Weekly Breaking Research Updates

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

Ketamine

[PDF] Transscalene Brachial Plexu Approach for Brachial Plexus

SR Totawar – Age, 2015

tchy action of the block, the block was converted to general anesthesia. If in case surg e effect

of the block wore off, rescue analgesia with intravenous ketamine given. In the circumstance

of nesthesia. If in case surgery was unduly us ketamine given.

 

Giuseppe D’Agostino1, 2*, Claudia Cristiano1, 2, 3, David J. Lyons2, Rita Citraro4, Emilio Russo4

C Avagliano, R Russo, GM Raso, R Meli, G De Sarro… – 2015

pharmacological PPAR-α agonist treatment in mice improves behavior in a pharmacological

model of ketamine-induced behavioral dysinhibition and repetitive behavior in BTBR T+ tf/J mice.

Keywords: lipids; nuclear receptor; ketamine; memory; neurodevelopmental disorders;

 

[PDF] Efficacy conventional intersc approach Vs novel transscal of brachial plexus block

SR Totawar – 2015

In the circumstance of inad anaesthesia. If in case surgery was undu intravenous

ketamine given. If in case surgery was unduly prolonged and the effect of the block

wore off, rescue analgesia with intravenous ketamine given.

 

Radiofrequency Ablation of the Pancreas: Protective Effect of Local Cooling Techniques

A Geranios, E Pikoulis, A Papalois, M Kontos… – The American Surgeon, 2015

1). Surgical Procedure The animals were anesthetized with ketamine (15–20 mg/kg) and

midazolam (0.5 mg/kg) in- tramuscularly and then intubated. The maintenance of anesthesia

was achieved by thiopental (3.5 mg/kg/hr) and fentanyl (15 mg/kg/hr).

 

[HTML] Original Study Enhancement of Acute Tendon Repair Using Chitosan Matrix

E Melamed, BG Beutel, D Robinson – Am J Orthop, 2015

Tikva, Israel. The rats were anesthetized with ketamine 90 mg/kg and xylazine 10

mg/kg, both administered intramuscularly, and anesthesia was prolonged as needed

with 2% isoflurane, administered by nose cone. The skin

 

[PDF] Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia

HCS Abeysinghe, L Bokhari, GJ Dusting, C Roulston – J Neurol Neurophysiol, 2015

food and water. Rats were anaesthetized using a mixture of Ketamine/Xylazine

(75 mg/kg: 10 mg/kg respectively ip) and maintained throughout surgery by inhalation

of isoflurane (95% oxygen and 5% isoflurane). A 23-gauge

 

Antiseizure medications

S Sanders – Seizures in Dogs and Cats

felbamate (FBM); ketamine (KET); lacosamide (LCM). Summary. The uncommon drugs include

felbamate (FBM), ketamine (KET), lacosamide (LCM), and propofol (PRO). Some of the rarely

used drugs are carbamazepine, ethosuximide, and valproic acid. Get PDF (344K).

 

Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline …

M Grobman, A Graham, H Outi, JR Dodam, CR Reinero – Journal of Feline Medicine …, 2015

23 Briefly, ketamine (30 mg IV) was used as a premedicant, propofol was used for induction

(6 mg/kg) and maintenance (0.3 mg/kg/min), and cisatracurium (0.1 mg/kg IV of with additional

doses of 0.01–0.02mg/kg titrated to effect) was administered for neuromuscular blockade.

 

[PDF] Evaluation of Anti-inflammatory and Analgesic Activities of Cymbopogon citratus in vivo-Polyphenols Contribution

R Garcia, JP Ferreira, G Costa, T Santos, F Branco… – Research Journal of …, 2015

Ketamine (Ketalar, 7.7 mg kgG )1 was purchased from Parke-Davis, Pfizer (Seixal,

Portugal) Chlorpromazine (Largatil, 2.3 mg kgG )1 was purchased from

Rhône-Poulenc Rores, Laboratório Vitória SA (Amadora, Portugal).

 

Acute neurokinin-1 receptor antagonism fails to dampen airflow limitation or airway eosinophilia in an experimental model of feline asthma

M Grobman, S Krumme, H Outi, JR Dodam… – Journal of Feline Medicine …, 2015

19 Briefly, ketamine (30 mg IV) was used as a premedicant, propofol was used for induction

(6 mg/kg) and maintenance (0.3 mg/kg/min), and cisatracurium (0.1mg/kg IV, with additional doses

of 0.01–0.02 mg/kg titrated to effect) was administered for neuromuscular blockade.

 

Radiofrequency Ablation (RFA)

 

Radiofrequency Ablation of the Pancreas: Protective Effect of Local Cooling Techniques

A Geranios, E Pikoulis, A Papalois, M Kontos… – The American Surgeon, 2015

Pancreatic carcinoma is one of the commonest malignant diseases today and the majority of

patients are suitable for palliative treatment only. Radiofrequency ablation (RFA) has been

used extensively for the treatment of solid organ tumors but little is known on the efficacy

 

Effects of renal denervation from the intima and the adventitia of renal arteries on renal sympathetic nerve activity in dogs: a comparative study

M Bai, C Yang, C Gao, X Wang, H Liu, Y Zhang, J Liu… – Cardiology, 2015

A cardiac radiofrequency ablation catheter was then applied to ablate the adventitia from the

outside, also of 8 W or less and lasting up to 2 min each to obtain up to six ablations separated

both longitudinally and rotationally, which was the same as the ablation of renal

 

[PDF] Laryngopharyngeal Reflux: a Syndrome that Mimics Asthma

M Merchant – Proceedings of UCLA Healthcare, 2015

Surgical options include minimally invasive procedures such as radiofrequency ablation of the

lower esophageal sphincter as well as endoscopic Nissen Fundoplication, a procedure where

the surgeon wraps the stomach around the distal esophagus to create a tight valve.

 

Helical DeNervation Ablation Catheter Apparatus

J Mogul – US Patent 20,150,126,992, 2015

sympathetic nerves which run through the adventitia of the renal arteries using radiofrequency

(RF) energy The catheter’s RF-ablation electrode(s) will then be deployed by movement of the

slider the endoluminal, or inner arterial, surface of the artery in order to ablate the renal

 

Method and Apparatus for Tissue Ablation

VK Sharma, H Jabs – US Patent 20,150,126,990, 2015

can use one or more sources of infrared, electromagnetic, acoustic or radiofrequency energy

to anal canal; engaging the targeted hemorrhoid by suctioning the hemorrhoid into the ablation

device; and, delivering the ablative agent to the hemorrhoid to ablate the hemorrhoid

 

[PDF] N. Ayez1, EP van der Stok1, DJ Grünhagen1, J. Rothbarth1, E. van Meerten2, AM Eggermont3, C. 5 Verhoef1 6 7

DJ Grünhagen – 2015

Local treatment was performed in 122 170 patients (47%) (surgery, radiofrequency ablation,

stereotactic radiotherapy), 112 patients (43%) had 171 palliative chemotherapy and 29 patients

(11%) received neither chemotherapy nor local treatment. 172

 

METHOD AND SYSTEM FOR SKIN TREATMENT

M Jurna, JA Palero, MR Horton – US Patent 20,150,126,913, 2015

The modifier is configured to decrease the electrical impedance for the radiofrequency energy,

in particular exploited concurrent with and/or directly subsequent to the burning and/or ablation

step and as the aforementioned 70° C., and/or the laser is used to ablate skin portions

 

Operative Techniques in Thoracic and Esophageal Surgery

M Hawn – 2015

 

