Signal Activity Data May Unlock Some Answers Behind Causes of Neuropathic Pain

Signal Activity Data May Unlock Some Answers Behind Causes of Neuropathic Pain

Clinicians seeking greater understanding of the neural activity behind pain can turn to the results of a University of Western Ontario study, which identified variations in neural activity associated with pain processing between control and neuropathic pain groups. These differences in signal activity—particularly in regions critical to endogenous analgesia—may represent a key step in elucidating the pathophysiology that underlies chronic neuropathic pain syndromes.Screen Shot 2015-10-19 at 3.46.52 PM

“Neuropathic pain affects approximately 5% of North Americans, and is considered to be caused by a lesion to the peripheral or central nervous system, trauma or disease,” said Jordan Leitch, MD, a resident at the London, Ontario, institution. “It’s characterized by either spontaneous episodic pain or pathological amplification of pain following a stimulus. In general, neuropathic pain is considered to be an expression of a maladaptive plasticity in the pain system that results in this constant state.”

During testing, functional MRI data were acquired while noxious stimuli were applied at the various pressures the patients had indicated the previous day. The researchers chose standardized pain ratings in lieu of standardized mechanical stimuli because pain response is subjective and varies widely between individuals.

As Dr. Leitch reported at the 2015 annual meeting of the Canadian Anesthesiologists’ Society (abstract 86017), both the volunteers and pain patients exhibited overall positive signal change at a pain rating of 2 and negative signal change at a pain rating of 6 in the midbrain and rostral medulla of the brainstem. However, consistent differences were observed between groups in the ipsilateral dorsal horn of the spinal cord, rostral ventromedial medulla and periaqueductal gray matter—three regions known to play an important role in nociceptive pain processing as well as the endogenous descending modulation of pain.

“In those regions, which we know are associated with ascending nociceptic transmission and the endogenous descending modulation of pain, we’re seeing positive signal change in the control group, but not much of anything in the carpal tunnel group,” she said.

“Another area we found interesting was around the dorsal horn of the cervical spinal cord, which is where the median nerve originates,” Dr. Leitch said. “And in the control group , we saw some variability from baseline, but not much deviation. But when we looked at the carpal tunnel patients, the times that correspond to pain levels 2, 4 and 6 show persistent positive signal changes that don’t follow what we would expect from controls.”

This study, the investigators concluded, is one of the first to identify variations in neural activity associated with pain processing. “I think seeing is believing in terms of pain,” she added. “This could be an important first step in the quantitative assessment of pain, in terms of both the diagnosis and treatment effect. In general, it’s a step towards a method to objectively visualize a sensation that has traditionally been completely limited to our patients’ subjective description.

“Obviously these signal changes are open to interpretation, but they could be the manifestation of the maladaptive plasticity that is postulated to be one of the causes of neuropathic pain,” Dr. Leitch explained. This research may contribute to future studies investigating endogenous analgesia and pain processing in patient groups, which may facilitate the optimization of pain management and improve quality of life for patients suffering from chronic neuropathic pain, he said.

Dr. Leitch was awarded second place at the meeting’s Residents’ Research Competition.

—Michael Vlessides

Weekly Breaking Pain Research Updates

Weekly Breaking Pain Research Updates

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

Ketamine

Ketamine Derivatives

JW Sleigh, WA Denny, J Jose, SA Gamage, MG Harvey… – US Patent 20,150,259,277, 2015

Abstract: The present invention relates to ketamine derivatives of the formula (I),

pharmaceutical compositions comprising them, and methods for treating pain comprising

administering them, and their use in the manufacture of medicaments for treating pain.

Comparing the hemodynamic parameters and seizure duration between ketamine and thiopental during Electroconvulsive therapy in patients with Major depressive …

M Mohseni, A Ghanbari, MA Motazedi Ghajar… – Anesthesiology and Pain, 2015

Aim and Background: Today the effect of Electroconvulsive therapy (ECT) in cure of Major

depressive disease (MDD), and psychiatric patients is well accepted and usage of this

method is developed every day. In this regard, selecting the most effective hypnotic drugs

The antinociceptive efficacy of morphine-ketamine-magnesium combination is influenced by the order of medication administration.

SM Vučkovič, VKR Savič, DP Srebro, BM Medič… – European review for …, 2015

OBJECTIVE: Ketamine and magnesium, both N-methyl-D-aspartate (NMDA) receptor

antagonists, enhance the antinociceptive effects of opioid analgesics in different animal

models of pain, as well as in humans. This study aimed at evaluating whether magnesium

[HTML] Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

S Klein, CB Herath, R Schierwagen, J Grace… – PLOS ONE, 2015

Cholestatic model. BDL was performed in 40 rats (180g) after anesthesia with ketamine/xylazine

(78mg/kg and 10mg/kg body weight) as previously described [12]. Briefly rats were anesthetized

with ketamine/xylazine (78mg/kg and 10mg/kg body weight), respectively.

[HTML] Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction

AL Leblond, K Klinkert, K Martin, EC Turner, AH Kumar… – PLOS ONE, 2015

Procedures were performed under anesthesia induced by ketamine (90mg/kg), xylazine

(10mg/kg) and urethane (1.25mg/kg) and analgesia by ip delivery of carprofen (5 mg/Kg). Mice

were anesthetized with ketamine (90mg/kg), xylazine (10mg/kg) and urethane (1.25mg/kg).

Morphological Pulmonary Diffusion Capacity for Oxygen of Burmese Pythons (Python molurus): a Comparison of Animals in Healthy Condition and with Different …

JM Starck, I Weimer, H Aupperle, K Müller… – Journal of Comparative …, 2015

Snakes were anaesthetized (1 mg/kg diazepam intramuscularly [i/m]; Faustan; Temmler Pharma,

Marburg, Germany, followed by 40 mg/kg ketamine hydrochloride i/m; Ketavet; Pfizer Pharma,

Berlin, Germany) and placed in the CT scanner (Brilliance CT 6; Philips, Hamburg

[PDF] Articles in PresS. Am J Physiol Lung Cell Mol Physiol (March 27, 2015). doi: 10.1152/ajplung. 00291.2014

BA MacKenzie, I Henneke, S Hezel, D Al Alam… – 2015

Mice were genotyped as described previously (3, 12, 34). 148 149 Bleomycin administration

150 10–14 week-old female mice were anaesthetized with a mixture of 0.6 µl/g Ketamine 10%

151 (100 mg/ml) and 0.3 µl/g Dormitor 10% (0.5 mg/ml) dissolved in 0.7% saline.

Anesthesia for Endoscopy

M Asakawa – Veterinary Clinics of North America: Small Animal …, 2015

26 Another study found that a combination of acepromazine and butorphanol followed by induction

with propofol had minimal effect on splenic volume, whereas medetomidine and butorphanol

as premedicants followed by ketamine and diazepam for induction were associated

[HTML] Generation and Characterization of Live Attenuated Influenza A (H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation

S Shcherbik, N Pearce, A Balish, J Jones, S Thor… – PLOS ONE, 2015

replication in multiple organs. Anesthesia occurred through an intramuscular injection

of a ketamine-xylazine-atropine cocktail (25 mg/kg ketamine, 2 mg/kg xylazine,

and 0.05 mg/kg of atropine). For euthanasia, ferrets were

[HTML] Standardized surgical approaches to ear surgery in rats

P Li, D Ding, K Gao, R Salvi – Journal of Otology, 2015

studies using rats. 2. Anesthesia and pre-operative preparation. Health SD rats

weighing about 250 g were selected and anesthetized with intraperitoneal ketamine

(100 mg/kg) and chlorpromazine (5 mg/kg). The skin around

Radiofrequency Ablation (RFA)

Is radiofrequency ablation of lung metastases the most radical treatment?

M Zielinski, R Zaimi, P Sabatier, P Bagan – European Journal of Surgical Oncology, 2015

We read with interest the article on long term results of radiofrequency ablation (RFA) to lung

metastases from colorectal cancer 1. This article is an interesting retrospective analysis on

long term survival in patients with lung metastases from colorectal cancer treated with this

Uninterrupted new oral anticoagulants compared to uninterrupted Vitamin K antagonists in ablation of atrial fibrillation. A Meta-analysis

R Nairooz, K Ayoub, P Sardar, J Payne, A Almomani… – Canadian Journal of …, 2015

NOAC= new oral anticoagulant, VKA=vitamin K antagonist, N/A=not available, TEE=

trans-esophageal echocardiogram, ICE= intra-cardiac echocardiogram, UFH=

unfractionated heparin, s= seconds, RFA= radiofrequency ablation.

Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome

P Gal, NF Marrouche – European Heart Journal, 2015

Post-ablation DE-MRI allows for assessment of the total scar burden, complete encirclement

of pulmonary veins, and the assessment of residual fibrosis, which were all reported to

be strong predictors of arrhythmia recurrences post-ablation.

Imaging Hepatocellular Carcinoma with Dynamic CT Before and After Transarterial Chemoembolization: Optimal Scan Timing of Arterial Phase

M Saake, MM Lell, A Eller, W Wuest, M Heinz, M Uder… – Academic Radiology, 2015

In eight patients previous TACE and in five patients previous radiofrequency ablation had been

performed and follow-up imaging had demonstrated HCC recurrence. First, in a part of our cohort

the HCCs had been treated previously by TACE or radiofrequency ablation.

Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial

K Kaitani, K Inoue, A Kobori, Y Nakazawa, T Ozawa… – European Heart Journal, 2015

fasttrack ★ Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation

for Atrial Fibrillation (EAST-AF) trial. Kazuaki Kaitani, Koichi Inoue, Atsushi Kobori,

Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro

PAEDIATRIC CT EXPOSURE PRACTICE IN THE COUNTY OF RIO DE JANEIRO: THE NEED TO ESTABLISH DIAGNOSTIC REFERENCE LEVELS

FM de Jesus, LAG Magalhães, S Kodlulovich – Radiation Protection Dosimetry, 2015

are essential for the diagnosis and monitoring of patients with complex cardiovascular disease

(2–4) , for the diagnosis of pulmonary embolism (5) and for guiding interventional procedures,

such as radiofrequency ablation, biopsy, abscess drainage and nephrostomy (6) . In

Substrate Mapping for Unstable Ventricular Tachycardia

P Santangeli, FE Marchlinski – Heart Rhythm, 2015

Scar dechanneling, linear ablation through sites matching VT with pacing and the core isolation

approach focus on more discrete and/or inducible arrhythmias by means of physiological

maneuvers, although this does not necessarily translate in less radiofrequency lesions to

[HTML] Evaluation and management of chronic coccygodynia: Fluoroscopic guided injection, local injection, conservative therapy and surgery in non-oncological pain

A Galhom, M al-Shatouri, SA El-Fadl – The Egyptian Journal of Radiology and …, 2015

23). The beneficial effect was retained with repeated injections (21). Radiofrequency

ablation using two needles achieved a pain reduction of >50% for an average duration

of 2.2 months, in a series of 13 patients (24). Another

[HTML] Assessment of prognosis of patients with stage II colon cancer

S Martins, P Martins – Journal of Coloproctology, 2015

Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined

resection/ablation for colorectal liver metastases. Ann. Surg., 239 (2004), pp. 818–825 discussion

825–27. 9; K. Lang, JR Korn, DW Lee, LM Lines, CC Earle, J. Menzin;

Energy delivery systems and uses thereof

DW van der Weide, PF Laeseke, FT Lee, CL Brace – US Patent 9,119,649, 2015

tissue for a wide variety of applications, including medical procedures (eg, tissue ablation,

resection, cautery the device is configured to deliver a sufficient amount of energy to ablate the

tissue In some embodiments, the energy is microwave energy and/or radiofrequency energy  

Chronic Regional Pain Syndrome (CRPS/RSD)

Side-Channel Assisted Modeling Attacks on Feed-Forward Arbiter PUFs Using Silicon Data

R Kumar, W Burleson – … : 11th International Workshop, RFIDsec 2015, New …, 2015

However, the performance of modeling attacks is impacted by the presence of

error-prone CRPs in the training set. To that extent error-prone CRPs. The terms

“error-prone” and “error- inflicted” refer to the same set of CRPs.

Making Invisible Intersectionality Visible Through Theater of the Oppressed in Teacher Education

B Powers, PB Duffy – Journal of Teacher Education, 2015

Thank you! We ended there on the first day. Day 2. After initial warm-ups, the students broke up

into four groups. Each group, of about five to six students, was asked to create two to three

tableaux that explored their positions within schools as it relates to the course of CRPs.

Energy geographies: thinking critically about energy issues in the classroom

E Delgado – Journal of Geography in Higher Education, 2015

Analysis of suicide attempts and completions at the South Texas Veterans Health Care System: a retrospective review

R Oliveira, TA Moore, CA Gutierrez – Mental Health Clinician, 2015

Additional information collected included psychiatric medications used during the review period,

including psychiatric MPRs for 6 months before the suicide attempt. The MPRs were calculated

manually using the prescription refill history available in CRPS.

[PDF] Cadmium toxicity in diazotrophic Anabaena spp. adjudged by hasty up-accumulation of transporter and signaling and severe down-accumulation of nitrogen …

S Rai, S Singh, LC Rai – 2015

Percentage of total protein variability explained in PC1 and PC2 is given in parenthesis.

Protein spots in red color represent variables whereas text in blue color indicates time points.

Fig. 5. Cluster analysis of Cd responsive (CRPs) in Anabaena spp.

[PDF] The migraine brain in transition: girls vs boys

V Fariaa, N Erpeldinga, A Lebela, A Johnsona… – 2015

Page 1. NUMBER 1 OF 1 AUTHOR QUERIES DATE 7/25/2015 JOB NAME PAIN ARTICLE

PAIN-D-14-13318 QUERIES FOR AUTHORS V. Faria et al. THIS QUERY FORM MUST

BE RETURNED WITH ALL PROOFS FOR CORRECTIONS

Structure-function relationships in mammalian Histidine-Proline-Rich Glycoprotein

F Ronca, A Raggi – Biochimie, 2015

Histidine-proline-rich glycoprotein (HPRG), or histidine-rich glycoprotein (HRG), is a serum

protein that is synthesized in the liver and is actively internalis.

Fibromyalgia

[PDF] Adult attention-deficit and hyperactivity disorder and fibromyalgia: a case-control study

A Golimstok, MC Fernandez, MM Garcia Basalo – Neuro Open J, 2015

ABSTRACT Introduction: Fibromyalgia syndrome (FMS) is a disorder characterized by

widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues.

An association between attention deficit and fibromyalgia was reported. However, to our

Fasting and rheumatic diseases (ahead of publication)

MH Jokar – Journal of Fasting and Health, 2015

Predicting chronic symptoms after an acute “stressor”—lessons learned from 3 medical conditions.

Med Hypotheses 2004;63:653-8. 17-Chervin RD, Teodorescu M, Kushwaha R, et al. Objective

measures of disordered sleep in fibromyalgia. J Rheumatol 2009;36:2009-16.

… —With treatment approaches for fibromyalgia evolving over the course of modern medicine, many clinicians are reviewing the Diagnosing and Treating Fibromyalgia: …

C Palsy, CPCLE Row

The pathophysiology of fibromyalgia includes central sensitization (amplification of pain in

the spinal cord via spontaneous nerve activity, expanded receptive fields, and augmented

stimulus responses), abnormalities of descending inhibitory pain pathways (dysfunction in

[HTML] Select a Site

V Promise, VO Heritage, B Areas, L Diabetes…

Neuroscience covers both mental disorder and pain manifestations. Mental disorder covers Bipolar

Disorder, Schizophrenia,Depression and General Anxiety Disorder while pain includes Diabetic

neuropathy, Fibromyalgia and chronic pain. 54th ed. Lange; 2015. Fibromyalgia.

The measurement of bridging social capital in population health research

E Villalonga-Olives, I Kawachi – Health & Place, 2015

capital (a combination of social resources that can be beneficial to a person’s physical health

and well-being), personal coping strategies, and additional personal and disease-related factors,

contribute to the functioning and quality of life (QoL) of fibromyalgia (FM) patients.

Therapeutic Effects of the Mineral Waters from Copahue Spa

AM Monasterio, F Armijo, F Maraver – Copahue Volcano, 2015

and chondrolysis, Fioravanti et al. (2011) reported: • A reduction in the levels of

circulating pros- taglandins E2 (PGE-2) and leukotriene B4 (LT-B4) in patients with

osteoarthritis or fibromyalgia. • Reductions in tumour necrosis

Seven Steps to Choosing Joy!: Discover the Power of Your Inner Wisdom

L Ackles – 2015

DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING

IR Vlahov, CP Leamon – US Patent 20,150,258,203, 2015

any one of the preceding embodiments wherein the disease is selected from the group consisting

of arthritis, including rheumatoid arthritis and osteoarthritis, glomerulonephritis, proliferative

retinopathy, restenosis, ulcerative colitis, Crohn’s disease, fibromyalgia, psoriasis and ..

Latest Pain Research News!

Latest Pain Research News!

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

Ketamine

 

[HTML] Upper urinary tract damage caused by ketamine snorting—A report of nine cases

HY Lee, YC Hsu, CY Hsu, ECL Chou, CC Li, YS Juan… – Urological Science, 2015

Objective The toxicity of ketamine to genitourinary system not only involved in lower urinary

tract, which include urinary frequency, urgency, suprapubic pain, dysuria and hematuria, but

also upper urinary tracts. However, the reports of ketmaine-induced upper urinary tract

 

Inconsistency of allometric scaling for dissociative anesthesia of wild felids

AB Carregaro, GC Freitas, SP Bisetto, NV Xavier… – Veterinary anaesthesia and …, 2015

Keywords: allometric scaling; dissociative anesthesia; ketamine; metabolic rate; xylazine.

Abstract. Objective. To evaluate allometric scaling for ketamine–xylazine (KX) anesthesia

in wild felids using domestic cats for reference. Study design.

 

[PDF] The ERα-PI3K Cascade in Pro-opiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice

L Zhu, P Xu, X Cao, Y Yang, AO Hinton Jr, Y Xia… – Endocrinology, 2015

Hypothalamic ER -p85 interaction and phosphorylation of AKT in response to icv PPT

Female C57Bl6 mice (12 weeks) were anesthetized with ip injections of

ketamine/xylazine cocktail (100 mg/kg ketamine and 10 mg/kg xylazine).

 

[HTML] Effects of leptin on sympathetic nerve activity in conscious mice

DA Morgan, F Despas, K Rahmouni – Physiological Reports, 2015

Here, we examined the sympathetic responses evoked by leptin in conscious mice. Mice

were instrumented, under ketamine/xylazine anesthesia, with renal or lumbar SNA

recordings using a thin (40 gauge) bipolar platinum–iridium wire.

 

[PDF] Treatment of Pain with Antidepressants

B Kerr, C Benson, K Mifflin, SJB Jesudasan, S Dursun… – Klinik Psikofarmakoloji …, 2015

depression43-45. There has been a great deal of interest in the NMDA receptor antagonist

ketamine and its rapid acting antidepressant action when infused46,47, and it is interesting that

this drug has also been used in treatment of therapy-resistant chronic pain48.

