by admin | Nov 5, 2015 | Uncategorized
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli
F Hu, G Ding, Z Zhang, LA Gatto, S Hawgood… – Innate Immunity, 2015
… UTI was induced as previously described, 30 with some modifications. In brief, mice were
anesthetized by ip injection with ketamine/xylazine (90 mg/kg ketamine and 10 mg/kg xylazine),
and were gently massaged and pushed down on the bladder to expel urine. …
[PDF] Comparison of propofol and ketofol in minor gynecologic interventions
Y Işık, Z Kurdoğlu, U Göktaş, İ Katı, D Sözen – J Clin Exp Invest www. jceionline. org …, 2015
… Propofol is administered as an infusion instead of in repeated doses, which prevents
dose-dependent respiratory and cardiovascular system depression and pro- vides controlled
sedation [1]. Ketamine is preferred for premedication, anesthesia induction and main- tenance …
Anesthesia Complications of Pediatric Radiotherapy
V Verma, AB Beethe, M LeRiger, RR Kulkarni, M Zhang… – Practical Radiation …, 2015
… While agents such as ketamine (complication rates approaching 23-24%) have been used
in the past, other agents such as propofol and volatile anesthetics have lower complication
rates due to improved drug side effect profiles (0.01-3.5%). …
[HTML] Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway
R Rajkumar, Y Wu, U Farooq, WH Tan, GS Dawe – Brain Research Bulletin, 2015
… Ketamine (Parnell Manufacturing Pty Ltd; Alexandria, NSW, Australia), xylazine (Ilium Xylazil,
Troy Laboratories Pty Ltd; Glendenning, NSW, Australia), enrofloxacin (Baytril 5%, Bayer Health
Care; Seoul, Korea) and carprofen (Carprieve, Norbrook Laboratories (GB), Ltd …
The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect
K Pytka, A Dziubina, K Młyniec, A Dziedziczak… – Pharmacological Reports, 2015
Depression is one of the most common mental disorders and social issue worldwide. Although
there are many antidepressants available, the effectiveness of the th.
[HTML] Communicating with mismatch and tension: treatment provision experiences of primary care doctors treating patients with overactive bladder in Hong Kong
JY Siu – BMC Family Practice, 2015
… [P6]. During the study period, the symptoms of OAB, particularly urinary frequency and
urinary incontinence, were identified by government antisubstance abuse public service
announcements as signs and consequences of ketamine abuse. …
Hydrogen sulfide (H 2 S) attenuates uranium-induced acute nephrotoxicity through oxidative stress and inflammatory response via Nrf2-NF-κB pathways
J Zheng, T Zhao, Y Yuan, N Hu, X Tang – Chemico-Biological Interactions, 2015
… sacrificed. After urine collection, rats were anesthetized by an ip injection of
ketamine-xylazine (50 mg/kg ketamine and 5 mg/kg xylazine), and blood samples
were obtained directly from the heart ventricle in anesthetized animals. …
[PDF] General discussion and future perspectives
SA Bouwense, M de Vries, LT Schreuder, SS Olesen… – PDF hosted at the Radboud …, 2015
… even if technically successful. If central nervous system pain processing is altered,
specific treatment targeting these changes should be instituted (eg gabapentinoids,
ketamine or tricyclic antidepressants). Suitable tools are …
Propofol target-controlled infusion for sedated gastrointestinal endoscopy: A comparison of propofol alone versus propofol–fentanyl–midazolam
CD Hsu, JM Huang, YP Chuang, HY Wei, YC Su… – The Kaohsiung Journal of …, 2015
… The currently used regimens include propofol, benzodiazepines (such as midazolam and
diazepam), opioids (such as fentanyl and remifentanil), ketamine, and de-dexmedetomidine
[3], [4], [5] and [6]. Among them propofol has become popular in developed countries, because …
[PDF] A Critical Case of Closed Cervix Pyometra in a Bitch
JK Agrawal, A Saxena, P Kumar, A Patel – International Journal of Livestock Research, 2015
… General anethesia was induced and maintained by a combination of ketamine hydrochloride @
5mg/kg and Xylazine @ 0.2mg/kg body weight intravenously following premedication with atropine
sulphate @ 0.04mg/kg body weight. Laparotomy was performed …
Radiofrequency Ablation (RFA)
Treatment of Neuroendocrine Liver Metastases
HA Farley, RF Pommier – Surgical Oncology Clinics of North America, 2015
… Treatment options: radiofrequency ablation. RFA is another technique used to treat
neuroendocrine metastases of the liver, but it has limitations. One can ablate a limited number
of lesions (generally up to 5), of limited size (generally <5 cm in diameter), provided they are …
[PDF] Ablative Techniques in Advanced Pancreatic Cancer: Do They Affect The Quality of Life?–Review
D Dimitrov, H Feradova, D Gincheva, L Dall’Olio – JOP. J Pancreas (Online), 2015
… Such ablative therapies are high-intensity focused ultrasound (HIFU), radiofrequency
ablation (RFA), irreversible electroporation (IRE), iodine-125, iodine-125–cryosurgery,
photodynamic therapy (PDT) and microwave ablation [8]. …
Minimally Invasive Techniques for Resection of Pancreatic Neuroendocrine Tumors
GGF Ranvier, D Shouhed, WB Inabnet – Surgical Oncology Clinics of North America, 2015
Please note that Internet Explorer version 8.x will not be supported as of January 1,
2016. Please refer to this blog post for more information. Close. …
[HTML] Colorectal Liver Metastasis, Primary Gallbladder Carcinoma and Myelofibrosis Present Simultaneously in a Liver Resection Specimen
SA Gray, MH Raber, E Provoost, GJ Toes, JM Klaase – Case Reports in …, 2015
… An elective operation was scheduled, and the surgeon performed a wedge resection of segments
5 and 7 of the liver, and a radiofrequency ablation was used to treat a lesion in segment 3.
Although the suspicion of gallbladder carcinoma at the time of surgery was low, the …
Nontraumatic Cervical Spine for Primary Care Providers
CR Hemmer – The Journal for Nurse Practitioners, 2015
… physical therapy, a home traction unit, transcutaneous electrical nerve stimulation, epidural steroid
injections, selective nerve root blocks (transforaminal injections), botulinum toxin type A injections,
medication management, radiofrequency ablation, and surgical correction. …
Surgical Management of Adrenocortical Carcinoma: An Evidence-Based Approach
J Datta, RE Roses – Surgical Oncology Clinics of North America, 2015
Please note that Internet Explorer version 8.x will not be supported as of January 1,
2016. Please refer to this blog post for more information. Close. …
SYSTEM AND METHOD FOR RECONSTRUCTING CARDIAC SIGNALS ASSOCIATED WITH A COMPLEX RHYTHM DISORDER
S Narayan, R Sehra – US Patent 20,150,289,807, 2015
… For instance, ablation success for atrial tachycardias (a ‘simple’ disorder) may be as low as 70%. …
Thus, ablating the cause of a heart rhythm disorder can be challenging, and even experienced
practitioners may require hours to ablate certain ‘simple’ rhythm disorders …
[HTML] RADIONUCLIDE IMAGING AND THERAPY OF NEUROENDOCRINE TUMOURS
S Navalkissoor, G Gnanasegaran – Journal of Cancer & Allied Specialties, 2015
… These include surgical debulking, chemotherapy, molecular targeted therapies (eg sunitinib
and everolimus), interferon, somatostatin analogues, local therapies (eg radiofrequency ablation
or embolisation) and peptide receptor radionuclide therapy (PRRT). …
[PDF] Successful Radiofrequency Pulmonary Vein Isolation In A Patient With Pneumonectomy
F Kilicaslan, EE Gul, C Erol
… Circumferential radiofrequency ablation of ipsilateral PVs was done (30-35 W, 17
mL/min) with irrigated catheter (Sprinklr, Medtronic, Minneapolis, USA) and both,
entrance and exit blocks were achieved after the ablation. Interestingly …
[PDF] Ablation Is A Treatment Option Without Permanent Pacemaker Implantation For Bradycardia With Persistent Atrial Fibrillation
W Yamada, K Tanimoto, M Yamada, K Inagawa…
… Page 5. Rotational Atriography Of Left Atrium – A Imaging Technique Used To Support Left Atrial
Radiofrequency Ablation: A Comparison Of Anatomical Data Of Left Atrium F. Lehar, Z. Starek,
J. Jez, J. Wolf, T. Kulik, A. Zbankova, M. Novak Department of Cardiology, ICRC/St. …
Complex Regional Pain Syndrome (CRPS/RSD)
[PDF] Do insiders trade on mispricing after earnings announcements?
JP Fidrmuc, J Novák, H Contreras – 2015
Page 1. Do insiders trade on mispricing after earnings announcements? Jana P.
Fidrmuc∗ Warwick Business School Jirı Novák† Charles University Harold Contreras‡
Warwick Business School October 21, 2015 Abstract This …
[PDF] A predictive framework for evaluating models of semantic organization in free recall
NW Morton, SM Polyn – Journal of Memory and Language, 2015
Research in free recall has demonstrated that semantic associations reliably influence the
organization of search through episodic memory. However, the specific.