Apparatus and Methods Related to Constrained Deployment of Cryogenic Balloons for Limited Cryogenic Abiation of Vessel Walls

B Kelly, J Kelly, G Kelly, B Mullins – US Patent 20,150,126,986, 2015

As compared to ablation lesions formed via radiofrequency energy, cryotherapy typically utilizes

much less power vessel wall and thus results in a smaller nominal treatment area/ablation pattern

than In another embodiment (not shown), if it is desired to ablate more than half of

 

[PDF] Long-term efficacy of radiofrequency ablation compared to surgical resection for the treatment of small hepatocellular carcinoma

X Bu, Z Ge, J Ma, S Guo, Y Wang, J Liu

Xiangyang Bu1,2*, Zhong Ge3*, Jian Ma4, Shanyuan Guo5, Yi Wang3, Jun Liu6 1Department

of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250021, China; 2Department

of Hepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao 266011, China;

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

Evolving Chinese Restaurant Processes for Modeling Evolutionary Traces in Temporal Data

P Wang, C Zhou, P Zhang, W Feng, L Guo, B Fang – Advances in Knowledge …, 2015

To model cluster branching over time, ECRP lets each cluster in current epoch form a Chinese

Restaurant Process (CRP) and uses the combination of cluster-specific CRPs as the prior for

clusters in the next epoch. where ωt−1,k and ωt,O are the weights of CRPs.

 

Practical Problems With Clinical Guidelines for Breast Cancer Prevention Based on Remaining Lifetime Risk

AS Quante, AS Whittemore, T Shriver, JL Hopper… – Journal of the National …, 2015

To evaluate discrimination, we computed the overall AUC and we plotted case risk

percentiles (CRPs, also called standardized placement values) (21) for the subjects who

developed breast cancer within 10 years of recruitment (case patients).

 

PIPERIDINE COMPOUND AND ITS USE IN PEST CONTROL

S Arimori – US Patent 20,150,126,516, 2015

A01N43/58. Related US Applications: 20040209906, Composition comprising

ketanserin AND AN ALKANOYL L-CARNITINE FOR THE TREATMENT OF CRPS,

October, 2004, Cavazza et al. 20070249732, USE OF CERTAIN

 

[PDF] News from the Patient Liaison Committee: The brave new world ‘How are pain services evolving–the impact on patients?’

A Chuter – Reltebon® Oxycodone Prolonged-release Tablets, 2015

Page 16. March 2015 Vol 13 No 1 l Pain News 13 Pain News 2015, Vol 13 (1)

13–14 © The British Pain Society 2015 News After months of planning by Geraldine

Granath, Colin Preece, Liz Killick, Austin Leach and Antony Chuter

 

SYSTEMS AND METHODS FOR COMPOUND MOTOR ACTION POTENTIAL MONITORING WITH NEUROMODULATION OF THE PELVIS AND OTHER BODY …

KD Benson, VR Lucente, JR Miklos – US Patent 20,150,126,894, 2015

Neuromodulation has also been used safely and effectively to help relieve chronic back pain,

pain from cancer and other nerve injuries, and pain from Complex Regional Pain Syndrome

(CRPS) and Reflex Sympathetic Dystrophy (RSD), greatly improving the quality of life for

 

[PDF] EXPLORATION OF FACTORS ASSOCIATED WITH PATIENT ADHERENCE IN UPPER EXTREMITY REHABILITATION: A MIXED-METHODS EMBEDDED DESIGN

EV Smith-Forbes – 2015

Multi-joint Fracture Multiple 0.0% 0.0% 0.0% 2.0% CRPS 0.0% 0.0% 0.0% 1.6% Nerve Injury

0.0% 0.0% 0.0% 1.2% MCID= minimal clinical important difference, DRUJ= distal radio-ulnar

joint, CRPS = complex regional pain syndrome, ROC = receiver operator characteristics

 

[PDF] Temperature Dependent Dielectric Model at 1.4 GHz for an Agricultural Soil Thawed and Frozen

VL Mironov, AY Karavaysky

0.513 The results of validation measurements for the soil CRPs are displayed in

Fig. range. To obtain the error of the developed model, we correlated the predicted

CRPs with the ones especially measured for validation. In Fig.

 

[PDF] A Bayesian A Bayesian Beta Markov Random Beta Markov Random Field Calibration of the Term structure of implied risk neutral densities densities

R Casarin, FR Casarin, F Leisen, GMGMG Molina…

Page 1. A Bayesian A Bayesian Beta Markov Random Beta Markov Random Field Calibration

of the Term structure of implied risk neutral densities densities Roberto Casarin, Fabrizio Roberto

Casarin, Fabrizio Leisen, German Molina German Molina German Molina,

 

 

Fibromyalgia

 

[PDF] Heart rate turbulence analysis in female patients with fibromyalgia

O Solak, H ToktasIV – 2015

OBJECTIVE: Fibromyalgia is characterized by diffuse musculoskeletal pain and discomfort.

There are several reports regarding autonomic nervous system dysfunction in patients with

fibromyalgia. Heart rate turbulence is expressed as ventriculophasic sinus arrhythmia and

 

[HTML] FIBROMYALGIA: CURABLE

ME Platt – Alternative Medicine, 2015

Abstract From a survival standpoint, the body always wants to make sure the brain has

enough fuel.[…] any time the body detects a low amount of fuel in the brain, it releases

adrenaline to raise sugar levels.[…] use of these methods often leads to a cure for

 

[PDF] Association of Impaired Sleep Quality in Patients With Burning Mouth Syndrome: A Case-Control Study

F Arbabi-Kalati, NM Bakhshani, B Tahmtan… – 2015

deprivation. Sleep deprivation can also lead to mood changes, insomnia and fatigue,

affecting pain sensation (2). Patients with known fibromyalgia have a lower noc- turnal

sleep quality compared to controls and have more insomnia

 

Dizziness, Lightheadedness, and Syncope in a Patient with Type 2 Diabetes

S Paturi, JL Gilden, F FCP – Diabetes Case Studies: Real Problems, Practical …, 2015

 

Vagally mediated heart rate variability in headache patients—a systematic review and meta-analysis

J Koenig, DWP Williams, AH Kemp, JF Thayer – Cephalalgia, 2015

capabilities (21). Lower vmHRV is reported in a variety of chronic painful conditions,

such as chronic neck pain (22), chronic pelvic pain (23), complex regional pain (24),

fibromyalgia (25,26) and irritable bowel syndrome (27). In

 

Novel Therapeutic Uses of Mu-Opiate Receptor Peptides

TE Maione – US Patent 20,150,126,455, 2015

pain. 16. The method, according to claim 1, used to reduce chronic noncancer pain

selected from pain associated with arthritis, neuropathy, low back pain, osteoarthritis,

fibromyalgia, headache, and diabetic neuropathy. 17.

 

Brain-gut axis: gastroenterology-IBS

J Wright – The Specialist Forum, 2015

to controls. Interestingly, this hypoalgesia was even greater in patients with concomitant

fibromyalgia, suggesting a commonality between these two symptom-driven diagnoses.

Anticipatory factors may also play a part. In experiments

 

[PDF] A Pilot Study Measuring Outcomes of Managing Fascial Health for Individuals With Fibromyalgia

KB Segarra

Abstract This article examines the outcomes of managing fascial health for persons

diagnosed with fibromyalgia based on the protocol developed by the author, Dr. Kirstie

Bender Segarra, and implemented in a pilot study of five clients. The protocol was

 

[PDF] The Somatosensory Amplification in Vitiligo and Chronic Urticaria Patients: A Controlled Study

M Sukan, F Maner – J Neurol Disord, 2015

Amplification may be a pathogenic mechanism in certain specific amplification

disorders such as fibromyalgia and irritable bowel syndrome [9]. Some individuals

are generally more sensitive to bodily sensation than others.