 

Use of LigaSure on bile duct in rats. An experimental study.

A Marte, L Pintozzi – Minerva pediatrica, 2015

in rats. MATERIALS AND METHODS: Thirty Wistar rats weighing 70 to 120gr were

employed for this study. The animals were all anaesthetized with intraperitoneal

Ketamine and then divided into three groups. The first group

 

[HTML] Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats

RA Maheshwari, F Dhakwala, R Balaraman, AK Seth… – Indian Journal of …, 2015

Standard drug Calcium Sandoz (cholecalciferol), ketamine hydrochloride, diazepam, povidone,

and ampicillin were purchased from commercial market. The rats were anesthetized with injection

of ketamine hydrochloride (40 mg/kg. ip) and diazepam (5 mg/kg, im).

 

Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala

K László, A Kovács, O Zagoracz, T Ollmann, L Péczely… – Behavioural Brain Research, 2015

00 h. 2.2. Surgery. Rats were anesthetized ip by ketamine supplemented with

diazepam (Calypsol and Seduxen, Richter Gedeon, Hungary, ketamine: 80

mg/kg body weight, diazepam: 20 mg/kg body weight). Animals were

 

Minocycline Attenuates Depressive‐like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway

SSS Saravi, SE Mousavi, SSS Saravi, AR Dehpour – Basic & Clinical Pharmacology & …, 2015

Testicular Torsion/Detorsion Animals were anaesthetized with intraperitoneal injection of ketamine

HCl (50 mg/kg) and chlorpromazine (25 mg/kg). 30 days. Testosterone assay At day 30, the rats

were anaesthetized with intraperitoneal injection of ketamine HCl (50 mg/kg)

 

Spinal Reflexes and Windup In Vitro: Effects of Analgesics and Anesthetics

I Rivera‐Arconada, C Roza, JA Lopez‐Garcia – CNS Neuroscience & Therapeutics, 2015

Spinal cord mechanisms may contribute toward analgesia and akinesia. Ketamine.

The general anesthetic ketamine is a noncompetitive blocker of NMDA receptors

that also shows activity on several ionic channels. As expected

 

Augmentation Therapy With Serial Intravenous Ketamine Over 18 Months in a Patient With Treatment Resistant Depression.

S Hassamal, M Spivey, AK Pandurangi – Clinical Neuropharmacology, 2015

Abstract Major depressive disorder is a severe illness that affects 3% to 7% of adults

annually in the United States. About 30% of these individuals are refractory to multiple

treatment trials. Recent reports have found a significant and almost immediate

 

Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells Via a GSK‐3β‐Dependent Mechanism

HY Shyu, CJ Ko, YC Luo, HY Lin, SR Wu, SW Lan… – Journal of Cellular …, 2015

Abstract Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal

recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous

effects, including renal failure; however, the underlying mechanism is poorly understood.

 

More effective induction of anesthesia using midazolam-butorphanol-ketamine-sevoflurane compared with ketamine-sevoflurane in the common marmoset monkey ( …

H ISHIBASHI – Journal of Veterinary Medical Science, 2015

The common marmoset has been increasingly used for research in the biomedical field;

however, there is little information available regarding effective methods of anesthesia in this

species. This study retrospectively analyzed 2 regimens of anesthesia induction:

 

[HTML] Comparison of Ketamine–Medetomidine-butorphanol and Ketamine–dexmedetomidine-butorphanol Anesthesia in Rats

R Costea, D Lastofka, M Mehedinţu – Agriculture and Agricultural Science Procedia, 2015

Abstract We evaluated the effect of ketamine-dexmedetomidine-butorphanol (K, 80 mg/kg;

D, 0.25 mg/kg, B, 0.5 mg/kg) and ketamine-medetomidine-butorphanol (K, 80 mg/kg; M, 0.25

mg/kg, B, 0.5 mg/kg) administered intraperitoneally, during anesthesia and immediate

 

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increased survival after pneumococcal superinfection

K Reppe, P Radünzel, K Dietert, T Tschernig, T Wolff… – Infection and Immunity, 2015

Five days after IAV infection, 114 the mice were anesthetized intraperitoneally

(ip) with ketamine (80 mg/kg, Ketavet®, Pfizer, 115 re-suspended in sterile PBS.

Mice were anesthetized ip with ketamine and xylazine and 123

 

Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load

S Choudhury, K Kannan, BS Maruti, MP Addison… – European Journal of …, 2015

ad libitum. The animals were anesthetized by injection of xylazine (10 µg/g body

weight, intraperitoneally) and ketamine (80 µg/g body weight, intraperitoneally) and

a 2-cm ventral midline incision was performed. The cecum

 

[HTML] Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

YJ Lai, GJ Chang, YH Yeh, JHS Pang, CC Huang… – PLOS ONE, 2015

All the surgery was performed under ketamine and xylazine ip anesthesia, and all efforts were

made to minimize suffering. Housing and maintenance was provided by Chang Gung University,

All animals were fed a standard chow diet with free access to water.

 

[HTML] Serotonin 5-HT 7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg 2+-ATPase imbalances in spinal cord-injured male rats

A Norouzi-Javidan, J Javanbakht, F Barati, N Fakhraei… – Diagnostic Pathology, 2015

Animals were anesthetized by intraperitoneal injection of a mixture of ketamine hydrochloride

(75 mg/kg) and xylazine hydrochloride (5 mg/kg). All animals were anesthetized (ketamine

hydrochloride 10 % + xylazine 2 %, in 80 and 5 mg/kg doses, respectively).

 

[HTML] Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis

M Ishizuka, Y Miyazaki, M Masuo, K Suhara, T Tateishi… – PLOS ONE, 2015

They were then placed under light anesthesia with 100 mg/kg ketamine and 10 mg/kg xylazine,

and 5 μg of PDE in 25 μl of 0.9% saline was sprayed into each mouse’s trachea using an

intratracheal MycroSprayer® aerosolizer (Penn-century, Wyndmoor, PA, USA).

 

Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model

Z Tang, S Li, P Han, J Yin, Y Gan, Q Liu, J Wang… – Journal of Neurochemistry, 2015

blinded to the randomization. Permanent Middle Cerebral Artery Occlusion (pMCAO) Mice were

under Ketamine/Xylazine anesthesia (80 mg/kg Ketamine and 10mg/kg Xylazine, injected ip).

Standard aseptic surgical procedures were used throughout the procedure. The

 

Radiofrequency Ablation (RFA)

 

Effectiveness and safety of computed tomography-guided radiofrequency ablation of renal cancer: a 14-year single institution experience in 203 patients

JD Iannuccilli, DE Dupuy, MD Beland, JT Machan… – European Radiology, 2015

Objectives To define effectiveness and safety of CT-guided radiofrequency ablation (RFA) of

renal tumours and prognostic indicators for treatment success. Methods Patients with a

single treatment of a solitary, biopsy-proven renal tumour with intent to cure over a 14-year

 

Outcomes associated with ablation compared to combined ablation and transilluminated powered phlebectomy in the treatment of venous varicosities.

AT Obi, BN Reames, TJ Rook, SO Mouch, A Zarinsefat… – Phlebology/Venous Forum …, 2015

RESULT: Venous clinical severity scores improved more with radiofrequency ablation +

transilluminated powered phlebectomy as compared to radiofrequency ablation alone

(3.8 ± 3.4 vs. 3.2 ± 3.1, p = 0.018). radiofrequency ablation alone.

 

Minimally invasive procedures for the management of vertebral bone pain due to cancer: The EAPC recommendations

S Mercadante, P Klepstad, G Paula Kurita, P Sjøgren… – Acta Oncologica, 2015

Radiofrequency ablation (RFA). RFA resulted more effective than radiotherapy and surgical

stabilization [99. Di Francesco A, Flamini S, Zugaro L, Zoccali C. Preoperative

radiofrequency ablation in painful osteolytic long bone metastases.

 

[HTML] Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis: A single-center retrospective cohort study

F Zhang, J Yan, XB Feng, F Xia, XW Li, KS Ma, P Bie – World J Gastroenterol, 2015

These procedures include liver transplantation, resection, and radiofrequency ablation[ 5 ]. Liver

transplantation may be the best treatment option for cirrhotic patients with HCC because it involves

the simultaneous removal of both the cirrhotic liver and HCC[ 6 ]. However, the

 

Ethanol ablation in post-biopsy liver hemorrhage following two failed Embolizations

MC Pope, DH Ballard, AL Sticker, C Ahuja… – Clinical Imaging, 2015

C. The feeding vessels were identified and ablated with an additional 10 mL ethanol injection.

to ultrasound-guided percutaneous ethanol injection for achieving hemostasis include techniques

such as cryoablation, radiofrequency (RF)-ablation, and cyanoacrylate glue

 

[PDF] Catheter Ablation of Fascicular Ventricular Tachycardia: Long Term Clinical Outcomes and Mechanisms of Recurrence

Y Liu, Z Fang, B Yang, P Kojodjojo, H Chen, W Ju… – Circulation: Arrhythmia and …, 2015

ablated. Arrhythmia recurrences after an initially successful ablation were caused by recurrent

FVT involving the Key words: ventricular tachycardia, radiofrequency, idiopathic left ventricular

tachycardia, fascicular ventricular tachycardia, outcomes, radiofrequency ablation

 

Liver metastases from adenocarcinomas of unknown primary site: management and prognosis in 68 consecutive patients

E Algin, A Ozet, O Gumusay, G Yilmaz, S Buyukberber… – Wiener klinische …, 2015

shown in Fig. 1. Among 39 patients who were managed with chemo- therapy, 12

patients received additional locoregional therapies including radiofrequency ablation

or transar- terial chemoembolization. Median OS was 9.4

 

[HTML] The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Q Pang, K Qu, JY Zhang, SD Song, SS Liu, MH Tai… – Medicine, 2015

Abbreviations: HBV = hepatitis B virus, HCC = hepatocellular carcinoma, HCV = hepatitis C virus,

HR = hazard ratio, MPV = mean platelet volume, OS = overall survival, PLT = platelet count, RFA =

radiofrequency ablation, RFS = recurrence-free survival, TACE = transcatheter

 

Safety and Feasibility of Open Chest Epicardial Mapping and Ablation of Ventricular Tachycardia During the Period of Left Ventricular Assist Device Implantation

M Patel, F Rojas, FR Shabari, L Simpson, W Cohn… – Journal of Cardiovascular …, 2015

Endocardial and epicardial radiofrequency ablation of ventricular tachycardia associated with

dilated cardiomyopathy: The importance of low-voltage scars. Comparison of epicardial

cryoablation and irrigated radiofrequency ablation in a swine infarct model.