6-, 7-, OR 8-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
GW Muller, H Man – US Patent 20,150,291,555, 2015
… Examples of diseases or disorders include, but are not limited to, cancer, disorders associated
with angiogenesis, pain including, but not limited to, Complex Regional Pain Syndrome (“CRPS”),
Macular Degeneration (“MD”) and related syndromes, skin diseases, pulmonary …
[PDF] Psychological distress and stressful life events in pediatric complex regional pain syndrome
MD Hannah Brehmer, MD Boris Zernikow
… Complex regional pain syndrome (CRPS) is increasingly recog- nized as a serious pain
disorder in children and adolescents. … Specifically, it is not known which factors precipitate
CRPS and which result from the ongoing painful disease. …
[PDF] In the High Court of New Zealand Wellington Registry
L SEALES, SAOFL SEALES
… Pain News 11 (1) 2013 pages 30-33. Safarfashandi Z, Munglani R, Safarfashandi L, Sadheura
J, Jenner C “The incidence of complex regional pain syndrome (CRPS) post trauma and the
possible role of tight plaster of Paris in the aetiology of CRPS“. …
[PDF] Assessment Report
CO Onyango, Y Suwa, Y Pinto
… directory ….. 18 – Table 5: List of ASTI publications in Phase II 3 ….. 20 Table 6: Summary of
ex-post impact assessments by CGIAR Centres, CRPs and SPIA ….. 29 …
[PDF] Hereditary Immunity against Infectious Diseases
IA Shabarov, ZI Urmancheeva, SN Rumyantsev…
Page 1. 1 Innovative Immunology | www.austinpublishinggroup.com/ebooks Copyright
© Rumyantsev SN.This book chapter is open access distributed under the Creative
Commons Attribu- tion 4.0 International License, which …
Encyclopedia of Exploration Geophysics
M this Chapter
Page 1. U1-1 Abstract To produce a reliable image of the subsur- face, we must use
a depth-migration scheme that requires a detailed model of the parameter fields for
use by migration. Obtaining reliable values of all parameters …
Fibromyalgia
[PDF] Does “Multiple Labeling” Benefit or Harm in Fibromyalgia Patients
E Trallero, C Alegre – Fibrom open, 2015
A systematic review showed that there is no evidence an accurate diagnosis of fibromyalgia
per se could worsen prognosis in patients with this condition [1]. Indeed, it could be useful to
reduce healthcare utilization by patients. Nevertheless, social and individual long-term …
[PDF] Comparison between Depression Levels of Women with Knee Osteoarthritis, Rheumatoid Arthritis, and Fibromyalgia Syndrome: A Controlled Study
D Karşılaştırılması, BK Çalışma – 2015
DOI: 10.5152/tftrd.2015.87894 Turk J Phys Med Rehab 2015;61:197-202 Türk Fiz Tıp Rehab
Derg 2015;61:197-202 … Comparison between Depression Levels of Women with … Diz
Osteoartrit, Romatoid Artrit ve Fibromiyalji Sendromlu Kadınlarda Depresyon …
NOVEL BIPHENYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR …
CH Lee, K Lee – US Patent 20,150,291,509, 2015
… group consisting of dermatitis, allergy, atopy, conjunctivitis, periodontitis, rhinitis, tympanitis,
pharyngolaryngitis, tonsillitis, pneumonia, gastric ulcer, gastritis, Crohn’s disease, colitis, irritable
colitis, hemorrhoids, gout, ankylosing spondylitis, lupus, fibromyalgia, psoriasis, arthritis …
[PDF] Recent advances in massage therapy–a review
SL LIU, W Qi, H Li, YF WANG, XF YANG, ZM LI, Q Lu… – Eur Rev Med Pharmacol Sci, 2015
… in animal models. In a randomized trial conducted by Ekici et al13, application of
MLD to women with fibromyalgia resulted in improvements regarding pain, health
status, and health-related quality of life. Lancaster and Crow14 …
Immediate Effect of Basic Body Awareness Therapy on Heart Rate Variability
AM Mantovani, CEPT Fregonesi, RMR Lorençoni… – … Therapies in Clinical …, 2015
To determine the immediate effect of a Basic Body Awareness Therapy (BAT) session on
measures of heart rate variability (HRV) in healthy young people.13 healthy.
[PDF] Radial shock wave therapy in the treatment of lateral epicondylitis
JD Rompe, J Decking, C Schoellner, C Theis…
… P009-e Gait analysis: An objective measurement for subgrouping fibromyalgia patients B. Auvinet
a,*, D. Chaleil b, J. Cabane c, A. Dumolard d, P. Hatron e, R. Juvin d, M. Lanteri-minet f, Y. Mainguy
g, L. Negre-pages h, F. Pillard i, D. Riviere i, Y. Maugars j a Clinique, 8, rue des …
2-OXO-2, 3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS
D Brunner, J Malberg, BG Shankar, S Kolczewski… – US Patent 20,150,284,386, 2015
… Fibromyalgia, which is a syndrome characterized by chronic generalized pain associated with
different somatic symptoms, such as sleep disturbances, fatigue, stiffness, balance problems,
hypersensitivity to physical and psychological environmental stimuli, depression and …
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
JE Campbell, P Jones – US Patent 20,150,291,626, 2015
… affective disorder, seasonal affective disorder, obsessive-compulsive disorder, attention deficit
disorder, attention deficit hyperactivity disorder, vertigo, pain, neuropathic pain, sensitization
accompanying neuropathic pain, inflammatory pain, fibromyalgia, migraine, cognitive …
[PDF] How is Qigong Conducive to Women’s Health
FK Cheng – Int J Complement Alt Med, 2015
… Likewise, Tai Chi is beneficial for treating fibromyalgia, achieving better symptomatology,
aerobic capacity, dynamic balance, body strength, and walking distance [112]. Psychological
health: Studies inform the effects of Baduanjin on mental well-being. …
[HTML] Recommendations to the primary care practitioners and the patients for managing pelvic pain, especially in painful bladder syndrome for early and better prognosis
KJ Chung, ANY Han, KH Kim – Journal of Exercise Rehabilitation, 2015
… Scholar]. Nickel JC., Tripp DA., Pontari M., Moldwin R., Mayer R., Carr LK., Doggweiler R., Yang
CC., Mishra N., Nordling J. Interstitial cystitis/painful bladder syndrome and associated medical
conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic …
by admin | Nov 2, 2015 | Uncategorized
New research reveals that greater frequency and duration of daytime napping are associated with more severe symptomatology in patients with fibromyalgia.
According to the study results, published in BMC Musculoskeletal Disorders (2015 Feb 7;16:13. doi: 10.1186/ s12891-015-0464-y), the majority of participants reported using daytime napping as a strategy for coping with poor sleep and fibromyalgia symptoms. “Participants who regularly took a daytime nap were found to have a higher number of comorbidities, increased levels of pain, fatigue, sleep problems, memory difficulties and mood disturbance in comparison to participants with fibromyalgia who napped less regularly or not at all,” reported Alice Theadom, PhD, senior research fellow at the National Institute for Stroke and Applied Neurosciences, in Auckland, New Zealand.
Whereas previous research has shown sleep to be problematic for people with fibromyalgia, uncertainty remains over whether daytime napping is a beneficial or detrimental coping strategy.
“We found that poor sleep has been linked to poorer outcomes, and we found associations between difficulty falling asleep or waking up during the night with greater levels of pain and fatigue and other symptoms in this condition,” Dr. Theadom stated. “What we were looking at specifically in this study, however, was the impact of how people use daytime naps as a way of managing feelings of fatigue or tiredness during the day.”
An online questionnaire of 1,044 adults who reported napping on a daily basis showed that 18.9% napped in the morning of a typical weekday, 58.8% napped in the afternoon and 25% napped in the evening. It was also revealed that 86.5% of participants found themselves taking a nap without intending to, Dr. Theadom reported.
“Daytime napping was significantly associated with higher levels of pain, feelings of low mood and anxiety, and people feeling more fatigued, as well as memory difficulties and difficulty sleeping at night,” she said. “So daytime napping seemed to be linked to quite a range of symptoms.”
Daytime napping was also associated with a high rate of comorbid conditions, including arthritis (20%), irritable bowel syndrome (15%) and asthma (13%). Of those surveyed, 5.1% reported a psychiatric condition and 11.2% had depression, Dr. Theadom said. Finally, the duration of naps was found to have an influence on the impact of symptoms.
Those who engaged in daytime naps for longer than 30 minutes had greater memory difficulties and levels of depression than those who napped for shorter periods (P<0.010).
The most common reasons for taking a nap included tiredness/exhaustion (94.1%), feeling unwell (67.2%), catching up from the previous night’s poor sleep (59.6%), headache (42.6%) and pain (26.2%).
Although studies of people unaffected by a medical condition have shown a direct correlation between duration of napping and performance outcomes, Dr. Theadom stressed that the data for those with fibromyalgia remain inconclusive. Further research is needed, she said, to understand whether daytime napping is detrimental to symptom severity or whether it can be recommended as a strategy to manage symptoms.