 

Psychotherapy and mental health as a psychological science discipline

HU Wittchen, S Härtling, J Hoyer – Verhaltenstherapie, 2015

which behavioural factors play a significant role in the initiation, maintenance and rehabilitation,

such as cancer (eg [Fors et al., 2011]), cardiovascular disease (eg [Gulliksson et al., 2011]),

metabolic disease and obesity (eg [Grilo et al., 2012]), and fibromyalgia [Kashikar-Zuck et

New discoveries for the treatment of pain

New discoveries for the treatment of pain

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Ketamine-A Narrative Review of Its Uses in Medicine.

BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015

One of the most fascinating drugs in the anesthesiologist’s armament is ketamine, an N-

methyl-D-aspartate receptor antagonist with a myriad of uses. The drug is a dissociative

anesthetic and has been used more often as an analgesic in numerous hospital units,

 

Acute administration of ketamine inhibited stress induced pro-inflammatory cytokines in hippocampus of rats

G Unal, G Terzioglu, C Sahin, GY Demirel, F Aricioglu – Bulletin of Clinical …, 2015

Objective: Major depression is a complex and devastating disease which one-third of

patients still do not respond to current treatments. It has been demonstrated that there is a

correlation between high levels of plasma cytokines such as IL-1β, IL-6, IL-18 and TNF-α

 

The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.

GS Aylan, N Sarper, U Demirsoy, E Zengin, E Çakmak – Turkish journal of …, 2015

OBJECTIVE: The aim of this study is to investigate the efficacy and safety of sedoanalgesia

performed outside the operating room by pediatricians trained in advanced airway

management and life support. MATERIALS AND METHODS: Midazolam and ketamine …

 

[HTML] Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and …

GS Vasconcelos, NC Ximenes, CNS de Sousa… – Schizophrenia Research, 2015

Abstract Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid

(ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied

the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of

 

Low Dose Ketamine Infusion For Managing Acute Pain

M Yetim, S Tekindur, Y Emrah Eyi – The American Journal of Emergency Medicine, 2015

Dear Editor, We read with great interest the article “Short (low-dose) ketamine infusion for

managing acute pain in the ED: case-report series” written by Goltser et al (1). We believe

that this original study provides a new and insightful approach to pain management in

 

[PDF] Symptomatic remission and hippocampus volume in schizophrenia

PT Chang, JF Lirng, YH Chou – Bulletin of Clinical Psychopharmacology, 2015

1):S146-S7 [Abstract:0577] Neuroimaging in psychiatry Alterations in resting state electrocortical

network oscillations, schizophrenia-like symptoms and their relationships induced with the

administration of the NMDA receptor antagonist ketamine in human volunteers

 

G535 (P) The development and implementation of a policy promoting parental (patient) involvement in escalation of clinical care

MA Webster, C Haines, J Fraser – Archives of Disease in Childhood, 2015

www.midstaffspublicinquiry.com/report (accessed 28 Nov 2014) G536(P) THE CHALLENGES

OF SETTING UP A KETAMINE SEDATION SERVICE IN THE PAEDIATRIC ED – LEARNING

LESSONS AND EFFECTING CHANGE 1E Dewhirst, 1C Whitehouse, 2T Waterfield.

 

[PDF] Eyes tell the psychopathology: preliminary findings

H Balibey, C Basoglu, A Ates, A Algul, R Tutuncu… – Bulletin of Clinical …, 2015

On the other hand, the behavioral and pharmacological effects of the noncompetitive

N-methyl-D-aspartate (NMDA) receptor antagonist ketamine have been used to study

important aspects of psychotomimetic action in humans.

 

Adjunctive Use of Ceftriaxone and Sodium Valproate in the Management of Tetanus: A Case Report and Literature Review

S Oriaifo, N Oriaifo, M Oriaifo, E Okogbenin, E Omogbai – Journal of Biology, …, 2015

immune globulin. Control of spasms was mainly by the use of the GABAergic-

enhancing drugs diazepam and sodium valproate combined with the use of the

anti-excitotoxics magnesium sulphate and ketamine. The introduction

 

PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

T Arai, K Tsuchiya, E Matsumura – Organic Letters, 2015

adduct (27%, 80% ee). The formation of the chiral N,O-acetal inspired us to optimize

the reaction conditions for the addition of methanol to an isatin-derived

N-Boc-ketamine (1a), as shown in Table 1. Table 1. Optimization of

 

Radiofrequency Ablation (RFA)

 

Radiofrequency Ablation for Atrial Fibrillation: Trends in Patients, Clinical Outcomes, and Resources Among Medicare Beneficiaries from Fiscal Year 2010 to Fiscal …

MR Reynolds, AD Kugelmass, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015

Abstract Introduction: The objective of this analysis was to report four year trends among

Medicare beneficiaries (MB) undergoing Radiofrequency Ablation (RFA) to treat Atrial

Fibrillation (AF). Methods: This retrospective study examined both the Medicare Provider

 

Systematic review and meta-analysis of perinatal outcomes following radiofrequency ablation and bipolar cord occlusion in monochorionic pregnancies

K Gaerty, RM Greer, S Kumar – American Journal of Obstetrics and Gynecology, 2015

Objective The aim of this study was to analyse perinatal outcomes following selective

reduction in monochorionic pregnancies using either radiofrequency ablation (RFA) or

bipolar cord occlusion (BCO). Study Design This was a systematic review and meta-

 

Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer

S Safi, G Rauch, J Kunz, T Schneider, M Bischof… – Respiration, 2015

Background: The best therapy for patients with stage I non-small cell lung cancer (NSCLC)

who are medically unfit for lobectomy or prefer not to undergo surgery has not yet been

demonstrated. Objectives: We analyzed data from our prospective database to evaluate

 

The efficacy of radio-frequency ablation for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage …

Y Naya, T Nakamura, M Oishi, T Ueda, H Nakanishi… – International Journal of …, 2015

Okuma et al. [14] reported that tumors under 20 mm in size can be completely ablated in lung

tumor. Cancer 3:1409–1419 7. Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation

of unresectable primary and metastatic hepatic malignancies. Results in 123 patients.

 

Metastastectomy for metachronous pulmonary and hepatic metastases from nasopharyngeal carcinoma: Report of 6 cases and review of the literature

SJM Lim, NG Iyer, LL Ooi, HN Koong, A Chung, HK Tan… – Head & Neck, 2015

not prevent disease progression in the long term. Surgery and radiofrequency ablation have ten

patients who underwent radiofrequency ablation +/- adjuvant chemotherapy had a median survival

period of 77.1 months compared to 32.4 months in another ten patients who only

 

[HTML] Lobulated Enhancement Evaluation in the Follow-Up of Liver Metastases Treated by Stereotactic Body Radiation Therapy

H Jarraya, P Borde, X Mirabel, O Ernst, T Boulanger… – International Journal of …, 2015

have limitations for the evaluation of targeted therapies; for example, imatinib for gastrointestinal

stromal tumors (GIST) and bevacizumab for colorectal liver metastasis 8, 9 and 10 or other local

treatments, such as lung tumor SBRT (11), liver radiofrequency ablation (12), and

 

Percutaneous microwave ablation of thyroid nodules: effects on thyroid function and antibodies

K Heck, C Happel, F Grünwald, H Korkusuz – International Journal of Hyperthermia, 2015

The results demonstrated that in all 30 sessions the complete volume of the 34

nodules could be ablated. The treatment al. Radiofrequency ablation of benign thyroid

nodules: Safety and imaging follow-up in 236 patients. Eur

 

Current state of the treatment of perforating veins

ED Dillavou, M Harlander-Locke, N Labropoulos… – Journal of Vascular Surgery: …, 2015

Table II. Technical success of radiofrequency ablation (RFA), endovenous laser ablation (EVLA),

and ultrasound-guided foam sclerotherapy (UGFS). Primary author (year), Perforator treatment

modality, No. 14, 15, 18 and 26. Radiofrequency ablation (RFA).