 

Contact Force Variability during Catheter Ablation of Atrial Fibrillation: The Role of Atrial Rhythm and Ventricular Contractions: Co-Force AF Study

A Sarkozy, D Shah, J Saenen, J Sieira, T Phlips… – Circulation: Arrhythmia and …, 2015

3 Background Lesion formation by using radiofrequency (RF) current depends on the power

delivered, duration of energy application, temperature, tip size, and tip orientation. given RF power1.

Irrigated tip ablation catheters capable of real-time CF measurement have

 

[HTML] Pulmonary vein isolation using the visually guided laser balloon: a prospective, multicenter, and randomized comparison to standard radiofrequency ablation

SR Dukkipati, F Cuoco, I Kutinsky, A Aryana… – Journal of the American …, 2015

Background Balloon catheters have been designed to facilitate pulmonary vein (PV)

isolation in patients with paroxysmal atrial fibrillation (AF). The visually guided laser balloon

(VGLB) employs laser energy to ablate tissue under direct visual guidance. Objectives

 

Optimal Temperature for Radiofrequency Ablation of Lumbar Medial Branches for Treatment of Facet‐Mediated Back Pain

S Costandi, M Garcia‐Jacques, T Dews, M Kot, K Wong… – Pain Practice, 2015

Background Radiofrequency ablation (RFA) of the medial branch nerves that innervate the

facet joints is a well-established treatment modality; however, studies to determine the

optimal radiofrequency ablation temperature are lacking. A wide range (70 to 90 C) has

 

[HTML] Catheter Ablation of Atrial Fibrillation: Advent of Second-Generation Technologies

E Buch, K Shivkumar – Journal of the American College of Cardiology, 2015

and wide-area isolation (5), with or without additional lesion sets targeting non-PV

foci (6) or modifying atrial substrate. All of these techniques initially used

point-by-point ablation with radiofrequency (RF) ablation catheters.

 

[HTML] Computed tomography-guided percutaneous trephine removal of the nidus in osteoid osteoma patients: experience of a single center in Brazil

M Petrilli, AA Senerchia, AS Petrilli, HM Lederman… – Radiologia Brasileira, 2015

Osteoid osteoma: CTguided percutaneous radiofrequency ablation and follow-up in 47 patients.

J Vasc Interv Radiol. 2001;12:717–722. Peyser A, Applbaum Y, Khoury A, et al. Osteoid osteoma:

CT-guided radiofrequency ablation using a water-cooled probe. Ann Surg Oncol.

 

Proton beam therapy for metastatic liver tumors

N Fukumitsu, T Okumura, D Takizawa, H Makishima… – Radiotherapy and Oncology, 2015

The maximal diameter of the lesions was 1–18 cm (median, 4 cm). Of the 140 patients, 87

had received another form of treatment before PBT, such as chemotherapy, radiofrequency

ablation, transcatheter arterial chemoembolization, and surgery.

 

Accuracy of Late Gadolinium Enhancement-Magnetic Resonance Imaging in the Measurement of Left Atrial Substrate Remodeling in Patients With Rheumatic Mitral …

D Zhu, Z Wu, RJ van der Geest, Y Luo, J Sun, J Jiang… – International Heart Journal, 2015

We enrolled adult patients with rheumatic mitral valve disease and persistent AF who un-

derwent open-heart surgery for mitral valve replacement with concurrent radiofrequency

ablation for AF at our institution between February 2013 and March 2014.

 

Predictive value of nodule size and differentiation in HCC recurrence after liver transplantation

GG Piero, P Domenico, F Di Benedetto, M Elena… – Surgical Oncology, 2015

Generally, radiofrequency ablation (RFA) was proposed in cases of a single tumor less than 3

cm, whereas a single tumor > 3 cm or multifocal lesions in patients with impaired liver function

were directed instead to treatment with trans-arterial chemoembolization (TACE).

 

Radiofrequency ablation or stripping of large-diameter incompetent great saphenous varicose veins with C2 or C3 disease

EV Shaidakov, AG Grigoryan, EA Ilyukhin, VL Bulatov… – Journal of Vascular Surgery: …, 2015

Objective The objectives of this study were to compare the results of radiofrequency ablation

(RFA) and stripping for large-diameter varicose target veins for the period of 1 year, based

on a composite end point; to analyze the pain severity on a digital rating scale for 7 days

 

Clinical outcomes and risk factors of hepatocellular carcinoma treated by liver transplantation: A multi-centre comparison of living donor and deceased donor …

Z Hu, Z Qian, J Wu, J Zhou, M Zhang, L Zhou, S Zheng – Clinics and Research in …, 2015

HCC: hepatocellular carcinoma; LDLT: living donor liver transplantation; DDLT: deceased donor

liver transplantation; GWRW: graft weight/recipient weight; TACE: transcatheter arterial

chemoembolisation; RFA: radiofrequency ablation; PEI: percutaneous ethanol injection; ICU

 

[PDF] Hepatocellular carcinoma treatment strategies–a case-based review

R Alves, MT Gomes, CS Macedo, HP Miranda, F Nery – Journal of Solid Tumors, 2015

Resection techniques have been refined, from the use of new radiofrequency ablation resection

devices to laparoscopic approaches, both showing to diminished blood loss [1, 2]. A recent

meta-analysis showed that laparoscopic approach decreases blood loss, transfusion

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

Skin sympathetic function in complex regional pain syndrome type 1

A Poudel, M Asahina, Y Fujinuma, Y Yamanaka… – Clinical Autonomic …, 2015

10.1007/s10286-015-0314-x. Copyright information. Abstract. Purpose. Cutaneous

sympathetic pathophysiology in complex regional pain syndrome type 1 (CRPS-1) is

not yet completely understood. To evaluate cutaneous sympathetic

 

Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

WW Li, TZ Guo, X Shi, Y Sun, T Wei, DJ Clark… – Neuroscience, 2015

hypersensitivity. Abstract. Tibia fracture in rodents induces substance P

(SP)-dependent keratinocyte activation and inflammatory changes in the hindlimb,

similar to those seen in complex regional pain syndrome (CRPS). In

 

Economic impact of mgnregp on rural livelihood security in tumkur district, karnataka–a sam analysis

CHR Gowda – 2015

Item Type: Thesis (Masters). Divisions: RP-Market Institutions and Policies. CRPS: CGIAR

Research Program on Policies, Institutions, and Markets. Uncontrolled Keywords: Economic

Impact, MGNREGP, Rural Livelihood Security, Karnataka, SAM analysis.

 

[PDF] DMSA-coated Iron Oxide Nanoparticle Greatly Affect the Expression of Genes Coding Cysteine-rich Proteins by its DMSA Coating

L Zhang, X Wang, J Zou, Y Liu, J Wang – Chemical Research in Toxicology, 2015

times. The results revealed that about one fourth of DEGs coded cysteine-rich proteins

(CRPs) in all cells under each treatment, indicating that the nanoparticles greatly

affected the expressions of CRP-coding genes. Additionally

 

Changing appearance using visual illusions improves ownership of the painful hand in complex regional pain syndrome

J Lewis, C McCabe, R Newport – 2015

Abstract. Background and aims People with Complex Regional Pain Syndrome (CRPS)

experience a diminished sense of ownership of their painful limb. Thirty nine patients with CRPS

of one arm were randomly allocated to either a control or experimental group.

 

The role of genetically‐engineered pigs in xenotransplantation research

DKC Cooper, B Ekser, J Ramsoondar, C Phelps… – The Journal of Pathology, 2015

This is because of the expression of human complement-regulatory proteins (CRPs) on the

surface of vascular endothelial cells. Pigs have similar CRPs, but these are relatively inefficient

at protecting the pig cells from human complement-mediated injury [13].

 

Individuality: How knowledge of body perception disturbance can inform treatment

J Lewis – 2015

Lewis, J. (2015) Individuality: How knowledge of body perception disturbance can inform

treatment. In: International Association of the Study of Pain (IASP) CRPS SIG, Zurich, Switzerland,

31 August – 1 September 2015. [img] Preview. PDF 1MB. Abstract.

 

Spinal Cord Stimulation (SCS) and Functional Magnetic Resonance Imaging (fMRI): Modulation of Cortical Connectivity With Therapeutic SCS

M Deogaonkar, M Sharma, C Oluigbo, DM Nielson… – … : Technology at the Neural …, 2015

Methods. Ten patients with complex regional pain syndrome (CRPS) or neuropathic leg pain

underwent thoracic epidural spinal cord stimulator implantation. Stimulation parameters associated

with “optimal” pain reduction were evaluated prior to imaging studies.