“It’s really important that we try to unpick this so we can make fruitful recommendations to patients who are experiencing difficulties in fatigue,” Dr. Theadom concluded. “We need to provide guidelines so that patients know whether to use the daytime nap or not, and if so, for how long and when.”
“Fibromyalgia is a disorder not only about pain,” said Stuart Silverman, MD, FACP, FACR, former medical director and founder of the multidisciplinary outpatient Fibromyalgia and Chronic Pain Program at Cedars-Sinai in Los Angeles, “but about fatigue, sleep, cognitive dysfunction and also irritable bowel and irritable bladder. People who have more severe fibromyalgia, in terms of decreased functioning, also have more pain, more fatigue, more cognitive problems and more sleep disorders. This study is reinforcing our concept of fibromyalgia as a multisymptom illness. It is more than pain.”
—Chase Doyle
by admin | Nov 2, 2015 | Uncategorized
Ketamine May Reduce Chronic Pain in Adolescents
Subanesthetic ketamine infusions are a safe and effective way to relieve chronic pain in adolescents, a new study suggests.
Ketamine, a Schedule III drug, has been used successfully to treat various chronic pain syndromes in adults, according to researchers from Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, in Washington, D.C., who conducted a longitudinal case series to determine the feasibility of ketamine injections in an outpatient setting.
“Our purpose was to look at the clinical outcomes related to our adolescents who were receiving what we considered subanesthetic dosing of ketamine,” said study author Kathy Ann Sheehy, CNS, a nurse specialist at the hospital.
The study included 63 adolescents with chronic pain conditions such as complex regional pain syndrome (CRPS), fibromyalgia and headache, and were treated in the hospital’s tertiary outpatient interdisciplinary Pain Medicine Care Complex from January 2013 to April 2014. The patients received 111 treatments (277 ketamine infusions; maximum dose of 1 mg/kg per hour) during the study period. They were divided into two groups: CRPS (n=23) and all other chronic pain syndromes (n=40). Main outcome measures were self-reported pain scores using a numeric rating scale and morphine-equivalent intake.
The researchers found that ketamine significantly decreased pain scores in 37% of the injections administered. A reduction of 20% or greater was considered significant. Patients with CRPS experienced the greatest reduction compared with the other chronic pain syndromes (P=0.029). The researchers noted that the ketamine infusions did not change the overall morphine-equivalent intake (P=0.3).
“When we looked at the difference between the types of pain syndromes, CRPS was the one that was the most statistically significant as a pain syndrome for reduction in pain scores and reduction in opioid use,” Ms. Sheehy said. “[With] the other pain scores, although overall there was a reduction, we didn’t see a reduction in headaches or other types of complex pain syndromes.”
An analysis of comorbidities showed that:
- 23% of the patients had psychiatric/psychological disorders (e.g., anxiety, depression, bipolar disorder);
- 10% had a history of trauma;
- 10% had postural orthostatic tachycardia syndrome (POTS);
- 7% had diabetes mellitus;
- 7% had a malignancy; and
- 5% had sickle cell disease.
The researchers found that the patients with POTS and trauma experienced the greatest pain reduction and chronic headache patients had the smallest decrease. “Our assumption for that is that both of those are autonomic sympathetic conditions, and most of our CRPS kids actually had trauma,” Ms. Sheehy said.
No adverse events were reported and the ketamine injections were well tolerated, according to the study authors. They said more research on complex pain syndromes, especially CRPS in adolescents, is needed.
by admin | Oct 19, 2015 | Uncategorized
Clinicians seeking greater understanding of the neural activity behind pain can turn to the results of a University of Western Ontario study, which identified variations in neural activity associated with pain processing between control and neuropathic pain groups. These differences in signal activity—particularly in regions critical to endogenous analgesia—may represent a key step in elucidating the pathophysiology that underlies chronic neuropathic pain syndromes.
“Neuropathic pain affects approximately 5% of North Americans, and is considered to be caused by a lesion to the peripheral or central nervous system, trauma or disease,” said Jordan Leitch, MD, a resident at the London, Ontario, institution. “It’s characterized by either spontaneous episodic pain or pathological amplification of pain following a stimulus. In general, neuropathic pain is considered to be an expression of a maladaptive plasticity in the pain system that results in this constant state.”
During testing, functional MRI data were acquired while noxious stimuli were applied at the various pressures the patients had indicated the previous day. The researchers chose standardized pain ratings in lieu of standardized mechanical stimuli because pain response is subjective and varies widely between individuals.
As Dr. Leitch reported at the 2015 annual meeting of the Canadian Anesthesiologists’ Society (abstract 86017), both the volunteers and pain patients exhibited overall positive signal change at a pain rating of 2 and negative signal change at a pain rating of 6 in the midbrain and rostral medulla of the brainstem. However, consistent differences were observed between groups in the ipsilateral dorsal horn of the spinal cord, rostral ventromedial medulla and periaqueductal gray matter—three regions known to play an important role in nociceptive pain processing as well as the endogenous descending modulation of pain.
“In those regions, which we know are associated with ascending nociceptic transmission and the endogenous descending modulation of pain, we’re seeing positive signal change in the control group, but not much of anything in the carpal tunnel group,” she said.
“Another area we found interesting was around the dorsal horn of the cervical spinal cord, which is where the median nerve originates,” Dr. Leitch said. “And in the control group , we saw some variability from baseline, but not much deviation. But when we looked at the carpal tunnel patients, the times that correspond to pain levels 2, 4 and 6 show persistent positive signal changes that don’t follow what we would expect from controls.”
This study, the investigators concluded, is one of the first to identify variations in neural activity associated with pain processing. “I think seeing is believing in terms of pain,” she added. “This could be an important first step in the quantitative assessment of pain, in terms of both the diagnosis and treatment effect. In general, it’s a step towards a method to objectively visualize a sensation that has traditionally been completely limited to our patients’ subjective description.
“Obviously these signal changes are open to interpretation, but they could be the manifestation of the maladaptive plasticity that is postulated to be one of the causes of neuropathic pain,” Dr. Leitch explained. This research may contribute to future studies investigating endogenous analgesia and pain processing in patient groups, which may facilitate the optimization of pain management and improve quality of life for patients suffering from chronic neuropathic pain, he said.
Dr. Leitch was awarded second place at the meeting’s Residents’ Research Competition.
—Michael Vlessides
by admin | Oct 1, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Ketamine Derivatives
JW Sleigh, WA Denny, J Jose, SA Gamage, MG Harvey… – US Patent 20,150,259,277, 2015
Abstract: The present invention relates to ketamine derivatives of the formula (I),
pharmaceutical compositions comprising them, and methods for treating pain comprising
administering them, and their use in the manufacture of medicaments for treating pain. …
Comparing the hemodynamic parameters and seizure duration between ketamine and thiopental during Electroconvulsive therapy in patients with Major depressive …
M Mohseni, A Ghanbari, MA Motazedi Ghajar… – Anesthesiology and Pain, 2015
Aim and Background: Today the effect of Electroconvulsive therapy (ECT) in cure of Major
depressive disease (MDD), and psychiatric patients is well accepted and usage of this
method is developed every day. In this regard, selecting the most effective hypnotic drugs …
The antinociceptive efficacy of morphine-ketamine-magnesium combination is influenced by the order of medication administration.
