Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

Ketamine

Ketamine Derivatives

JW Sleigh, WA Denny, J Jose, SA Gamage, MG Harvey… – US Patent 20,150,259,277, 2015

Abstract: The present invention relates to ketamine derivatives of the formula (I),

pharmaceutical compositions comprising them, and methods for treating pain comprising

administering them, and their use in the manufacture of medicaments for treating pain.

Comparing the hemodynamic parameters and seizure duration between ketamine and thiopental during Electroconvulsive therapy in patients with Major depressive …

M Mohseni, A Ghanbari, MA Motazedi Ghajar… – Anesthesiology and Pain, 2015

Aim and Background: Today the effect of Electroconvulsive therapy (ECT) in cure of Major

depressive disease (MDD), and psychiatric patients is well accepted and usage of this

method is developed every day. In this regard, selecting the most effective hypnotic drugs

The antinociceptive efficacy of morphine-ketamine-magnesium combination is influenced by the order of medication administration.

SM Vučkovič, VKR Savič, DP Srebro, BM Medič… – European review for …, 2015

OBJECTIVE: Ketamine and magnesium, both N-methyl-D-aspartate (NMDA) receptor

antagonists, enhance the antinociceptive effects of opioid analgesics in different animal

models of pain, as well as in humans. This study aimed at evaluating whether magnesium

[HTML] Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

S Klein, CB Herath, R Schierwagen, J Grace… – PLOS ONE, 2015

Cholestatic model. BDL was performed in 40 rats (180g) after anesthesia with ketamine/xylazine

(78mg/kg and 10mg/kg body weight) as previously described [12]. Briefly rats were anesthetized

with ketamine/xylazine (78mg/kg and 10mg/kg body weight), respectively.

[HTML] Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction

AL Leblond, K Klinkert, K Martin, EC Turner, AH Kumar… – PLOS ONE, 2015

Procedures were performed under anesthesia induced by ketamine (90mg/kg), xylazine

(10mg/kg) and urethane (1.25mg/kg) and analgesia by ip delivery of carprofen (5 mg/Kg). Mice

were anesthetized with ketamine (90mg/kg), xylazine (10mg/kg) and urethane (1.25mg/kg).

Morphological Pulmonary Diffusion Capacity for Oxygen of Burmese Pythons (Python molurus): a Comparison of Animals in Healthy Condition and with Different …

JM Starck, I Weimer, H Aupperle, K Müller… – Journal of Comparative …, 2015

Snakes were anaesthetized (1 mg/kg diazepam intramuscularly [i/m]; Faustan; Temmler Pharma,

Marburg, Germany, followed by 40 mg/kg ketamine hydrochloride i/m; Ketavet; Pfizer Pharma,

Berlin, Germany) and placed in the CT scanner (Brilliance CT 6; Philips, Hamburg

[PDF] Articles in PresS. Am J Physiol Lung Cell Mol Physiol (March 27, 2015). doi: 10.1152/ajplung. 00291.2014

BA MacKenzie, I Henneke, S Hezel, D Al Alam… – 2015

Mice were genotyped as described previously (3, 12, 34). 148 149 Bleomycin administration

150 10–14 week-old female mice were anaesthetized with a mixture of 0.6 µl/g Ketamine 10%

151 (100 mg/ml) and 0.3 µl/g Dormitor 10% (0.5 mg/ml) dissolved in 0.7% saline.

Anesthesia for Endoscopy

M Asakawa – Veterinary Clinics of North America: Small Animal …, 2015

26 Another study found that a combination of acepromazine and butorphanol followed by induction

with propofol had minimal effect on splenic volume, whereas medetomidine and butorphanol

as premedicants followed by ketamine and diazepam for induction were associated

[HTML] Generation and Characterization of Live Attenuated Influenza A (H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation

S Shcherbik, N Pearce, A Balish, J Jones, S Thor… – PLOS ONE, 2015

replication in multiple organs. Anesthesia occurred through an intramuscular injection

of a ketamine-xylazine-atropine cocktail (25 mg/kg ketamine, 2 mg/kg xylazine,

and 0.05 mg/kg of atropine). For euthanasia, ferrets were

[HTML] Standardized surgical approaches to ear surgery in rats

P Li, D Ding, K Gao, R Salvi – Journal of Otology, 2015

studies using rats. 2. Anesthesia and pre-operative preparation. Health SD rats

weighing about 250 g were selected and anesthetized with intraperitoneal ketamine

(100 mg/kg) and chlorpromazine (5 mg/kg). The skin around

Radiofrequency Ablation (RFA)

Is radiofrequency ablation of lung metastases the most radical treatment?