 

[PDF] Similarity-based semi-local estimation of EMOS models

S Lerch, S Baran – arXiv preprint arXiv:1509.03521, 2015

The most popular scoring rules providing summary measures of predictive performance are the

logarithmic score, ie, the negative logarithm of the predictive PDF evaluated at the verifying

observation, and the continuous ranked probability score (CRPS; Gneiting and Raftery

 

Review of Plastic Surgery

DW Buck II – 2015

 

[PDF] Independent CRP-Commissioned External Evaluation of the CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)

J Compton, D McLean, B Emmens, M Balagamwala – 2015

development partners (IFPRI, 2011). CRPs are not legal entities and therefore legal

and financial responsibility for A4NH ultimately rests with the lead CGIAR Center

and its Board of Trustees (IFPRI- BOT). 2. IFPRI is legally

 

[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis

C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015

Different diseases could lead to neuro- pathic pain including postsurgical pain, post-herpetic

neuralgia (PHN), spinal cord stenosis (SCS), Complex Regional Pain Syndrome (CRPS), Diabetic

peripheral neuropathy (DPN), and chemotherapy induced pe- ripheral neuropathy.

 

Traumatic Life Events and Psychopathology in a High Risk, Ethnically Diverse Sample of Young Children: A Person-Centered Approach

MJ Hagan, MJ Sulik, AF Lieberman – Journal of abnormal child psychology, 2015

Conditional response probabilities (CRPs) are defined as the probability that an

individual from a specific latent class will endorse an item. CRPs provide across

classes. CRPs for the exploratory LCA model are shown in Fig.

 

Two placebo-controlled, randomized withdrawal studies to evaluate the fentanyl 1-day patch in opioid-naïve patients with chronic pain

T Arai, Y Kashimoto, Y Ukyo, Y Tominaga, K Imanaka – Current Medical Research …, 2015

study]) and the other study included opioid-naïve subjects with neuropathic pain (post- herpetic

neuralgia, complex regional pain syndrome [CRPS], or chronic postoperative pain; included: had

osteoarthritis, low back pain, post-herpetic neuralgia, CRPS, or chronic

 

[PDF] Challenges of Peripheral Nerve Stimulator Implantation in a Patient with New Onset Thrombocytopenia

S Thompson

We present a patient with complex regional pain syndrome (CRPS)-like symptoms of the lateral

femoral cutaneous nerve after laparoscopic hysterectomy who underwent successful

ultrasound-guided PNS trial using SCS leads and unfortunate delayed implantation due to

 

Improving student learning via mobile phone video content: Evidence from the BridgeIT India project

M Wennersten, ZB Quraishy, M Velamuri – International Review of Education

 

[PDF] The Association Between Soft Tissue Releases and Bony Resections Performed During Total Knee Arthroplasty and Patients’ Pain and Satisfaction Postoperatively

M Carter – 2015

Page 1. Western University Scholarship@Western Electronic Thesis and Dissertation Repository

September 2015 The Association Between Soft Tissue Releases and Bony Resections Performed

During Total Knee Arthroplasty and Patients’ Pain and Satisfaction

 

[PDF] Parthasarathy Rao and Cynthia Bantilan. 2015. Grain Legumes Production, Consumption and Trade Trends in Developing Countries

S Nedumaran, P Abinaya, P Jyosthnaa, B Shraavya

Markets (PIM). Financial support by CRPs Grain Legumes and Policies, Institutions

and Markets are gratefully acknowledged. This working paper has gone through

the standard peer-review procedure of ICRISAT. The authors

 

NEUROMODULATORY DEVICES, SYSTEMS, AND METHODS FOR TREATING FIBROMYALGIA

AR Rezai, M Deogaonkar – US Patent 20,150,251,008, 2015

In subjects with fibromyalgia as well as other conditions (eg, hot flashes, CRPS, etc.),

clinicians have used pharmacological blockade of the sympathetic nervous system, and

in particular the stellate ganglion, to achieve some clinical benefit.

 

Fibromyalgia

 

Psychiatric Disorders in Young Adults Diagnosed with Juvenile Fibromyalgia in Adolescence.

NR Cunningham, ST Tran, AM Lynch-Jordan, TV Ting… – The Journal of …, 2015

OBJECTIVE: Adolescents with juvenile-onset fibromyalgia (JFM) have increased rates of

psychiatric disorders, but to our knowledge no studies have examined psychiatric disorders

in adolescents with JFM when they enter young adulthood. This study examined the

 

Fibromyalgia beyond reductionism. Heart rhythm fractal analysis to assess autonomic nervous system resilience

C Lerma, LA Martinez-Martinez, N Ruiz, A Vargas… – Scandinavian Journal of …, 2015

Objectives: The prevailing linear reductionist medical model seems unable to explain

complex multisymptomatic illnesses such as fibromyalgia (FM) and similar maladies.

Paradigms derived from the complexity theory may provide a coherent framework for

 

Exploring the role of peripheral mechanisms: An evaluation of a theory-based approach to reducing symptoms of fibromyalgia

K Mooney – 2015

Abstract: This mixed method study presented an integrative approach for the treatment of

fibromyalgia, the rationale that justifies the approach, and an evaluation of two integrated

components of this protocol designed to mitigate symptoms of fibromyalgia. Considering

 

Chronic Widespread Back Pain is Distinct from Chronic Local Back Pain: Evidence from Quantitative Sensory Testing, Pain Drawings, and Psychometrics.

A Gerhardt, W Eich, S Janke, S Leisner, RD Treede… – The Clinical journal of pain, 2015

Therefore, this study compared quantitative-sensory-testing (QST) profiles of

non-specific chronic back pain patients with CLP (n=48) and CWP (n=29) with

pain-free controls (PCs, n=40) and Fibromyalgia patients (FMS, n=90).

 

Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation.

LM Tracy, L Ioannou, KS Baker, SJ Gibson… – PAIN, 2015

frequency HRV in chronic pain, implicating a decrease in parasympathetic activation.

These effects were heavily influenced by fibromyalgia studies. Future research would

benefit from wider use of standardised definitions of

 

[HTML] Analgesic effect of cathodal transcranial current stimulation over right dorsolateral prefrontal cortex in subjects with muscular temporomandibular disorders: study …

RA Brandão Filho, AF Baptista, RAFS Brandão… – Trials, 2015

In a fibromyalgia study using transcranial magnetic stimulation (TMS), the authors found higher

thresholds in both sides of the resting motor cortex with lower up regulation responses.

Furthermore, they found lower intracortical facilitation and inhibition.

 

Clinical Research Methodology 1: Study Designs and Methodologic Sources of Error

DI Sessler, PB Imrey – Anesthesia & Analgesia, 2015

The distinction can be nonobvious. For example, consider a study in which investigators compared

anesthetic requirement in patients with and without fibromyalgia. But, in fact, fibromyalgia is the

exposure in this study and anesthetic requirement is the outcome.

 

[HTML] Economic evaluation in chronic pain: a systematic review and de novo flexible economic model

W Sullivan, M Hirst, S Beard, D Gladwell, F Fagnani… – The European Journal of …, 2015

While the attributes and management of specific diseases associated with chronic pain, such

as fibromyalgia and osteoarthritis, and different analgesic requirements for neuropathic versus

other chronic pain may have justifiably led to modelling heterogeneity, clinical

 

[PDF] Evaluation of the Immediate Effect of Auricular Acupuncture on Pain and Electromyographic Activity of the Upper Trapezius Muscle in Patients with Nonspecific Neck …

ACO Silva, DA Biasotto-Gonzalez, DM Santos… – … -Based Complementary and …, 2015

NS-NP could contribute to the following: (i) a standardization of the points to be used as stimuli

for the treatment of abnormalities caused in this muscle by mechanical injuries, myofacial tension

(with or without trigger-points), and systemic diseases such as fibromyalgia; (ii) an

 

Ehlers Danlos syndrome and gastrointestinal manifestations: a 20‐year experience at Mayo Clinic

AD Nelson, MA Mouchli, N Valentin, D Deyle… – Neurogastroenterology & …, 2015

hernia,[7] rectal evacuation disorder,[8] diverticulosis, gastritis,[9] constipation, diarrhea, nausea,

vomiting, abdominal pain, and reflux disease.[10] Several non-musculoskeletal symptoms often

found in patients with functional GI disorders such as fibromyalgia, fatigue, cognitive

 

[HTML] Real-life assessment of the validity of patient global impression of change in fibromyalgia

E Rampakakis, PA Ste-Marie, JS Sampalis, A Karellis… – RMD Open, 2015

Objectives Patient Global Rating of Change (GRC) scales are commonly used in routine

clinical care given their ease of use, availability and short completion time. This analysis

aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC

 

[HTML] Increased Risk of Coronary Heart Disease in Patients with Primary Fibromyalgia and Those with Concomitant Comorbidity—A Taiwanese Population-Based Cohort …

CH Su, JH Chen, JL Lan, YC Wang, CH Tseng, CY Hsu… – PLOS ONE, 2015

Objectives Fibromyalgia has seldom been associated with coronary heart disease (CHD).