 

Irreversible Electroporation of the Pancreas Is Feasible and Safe in a Porcine Survival Model.

S Fritz, CM Sommer, D Vollherbst, MF Wachter… – Pancreas, 2015

From a histopathological point of view, the ablated area was character- ized by cellular eosinophila

The ability of IRE to ablate undesirable tissue near large blood vessels and damageable of the

electric field to which the tissue is exposed.13 Radiofrequency ablation has been

 

An Analysis of Patients Transferred to a Tertiary Oncological Intensive Care Unit for Defined Procedures

S Kamat, S Chawla, P Rajendram, SM Pastores… – American Journal of Critical …, 2015

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Complex Regional Pain Syndrome (CRPS/RSD)

 

Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS

AS Won, CA Tataru, CM Cojocaru, EJ Krane… – Pain Medicine, 2015

Letter to the Editor. Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. How

to Cite. Won, AS, Tataru, CA, Cojocaru, CM, Krane, EJ, Bailenson, JN, Niswonger, S. and Golianu,

B. (2015), Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS.

 

A dynamic PUF anti-aging authentication system based on restrict race code

B Li, S Chen – Science China Information Sciences, 2015

Based on the CRP mechanism, the PUF circuit can produce chip-unique responses when

challenges are applied to it and stored in the database by the way of CRPs. (2) Authentication.

The expected data in the database are called CRPs in paper.

 

Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?

RG Boles, EA Zaki, JR Kerr, K Das, S Biswas… – Mitochondrion, 2015

Herein, we tested for these variants in chronic fatigue, CRPS, SIDS and depression. CVS = cyclic

vomiting syndrome, Fxn abd pain = functional abdominal pain (a common pediatric functional

syndrome), IBS = irritable bowel syndrome, CRPS = complex regional pain syndrome.

 

[HTML] TURAN and EVAN Mediate Pollen Tube Reception in Arabidopsis Synergids through Protein Glycosylation

H Lindner, SA Kessler, LM Müller, H Shimosato-Asano… – 2015

Abbreviations:: ConA, Concanavalin A; CRPs, cysteine-rich polypeptides; CrRLK1L, Catharanthus

roseus receptor-like kinase 1-like subfamily; DAE, days after emasculation; DAP, days after

pollination; DAPI, 4′,6-diamidino-2-phenylindole; DEFL, defensin-like protein; Dol-P

 

Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to post-fracture nociceptive sensitization.

X Shi, T Guo, T Wei, W Li, DJ Clark, WS Kingery – PAIN, 2015

neuropeptide-dependent nociceptive and inflammatory changes in the hindlimbs of rats similar

to those seen in complex regional pain syndrome (CRPS). Inflammatory changes inflammatory

mediators contributing to nociceptive sensitization in a rodent fracture model of CRPS.

 

Ketamine-A Narrative Review of Its Uses in Medicine.

BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015

pain clinics, and in the prehospital realm. It has been used to treat postoperative pain, chronic

pain, complex regional pain syndrome (CRPS), phantom limb pain (PLP), and other neuropathic

conditions requiring anal- gesia. CRPS has remained a difficult-to-treat entity.

 

Trends in Coronary Revascularization Procedures among Medicare Beneficiaries between Fiscal Years 2010 and 2013

A Kugelmass, MR Reynolds, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015

Mortality rates were highest and increasing for MBs presenting with STEMI across all procedures.

Conclusions: The overall volume of CRPs among MBs is declining and more MBs are presenting

with an AMI, and overall mortality rates are increasing year over year.

 

CORD STIMULATIONS IN PATIENTS WITH COMPLEX REGIONAL PAIN SYNDROME: A RANDOMIZED PLACEBO CONTROLLED TRIAL

N Kriek, J Groeneweg, D Stronks, F Huygen

N. Kriek, J. Groeneweg, D. Stronks, F. Huygen Center for pain management, Erasmus MC,

Rotterdam, The Netherlands Objectives: Spinal cord stimulation (SCS) is an effective invasive

therapy to treat neuropathic pain states including complex regional pain syndrome (CRPS).

 

[HTML] Diagnostic value of C-reactive protein to rule out infectious complications after major abdominal surgery: a systematic review and meta-analysis

SL Gans, JJ Atema, S van Dieren, BG Koerkamp… – International Journal of …, 2015

The posttest odds were calculated by multiplying the pretest odds with the positive and

negative LR. Posttest probabilities for a high and a low CRPs were calculated and presented

in a graph for pretest probabilities across the range of 0 to 100 %.

 

[HTML] World congress comes to you 7: Yes we can (control chronic pain)

V Bellan

If you want more information on CRPS you might find what we know about CRPS helpful as

well as these resources by the Royal College of Physicians. You can also read recent research

published by the team and browse through our CRPS blog articles.

 

Fibromyalgia

 

Factors Associated With Time to Diagnosis in Fibromyalgia

G Chodick, D Weitzman, Y Bar-On, V Shalev, H Amital – Journal of Patient-Centered …, 2015

Background/Aims: The diagnosis of fibromyalgia, a chronic debilitating disorder, is

complicated and affected by various factors of the patient and the caregiver. The objectives

of this study were to investigate the time passing from initial complaints to diagnosis and to

 

[PDF] Central Sensitization Syndrome and the Initial Evaluation of a Patient with Fibromyalgia: A Review

KC Fleming, MM Volcheck – Rambam Maimonides Med J, 2015

ABSTRACT In both primary care and consultative practices, patients presenting with

fibromyalgia (FM) often have other medically unexplained somatic symptoms and are

ultimately diagnosed as having central sensitization (CS). Central sensitization

 

Does low bone density influence symptoms and functional status in patients with fibromyalgia? Observations from rural South India

AS Babu, FM Ikbal, MS Noone, AN Joseph, D Danda – International Journal of …, 2015

Results Low BMD was seen in 81.6%(129/158) of the persons screened. FMS was seen in

37/158 persons, of which 31/37 (83.7%) had low BMD. Conclusion FMS with low bone

density leads to higher levels of pain and a poorer QoL compared to those without FMS.

 

[PDF] Walking as physical exercise in Fibromyalgia: An elicitation study from the Theory of Planned Behavior

MÁ Pastor, S López-Roig, Y Sanz, C Peñacoba – anales de psicología, 2015

Abstract: This study is the first phase of the formative research recommended in the Theory

of Planned Behavior for the development of an intervention. Our aims are to identify modal

beliefs about the performance of an exercise pattern in people with fibromyalgia, to test

 

… advances in spinal cord and brainstem fMRI provide an unprecedented view of human pain processing and alterations to pain mechanisms in fibromyalgia

R Bosma – 2015

Abstract: Functional MRI of the human spinal cord and brainstem has tremendous potential

to enhance our basic understanding of healthy subcortical function, and impact our ability to

accurately diagnose and treat injury and disease. Despite this potential, there are many

 

Understanding High Blood Pressure

S Aziz – 2015

 

Overcoming Low Self-Esteem with Mindfulness

D Ward – 2015

 

[HTML] Efficacy and processes of change in acceptance and commitment therapy for chronic pain

M Kemani – 2015

The first trial utilized a wait-list control condition and included women with fibromyalgia (Study

I). Assessments were done pre- and post-treatment and at 3-month follow-up. Acceptance and

commitment therapy for fibromyalgia: A randomized controlled trial.