SM Vučkovič, VKR Savič, DP Srebro, BM Medič… – European review for …, 2015
OBJECTIVE: Ketamine and magnesium, both N-methyl-D-aspartate (NMDA) receptor
antagonists, enhance the antinociceptive effects of opioid analgesics in different animal
models of pain, as well as in humans. This study aimed at evaluating whether magnesium …
[HTML] Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
S Klein, CB Herath, R Schierwagen, J Grace… – PLOS ONE, 2015
… Cholestatic model. BDL was performed in 40 rats (180g) after anesthesia with ketamine/xylazine
(78mg/kg and 10mg/kg body weight) as previously described [12]. … Briefly rats were anesthetized
with ketamine/xylazine (78mg/kg and 10mg/kg body weight), respectively. …
[HTML] Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction
AL Leblond, K Klinkert, K Martin, EC Turner, AH Kumar… – PLOS ONE, 2015
… Procedures were performed under anesthesia induced by ketamine (90mg/kg), xylazine
(10mg/kg) and urethane (1.25mg/kg) and analgesia by ip delivery of carprofen (5 mg/Kg). … Mice
were anesthetized with ketamine (90mg/kg), xylazine (10mg/kg) and urethane (1.25mg/kg). …
Morphological Pulmonary Diffusion Capacity for Oxygen of Burmese Pythons (Python molurus): a Comparison of Animals in Healthy Condition and with Different …
JM Starck, I Weimer, H Aupperle, K Müller… – Journal of Comparative …, 2015
… Snakes were anaesthetized (1 mg/kg diazepam intramuscularly [i/m]; Faustan; Temmler Pharma,
Marburg, Germany, followed by 40 mg/kg ketamine hydrochloride i/m; Ketavet; Pfizer Pharma,
Berlin, Germany) and placed in the CT scanner (Brilliance CT 6; Philips, Hamburg …
[PDF] Articles in PresS. Am J Physiol Lung Cell Mol Physiol (March 27, 2015). doi: 10.1152/ajplung. 00291.2014
BA MacKenzie, I Henneke, S Hezel, D Al Alam… – 2015
… Mice were genotyped as described previously (3, 12, 34). 148 149 Bleomycin administration
150 10–14 week-old female mice were anaesthetized with a mixture of 0.6 µl/g Ketamine 10%
151 (100 mg/ml) and 0.3 µl/g Dormitor 10% (0.5 mg/ml) dissolved in 0.7% saline. …
Anesthesia for Endoscopy
M Asakawa – Veterinary Clinics of North America: Small Animal …, 2015
… 26 Another study found that a combination of acepromazine and butorphanol followed by induction
with propofol had minimal effect on splenic volume, whereas medetomidine and butorphanol
as premedicants followed by ketamine and diazepam for induction were associated …
[HTML] Generation and Characterization of Live Attenuated Influenza A (H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation
S Shcherbik, N Pearce, A Balish, J Jones, S Thor… – PLOS ONE, 2015
… replication in multiple organs. Anesthesia occurred through an intramuscular injection
of a ketamine-xylazine-atropine cocktail (25 mg/kg ketamine, 2 mg/kg xylazine,
and 0.05 mg/kg of atropine). For euthanasia, ferrets were …
[HTML] Standardized surgical approaches to ear surgery in rats
P Li, D Ding, K Gao, R Salvi – Journal of Otology, 2015
… studies using rats. 2. Anesthesia and pre-operative preparation. Health SD rats
weighing about 250 g were selected and anesthetized with intraperitoneal ketamine
(100 mg/kg) and chlorpromazine (5 mg/kg). The skin around …
Radiofrequency Ablation (RFA)
Is radiofrequency ablation of lung metastases the most radical treatment?
M Zielinski, R Zaimi, P Sabatier, P Bagan – European Journal of Surgical Oncology, 2015
We read with interest the article on long term results of radiofrequency ablation (RFA) to lung
metastases from colorectal cancer 1. This article is an interesting retrospective analysis on
long term survival in patients with lung metastases from colorectal cancer treated with this …
Uninterrupted new oral anticoagulants compared to uninterrupted Vitamin K antagonists in ablation of atrial fibrillation. A Meta-analysis
R Nairooz, K Ayoub, P Sardar, J Payne, A Almomani… – Canadian Journal of …, 2015
… NOAC= new oral anticoagulant, VKA=vitamin K antagonist, N/A=not available, TEE=
trans-esophageal echocardiogram, ICE= intra-cardiac echocardiogram, UFH=
unfractionated heparin, s= seconds, RFA= radiofrequency ablation. …
Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome
P Gal, NF Marrouche – European Heart Journal, 2015
… Post-ablation DE-MRI allows for assessment of the total scar burden, complete encirclement
of pulmonary veins, and the assessment of residual fibrosis, which were all reported to
be strong predictors of arrhythmia recurrences post-ablation. …
Imaging Hepatocellular Carcinoma with Dynamic CT Before and After Transarterial Chemoembolization: Optimal Scan Timing of Arterial Phase
M Saake, MM Lell, A Eller, W Wuest, M Heinz, M Uder… – Academic Radiology, 2015
… In eight patients previous TACE and in five patients previous radiofrequency ablation had been
performed and follow-up imaging had demonstrated HCC recurrence. … First, in a part of our cohort
the HCCs had been treated previously by TACE or radiofrequency ablation. …
Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial
K Kaitani, K Inoue, A Kobori, Y Nakazawa, T Ozawa… – European Heart Journal, 2015
… fasttrack ★ Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation
for Atrial Fibrillation (EAST-AF) trial. Kazuaki Kaitani, Koichi Inoue, Atsushi Kobori,
Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro …
PAEDIATRIC CT EXPOSURE PRACTICE IN THE COUNTY OF RIO DE JANEIRO: THE NEED TO ESTABLISH DIAGNOSTIC REFERENCE LEVELS
FM de Jesus, LAG Magalhães, S Kodlulovich – Radiation Protection Dosimetry, 2015
… are essential for the diagnosis and monitoring of patients with complex cardiovascular disease
(2–4) , for the diagnosis of pulmonary embolism (5) and for guiding interventional procedures,
such as radiofrequency ablation, biopsy, abscess drainage and nephrostomy (6) . In …
Substrate Mapping for Unstable Ventricular Tachycardia
P Santangeli, FE Marchlinski – Heart Rhythm, 2015
… Scar dechanneling, linear ablation through sites matching VT with pacing and the core isolation
approach focus on more discrete … and/or inducible arrhythmias by means of physiological
maneuvers, although this does not necessarily translate in less radiofrequency lesions to …
[HTML] Evaluation and management of chronic coccygodynia: Fluoroscopic guided injection, local injection, conservative therapy and surgery in non-oncological pain
A Galhom, M al-Shatouri, SA El-Fadl – The Egyptian Journal of Radiology and …, 2015
… 23). The beneficial effect was retained with repeated injections (21). Radiofrequency
ablation using two needles achieved a pain reduction of >50% for an average duration
of 2.2 months, in a series of 13 patients (24). Another …
[HTML] Assessment of prognosis of patients with stage II colon cancer
S Martins, P Martins – Journal of Coloproctology, 2015
… Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined
resection/ablation for colorectal liver metastases. Ann. Surg., 239 (2004), pp. 818–825 discussion
825–27. 9; K. Lang, JR Korn, DW Lee, LM Lines, CC Earle, J. Menzin; …
Energy delivery systems and uses thereof
DW van der Weide, PF Laeseke, FT Lee, CL Brace – US Patent 9,119,649, 2015
… tissue for a wide variety of applications, including medical procedures (eg, tissue ablation,
resection, cautery … the device is configured to deliver a sufficient amount of energy to ablate the
tissue … In some embodiments, the energy is microwave energy and/or radiofrequency energy …
Chronic Regional Pain Syndrome (CRPS/RSD)
Side-Channel Assisted Modeling Attacks on Feed-Forward Arbiter PUFs Using Silicon Data
R Kumar, W Burleson – … : 11th International Workshop, RFIDsec 2015, New …, 2015
… However, the performance of modeling attacks is impacted by the presence of
error-prone CRPs in the training set. To that extent … error-prone CRPs. The terms
“error-prone” and “error- inflicted” refer to the same set of CRPs. …
Making Invisible Intersectionality Visible Through Theater of the Oppressed in Teacher Education
B Powers, PB Duffy – Journal of Teacher Education, 2015
… Thank you! We ended there on the first day. Day 2. After initial warm-ups, the students broke up
into four groups. Each group, of about five to six students, was asked to create two to three
tableaux that explored their positions within schools as it relates to the course of CRPs. …
Energy geographies: thinking critically about energy issues in the classroom
E Delgado – Journal of Geography in Higher Education, 2015
Analysis of suicide attempts and completions at the South Texas Veterans Health Care System: a retrospective review
R Oliveira, TA Moore, CA Gutierrez – Mental Health Clinician, 2015
… Additional information collected included psychiatric medications used during the review period,
including psychiatric MPRs for 6 months before the suicide attempt. The MPRs were calculated
manually using the prescription refill history available in CRPS. …
[PDF] Cadmium toxicity in diazotrophic Anabaena spp. adjudged by hasty up-accumulation of transporter and signaling and severe down-accumulation of nitrogen …
S Rai, S Singh, LC Rai – 2015
… Percentage of total protein variability explained in PC1 and PC2 is given in parenthesis.
Protein spots in red color represent variables whereas text in blue color indicates time points.
Fig. 5. Cluster analysis of Cd responsive (CRPs) in Anabaena spp. …
[PDF] The migraine brain in transition: girls vs boys
V Fariaa, N Erpeldinga, A Lebela, A Johnsona… – 2015
Page 1. NUMBER 1 OF 1 AUTHOR QUERIES DATE 7/25/2015 JOB NAME PAIN ARTICLE
PAIN-D-14-13318 QUERIES FOR AUTHORS V. Faria et al. THIS QUERY FORM MUST
BE RETURNED WITH ALL PROOFS FOR CORRECTIONS …
Structure-function relationships in mammalian Histidine-Proline-Rich Glycoprotein
F Ronca, A Raggi – Biochimie, 2015
Histidine-proline-rich glycoprotein (HPRG), or histidine-rich glycoprotein (HRG), is a serum
protein that is synthesized in the liver and is actively internalis.
Fibromyalgia
[PDF] Adult attention-deficit and hyperactivity disorder and fibromyalgia: a case-control study
A Golimstok, MC Fernandez, MM Garcia Basalo – Neuro Open J, 2015
ABSTRACT Introduction: Fibromyalgia syndrome (FMS) is a disorder characterized by
widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues.
An association between attention deficit and fibromyalgia was reported. However, to our …
Fasting and rheumatic diseases (ahead of publication)
MH Jokar – Journal of Fasting and Health, 2015
… Predicting chronic symptoms after an acute “stressor”—lessons learned from 3 medical conditions.