The aim of this study was to evaluate the risk of CHD in patients with fibromyalgia. Methods

We used a dataset of one million participants, systemically scrambled from the Taiwanese

 

[HTML] Group cognitive-behavioral therapy for chronic pain adults: review of Brazilian trials

LF Kirchner, CC Jorge, MJD Reis – Revista Dor, 2015

26 . With regard to studied population, table 1 shows predominance of females in all studies,

being fibromyalgia (FM) the most frequent diagnosis. Nevertheless, literature assertiveness,

3. (6 to 8), Fibromyalgia (100%), VAS. LSSI. RAS. Lorençatto

 

[HTML] Chronic Pain Pharmacological Treatment in Patients with Depressive Disorders

C Aurilio, MC Pace, MB Passavanti, V Pota, P Sansone… – Journal of Psychiatry, 2015

Patients with fibromyalgia present a reduced dopamine presynaptic activity in great many

brain regions, included hippocampus. Neurocircuits and neurochemistry. [50] published

a review on amitriptyline for neuropathic pain and fibromyalgia.

 

Medical Marijuana Patient Counseling Points for Healthcare Professionals Based on Trends in the Medical Uses, Efficacy, and Adverse Effects of Cannabis-Based …

JR Parmar, BD Forrest, RA Freeman – Research in Social and Administrative …, 2015

All three medications have similarly been used in improving sleep, fibromyalgia, rheumatoid

arthritis associated pain, and spasticity in MS. A complete list of medical uses and included

publications can be reviewed in Table 5. Table 5. Fibromyalgia, 1 16, 16,

 

Identification and description of controlled clinical trials published in Physiotherapy journals in Spain

M Turrillas, M Sitjà‐Rabert, H Pardo… – Journal of Evaluation in …, 2015

16.7% of the identified studies were multicentric. Traumatology and orthopaedics was the most

studied field (33.3%) followed by neurology (15.4%). The most researched health problems were

back pain (17.24%) fibromyalgia, arthrosis and stroke (6.8% each).

 

[HTML] Serum calprotectin (S100A8/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis

J Hurnakova, J Zavada, P Hanova, H Hulejova, M Klein… – Arthritis Research & …, 2015

which is obtained by using several composite indexes [4–7]. Nevertheless, a clinical examination

might lack sensitivity in patients with mild synovitis, be limited in patients with established

deformities, and be overestimated in patients with concomitant fibromyalgia or other

 

[HTML] Systematic review of the measurement properties of self-report physical activity questionnaires in healthy adult populations

Z Silsbury, R Goldsmith, A Rushton – BMJ Open, 2015

6 The review found strong evidence for effectiveness within cardiovascular disease, type 2

diabetes and obesity; and strong evidence for improved symptom management and quality of

life for patients with cancer, osteoarthritis, osteoporosis, fibromyalgia and depression.

 

[PDF] Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis

C Compagnone, F Tagliaferri – Acta Bio Medica Atenei Parmensis, 2015

JOP 2003; 4 (1): 1-10. 4. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Ami- triptyline for

neuropathic pain and fibromyalgia in adults. Review. 5. Moore RA, Wiffen PJ, Derry S, Toelle

T, Rice AS. Gabapen- tin for chronic neuropathic pain and fibromyalgia in adults.

 

Illness deception

SB Nimmo – Occupational Medicine, 2015

In a survey of US neuropsychologists, prevalence of malingering and symptom exaggeration

was found to be minor head injury 39%, fibromyalgia/chronic fatigue syndrome 35%, chronic

pain 31%, personal injury cases 29%, disability or workers compensation 30% and

Comprehensive Management Of Chronic Knee Pain

Comprehensive Management Of Chronic Knee Pain

Comprehensive Management Of Chronic Knee PainScreen Shot 2015-08-31 at 1.49.16 PM

Knee pain is a very common complaint that can be debilitating when severe. A proper evaluation must begin with a thorough history and physical examination.

If the patient is not a surgical candidate, there are several conservative treatment options—such as physical therapy for retraining of proper mechanics, kinesiology taping to improve proprioception, acupuncture and chiropractic treatment—that may alleviate the patient’s symptoms (Figure 1).

Screen Shot 2015-08-31 at 1.54.50 PM

 

 

 

 

 

 

 

 

 

Depending on the nature of the pain, a variety of analgesic medications may be prescribed, including anti-inflammatory drugs, membrane-stabilizing agents and in severe cases, opioid analgesics. Unfortunately, these medications may not significantly reduce the pain and their long-term compliance may be limited by untoward side effects. Additionally, many patients have intractable chronic pain after more invasive treatment options such as a total knee arthroplasty (TKA). Studies have reported that 20% of patients undergoing TKA have persistent postsurgical pain.1 These patients often present to the pain clinic frustrated by the failure of conservative and possible surgical interventions. Fortunately, depending on the pain generator, there is a wide array of interventional treatment options that can be implemented (Figure 2).
Screen Shot 2015-08-31 at 1.55.13 PM

 

History and physical

Diagnostic workup (ultrasound, x-ray, MRI, NCS/EMG)
Possible surgical candidate?

If yes, consider early orthopedic referral
If no, consider conservative management

Manual therapy (PT, chiropractor/DME)
Analgesics (ibuprofen, NSAIDs)
Behavioral, psych (biofeedback, relaxation techniques)

Figure 1. Conservative treatment algorithm.
DME, durable medical equipment; EMG, electromyography; MRI, magnetic resonance imaging; NCS, nerve conduction study; NSAID, nonsteroidal anti-inflammatory drug; PT, physical therapy
Failed conservative treatment
Phase 1

Image-guided knee steroid/hyaluronic acid injection
Image-guided knee stem cell/PRP injections

Phase 2

Saphenous and lateral femoral cutaneous nerve block; RFA if successful
Femoral nerve block, RFA if successful
Lumbar sympathetic plexus block (L2, L3); RFA if successful
Genicular nerve block; RFA if successful
Lumbar SCS trial; permanent implant if successful
PNS trial; permanent implant if successful

Phase 3

Refer back to orthopedic surgeon for reevaluation
Figure 2. Nonsurgical knee pain.
PNS, peripheral nerve stimulation; PRP, platelet-rich plasma; RFA, radiofrequency ablation; SCS, spinal cord stimulation

Evaluation

The primary nerve innervation of the knee arises anteriorly from the femoral nerve and posteriorly from the sciatic nerve. These nerves give rise to a number of smaller branches that provide sensation to a variety of specific regions around the knee (Figure 3). The saphenous nerve branches from the femoral nerve and provides sensation over the distal aspect of the medial two-thirds of the thigh. The lateral one-third of the distal thigh is supplied by the superficial femoral cutaneous nerve. The superior medial, inferior medial, and middle genicular nerves arise from the tibial nerve—the medial division of the sciatic nerve. The superior lateral, inferior lateral, and recurrent tibial genicular nerves arise from the common peroneal nerve—the lateral division of the sciatic nerve.2
Screen Shot 2015-08-31 at 2.01.21 PM

Figure 3. Innervation of the knee.

A thorough history and physical can aid the clinician in developing a focused differential diagnosis and effectively managing the patient with knee pain. Specific location of the pain, cause of the pain, duration of symptoms, alleviating and/or exacerbating factors, associated ipsilateral back and/or hip pain, and the outcome of any previous interventions should be investigated. The physical exam should always begin with inspection of the knee to assess for signs of gross deformity, edema, or cellulitis. Provocative exam maneuvers such as the valgus/varus stress, anterior/posterior drawer, Lachman’s test, McMurray’s test, and the patellar grind test may provide a great deal of information whether positive or negative. If bony etiology is suspected, imaging should include an x-ray of the knee. However, if soft tissue pathology is suspected, an ultrasound or a magnetic resonance imaging scan of the knee may be more appropriate. Furthermore, given that it is common for knee pain to be a manifestation of referred back or hip pain, imaging of these regions as well as electrodiagnostic studies may be appropriate. Electrodiagnostic studies also should be completed if there is any concern for neuropathy. Correlating the patient’s symptoms and physical exam findings with abnormal diagnostic test results can help to condense the differential diagnosis and aid in tailoring a treatment plan.3

Current Evidence for Interventional Therapy

There is a growing body of literature that supports the use of a variety of interventional procedures in the management of knee pain. Raynauld et al demonstrated improved pain relief with intraarticular steroid injection versus saline over a 2-year period with repeated injections every 3 months.4 Neustadt et al showed that intraarticular hyaluronic acid injections brought about some symptomatic pain relief compared with placebo.5 A study by Choi et al revealed that radiofrequency ablation of the superior medial, superior lateral, and inferior medial genicular nerves produced significant pain relief in patients with knee osteoarthritis.6 Wakitani et al demonstrated repair of articular cartilage defects following intraarticular injection of human autologous mesenchymal stem cells.7

Ultrasound Versus Fluoroscopically Guided Injections

Screen Shot 2015-08-31 at 2.03.08 PM
Figure 4. Knee ultrasound.
Arrowheads, medial collateral ligament
Medial meniscus
Distal hip adductor muscles can be seen at the top of the image.

Incorrect placement of injectate within the knee can lead to increased pain and decreased therapeutic benefit. The literature suggests that there is an increased rate of successful intraarticular placement using image guidance compared with blind injections (ie, using surface anatomic landmarks). In light of this, ultrasound and fluoroscopy are both frequently used to perform interventional procedures for knee pain. Each has advantages and disadvantages with respect to a given procedure. Fluoroscopy provides better visualization of the knee joint, which improves the likelihood of successful intraarticular injection. Given the relatively radiopaque appearance of periosteum and hardware from prior TKA, this is ideal for genicular nerve blocks. However, the patient is subjected to radiation exposure with its usage. Ultrasound allows for better visualization of soft tissue structures, which can dramatically improve the success rate of peripheral nerve and bursa injections in this region (Figure 4). The normal characteristic appearance of various anatomic structures in the region of the knee aid the interventionalist in target localization. Given the real-time dynamic nature of this imaging modality, the needle tip and/or injectate can be easily visualized for both intra- and extraarticular injections to confirm accurate location.8,9 For ease of access into the intraarticular joint space, we recommend performing procedures with the patient in the supine position with the knee maximally flexed to approximately 135 degrees. It is important to note that ultrasound is user-dependent, which makes for more variable results.