 

[PDF] Evaluation of psychiatry consultations requested for inpatients in a university hospital

H Mayda, HI Guzel, Y Gorucu, E Bagcioglu – Bulletin of Clinical Psychopharmacology, 2015

[Abstract:0282] Psychosomatic disorders Metacognitive evaluation in patients with fibromyalgia

syndrome In this study, we tested the assumption that patients with Fibromyalgia Syndrome (FMS)

experience more metacognitive thoughts compared to healthy individuals.

 

[PDF] Investigation of state and trait anxiety levels among pharmacy students in TRNC

YH Balcıoglu, E Duran – Bulletin of Clinical Psychopharmacology, 2015

Bulletin of Clinical Psychopharmacology 2015;25(Suppl. 1):S93-S4 [Abstract:0452] Anxiety,

stress, and adjustment disorders Angiotensin-converting enzyme and

methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome

Emerging Research

Emerging Research

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Rapid antidepressant Action and Restoration of Excitatory Synaptic Strength after Chronic Stress by Negative Modulators of alpha5-containing GABAA Receptors.

J Fischell, AM Van Dyke, MD Kvarta, TA LeGates… – … : official publication of the …, 2015

The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but

has troubling side-effects. We hypothesized that negative allosteric modulators of

GABAA receptors would exert similar effects on brain activity

 

Temporal evoltion on MRI of successful treatment of rabies

A Lu, P Shah, P Shen, P Lee, AE Nidecker… – Clinical Imaging, 2015

Her treatment regimen came to be known as the “Milwaukee protocol” [1]. Briefly, the

protocol consists of using a sedative agent such as ketamine, midazolam, propofol, or

a combination to place the patient in a medically induced coma.

 

[PDF] A Gelatin-Based Prophylactic Sealant for Bowel Wall Closure, Initial Evaluation in Mid-rectal Anastomosis in a Large Animal Model

Y Kopelman, Y Nir, Y Siman-Tov, B Person, O Zmora – J Gastrointest Dig Syst, 2015

Preemptive analgesia (intramuscular Dipyron 1 gr) was given to all any amounts prior to surgery.

The animals were anesthetized with a combination of Ketamine 22 mg/mL and Xylazine injection

(Apectrum Chemicals and Laboratory Products, Gardena, California) 1 mg/kg IM.

 

[PDF] The optimal fitting model for aging-related receptive field size curve of macaque V1 neurons

J Cui, H Ding, L Wang, J Qiang – … on Mechatronics, Electronic, Industrial and Control …, 2015

of 28 years. An initial ophthalmological examination was performed under ketamine

(100 mg/kg im, Ketalar, Parke-Davis, Morris Plains, NJ, USA) anesthesia to screen

for monkeys with ocular pathology. B. Visual Stimulation

 

[PDF] Preventing Testicular Damage in Genital Burns With Cooling: An Experimental Study

AE Abalı, H Özdemir

The sham group (S group) consisted of 10 healthy testes. In this group, rats were anesthetized

with an intraperitoneal injection of 100 mg/kg ketamine hydrochloride (Alfamine 10%, Alfasan,

Holland) and 10 mg/kg Animals were killed by high-dose ketamine HCl.

 

[PDF] JAMES A. McNAMARA, JR., DDS, Ph. DT

T KURODA

Page 2. Ketamine & Phencyclidine . . . Dosage, prepared according to levels

recommended by other investigators-fit10:11 was as fol- lows: phencyclidine HCl,

1.5 ngkg. of body weight (intramuscular); ketamine HCI, 25 mgjkg.

 

Fine-scale genetic structure of the ringtail (Bassariscus astutus) in a Sky Island mountain range

RC Lonsinger, RM Schweizer, JP Pollinger, RK Wayne… – Journal of Mammalogy, 2015

Traps were baited with dry cat food and either loganberry paste or sardines. Captured ringtails

were anesthetized using a mixture of medetomidine hydrochloride (50 µg/kg) and ketamine

hydrochloride (5mg/kg) injected intramuscularly (Orion Corporation, Espoo, Finland).

 

[PDF] Evaluation of the Effect of Alfalfa Extract on Breast Cancer

F Nabatchian, SMH Aghoosi, A Mordadi, F Khodaverdi – J. Appl. Environ. Biol. Sci, 2015

normal saline. In the solution, the tumor was cut into 3 mm2 pieces. Then, the mice

in the first and second groups were anesthetized with intraperitoneal injection of

ketamine (10 mg/kg) and xylene (5 mg/kg). The tumor pieces

 

Effects of light pollution on seasonal estrus and daily rhythms in a nocturnal primate

T LeTallec, M Théry, M Perret – Journal of Mammalogy, 2015

Ltd, Saint-Paul, Minnesota) previously implanted in the visceral cavity under general anesthesia

and under veterinary supervision (Diazepam-Valium: 1mg/100g, subcutaneous injection; Ketamine

hydrochloride-Imalgen: 10mg/100g, intraperitoneal injection; postoperative

 

[PDF] Evaluation of Cissampelos pareira root for antifertility activity

J Samanta, S Bhattacharya, AC Rana – Journal of Pharmacy Research Vol, 2015

from D1 pregnancy. On day 12th day (D12) all the rats of control and treated group

were anaesthetized with normal dose of ketamine-xylazine anaesthesia15 and

laparotomized to count the no. of implants of each rat. 2.3.6. Effectsof

 

 

Radiofrequency Ablation (RFA)

 

[HTML] Transcatheter embolization therapy in liver cancer: an update of clinical evidences

YXJ Wáng, T De Baere, JM Idée, S Ballet – Chinese Journal of Cancer Research, 2015

2-4). For the treatment of early stage HCC, curative therapies including liver transplantation,

hepatic resection, and radiofrequency ablation (RFA) are coagulative necrosis of both the tumor

and a rim of surrounding parenchymal tissue producing a margin of ablated non-tumoral

 

CATHETER WITH ATRAUMATIC TIP

ES Olson, JV Kauphusman, LK Nemec, TT Tegg – US Patent 20,150,112,331, 2015

According to at least one medical study (See, eg, Ikeda et al., Radiofrequency Ablation Catheter

with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine

Heart, Conference Proceedings of the Hearth Rhythm Society, May 2008 and

 

ELECTRICAL STIMULATION OF THE CAROTID ARTERY

I Gillbe – US Patent 20,150,112,359, 2015

or bodies without heating the tissues to a temperature at which they are ablated such that the

RF energy delivered is of a non-thermal nature, so that ablation and possible As previously

described, pulsed radiofrequency is employed for this purpose; comprising short bursts of

 

METHOD TO REDUCE SENSE OF TASTE AND FOOD INTAKE

H Li – US Patent 20,150,112,326, 2015

To ablate the subsurface tissue without ablating the surface tissue of the mouth, a room During

a heat induced ablation with fluid cooling, ablation head and the tissue surface in delivered into

it from an energy source such as ultrasound, microwave, and radiofrequency current.