Med Hypotheses 2004;63:653-8. 17-Chervin RD, Teodorescu M, Kushwaha R, et al. Objective
measures of disordered sleep in fibromyalgia. J Rheumatol 2009;36:2009-16. …
… —With treatment approaches for fibromyalgia evolving over the course of modern medicine, many clinicians are reviewing the Diagnosing and Treating Fibromyalgia: …
C Palsy, CPCLE Row
The pathophysiology of fibromyalgia includes central sensitization (amplification of pain in
the spinal cord via spontaneous nerve activity, expanded receptive fields, and augmented
stimulus responses), abnormalities of descending inhibitory pain pathways (dysfunction in …
[HTML] Select a Site
V Promise, VO Heritage, B Areas, L Diabetes…
Neuroscience covers both mental disorder and pain manifestations. Mental disorder covers Bipolar
Disorder, Schizophrenia,Depression and General Anxiety Disorder while pain includes Diabetic
neuropathy, Fibromyalgia and chronic pain. … 54th ed. Lange; 2015. Fibromyalgia. …
The measurement of bridging social capital in population health research
E Villalonga-Olives, I Kawachi – Health & Place, 2015
… capital (a combination of social resources that can be beneficial to a person’s physical health
and well-being), personal coping strategies, and additional personal and disease-related factors,
contribute to the functioning and quality of life (QoL) of fibromyalgia (FM) patients. …
Therapeutic Effects of the Mineral Waters from Copahue Spa
AM Monasterio, F Armijo, F Maraver – Copahue Volcano, 2015
… and chondrolysis, Fioravanti et al. (2011) reported: • A reduction in the levels of
circulating pros- taglandins E2 (PGE-2) and leukotriene B4 (LT-B4) in patients with
osteoarthritis or fibromyalgia. • Reductions in tumour necrosis …
Seven Steps to Choosing Joy!: Discover the Power of Your Inner Wisdom
L Ackles – 2015
DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING
IR Vlahov, CP Leamon – US Patent 20,150,258,203, 2015
… any one of the preceding embodiments wherein the disease is selected from the group consisting
of arthritis, including rheumatoid arthritis and osteoarthritis, glomerulonephritis, proliferative
retinopathy, restenosis, ulcerative colitis, Crohn’s disease, fibromyalgia, psoriasis and ..
by admin | Sep 23, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
[HTML] Upper urinary tract damage caused by ketamine snorting—A report of nine cases
HY Lee, YC Hsu, CY Hsu, ECL Chou, CC Li, YS Juan… – Urological Science, 2015
Objective The toxicity of ketamine to genitourinary system not only involved in lower urinary
tract, which include urinary frequency, urgency, suprapubic pain, dysuria and hematuria, but
also upper urinary tracts. However, the reports of ketmaine-induced upper urinary tract …
Inconsistency of allometric scaling for dissociative anesthesia of wild felids
AB Carregaro, GC Freitas, SP Bisetto, NV Xavier… – Veterinary anaesthesia and …, 2015
… Keywords: allometric scaling; dissociative anesthesia; ketamine; metabolic rate; xylazine.
Abstract. … Objective. To evaluate allometric scaling for ketamine–xylazine (KX) anesthesia
in wild felids using domestic cats for reference. Study design. …
[PDF] The ERα-PI3K Cascade in Pro-opiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice
L Zhu, P Xu, X Cao, Y Yang, AO Hinton Jr, Y Xia… – Endocrinology, 2015
… Hypothalamic ER -p85 interaction and phosphorylation of AKT in response to icv PPT
Female C57Bl6 mice (12 weeks) were anesthetized with ip injections of
ketamine/xylazine cocktail (100 mg/kg ketamine and 10 mg/kg xylazine). …
[HTML] Effects of leptin on sympathetic nerve activity in conscious mice
DA Morgan, F Despas, K Rahmouni – Physiological Reports, 2015
… Here, we examined the sympathetic responses evoked by leptin in conscious mice. Mice
were instrumented, under ketamine/xylazine anesthesia, with renal or lumbar SNA
recordings using a thin (40 gauge) bipolar platinum–iridium wire. …
[PDF] Treatment of Pain with Antidepressants
B Kerr, C Benson, K Mifflin, SJB Jesudasan, S Dursun… – Klinik Psikofarmakoloji …, 2015
… depression43-45. There has been a great deal of interest in the NMDA receptor antagonist
ketamine and its rapid acting antidepressant action when infused46,47, and it is interesting that
this drug has also been used in treatment of therapy-resistant chronic pain48. …
Use of LigaSure on bile duct in rats. An experimental study.
A Marte, L Pintozzi – Minerva pediatrica, 2015
… in rats. MATERIALS AND METHODS: Thirty Wistar rats weighing 70 to 120gr were
employed for this study. The animals were all anaesthetized with intraperitoneal
Ketamine and then divided into three groups. The first group …
[HTML] Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats
RA Maheshwari, F Dhakwala, R Balaraman, AK Seth… – Indian Journal of …, 2015
… Standard drug Calcium Sandoz (cholecalciferol), ketamine hydrochloride, diazepam, povidone,
and ampicillin were purchased from commercial market. … The rats were anesthetized with injection
of ketamine hydrochloride (40 mg/kg. ip) and diazepam (5 mg/kg, im). …
Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala
K László, A Kovács, O Zagoracz, T Ollmann, L Péczely… – Behavioural Brain Research, 2015
… 00 h. 2.2. Surgery. Rats were anesthetized ip by ketamine supplemented with
diazepam (Calypsol and Seduxen, Richter Gedeon, Hungary, ketamine: 80
mg/kg body weight, diazepam: 20 mg/kg body weight). Animals were …
Minocycline Attenuates Depressive‐like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway
SSS Saravi, SE Mousavi, SSS Saravi, AR Dehpour – Basic & Clinical Pharmacology & …, 2015
… Testicular Torsion/Detorsion Animals were anaesthetized with intraperitoneal injection of ketamine
HCl (50 mg/kg) and chlorpromazine (25 mg/kg). … 30 days. Testosterone assay At day 30, the rats
were anaesthetized with intraperitoneal injection of ketamine HCl (50 mg/kg) …
Spinal Reflexes and Windup In Vitro: Effects of Analgesics and Anesthetics
I Rivera‐Arconada, C Roza, JA Lopez‐Garcia – CNS Neuroscience & Therapeutics, 2015
… Spinal cord mechanisms may contribute toward analgesia and akinesia. Ketamine.
The general anesthetic ketamine is a noncompetitive blocker of NMDA receptors
that also shows activity on several ionic channels. As expected …
Augmentation Therapy With Serial Intravenous Ketamine Over 18 Months in a Patient With Treatment Resistant Depression.
S Hassamal, M Spivey, AK Pandurangi – Clinical Neuropharmacology, 2015
Abstract Major depressive disorder is a severe illness that affects 3% to 7% of adults
annually in the United States. About 30% of these individuals are refractory to multiple
treatment trials. Recent reports have found a significant and almost immediate …
Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells Via a GSK‐3β‐Dependent Mechanism
HY Shyu, CJ Ko, YC Luo, HY Lin, SR Wu, SW Lan… – Journal of Cellular …, 2015
Abstract Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal
recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous
effects, including renal failure; however, the underlying mechanism is poorly understood. …
More effective induction of anesthesia using midazolam-butorphanol-ketamine-sevoflurane compared with ketamine-sevoflurane in the common marmoset monkey ( …
H ISHIBASHI – Journal of Veterinary Medical Science, 2015
The common marmoset has been increasingly used for research in the biomedical field;
however, there is little information available regarding effective methods of anesthesia in this
species. This study retrospectively analyzed 2 regimens of anesthesia induction: …
[HTML] Comparison of Ketamine–Medetomidine-butorphanol and Ketamine–dexmedetomidine-butorphanol Anesthesia in Rats
R Costea, D Lastofka, M Mehedinţu – Agriculture and Agricultural Science Procedia, 2015
Abstract We evaluated the effect of ketamine-dexmedetomidine-butorphanol (K, 80 mg/kg;
D, 0.25 mg/kg, B, 0.5 mg/kg) and ketamine-medetomidine-butorphanol (K, 80 mg/kg; M, 0.25
mg/kg, B, 0.5 mg/kg) administered intraperitoneally, during anesthesia and immediate …
Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increased survival after pneumococcal superinfection
K Reppe, P Radünzel, K Dietert, T Tschernig, T Wolff… – Infection and Immunity, 2015
… Five days after IAV infection, 114 the mice were anesthetized intraperitoneally
(ip) with ketamine (80 mg/kg, Ketavet®, Pfizer, 115 … re-suspended in sterile PBS.