Interventional Procedures

The following is a list of interventional procedures that are commonly performed in the treatment of chronic knee pain:

Intraarticular knee injections: steroids, hyaluronic acid, traumeel, platelet-rich plasma (PRP), and mesenchymal stem cells (Figure 5).
Extraarticular knee injections: steroids, traumeel, PRP, and mesenchymal stem cells.
Trigger-point injections.
Peripheral nerve blocks: saphenous, superficial femoral cutaneous, genicular nerves (Figure 6).
Radiofrequency ablation: saphenous, superficial femoral cutaneous, genicular nerves.
Lumbar sympathetic plexus block (typically at L2 and/or L3 level).
Peripheral nerve stimulation: saphenous, superficial femoral cutaneous.
Lumbar spinal cord stimulation: treatment of last resort.

Screen Shot 2015-08-31 at 2.04.57 PM
Figure 5. Mesenchymal stem cells.
Regenerative therapy can include platelet-rich plasma and stem cells. Mesenchymal stem cells may be procured from autograft bone marrow and
image

 

 

 

 

 

 

 

Screen Shot 2015-08-31 at 2.05.07 PM
Figure 6. Peripheral nerve stimulation.
The patient is a 19-year-old female collegiate softball player who failed multiple orthopedic knee surgeries and was unable to participate in athletic activities. Following placement of peripheral field stimulation of the knee, she was able to return to play.
Courtesy of Dr. William S. Rosenberg, Center for the Relief of
References

Beswick AD, Wylde V, Gooberman-Hill R, et al. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2(1).
Jacobson JA. Introduction. In: Jacobson JA, ed. Fundamentals of Musculoskeletal Ultrasound. Philadelphia, PA: Saunders; 2007:1-14.
Jacobson JA. Knee ultrasound. In: Jacobson JA, ed. Fundamentals of Musculoskeletal Ultrasound. Philadelphia, PA: Saunders; 2007:224-263.
Raynauld JP, Buckland-Wright C, Ward R, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee. Arthritis Rheum. 2003;48:370-377.
Neustadt D, Caldwell J, Bell M, et al. Clinical effects of intraarticular injection of high molecular weight hyaluronan (Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter trial. J Rheum. 2005;32:1928-1936.
Choi WJ, Hwang SJ, Song JG, et al. Radiofrequency treatment relieves chronic knee osteoarthritis pain: a double-blind randomized controlled trial. Pain. 2011;152:481-487.
Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. J Osteo Res Soc Inter. 2002;10:199-206.
Waldman SD. Pain Management. Philadelphia, PA: Saunders; 2011.
Hurdle M-FB. Ultrasound-guided knee injections. In: Narouze SN, ed. Atlas of Ultrasound-Guided Procedures in Interventional Pain Management. New York, NY: Springer; 2011:331-335

BY: Tory McJunkin, MD
Co-founder
Arizona Pain Specialists
Scottsdale, Arizona
Paul Lynch, MD
Co-founder
Arizona Pain Specialists
Scottsdale, Arizona
Jarron Tilghman, MD
Physical Medicine and Rehabilitation Physician
Rockhill Orthopaedic Specialists
Kansas City, Missouri
Patrick Hogan, DO
Anesthesiologist, interventional pain physician
Arizona Pain Specialists
North Phoenix, Arizona
Adam Wuollet, MD
Anesthesiologist, interventional pain physician
Arizona Pain Specialists
Phoenix, Arizona
Edward Swing, PhD
Research Director
Arizona Pain Specialists Scottsdale, Arizona

Worldwide Research Updates for Week of 8/13/2015

Worldwide Research Updates for Week of 8/13/2015

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

[HTML] Which Sedation is more Appropriate during Spinal Anesthesia: Propofol or Ketamine-Propofol Combination

H Güleç, ZB Tutal, M Şahap, M Babayiğit, H İnceöz… – Anaesth Pain & Intensive …, 2015

ABSTRACT Background and objective: Spinal anesthesia is a preferred method in daily

practice as it provides muscle relaxation and maintains spontaneous respiration during

surgical procedures. Opiods, midazolam, ketamine, propofol and dexmedetomidine are

 

[PDF] Evaluation of Use of Ketamine Hydrochloride for Induction of Anaesthesia in Rabbits with Experimentally Induced Unilateral Ureteral Obstruction

RI Udegbunam, KC Ogbanya, SO Udegbunam… – 2015

ABSTRACT This study investigated the anaesthetic characteristics of ketamine

hydrochloride in rabbits with Unilateral Ureteral Obstruction (UUO). Two groups of rabbits (B

and C) were anaesthetized with 30 mg kgG1 ketamine intravenously (IV) on days 7 and

 

Case 62: What Are the Safety Data for This Formulation?

JG Brock-Utne – Clinical Research, 2015

Discussion We were faced with this problem when we wanted to use ketamine intrathecally.

References 1. Brock-Utne JG, Mankowitz E, Kallichurum S, Downing JW. Effects of intrathecal

saline and ketamine with or without preservatives on the spinal nerve roots of monkeys.

 

[HTML] Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

W Tong, M Maira, M Gagnon, HU Saragovi – PLOS ONE, 2015

For pharmacological inhibition, the Src kinase inhibitor PP2 (20 μM) (Enzo Life Science),

NMDA-R antagonist ketamine (Bioniche Animal Health) (20 μM) or the PKA inhibitor H-89 (Sigma)

(20 ng/ml) were added to the resting cells 30 minutes before the indicated treatments.

 

[PDF] Development of Certified Reference Materials of Drug Abuse (Heroin, Etc) for Elimination of Measurement Error in Forensic Drugs

F Su, X Dai, H Li – Pharm Anal Acta, 2015

For the first time, we developed 9 illicit drug CRMs, including methamphetamine, heroin,

ketamine and others. CRMs Column Mobile phase Acetonitrile:water Flow Rate (mL/min)

Injection volume(uL) DAD (nm) Ketamine hydrochloride a 40:60* 1.5 20 210

 

[HTML] AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates

M Jeyanathan, Z Shao, X Yu, R Harkness, R Jiang, J Li… – PLOS ONE, 2015

Animals were euthanized first by anesthesia with ketamine (im 10 mg/kg) and then by a lethal

dose injection of sodium pentobarbital (iv 100 mg/kg). Experimental animals and handling.

Animals were anesthetized with ketamine (10 mg/kg) before handling.

 

The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction.

ME Chua, J Mendoza, IV See, E Esmena, D Aguila… – Canadian Urological …, 2015

Under sedation with isoflurane inhalation, all rats were subsequently anesthetized with

intraperitoneal (IP) ketamine (100 mg/kg) plus xylazine (15 mg/kg) after being preopera- tively

hydrated by subcutaneous injection of 5 cc saline mixed with indigo carmine (5,5

 

P-193TRACHEAL RESECTION WITH PATIENT UNDER LOCAL ANAESTHESIA AND SEDATION

FP Caronia, D Loizzi, A Fiorelli – Interactive CardioVascular and Thoracic Surgery, 2015

During the procedure the patient remained awake in conscious sedation achieved by bolus

of ketamine and midazolam. During the entire procedure the patient remained awake in

conscious sedation achieved by bolus of ketamine and midazolam.

 

[HTML] Neural Resolution of Formant Frequencies in the Primary Auditory Cortex of Rats

C Honey, J Schnupp – PLOS ONE, 2015

Anesthesia was induced by intraperitoneal injection of ketamine (Ketaset; Fort Dodge Animal

Health, Overland Park, Kansas, USA) and medetomidine (Domitor, Pfizer, Walton Oaks, Surrey,

UK), and maintained with intraperitoneal infusions of ketamine, medetomidine and

 

Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR

GS Masson, AR Nair, PPS Soares, LC Michelini… – American Journal of …, 2015

Analysis of Cardiovascular Parameters and Baroreflex Function 135 At the end of the protocols,

rats were anaesthetized (ketamine, 80 mg.kg−1 plus 136 calculated as BrS = –(P2×P3)/4. 152

After the physiologic measurements, animals were anesthetized (ketamine, 80 153

 

Combination of intravenous S-ketamine and oral tranylcypromine in treatment-resistant depression: A case report

L Bartova, SE Vogl, M Stamenkovic… – European …, 2015

Abstract Ketamine, a rapid-acting antidepressant and anti-suicidal agent, is thought to

increase brain monoamine levels by enhancing monoamine release or inhibiting

presynaptic monoamine-reuptake. Here we present two female inpatients suffering from

 

Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.

JW Wang, V Kivovich, L Gordon – Pediatric Emergency Care, 2015

Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain

subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,

leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical

 

Ketamine Abuse Syndrome

JW Wang, V Kivovich, L Gordon – 2015

Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain

subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,

leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical

 

Ondasetron Is More Likely Than Ketamine to Cause Ventricular Tachycardia

P Marzuillo, I Rabach, E Barbi – Pediatric Emergency Care, 2015

We read with interest the article published in the October 2014 issue of Pediatric Emergency

Care entitled “Ventricular tachycardia after ketamine sedation for fracture reduction.” Stukus

et al 1 described a 10-year-old female patient who experienced asymptomatic ventricular

 

The development of paper microfluidic devices for presumptive drug detection.

