromyalgia, the cause is a chemical change in the way the central nervous system (the brain and spinal cord) responds to pain, says Daniel Clauw, M.D., a rheumatology professor at the University of Michigan in Ann Arbor.
6. How do antidepressants ease my symptoms of fibromyalgia?
Some antidepressants have other effects too, Dr. Crofford says. The neurotransmitters they increase — serotonin and norepinephrine — also influence the way the brain responds to pain.
7. Are there medications to avoid?
People with fibromyalgia shouldn’t take opioids, including prescription pain medicines, such as Vicodin (acetaminophen and hydrocodone) and Oxycontin (oxycodone), she says.
“These medications actually contribute to the persistence of chronic pain,” she says. “They change the way your brain and spinal cord processes pain. When you stop them, there’s a rebound effect.”
This means your symptoms may actually worsen after you stop taking the drugs.
8. Will I need to make lifestyle changes?
Yes. Patients with the best results combine drug and non-drug therapies, Dr. Clauw says.
“You can’t just rely on pills,” Dr. Crofford adds.
For example, exercise is as important as medication. Inactivity disrupts the body’s natural rhythms and causes sleep problems, says Crofford. It actually leads to fatigue as well as deconditioning (muscle weakness), making daily activities more likely to cause injury and pain.
Overall, “staying in bed is one of the worst things you can do,” she says.
9. How can I exercise when it’s so hard to get up and move?
If your symptoms make exercise difficult, start off slowly, Dr. Crofford advises. Then begin to build endurance.
Find an activity you can do year-round.
If you’ve been inactive for a while, it can be as simple as taking the stairs instead of an elevator, Dr. Clauw says.
“If you haven’t had success in the past, try warm-water aerobics,” he suggests. This puts less stress on muscles and joints.
10. Is it possible to do too much?
Yes. Learn to pace your activities so you don’t overdo it on days you feel well, Dr. Crofford says. You’ll figure that out through trial and error.
11. How can I minimize a flare-up?
Think about what could have caused it. What was I doing the day before? Did I do too much? Or did I not move enough? Did something stressful happen?
Once you begin to see a pattern, avoid situations that cause you discomfort.But try not to dwell on it.
“With fibromyalgia, you may feel widespread pain followed by no symptoms at all,” Dr. Crofford says.
Focusing on symptoms always increases their severity.
Brooding about your condition can lead to depression too, she adds.
12. Other than exercise and medication, what else can reduce pain?
Don’t smoke. Exercise, get enough sleep, and eat a nutritious diet (including plenty of whole grains, fruits and vegetables).
These will keep your body strong and help you cope when symptoms of fibromyalgia flare, she advises.
Also, cognitive behavioral therapy (CBT) can teach you strategies to improve sleep, reduce stress and pace activities.
For basic, do-it-yourself CBT techniques, visit the Fibromyalgia Network website.
13. Will alternative therapies, such as massage, acupuncture, tai chi or yoga, help?
Some randomized trials show that yoga and tai chi help, Dr. Crofford says.
A 2010 study published in the New England Journal of Medicine studied 66 people with symptoms of fibromyalgia.
Half did stretching exercise, and the others practiced tai chi, which includes slow breathing, exercise and meditation — components thought to have physical, social and psychological effects.
The tai chi group showed significant improvement in their symptoms as well as sleep quality, mood and quality of life.
Although there’s no scientific evidence to back up other therapies like massage and acupuncture, some fibromyalgia sufferers claim they provide relief.
But you may actually have to try them before deciding if they work for you, Dr. Crofford adds.
14. What about supplements?
According to the National Center for Complementary and Alternative Medicine (NCCAM) it’s possible that low magnesium levels play a role in fibromyalgia, but there’s no conclusive evidence and more research is needed, Dr. Clauw says.
Still, he recommends magnesium to his patients because “it helps with the constipation associated with many fibromyalgia medications.”
15. How can I explain my disorder to friends and family?
“Bring your family to a doctor’s appointment,” Dr. Clauw says.
“The more educated they are, the better they can advocate for you.”
Symptoms of fibromyalgia are generally invisible to others, so “don’t get too caught up in trying to prove to people that you’re sick,” he advises.
Make sure family members are informed and supportive.
It will help when you need coaching.
“A fibromyalgia patient in the midst of a flare doesn’t want to exercise,” he says.
That’s when you need “gentle, nonjudgmental persuasion to get out of bed and go for a walk.”
By Ellen Wlody