Mice were anesthetized ip with ketamine and xylazine and 123 …
Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load
S Choudhury, K Kannan, BS Maruti, MP Addison… – European Journal of …, 2015
… ad libitum. The animals were anesthetized by injection of xylazine (10 µg/g body
weight, intraperitoneally) and ketamine (80 µg/g body weight, intraperitoneally) and
a 2-cm ventral midline incision was performed. The cecum …
[HTML] Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase
YJ Lai, GJ Chang, YH Yeh, JHS Pang, CC Huang… – PLOS ONE, 2015
… All the surgery was performed under ketamine and xylazine ip anesthesia, and all efforts were
made to minimize suffering. Housing and maintenance was provided by Chang Gung University,
All animals were fed a standard chow diet with free access to water. …
[HTML] Serotonin 5-HT 7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg 2+-ATPase imbalances in spinal cord-injured male rats
A Norouzi-Javidan, J Javanbakht, F Barati, N Fakhraei… – Diagnostic Pathology, 2015
… Animals were anesthetized by intraperitoneal injection of a mixture of ketamine hydrochloride
(75 mg/kg) and xylazine hydrochloride (5 mg/kg). … All animals were anesthetized (ketamine
hydrochloride 10 % + xylazine 2 %, in 80 and 5 mg/kg doses, respectively). …
[HTML] Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis
M Ishizuka, Y Miyazaki, M Masuo, K Suhara, T Tateishi… – PLOS ONE, 2015
… They were then placed under light anesthesia with 100 mg/kg ketamine and 10 mg/kg xylazine,
and 5 μg of PDE in 25 μl of 0.9% saline was sprayed into each mouse’s trachea using an
intratracheal MycroSprayer® aerosolizer (Penn-century, Wyndmoor, PA, USA). …
Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model
Z Tang, S Li, P Han, J Yin, Y Gan, Q Liu, J Wang… – Journal of Neurochemistry, 2015
… blinded to the randomization. Permanent Middle Cerebral Artery Occlusion (pMCAO) Mice were
under Ketamine/Xylazine anesthesia (80 mg/kg Ketamine and 10mg/kg Xylazine, injected ip).
Standard aseptic surgical procedures were used throughout the procedure. The …
Radiofrequency Ablation (RFA)
Effectiveness and safety of computed tomography-guided radiofrequency ablation of renal cancer: a 14-year single institution experience in 203 patients
JD Iannuccilli, DE Dupuy, MD Beland, JT Machan… – European Radiology, 2015
Objectives To define effectiveness and safety of CT-guided radiofrequency ablation (RFA) of
renal tumours and prognostic indicators for treatment success. Methods Patients with a
single treatment of a solitary, biopsy-proven renal tumour with intent to cure over a 14-year …
Outcomes associated with ablation compared to combined ablation and transilluminated powered phlebectomy in the treatment of venous varicosities.
AT Obi, BN Reames, TJ Rook, SO Mouch, A Zarinsefat… – Phlebology/Venous Forum …, 2015
… RESULT: Venous clinical severity scores improved more with radiofrequency ablation +
transilluminated powered phlebectomy as compared to radiofrequency ablation alone
(3.8 ± 3.4 vs. 3.2 ± 3.1, p = 0.018). … radiofrequency ablation alone. …
Minimally invasive procedures for the management of vertebral bone pain due to cancer: The EAPC recommendations
S Mercadante, P Klepstad, G Paula Kurita, P Sjøgren… – Acta Oncologica, 2015
… Radiofrequency ablation (RFA). … RFA resulted more effective than radiotherapy and surgical
stabilization [99. Di Francesco A, Flamini S, Zugaro L, Zoccali C. Preoperative
radiofrequency ablation in painful osteolytic long bone metastases. …
[HTML] Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis: A single-center retrospective cohort study
F Zhang, J Yan, XB Feng, F Xia, XW Li, KS Ma, P Bie – World J Gastroenterol, 2015
… These procedures include liver transplantation, resection, and radiofrequency ablation[ 5 ]. Liver
transplantation may be the best treatment option for cirrhotic patients with HCC because it involves
the simultaneous removal of both the cirrhotic liver and HCC[ 6 ]. However, the …
Ethanol ablation in post-biopsy liver hemorrhage following two failed Embolizations
MC Pope, DH Ballard, AL Sticker, C Ahuja… – Clinical Imaging, 2015
… C. The feeding vessels were identified and ablated with an additional 10 mL ethanol injection. …
to ultrasound-guided percutaneous ethanol injection for achieving hemostasis include techniques
such as cryoablation, radiofrequency (RF)-ablation, and cyanoacrylate glue …
[PDF] Catheter Ablation of Fascicular Ventricular Tachycardia: Long Term Clinical Outcomes and Mechanisms of Recurrence
Y Liu, Z Fang, B Yang, P Kojodjojo, H Chen, W Ju… – Circulation: Arrhythmia and …, 2015
… ablated. … Arrhythmia recurrences after an initially successful ablation were caused by recurrent
FVT involving the … Key words: ventricular tachycardia, radiofrequency, idiopathic left ventricular
tachycardia, fascicular ventricular tachycardia, outcomes, radiofrequency ablation …
Liver metastases from adenocarcinomas of unknown primary site: management and prognosis in 68 consecutive patients
E Algin, A Ozet, O Gumusay, G Yilmaz, S Buyukberber… – Wiener klinische …, 2015
… shown in Fig. 1. Among 39 patients who were managed with chemo- therapy, 12
patients received additional locoregional therapies including radiofrequency ablation
or transar- terial chemoembolization. Median OS was 9.4 …
[HTML] The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Q Pang, K Qu, JY Zhang, SD Song, SS Liu, MH Tai… – Medicine, 2015
… Abbreviations: HBV = hepatitis B virus, HCC = hepatocellular carcinoma, HCV = hepatitis C virus,
HR = hazard ratio, MPV = mean platelet volume, OS = overall survival, PLT = platelet count, RFA =
radiofrequency ablation, RFS = recurrence-free survival, TACE = transcatheter …
Safety and Feasibility of Open Chest Epicardial Mapping and Ablation of Ventricular Tachycardia During the Period of Left Ventricular Assist Device Implantation
M Patel, F Rojas, FR Shabari, L Simpson, W Cohn… – Journal of Cardiovascular …, 2015
… Endocardial and epicardial radiofrequency ablation of ventricular tachycardia associated with
dilated cardiomyopathy: The importance of low-voltage scars. … Comparison of epicardial
cryoablation and irrigated radiofrequency ablation in a swine infarct model. …
Contact Force Variability during Catheter Ablation of Atrial Fibrillation: The Role of Atrial Rhythm and Ventricular Contractions: Co-Force AF Study
A Sarkozy, D Shah, J Saenen, J Sieira, T Phlips… – Circulation: Arrhythmia and …, 2015
… 3 Background Lesion formation by using radiofrequency (RF) current depends on the power
delivered, duration of energy application, temperature, tip size, and tip orientation. … given RF power1.
Irrigated tip ablation catheters capable of real-time CF measurement have …
[HTML] Pulmonary vein isolation using the visually guided laser balloon: a prospective, multicenter, and randomized comparison to standard radiofrequency ablation
SR Dukkipati, F Cuoco, I Kutinsky, A Aryana… – Journal of the American …, 2015
Background Balloon catheters have been designed to facilitate pulmonary vein (PV)
isolation in patients with paroxysmal atrial fibrillation (AF). The visually guided laser balloon
(VGLB) employs laser energy to ablate tissue under direct visual guidance. Objectives …
Optimal Temperature for Radiofrequency Ablation of Lumbar Medial Branches for Treatment of Facet‐Mediated Back Pain
S Costandi, M Garcia‐Jacques, T Dews, M Kot, K Wong… – Pain Practice, 2015
Background Radiofrequency ablation (RFA) of the medial branch nerves that innervate the
facet joints is a well-established treatment modality; however, studies to determine the
optimal radiofrequency ablation temperature are lacking. A wide range (70 to 90 C) has …
[HTML] Catheter Ablation of Atrial Fibrillation: Advent of Second-Generation Technologies
E Buch, K Shivkumar – Journal of the American College of Cardiology, 2015
… and wide-area isolation (5), with or without additional lesion sets targeting non-PV
foci (6) or modifying atrial substrate. All of these techniques initially used
point-by-point ablation with radiofrequency (RF) ablation catheters. …
[HTML] Computed tomography-guided percutaneous trephine removal of the nidus in osteoid osteoma patients: experience of a single center in Brazil
M Petrilli, AA Senerchia, AS Petrilli, HM Lederman… – Radiologia Brasileira, 2015
… Osteoid osteoma: CTguided percutaneous radiofrequency ablation and follow-up in 47 patients.