 

MODULATION OF NERVES INNERVATING THE LIVER

BR Azamian, JA Coe, SB Vafai – US Patent 20,150,112,332, 2015

In some embodiments, the neuromodulation catheter is a radiofrequency (RF) ablation catheter

comprising about substantially 180 degrees of the vessel circumference to ablate in a In some

embodiments, other patterns of ablation electrode movement (regardless of inherent

 

BALLOON CATHETERS WITH FLEXIBLE CONDUCTING WIRES AND RELATED METHODS OF USE AND MANUFACTURE

MR Willard, DC Sutermeister, KR Larson, TA Ostroot… – US Patent 20,150,112,328, 2015

Sympathetic nerve ablation device 12 may be used to ablate nerves (eg, renal nerves) disposed

adjacent to the kidney K (eg, renal nerves Sympathetic nerve modulation device 12 may be

configured to deliver ablation energy, for example, radiofrequency energy, to a target

 

Current Control Methods and Systems

H Cadouri – US Patent 20,150,112,321, 2015

an energy field to a target site in the renal artery (eg, via radiofrequency ablation) have been above

45° C. (or above 60° C. in other cases) may induce thermal ablation of the In some patients, it

may be desirable to achieve temperatures that thermally ablate the target neural

 

DIAPHRAGM ENTRY FOR POSTERIOR SURGICAL ACCESS

SD Fleischman, R Neubert, EW Rogers – US Patent 20,150,112,145, 2015

Atrial fibrillation surgery involving radiofrequency, DC, microwave, ultrasound, laser or other

modes of thermal of focusing energy into local areas spaced at known distances from the ablation

device (in tissue in the ventricles from the diaphragm) are used to ablate the imaged

 

[PDF] ASRA/ESRA/INS/AAPM/WIP/NANS guidelines for interventional spine and pain procedures in patients on antiplatelets and anticoagulants

S Narouze, HT Benzon, D Provenzano, A Buvanendran…

C, cervical; T, thoracic; L, lumbar; S, sacral; MBNB, medial branch nerve block; RFA,

radiofrequency ablation *Patients with high risk for bleeding undergoing low or intermediate

risk procedures should be treated as internmediate or high risk repectively.

 

SYSTEM AND METHOD FOR TREATING URINARY TRACT DISORDERS

U Eshel – US Patent 20,150,112,413, 2015

transurethral microwave thermotherapy (temperatures over 46 degrees Celsius that cause tissue

ablation to exposed that the higher level of heat in the surrounding non-ablated tissue either It

includes a catheter with a sheathed radiofrequency antenna, surrounded by a flow of

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

What is the maximum safe tourniquet time in elective upper limb surgery?

N Sawant, GEB Giddins – Journal of Hand Surgery (European Volume), 2015

Two patients developed chronic regional pain syndrome type 1 (CRPS 1). In one patient this

was noticed 4 weeks following complex rheumatoid surgery. The tourniquet time was 2 hours

4 minutes and there was no immediate post-operative pain or distal paraesthesia.

 

RODENT RUN

MJ Dixon, PM Taylor, B Dixon – US Patent 20,150,107,525, 2015

[2] Millecamps, Laferrière, Ragavendran, Stone, Coderre: “Role of peripheral endothelin receptors

in an animal model of complex regional pain syndrome type 1 (CRPS-I)” J Pain, volume 151

(2010) pages 174-183; [3] Ugo Basile Leaflet for Von Frey Hairs (with grid) Cat. No.

 

Using Computing with Words for Managing Non-cooperative Behaviors in Large Scale Group Decision Making

FJ Quesada, I Palomares, L Martínez – Granular Computing and Decision-Making, 2015

sufficiently to reach the solution made. In order to overcome this drawback, Consensus

Reaching Processes (CRPs) were introduced as an additional phase in the resolution

process for GDM problems [17]. In a CRP, experts try

 

The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature

AC Young, TR Lubenow, A Buvanendran – Regional Anesthesia and Pain Medicine, 2015

Complex regional pain syndrome (CRPS) is neuropathic pain syndrome that is more common

in women, with some studies showing a higher prevalence among women aged 25 to 50

years. Patient 3 suffered from CRPS of the right upper extremity.

 

Decision Makers’ Opinions Changing Attitude-Driven Consensus Model under Linguistic Environment and Its Application in Dynamic MAGDM Problems

B Dutta, D Guha – Granular Computing and Decision-Making, 2015

Based on the concept of soft consensus, vari- ous consensus reaching processes

(CRPs) have been designed in the literature [22]. The existing CRPs for solving GDM

problems can be classified in two categories: static consensus

 

Peripheral Nerve Stimulationperipheral nerve stimulation

AS Hanna – Anatomy and Exposures of Spinal Nerves, 2015

Download Chapter (482 KB). Abstract. Peripheral nerve stimulation is an off-label use of spinal

cord stimulators. It is used for intractable pain in a peripheral nerve distribution, refractory to

medical management, especially with complex regional pain syndrome (CRPS ).

 

[HTML] External Fixation and Adjuvant Pins Versus Volar Locking Plate Fixation in Unstable Distal Radius Fractures: A Randomized, Controlled Study With a 5-Year Follow- …

JH Williksen, T Husby, JC Hellund, HD Kvernmo… – The Journal of Hand …, 2015

At the 5-year follow-up, 3 patients had died, 1 (with an extensor pollicis longus rupture) had moved

abroad, and 2 (1 patient with complex regional pain syndrome [CRPS]) withdrew from the study.

Carpal tunnel syndrome, 2, 1. CRPS, 0, 1. Extensor tendon synovitis, 0, 5.

 

Complex regional pain syndrome type I: a comprehensive review

M Bussa, D Guttilla, M Lucia, A Mascaro, S Rinaldi – Acta Anaesthesiologica …, 2015

Background. Complex regional pain syndrome type I (CRPS I), formerly known as reflex

sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a

minor injury to a limb. Pathophysiological mechanisms of CRPS I.

 

Phenotype-Specific Diagnosis of Functional (Psychogenic) Movement Disorders

AJ Espay, AE Lang – Current Neurology and Neuroscience Reports, 2015

Page 1. MOVEMENT DISORDERS (M OKUN, SECTION EDITOR) Phenotype-Specific

Diagnosis of Functional (Psychogenic) Movement Disorders Alberto J. Espay1,3 & Anthony

E. Lang2 © Springer Science+Business Media New York 2015

 

[PDF] Time-consistent calibration of short-term regional wind power ensemble forecasts

S SPäTH, L VON BREMEN, C JUNk, D HEINEMANN – 2015

For minimum score esti- mation, we use the continuous ranked probability score (crps). For

a forecast cumulative distribution function (cdf) Fp(x) and the verifying obser- vation y, the crps

can be calculated as: crps(Fp,y) = ∞ ∫ − Fp(x) − Θ(x − y) ]2 dx (4.4)

 

Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization

S Tomisawa, Y Sato, M Kamiya, Y Kumaki, T Kikukawa… – Protein Expression and …, 2015

The mouse Paneth cell α-defensins, termed cryptdins (Crps) 1 , are secreted into the lumen of

the small intestinal crypts in response to exposure to bacteria or bacterial antigens [6]. Among

the known isoforms, cryptdin-4 (Crp4) has the most potent antimicrobial activity [7

 

[PDF] Erythrocyte Sedimentation Rate, C-Reactive Protein and Procalcitonin in Infections of the Spine and Infections in Spinal Cord Injury Patients

JAL Buensalido, MP Reyes – Open Infectious Diseases Journal, 2015

One study reported a mean CRP of 3 mg/L in paraplegics, while a mixed paraplegia/tetraplegia

study that excluded patients with CRPs >10 mg/L, also showed a mean of 3 mg/L. Another group

noted that mean CRP level was 38 mg/L, or 27% higher, in SCI versus non-SCI

 

Fibromyalgia

 

The role of sleep in pain and fibromyalgia.