M Zielinski, R Zaimi, P Sabatier, P Bagan – European Journal of Surgical Oncology, 2015

We read with interest the article on long term results of radiofrequency ablation (RFA) to lung

metastases from colorectal cancer 1. This article is an interesting retrospective analysis on

long term survival in patients with lung metastases from colorectal cancer treated with this

Uninterrupted new oral anticoagulants compared to uninterrupted Vitamin K antagonists in ablation of atrial fibrillation. A Meta-analysis

R Nairooz, K Ayoub, P Sardar, J Payne, A Almomani… – Canadian Journal of …, 2015

NOAC= new oral anticoagulant, VKA=vitamin K antagonist, N/A=not available, TEE=

trans-esophageal echocardiogram, ICE= intra-cardiac echocardiogram, UFH=

unfractionated heparin, s= seconds, RFA= radiofrequency ablation.

Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome

P Gal, NF Marrouche – European Heart Journal, 2015

Post-ablation DE-MRI allows for assessment of the total scar burden, complete encirclement

of pulmonary veins, and the assessment of residual fibrosis, which were all reported to

be strong predictors of arrhythmia recurrences post-ablation.

Imaging Hepatocellular Carcinoma with Dynamic CT Before and After Transarterial Chemoembolization: Optimal Scan Timing of Arterial Phase

M Saake, MM Lell, A Eller, W Wuest, M Heinz, M Uder… – Academic Radiology, 2015

In eight patients previous TACE and in five patients previous radiofrequency ablation had been

performed and follow-up imaging had demonstrated HCC recurrence. First, in a part of our cohort

the HCCs had been treated previously by TACE or radiofrequency ablation.

Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial

K Kaitani, K Inoue, A Kobori, Y Nakazawa, T Ozawa… – European Heart Journal, 2015

fasttrack ★ Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation

for Atrial Fibrillation (EAST-AF) trial. Kazuaki Kaitani, Koichi Inoue, Atsushi Kobori,

Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro

PAEDIATRIC CT EXPOSURE PRACTICE IN THE COUNTY OF RIO DE JANEIRO: THE NEED TO ESTABLISH DIAGNOSTIC REFERENCE LEVELS

FM de Jesus, LAG Magalhães, S Kodlulovich – Radiation Protection Dosimetry, 2015

are essential for the diagnosis and monitoring of patients with complex cardiovascular disease

(2–4) , for the diagnosis of pulmonary embolism (5) and for guiding interventional procedures,

such as radiofrequency ablation, biopsy, abscess drainage and nephrostomy (6) . In

Substrate Mapping for Unstable Ventricular Tachycardia

P Santangeli, FE Marchlinski – Heart Rhythm, 2015

Scar dechanneling, linear ablation through sites matching VT with pacing and the core isolation

approach focus on more discrete and/or inducible arrhythmias by means of physiological

maneuvers, although this does not necessarily translate in less radiofrequency lesions to

[HTML] Evaluation and management of chronic coccygodynia: Fluoroscopic guided injection, local injection, conservative therapy and surgery in non-oncological pain

A Galhom, M al-Shatouri, SA El-Fadl – The Egyptian Journal of Radiology and …, 2015

23). The beneficial effect was retained with repeated injections (21). Radiofrequency

ablation using two needles achieved a pain reduction of >50% for an average duration

of 2.2 months, in a series of 13 patients (24). Another

[HTML] Assessment of prognosis of patients with stage II colon cancer

S Martins, P Martins – Journal of Coloproctology, 2015

Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined

resection/ablation for colorectal liver metastases. Ann. Surg., 239 (2004), pp. 818–825 discussion

825–27. 9; K. Lang, JR Korn, DW Lee, LM Lines, CC Earle, J. Menzin;

Energy delivery systems and uses thereof

DW van der Weide, PF Laeseke, FT Lee, CL Brace – US Patent 9,119,649, 2015

tissue for a wide variety of applications, including medical procedures (eg, tissue ablation,

resection, cautery the device is configured to deliver a sufficient amount of energy to ablate the

tissue In some embodiments, the energy is microwave energy and/or radiofrequency energy  

Chronic Regional Pain Syndrome (CRPS/RSD)

Side-Channel Assisted Modeling Attacks on Feed-Forward Arbiter PUFs Using Silicon Data

R Kumar, W Burleson – … : 11th International Workshop, RFIDsec 2015, New …, 2015

However, the performance of modeling attacks is impacted by the presence of

error-prone CRPs in the training set. To that extent error-prone CRPs. The terms

“error-prone” and “error- inflicted” refer to the same set of CRPs.

Making Invisible Intersectionality Visible Through Theater of the Oppressed in Teacher Education

B Powers, PB Duffy – Journal of Teacher Education, 2015

Thank you! We ended there on the first day. Day 2. After initial warm-ups, the students broke up

into four groups. Each group, of about five to six students, was asked to create two to three

tableaux that explored their positions within schools as it relates to the course of CRPs.