J Vasc Interv Radiol. 2001;12:717–722. … Peyser A, Applbaum Y, Khoury A, et al. Osteoid osteoma:
CT-guided radiofrequency ablation using a water-cooled probe. Ann Surg Oncol. …
Proton beam therapy for metastatic liver tumors
N Fukumitsu, T Okumura, D Takizawa, H Makishima… – Radiotherapy and Oncology, 2015
… The maximal diameter of the lesions was 1–18 cm (median, 4 cm). Of the 140 patients, 87
had received another form of treatment before PBT, such as chemotherapy, radiofrequency
ablation, transcatheter arterial chemoembolization, and surgery. …
Accuracy of Late Gadolinium Enhancement-Magnetic Resonance Imaging in the Measurement of Left Atrial Substrate Remodeling in Patients With Rheumatic Mitral …
D Zhu, Z Wu, RJ van der Geest, Y Luo, J Sun, J Jiang… – International Heart Journal, 2015
… We enrolled adult patients with rheumatic mitral valve disease and persistent AF who un-
derwent open-heart surgery for mitral valve replacement with concurrent radiofrequency
ablation for AF at our institution between February 2013 and March 2014. …
Predictive value of nodule size and differentiation in HCC recurrence after liver transplantation
GG Piero, P Domenico, F Di Benedetto, M Elena… – Surgical Oncology, 2015
… Generally, radiofrequency ablation (RFA) was proposed in cases of a single tumor less than 3
cm, whereas a single tumor > 3 cm or multifocal lesions in patients with impaired liver function
were directed instead to treatment with trans-arterial chemoembolization (TACE). …
Radiofrequency ablation or stripping of large-diameter incompetent great saphenous varicose veins with C2 or C3 disease
EV Shaidakov, AG Grigoryan, EA Ilyukhin, VL Bulatov… – Journal of Vascular Surgery: …, 2015
Objective The objectives of this study were to compare the results of radiofrequency ablation
(RFA) and stripping for large-diameter varicose target veins for the period of 1 year, based
on a composite end point; to analyze the pain severity on a digital rating scale for 7 days …
Clinical outcomes and risk factors of hepatocellular carcinoma treated by liver transplantation: A multi-centre comparison of living donor and deceased donor …
Z Hu, Z Qian, J Wu, J Zhou, M Zhang, L Zhou, S Zheng – Clinics and Research in …, 2015
… HCC: hepatocellular carcinoma; LDLT: living donor liver transplantation; DDLT: deceased donor
liver transplantation; GWRW: graft weight/recipient weight; TACE: transcatheter arterial
chemoembolisation; RFA: radiofrequency ablation; PEI: percutaneous ethanol injection; ICU …
[PDF] Hepatocellular carcinoma treatment strategies–a case-based review
R Alves, MT Gomes, CS Macedo, HP Miranda, F Nery – Journal of Solid Tumors, 2015
… Resection techniques have been refined, from the use of new radiofrequency ablation resection
devices to laparoscopic approaches, both showing to diminished blood loss [1, 2]. A recent
meta-analysis showed that laparoscopic approach decreases blood loss, transfusion …
Complex Regional Pain Syndrome (CRPS/RSD)
Skin sympathetic function in complex regional pain syndrome type 1
A Poudel, M Asahina, Y Fujinuma, Y Yamanaka… – Clinical Autonomic …, 2015
… 10.1007/s10286-015-0314-x. Copyright information. Abstract. Purpose. Cutaneous
sympathetic pathophysiology in complex regional pain syndrome type 1 (CRPS-1) is
not yet completely understood. To evaluate cutaneous sympathetic …
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture
WW Li, TZ Guo, X Shi, Y Sun, T Wei, DJ Clark… – Neuroscience, 2015
… hypersensitivity. Abstract. Tibia fracture in rodents induces substance P
(SP)-dependent keratinocyte activation and inflammatory changes in the hindlimb,
similar to those seen in complex regional pain syndrome (CRPS). In …
Economic impact of mgnregp on rural livelihood security in tumkur district, karnataka–a sam analysis
CHR Gowda – 2015
… Item Type: Thesis (Masters). Divisions: RP-Market Institutions and Policies. CRPS: CGIAR
Research Program on Policies, Institutions, and Markets. Uncontrolled Keywords: Economic
Impact, MGNREGP, Rural Livelihood Security, Karnataka, SAM analysis. …
[PDF] DMSA-coated Iron Oxide Nanoparticle Greatly Affect the Expression of Genes Coding Cysteine-rich Proteins by its DMSA Coating
L Zhang, X Wang, J Zou, Y Liu, J Wang – Chemical Research in Toxicology, 2015
… times. The results revealed that about one fourth of DEGs coded cysteine-rich proteins
(CRPs) in all cells under each treatment, indicating that the nanoparticles greatly
affected the expressions of CRP-coding genes. Additionally …
Changing appearance using visual illusions improves ownership of the painful hand in complex regional pain syndrome
J Lewis, C McCabe, R Newport – 2015
… Abstract. Background and aims People with Complex Regional Pain Syndrome (CRPS)
experience a diminished sense of ownership of their painful limb. … Thirty nine patients with CRPS
of one arm were randomly allocated to either a control or experimental group. …
The role of genetically‐engineered pigs in xenotransplantation research
DKC Cooper, B Ekser, J Ramsoondar, C Phelps… – The Journal of Pathology, 2015
… This is because of the expression of human complement-regulatory proteins (CRPs) on the
surface of vascular endothelial cells. Pigs have similar CRPs, but these are relatively inefficient
at protecting the pig cells from human complement-mediated injury [13]. …
Individuality: How knowledge of body perception disturbance can inform treatment
J Lewis – 2015
… Lewis, J. (2015) Individuality: How knowledge of body perception disturbance can inform
treatment. In: International Association of the Study of Pain (IASP) CRPS SIG, Zurich, Switzerland,
31 August – 1 September 2015. [img] Preview. PDF 1MB. Abstract. …
Spinal Cord Stimulation (SCS) and Functional Magnetic Resonance Imaging (fMRI): Modulation of Cortical Connectivity With Therapeutic SCS
M Deogaonkar, M Sharma, C Oluigbo, DM Nielson… – … : Technology at the Neural …, 2015
… Methods. Ten patients with complex regional pain syndrome (CRPS) or neuropathic leg pain
underwent thoracic epidural spinal cord stimulator implantation. Stimulation parameters associated
with “optimal” pain reduction were evaluated prior to imaging studies. …
[PDF] Similarity-based semi-local estimation of EMOS models
S Lerch, S Baran – arXiv preprint arXiv:1509.03521, 2015
… The most popular scoring rules providing summary measures of predictive performance are the
logarithmic score, ie, the negative logarithm of the predictive PDF evaluated at the verifying
observation, and the continuous ranked probability score (CRPS; Gneiting and Raftery …
Review of Plastic Surgery
DW Buck II – 2015
[PDF] Independent CRP-Commissioned External Evaluation of the CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
J Compton, D McLean, B Emmens, M Balagamwala – 2015
… development partners (IFPRI, 2011). CRPs are not legal entities and therefore legal
and financial responsibility for A4NH ultimately rests with the lead CGIAR Center
and its Board of Trustees (IFPRI- BOT). 2. IFPRI is legally …
[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis
C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015
… Different diseases could lead to neuro- pathic pain including postsurgical pain, post-herpetic
neuralgia (PHN), spinal cord stenosis (SCS), Complex Regional Pain Syndrome (CRPS), Diabetic
peripheral neuropathy (DPN), and chemotherapy induced pe- ripheral neuropathy. …
Traumatic Life Events and Psychopathology in a High Risk, Ethnically Diverse Sample of Young Children: A Person-Centered Approach
MJ Hagan, MJ Sulik, AF Lieberman – Journal of abnormal child psychology, 2015
… Conditional response probabilities (CRPs) are defined as the probability that an
individual from a specific latent class will endorse an item. CRPs provide … across
classes. CRPs for the exploratory LCA model are shown in Fig. …
Two placebo-controlled, randomized withdrawal studies to evaluate the fentanyl 1-day patch in opioid-naïve patients with chronic pain
T Arai, Y Kashimoto, Y Ukyo, Y Tominaga, K Imanaka – Current Medical Research …, 2015
… study]) and the other study included opioid-naïve subjects with neuropathic pain (post- herpetic
neuralgia, complex regional pain syndrome [CRPS], or chronic postoperative pain; … included: had
osteoarthritis, low back pain, post-herpetic neuralgia, CRPS, or chronic …
[PDF] Challenges of Peripheral Nerve Stimulator Implantation in a Patient with New Onset Thrombocytopenia
S Thompson
… We present a patient with complex regional pain syndrome (CRPS)-like symptoms of the lateral
femoral cutaneous nerve after laparoscopic hysterectomy who underwent successful
ultrasound-guided PNS trial using SCS leads and unfortunate delayed implantation due to …
Improving student learning via mobile phone video content: Evidence from the BridgeIT India project
M Wennersten, ZB Quraishy, M Velamuri – International Review of Education
[PDF] The Association Between Soft Tissue Releases and Bony Resections Performed During Total Knee Arthroplasty and Patients’ Pain and Satisfaction Postoperatively
M Carter – 2015
Page 1. Western University Scholarship@Western Electronic Thesis and Dissertation Repository
September 2015 The Association Between Soft Tissue Releases and Bony Resections Performed
During Total Knee Arthroplasty and Patients’ Pain and Satisfaction …
[PDF] Parthasarathy Rao and Cynthia Bantilan. 2015. Grain Legumes Production, Consumption and Trade Trends in Developing Countries
S Nedumaran, P Abinaya, P Jyosthnaa, B Shraavya
… Markets (PIM). Financial support by CRPs Grain Legumes and Policies, Institutions
and Markets are gratefully acknowledged. This working paper has gone through
the standard peer-review procedure of ICRISAT. The authors …
NEUROMODULATORY DEVICES, SYSTEMS, AND METHODS FOR TREATING FIBROMYALGIA
AR Rezai, M Deogaonkar – US Patent 20,150,251,008, 2015
… In subjects with fibromyalgia as well as other conditions (eg, hot flashes, CRPS, etc.),
clinicians have used pharmacological blockade of the sympathetic nervous system, and
in particular the stellate ganglion, to achieve some clinical benefit. …
Fibromyalgia
Psychiatric Disorders in Young Adults Diagnosed with Juvenile Fibromyalgia in Adolescence.