EH Choy – Nature reviews. Rheumatology, 2015

Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced

pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common

symptoms include nonrestorative sleep, fatigue, cognitive dysfunction, stiffness and mood

 

Nonpharmacological Treatments of Insomnia for Long-Term Painful Conditions: A Systematic Review and Meta-analysis of Patient-Reported Outcomes in …

NK Tang, ST Lereya, H Boulton, MA Miller, D Wolke… – Sleep, 2015

This study evaluated the effect of nonpharmacological sleep treatments on

patient-reported sleep quality, pain, and well-being in people with long-term cancer

and non-cancer (eg, back pain, arthritis, fibromyalgia) pain conditions.

 

COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY

S Hoffman – US Patent 20,150,111,878, 2015

Abstract: The present invention provides methods, compositions, and kits for treating intestinal

hyperpermeability in a subject in need thereof, including underlying diseases such as diabetes,

autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease

 

American College of Lifestyle Medicine Expert Panel Discussion Treat the Cause: Evidence-Based Practice*

JM Rippe, M Greger, DL Katz, JH Kelly, M Moore… – American Journal of …, 2015

Following this strategy, I am fostering clinical evaluation of coaching for fibromyalgia,

for which there is no good treatment other than exercise. However, it has taken 10

years to get to the place where we have enough coaches

 

Whole body vibration training in patients with COPD A systematic review

R Gloeckl, I Heinzelmann, K Kenn – Chronic Respiratory Disease, 2015

Abstract. In recent years, several studies have shown that whole body vibration training (WBVT)

may be a beneficial training mode in a variety of chronic diseases and conditions such as

osteoporosis, fibromyalgia, multiple sclerosis, or chronic low back pain.

 

[PDF] Fibromyalgia Syndrome AmongIraqi Patients with Systemic Lupus Erythematosus: A Case Control Study

ZS Al-Rawi, HAJ Badran, FI Gorial

Abstract: Objective: To determine the prevalence of fibromyalgia syndrome (FMS) among

Iraqi patients with systemic lupus erythematosus (SLE) and its association with disease

activity. Patients and methods: This case control study included 100 patients with SLE and

 

[PDF] Quality of life, sense of coherence and experiences with three different treatments in patients with psychological distress in primary care: a mixed-methods study

T Arvidsdotter, C Taft, B Marklund, S Kylén – BMC Complementary and Alternative …, 2015

More detailed data on the procedure are reported elsewhere [48]. The patients had a primary

diagnosis of depression, anxiety or panic disorders, severe stress, somatic symptoms/pain

(including irritable bowel syndrome, fibromyalgia, migraine, fatigue) or sleep disorders.

 

SULFUR-CONTAINING BICYCLIC COMPOUND

N Shiraishi, H Hoshii, W Hamaguchi, E Honjo… – US Patent 20,150,111,876, 2015

containing bicyclic compound having a PAM action of GABA B , and it use for preventing

and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum

disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot

 

TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY

R Aung-din – US Patent 20,150,111,930, 2015

respective receptors. They are indicated for such diverse and seemingly different

conditions as: focal onset seizures, post-herpetic neuralgia, diabetic peripheral

neuropathy, fibromyalgia, anxiety, and drug withdrawal syndromes. The

 

Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

YH Lee, SC Bae, SJ Choi, JD Ji, GG Song – Lupus, 2015

 

[HTML] Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia

B Regland, S Forsmark, L Halaouate, M Matousek… – 2015

Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue

syndrome) may respond most favorably to frequent vitamin B12 injections, in vital

combination with oral folic acid. However, there is no established algorithm for

 

Cardiovascular control in women with fibromyalgia syndrome: do casual methods provide non redundant information compared to more traditional approaches?

AR Zamunér, A Porta, CP Andrade, A Marchi, M Forti… – American Journal of …, 2015

Abstract The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have

been widely studied in FMS patients through the computation of linear indices of

spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However,

 

Aberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia

CM Brummett, AG Lohse, A Tsodikov, SE Moser… – Regional Anesthesia and …, 2015

Abstract Background and Objectives: Facet interventions for spine pain have high failure

rates, and preprocedural prediction of response is nearly impossible. A potential explanation

may be aberrant central pain processing as that existing in conditions like fibromyalgia. To

 

[HTML] Effects of Whole-Body Vibration Therapy in Patients with Fibromyalgia: A Systematic Literature Review

D Collado-Mateo, JC Adsuar, PR Olivares… – … -Based Complementary and …, 2015

Objective. To review the literature on the effects of whole-body vibration therapy in patients

with fibromyalgia. Design. Systematic literature review. Patients. Patients with fibromyalgia.

Methods. An electronic search of the literature in four medical databases was performed to

 

Six Syndromes with Surprising Psychotherapy Solutions

T Rodriguez, V Stern – Scientific American Mind, 2015

These links to content published by NPG are automatically generated. Cognitive behavioral

therapy for fibromyalgia. Utility of cognitive behavioral therapy as a treatment for insomnia in

patients with fibromyalgia. Nature Clinical Practice Rheumatology (01 Apr 2006).

 

Comorbid Conditions Do Not Differ in Children and Young Adults with Functional Disorders with or without Postural Tachycardia Syndrome

G Chelimsky, K Kovacic, M Nugent, A Mueller… – The Journal of Pediatrics, 2015

All patients underwent formal autonomic testing, Beighton scores assessment for joint

hypermobility (0-9), and fibromyalgia tender points (0-18) (43 subjects). Results. All subjects with

fibromyalgia by tender point-examination had a Beighton score ≥4 (P = .002). Conclusions.

 

Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias

S Regauer, B Eberz, C Beham‐Schmid – APMIS, 2015

Similar to other chronic pain syndromes among which are chronic pelvic and bladder pain,

fibromyalgia, and atopic dermatitis morphological correlates are hyperinnervation and increased

infiltrates of mast cells [3-5]. Activated mast cells release pre-stored or rapidly produced

 

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study

E Generaal, N Vogelzangs, GJ Macfarlane, R Geenen… – Annals of the Rheumatic …, 2015

Previous studies mostly defined chronic widespread pain, a cardinal symptom of the fibromyalgia

syndrome, as axial and bilateral pain above and below the waist.41 With this somewhat ‘less

stringent’ definition, we may have included some patients with milder pain.

 

Speed, science and optimal pain relief

RA Moore – International Journal of Clinical Practice, 2015

For example, a retrospective analysis of patients with chronic back pain or fibromyalgia revealed

that patients rated their treatment as successful if their pain was reduced by 50–70%, from a level

of 5–10 on a visual analogue scale (total score 10) to below three (no more than

 

[PDF] An Insight of D 鄄 Ribose Metabolic Imbalance in Type 2 Diabetes Mellitus

T SU, RQ HE – Progress in Biochemistry and Biophysics, 2015

14-15]. Ribose is often marked as a supplement for bodybuilders with a common

recommended daily dose of 5g or more and has also been used to reduce fatigue

in fibromyalgia and chronic fatigue syndrome [2,16]. Ribose

New study shines light on ketamine’s antidepressant effects

New study shines light on ketamine’s antidepressant effects

Ketamine, a long known anesthetic drug, has recently experienced resurgence in use due to the serendipitous discovery of new activities.  These new activities have afforded new treatment options for notoriously difficult to treat diseases such as depression and chronic pain.