Energy geographies: thinking critically about energy issues in the classroom

E Delgado – Journal of Geography in Higher Education, 2015

Analysis of suicide attempts and completions at the South Texas Veterans Health Care System: a retrospective review

R Oliveira, TA Moore, CA Gutierrez – Mental Health Clinician, 2015

Additional information collected included psychiatric medications used during the review period,

including psychiatric MPRs for 6 months before the suicide attempt. The MPRs were calculated

manually using the prescription refill history available in CRPS.

[PDF] Cadmium toxicity in diazotrophic Anabaena spp. adjudged by hasty up-accumulation of transporter and signaling and severe down-accumulation of nitrogen …

S Rai, S Singh, LC Rai – 2015

Percentage of total protein variability explained in PC1 and PC2 is given in parenthesis.

Protein spots in red color represent variables whereas text in blue color indicates time points.

Fig. 5. Cluster analysis of Cd responsive (CRPs) in Anabaena spp.

[PDF] The migraine brain in transition: girls vs boys

V Fariaa, N Erpeldinga, A Lebela, A Johnsona… – 2015

Page 1. NUMBER 1 OF 1 AUTHOR QUERIES DATE 7/25/2015 JOB NAME PAIN ARTICLE

PAIN-D-14-13318 QUERIES FOR AUTHORS V. Faria et al. THIS QUERY FORM MUST

BE RETURNED WITH ALL PROOFS FOR CORRECTIONS

Structure-function relationships in mammalian Histidine-Proline-Rich Glycoprotein

F Ronca, A Raggi – Biochimie, 2015

Histidine-proline-rich glycoprotein (HPRG), or histidine-rich glycoprotein (HRG), is a serum

protein that is synthesized in the liver and is actively internalis.

Fibromyalgia

[PDF] Adult attention-deficit and hyperactivity disorder and fibromyalgia: a case-control study

A Golimstok, MC Fernandez, MM Garcia Basalo – Neuro Open J, 2015

ABSTRACT Introduction: Fibromyalgia syndrome (FMS) is a disorder characterized by

widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues.

An association between attention deficit and fibromyalgia was reported. However, to our

Fasting and rheumatic diseases (ahead of publication)

MH Jokar – Journal of Fasting and Health, 2015

Predicting chronic symptoms after an acute “stressor”—lessons learned from 3 medical conditions.

Med Hypotheses 2004;63:653-8. 17-Chervin RD, Teodorescu M, Kushwaha R, et al. Objective

measures of disordered sleep in fibromyalgia. J Rheumatol 2009;36:2009-16.

… —With treatment approaches for fibromyalgia evolving over the course of modern medicine, many clinicians are reviewing the Diagnosing and Treating Fibromyalgia: …

C Palsy, CPCLE Row

The pathophysiology of fibromyalgia includes central sensitization (amplification of pain in

the spinal cord via spontaneous nerve activity, expanded receptive fields, and augmented

stimulus responses), abnormalities of descending inhibitory pain pathways (dysfunction in

[HTML] Select a Site

V Promise, VO Heritage, B Areas, L Diabetes…

Neuroscience covers both mental disorder and pain manifestations. Mental disorder covers Bipolar

Disorder, Schizophrenia,Depression and General Anxiety Disorder while pain includes Diabetic

neuropathy, Fibromyalgia and chronic pain. 54th ed. Lange; 2015. Fibromyalgia.

The measurement of bridging social capital in population health research

E Villalonga-Olives, I Kawachi – Health & Place, 2015

capital (a combination of social resources that can be beneficial to a person’s physical health

and well-being), personal coping strategies, and additional personal and disease-related factors,

contribute to the functioning and quality of life (QoL) of fibromyalgia (FM) patients.

Therapeutic Effects of the Mineral Waters from Copahue Spa

AM Monasterio, F Armijo, F Maraver – Copahue Volcano, 2015

and chondrolysis, Fioravanti et al. (2011) reported: • A reduction in the levels of

circulating pros- taglandins E2 (PGE-2) and leukotriene B4 (LT-B4) in patients with

osteoarthritis or fibromyalgia. • Reductions in tumour necrosis

Seven Steps to Choosing Joy!: Discover the Power of Your Inner Wisdom

L Ackles – 2015

DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING

IR Vlahov, CP Leamon – US Patent 20,150,258,203, 2015

any one of the preceding embodiments wherein the disease is selected from the group consisting

of arthritis, including rheumatoid arthritis and osteoarthritis, glomerulonephritis, proliferative

retinopathy, restenosis, ulcerative colitis, Crohn’s disease, fibromyalgia, psoriasis and ..

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