NR Cunningham, ST Tran, AM Lynch-Jordan, TV Ting… – The Journal of …, 2015
OBJECTIVE: Adolescents with juvenile-onset fibromyalgia (JFM) have increased rates of
psychiatric disorders, but to our knowledge no studies have examined psychiatric disorders
in adolescents with JFM when they enter young adulthood. This study examined the …
Fibromyalgia beyond reductionism. Heart rhythm fractal analysis to assess autonomic nervous system resilience
C Lerma, LA Martinez-Martinez, N Ruiz, A Vargas… – Scandinavian Journal of …, 2015
Objectives: The prevailing linear reductionist medical model seems unable to explain
complex multisymptomatic illnesses such as fibromyalgia (FM) and similar maladies.
Paradigms derived from the complexity theory may provide a coherent framework for …
Exploring the role of peripheral mechanisms: An evaluation of a theory-based approach to reducing symptoms of fibromyalgia
K Mooney – 2015
Abstract: This mixed method study presented an integrative approach for the treatment of
fibromyalgia, the rationale that justifies the approach, and an evaluation of two integrated
components of this protocol designed to mitigate symptoms of fibromyalgia. Considering …
Chronic Widespread Back Pain is Distinct from Chronic Local Back Pain: Evidence from Quantitative Sensory Testing, Pain Drawings, and Psychometrics.
A Gerhardt, W Eich, S Janke, S Leisner, RD Treede… – The Clinical journal of pain, 2015
… Therefore, this study compared quantitative-sensory-testing (QST) profiles of
non-specific chronic back pain patients with CLP (n=48) and CWP (n=29) with
pain-free controls (PCs, n=40) and Fibromyalgia patients (FMS, n=90). …
Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation.
LM Tracy, L Ioannou, KS Baker, SJ Gibson… – PAIN, 2015
… frequency HRV in chronic pain, implicating a decrease in parasympathetic activation.
These effects were heavily influenced by fibromyalgia studies. Future research would
benefit from wider use of standardised definitions of …
[HTML] Analgesic effect of cathodal transcranial current stimulation over right dorsolateral prefrontal cortex in subjects with muscular temporomandibular disorders: study …
RA Brandão Filho, AF Baptista, RAFS Brandão… – Trials, 2015
… In a fibromyalgia study using transcranial magnetic stimulation (TMS), the authors found higher
thresholds in both sides of the resting motor cortex with lower up regulation responses.
Furthermore, they found lower intracortical facilitation and inhibition. …
Clinical Research Methodology 1: Study Designs and Methodologic Sources of Error
DI Sessler, PB Imrey – Anesthesia & Analgesia, 2015
… The distinction can be nonobvious. For example, consider a study in which investigators compared
anesthetic requirement in patients with and without fibromyalgia. … But, in fact, fibromyalgia is the
exposure in this study and anesthetic requirement is the outcome. …
[HTML] Economic evaluation in chronic pain: a systematic review and de novo flexible economic model
W Sullivan, M Hirst, S Beard, D Gladwell, F Fagnani… – The European Journal of …, 2015
… While the attributes and management of specific diseases associated with chronic pain, such
as fibromyalgia and osteoarthritis, and different analgesic requirements for neuropathic versus
other chronic pain may have justifiably led to modelling heterogeneity, clinical …
[PDF] Evaluation of the Immediate Effect of Auricular Acupuncture on Pain and Electromyographic Activity of the Upper Trapezius Muscle in Patients with Nonspecific Neck …
ACO Silva, DA Biasotto-Gonzalez, DM Santos… – … -Based Complementary and …, 2015
… NS-NP could contribute to the following: (i) a standardization of the points to be used as stimuli
for the treatment of abnormalities caused in this muscle by mechanical injuries, myofacial tension
(with or without trigger-points), and systemic diseases such as fibromyalgia; (ii) an …
Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic
AD Nelson, MA Mouchli, N Valentin, D Deyle… – Neurogastroenterology & …, 2015
… hernia,[7] rectal evacuation disorder,[8] diverticulosis, gastritis,[9] constipation, diarrhea, nausea,
vomiting, abdominal pain, and reflux disease.[10] Several non-musculoskeletal symptoms often
found in patients with functional GI disorders such as fibromyalgia, fatigue, cognitive …
[HTML] Real-life assessment of the validity of patient global impression of change in fibromyalgia
E Rampakakis, PA Ste-Marie, JS Sampalis, A Karellis… – RMD Open, 2015
Objectives Patient Global Rating of Change (GRC) scales are commonly used in routine
clinical care given their ease of use, availability and short completion time. This analysis
aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC …
[HTML] Increased Risk of Coronary Heart Disease in Patients with Primary Fibromyalgia and Those with Concomitant Comorbidity—A Taiwanese Population-Based Cohort …
CH Su, JH Chen, JL Lan, YC Wang, CH Tseng, CY Hsu… – PLOS ONE, 2015
Objectives Fibromyalgia has seldom been associated with coronary heart disease (CHD).
The aim of this study was to evaluate the risk of CHD in patients with fibromyalgia. Methods
We used a dataset of one million participants, systemically scrambled from the Taiwanese …
[HTML] Group cognitive-behavioral therapy for chronic pain adults: review of Brazilian trials
LF Kirchner, CC Jorge, MJD Reis – Revista Dor, 2015
… 26 . With regard to studied population, table 1 shows predominance of females in all studies,
being fibromyalgia (FM) the most frequent diagnosis. Nevertheless, literature … assertiveness,
3. (6 to 8), Fibromyalgia (100%), VAS. LSSI. RAS. Lorençatto …
[HTML] Chronic Pain Pharmacological Treatment in Patients with Depressive Disorders
C Aurilio, MC Pace, MB Passavanti, V Pota, P Sansone… – Journal of Psychiatry, 2015
… Patients with fibromyalgia present a reduced dopamine presynaptic activity in great many
brain regions, included hippocampus. Neurocircuits and neurochemistry. … [50] published
a review on amitriptyline for neuropathic pain and fibromyalgia. …
Medical Marijuana Patient Counseling Points for Healthcare Professionals Based on Trends in the Medical Uses, Efficacy, and Adverse Effects of Cannabis-Based …
JR Parmar, BD Forrest, RA Freeman – Research in Social and Administrative …, 2015
… All three medications have similarly been used in improving sleep, fibromyalgia, rheumatoid
arthritis associated pain, and spasticity in MS. A complete list of medical uses and included
publications can be reviewed in Table 5. Table 5. … Fibromyalgia, 1 16, 16, …
Identification and description of controlled clinical trials published in Physiotherapy journals in Spain
M Turrillas, M Sitjà‐Rabert, H Pardo… – Journal of Evaluation in …, 2015
… 16.7% of the identified studies were multicentric. Traumatology and orthopaedics was the most
studied field (33.3%) followed by neurology (15.4%). The most researched health problems were
back pain (17.24%) fibromyalgia, arthrosis and stroke (6.8% each). …
[HTML] Serum calprotectin (S100A8/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis
J Hurnakova, J Zavada, P Hanova, H Hulejova, M Klein… – Arthritis Research & …, 2015
… which is obtained by using several composite indexes [4–7]. Nevertheless, a clinical examination
might lack sensitivity in patients with mild synovitis, be limited in patients with established
deformities, and be overestimated in patients with concomitant fibromyalgia or other …
[HTML] Systematic review of the measurement properties of self-report physical activity questionnaires in healthy adult populations
Z Silsbury, R Goldsmith, A Rushton – BMJ Open, 2015
… 6 The review found strong evidence for effectiveness within cardiovascular disease, type 2
diabetes and obesity; and strong evidence for improved symptom management and quality of
life for patients with cancer, osteoarthritis, osteoporosis, fibromyalgia and depression. …
[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis
C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015
… JOP 2003; 4 (1): 1-10. 4. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Ami- triptyline for
neuropathic pain and fibromyalgia in adults. … Review. 5. Moore RA, Wiffen PJ, Derry S, Toelle
T, Rice AS. Gabapen- tin for chronic neuropathic pain and fibromyalgia in adults. …
Illness deception
SB Nimmo – Occupational Medicine, 2015
… In a survey of US neuropsychologists, prevalence of malingering and symptom exaggeration
was found to be minor head injury 39%, fibromyalgia/chronic fatigue syndrome 35%, chronic
pain 31%, personal injury cases 29%, disability or workers compensation 30% and …