Ketamine has been called the pharmacologist’s nightmare due to it’s numerous mechanisms of action, making it difficult to pinpoint exactly what makes the drug so effective for specific diseases.  A new study published in Biological Psychiatry found that ketamine induced large-scale persistent network reconfiguration in monkeys.  The scientists believe that this activity may be critical for ketamine’s anti-depressive effects.

These findings could rapidly advance the development of a ketamine-based drug for the treatment of depression.  Moreover, it opens the door for more physicians to use existing ketamine therapeutics off label to treat depression that is resistant to conventional antidepressants.

Dr. Hanna’s clinical team at the Florida Spine Institute has used intravenous ketamine therapy to treat many types of disorders, including depression.  To learn more about intravenous ketamine infusions, click here.  To find out if ketamine therapy is right for you, please make an appointment with Dr. Hanna.

For full article, visit: http://www.sciencedirect.com/science/article/pii/S0006322315001535

9 Pain Pill Mistakes – Pain Medication Mistakes: Overdoses, Side Effects, and More

9 Pain Pill Mistakes – Pain Medication Mistakes: Overdoses, Side Effects, and More

Pain Pills

It’s been a hard day, and Joe’s back is killing him.

His wife has some Percocet left over from a trip to the dentist, and there’s that big bottle of Tylenol under the sink, so Joe grabs a couple of each and washes them down with a slug of beer.

Luckily for Joe, he’s a fictional character invented for this article. But there are a lot of real-life Joes out there making big mistakes with over-the-counter and prescription pain pills.

Can you spot Joe’s mistakes? Joe didn’t make every mistake in the book. But he made quite a few.

Here’s WebMD’s list of common pain pill mistakes, compiled with the help of pharmacist Kristen A. Binaso, RPh, spokeswoman for the American Pharmacists Association; and pain specialist Eric R. Haynes, MD, founder of Comprehensive Pain Management Partners in Trinity, Fla.

Pain Medications Mistake No.1: 
If 1 Is Good, 2 Must Be Better

Doctors prescribe pain pills at the doses they believe will offer the greatest benefit at the least risk. Doubling or tripling that dose won’t speed relief. But it can easily speed the onset of harmful side effects.

“The first dose of a pain medication may not work in five minutes the way you want. But this does not mean you should take five more,” Binaso says. “With some pain drugs, if you take additional doses, it makes the first dose not work as well. And with others, you end up in the emergency room.”

If you’ve given your pain medication time to work, and it still does not control your pain, don’t double down. See your doctor about why you’re still hurting.

“This ‘one is good so two must be better’ thing is a common problem,” Haynes says. “Patients should follow the instructions their doctor gives. Ask before leaving the office: Can I take an extra pill if I still hurt? What is the upper limit for this medication?”

Another bad idea is trying to boost the effect of one kind of pain pill by taking another.

“There may be ibuprofen, acetaminophen, and naproxen in the house, and a person may take them all,” Binaso says.

This can escalate into a very bad situation, Haynes says.

Pain Medications Mistake No. 2: 
Duplication Overdose

People often take over-the-counter pain drugs — and even prescription pain drugs — without reading the label. That means they often don’t know which drugs they’re taking. That’s never a good idea.

And if they take another over-the-counter drug — either for extra pain relief or for other reasons — they may be getting an overdose. That’s because many OTC drugs are combination pills that carry a full dose of pain pill ingredients.

In Joe’s case, he’s taken a prescription pain pill that contains acetaminophen along with a second full dose of acetaminophen from Tylenol, putting him at risk of injury.

Pain Medications Mistake No. 3: 
Drinking While Taking Pain Drugs

Pain medications and alcohol generally enhance each other’s effect. That’s why many of these prescription medications carry a “no alcohol” sticker.

That sticker shows a martini glass covered by the international “No” sign of a circle with a slash. But it applies to wine and beer just as much as it does to spirits.

“A common misperception is people see that sticker and think, ‘I’m OK as long as I don’t drink liquor — I can have a beer.’ But no alcohol means no alcohol,” Binaso says.

“The patient should heed that alcohol warning, because it can be a major problem if they do not,” Haynes says. “Alcohol can make you inebriated, and some pain medications can make you have that feeling as well. You can easily get yourself into trouble.”

Drinking alcohol can be a problem even with over-the-counter pain drugs.

Pain Medications Mistake No. 4: 
Drug Interactions

Before taking any pain pill, think about what other medicines, herbal remedies, and supplements you are taking. Some of these drugs and supplements may interact with pain medications or increase the risk of side effects.

For example, aspirin can affect the action of some non-insulin diabetes drugs; codeine and oxycodone can interfere with antidepressants.

You should give your doctor a complete list of all the drugs, herbs, and supplements you take — before getting any prescription.

If buying over-the-counter medications, Binaso recommends showing a list of everything else you’re taking to the pharmacist.

Pain Medications Mistake No. 5: 
Drugged Driving

Pain medications can make you drowsy. Different people react differently to different drugs.

“How I react to a pain medication is different from how you react,” Binaso says. “It may not make me drowsy, but may make you drowsy. So I recommend trying it at home first, and see how you feel. Don’t take two pills and go out driving.”

Pain Medications Mistake No. 6: 
Sharing Prescription Medicines

Unfortunately, it’s very common for people to share prescription medications with friends, relatives, and co-workers. Not smart, Haynes and Binaso say — particularly when it comes to pain medications.

“If a fairly healthy person is taking a medicine because she is in pain, and wants to give some pills to Uncle Joe because he is hurting — well, this is a potential problem,” Haynes says. “Uncle Joe may have a problem that keeps his body from eliminating the drug, or he may have an allergic reaction, or the drug may interact with a medication he is taking, with life-threatening results.”

Pain Medications Mistake No. 7: 
Not Talking to the Pharmacist

It’s not easy to read drug labels, even if you can make out the small print. If you have a question about either a prescription or OTC drug, ask the pharmacist.

“That’s why I’m in the store,” Binaso says. “You may have to wait a couple of minutes for me to finish what I’m doing. But you’ll get the information you need to take the right medicine the right way. Just say, ‘Tell me about this medicine; what should I be on the lookout for?'”

Pain Medications Mistake No. 8: 
Hoarding Dead Drugs

Joe’s wife is actually to blame for one of his mistakes. She should have disposed of those extra pain pills once she was over her dental pain.

Why? One reason is that pills stored at home start breaking down soon after their expiration date. That’s especially true of drugs kept in the moist environment of the bathroom medicine cabinet.

“People say, “That drug is only a year past its expiration date; isn’t it good?” But if you take a pill that’s broken down, it may not work — or you may end up in the emergency room because of reaction to a breakdown product. That is really common,” Binaso says.

Another reason that it’s dangerous to hoard is that the drugs may tempt someone else into making a very bad choice.

“Teen drug abuse is really up, especially with pain medications,” Binaso says. “It is not uncommon for kids to go to their parents’ or grandparents’ medicine cabinet and then go to a party and put the drugs in a bowl.”

Pain Medications Mistake No. 9: 
Breaking Unbreakable Pills

Pills are actually little drug-delivery machines. They don’t work the way they’re supposed to when taken apart the wrong way.

Scored pills should be cut only across the line, Binaso says. Those without scoring should not be cut at all, unless you’re specifically instructed to do so.

“When you start chopping up pills like that, the pill may not work,” she says. “We find more and more people are doing this. And then they say, “Oh, that pill had a really bad taste. That is because they cut away the coating.”

Source: Web MD
By Daniel J. DeNoon

Reviewed By David T. Derrer, MD

 

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