G Musile, L Wang, J Bottoms, F Tagliaro, B McCord – Analytical Methods, 2015

different lanes. A different colorimetric reaction occurs within each lane, permitting

the multiplexed detection of a variety of different compounds, including cocaine,

opiates, ketamine, and various phenethyl amines. Furthermore

 

[PDF] GLP-1 increases pre-ovulatory LH source and the number of mature follicles, as well as synchronizing the onset of puberty in female rats

V Outeiriño-Iglesias, M Romaní-Pérez… – Endocrinology, 2015

bregma. Cannulation was performed under ketamine/xylazine anesthesia (50

mg/kg and 5 mg/kg, respectively) and the correct placement of the cannula was

confirmed by postmortem injection of trypan- blue 0.5% (Sigma, St.

 

[HTML] Bispectral index-guided induction of anesthesia by ketofol infusion provides the same cardiovascular stability like that of etomidate infusion

HF Soliman – Ain-Shams Journal of Anaesthesiology, 2015

Get Permissions. Abstract, Introduction Various techniques have been tried to maintain

cardiovascular stability with anesthesia induction. This study compares the cardiovascular effects

of propofol-ketamine mixture versus etomidate during the induction of anesthesia.

 

[PDF] Anti-osteoporotic activity of ethanol extract of Terminalia arjuna (Roxb.) Wight & Arn. on ovariectomized rats

A Trivedi, HR Katti, MH Shalavadi, A Ramkishan… – Indian Journal of Natural …, 2015

Estrogen and Ketamine obtained from Neon Laboratories Ltd. Mumbai, India. After seven days

of acclimation, the rats were ovariectomized or Sham operated and then anesthetized with

Ketamine HCL (50 mg/kg, ip); the ovaries were removed bilaterally.

 

[HTML] Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles

W Cao, L Li, S Mii, Y Amoh, F Liu, RM Hoffman – PloS one, 2015

Animals were anesthetized by intramuscular injection of a 0.02 ml solution of 20 mg/kg

ketamine, 15.2 mg/kg xylazine, and 0.48 mg/kg acepromazine maleate. Non-transgenic nude

mice were anesthetized with a ketamine mixture (described above).

 

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin

KA Wunderlich, N Tanimoto, A Grosche, E Zrenner… – The FASEB Journal, 2015

Mice were dark- adapted (DA) overnight before the experiments and anesthetized with a

subcutaneous injection of a mixture of ketamine, xylazine, and physiologic saline. Ketamine

and xylazine were given at 66.7 and 11.7 mg/kg body weight, respectively.

 

Radiofrequency Ablation (RFA)

 

[PDF] Electrophysiological Bases of Torsion and Suction in the Continuous Cardiac Band Model

J Trainini, B Elencwajg, N López-Cabanillas… – Anat Physiol, 2015

early diastolic filling by the suction effect. We investigated the electrophysiological

basis of this mechanism, by electroanatomical left ventricular endoepicardial mapping

(EEM) in five patients, during radiofrequency ablation.

 

Uninterrupted Apixaban Safe and Effective in AF Ablation

EH Nichols – MD Conference Express, 2015

Summary. According to a multicenter, prospective registry study, uninterrupted apixaban used

in the periprocedural setting of radiofrequency catheter ablation in patients with atrial fibrillation

does not increase the risk of bleeding compared with uninterrupted warfarin.

 

Lateral Femoral Cutaneous Nerve Block

P Tumber, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Pain Pract. 2011;11(3):302–8.PubMedView Article; 15. Fowler IM, Tucker AA, Mendez RJ.

Treatment of meralgia paresthetica with ultrasound-guided pulsed radiofrequency ablation of

the lateral femoral cutaneous nerve. Pain Pract. 2012;12(5):394–8.PubMedView Article.

 

Sacroiliac Joint

PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Am J Phys Med Rehabil. 2006;85:997–1006.PubMedView Article; 6. Roberts S, Burnham R,

Ravichandiran K, Agur A, Loh E. Cadaveric study of sacroiliac joint innervation: implications

for diagnostic blocks and radiofrequency ablation. Reg Anesth Pain Med.

 

Ilioinguinal, Iliohypogastric, and Genitofemoral Nerve Blocks

D Bugada, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

2014;2014:371703. doi:10. 1155/ 2014/ 371703.PubMed CentralPubMed; 47. Terkawi AS,

Romdhane K. Ultrasound-guided pulsed radiofrequency ablation of the genital branch of the

genitofemoral nerve for treatment of intractable orchalgia. Saudi J Anaesth.

 

[HTML] Neoplastic disease after liver transplantation: focus on de novo neoplasms

P Burra, KI Rodríguez-Castro – World J Gastroenterol, 2015

Prognosis seems dismal according to reported cases, despite tapering of

immunosuppression, transarterial chemoembolization, radiofrequency ablation, hepatic

resection, or retransplantation. Strategies for preventing this neoplasm

 

Pediatric Nuclear Medicine

PJ Koo, FD Grant – Nuclear Medicine and PET/CT Cases, 2015

 

European Heart Rhythm Society, EHRA EUROPACE-CARDIOSTIM2015

RP Giugliano, S Bansilal, MP Bonaca, M Cavender… – MD Conference Express, 2015

Two registry studies examined the use of non–vitamin K antagonist oral anticoagulant

use in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation

(RFA). The first determined that AF patients can safely

 

[HTML] Propensity Score Matching Analysis of Changes in Alpha-Fetoprotein Levels after Combined Radiotherapy and Transarterial Chemoembolization for Hepatocellular …

Y Jeong, SM Yoon, S Han, JH Shim, KM Kim, YS Lim… – PLOS ONE, 2015

Advertisement.

 

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

N Lee, D Yoo, D Ling, MH Cho, T Hyeon, J Cheon – Chemical Reviews, 2015

When a resonant radiofrequency is irradiated, the nucleus absorbs the energy and the

number of the spins with a higher-energy state increases. During the relaxation process,

the excited nuclei emit a weak radiofrequency that can be detected.

 

Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency

D Hyun, SK Cho, SW Shin, KB Park, HS Park… – CardioVascular and …, 2015

Purpose To report the results of combined therapy with transarterial chemoembolization

(TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC)

considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE

 

The procedure outcome of laparoscopic resection for’small’hepatocellular carcinoma is comparable to vlaparoscopic radiofrequency ablation

M Casaccia, G Santori, G Bottino, P Diviacco… – 2015

Background: The aim of this study was to compare the effectiveness of laparoscopic liver

resection (LLR) and laparoscopic radiofrequency ablation (LRFA) in the treatment of small

nodular hepatocellular carcinoma (HCC). Patients And Methods: We enrolled 50 cirrhotic

 

PTH-177 Radiofrequency ablation for complicated barrett’s oesophagus: experience of a tertiary centre in northern ireland at 5 years

P Hall, O Reed, I Mainie – Gut, 2015

Abstract Introduction The 2013 British Society of Gastroenterology (BSG) guideline supports

first line use of endoscopic therapy in patients with dysplastic Barrett’s oesophagus or

intramucosal carcinoma (IMC). 1 Endoscopic mucosal resection (EMR) and

 

Observations on Attenuation of Local Electrogram Amplitude and Circuit Impedance During Atrial Radiofrequency Ablation: An In vivo Investigation Using a Novel …

A Bhaskaran, W Chik, C Nalliah, J Pouliopoulos… – Journal of Cardiovascular …, 2015

Aims To define the temporal characteristics of atrial lesion growth (lesion surface area), local

electrogram amplitude attenuation and circuit impedance decrement during in vivo Radio

Frequency (RF) ablation with direct endocardial visualization (DEV).

 

[HTML] Intraductal Radiofrequency Ablation Followed by Locoregional Tumor Treatments for Treating Occluded Biliary Stents in Non-Resectable Malignant Biliary Obstruction …

XH Duan, YL Wang, XW Han, JZ Ren, TF Li, JH Zhang… – PloS one, 2015

Objectives To determine the safety and feasibility of intraductal radiofrequency ablation

(RFA) followed by locoregional tumor treatments in patients with non-resectable malignant

biliary obstruction and stent re-occlusion. Methods Fourteen patients with malignant biliary

 

Sorafenib combined with radiofrequency ablation in the treatment of a patient with renal cell carcinoma plus primary hepatocellular carcinoma

G Gang, Y Hongkai, Z Xu – 2015

The combination of renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) is

extremely rare, and the prognosis for patients with these two cancers is poor. In the past

decade, molecular targeted therapy and radiofrequency ablation (RFA) have emerged

 

RADIOFREQUENCY ABLATION FOR BENIGN THYROID NODULES-A LOOK TOWARDS THE FUTURE OF INTERVENTIONAL THYROIDOLOGY

MA Lupo – Endocrine Practice, 2015

Welcome to the new Endocrine Practice website. Click HERE to access your account and reset

your password if this is your first visit. The IP ranges for your institution have already been added

to your account. You may wish to review this information under the Institutional

 

[PDF] Clinical Effect of Percutaneous Radiofrequency Ablation for Residual Lung Metastases from Breast Cancer After Systemic Chemotherapy

Y Wang, X Lu, Y Wang, J Zhou – Journal of the College of Physicians and Surgeons …, 2015

Breast Cancer (BC) is the most common malignant tumor in women and it is the leading cause

of death in women.1 The earliest and most frequent site of BC metastasis is the lungs and

bones, and no more than 5 – 20% of cases have only liver metastases.2 Metastatic BC

 

Recanalization of obstructed metallic uncovered biliary stent using endobiliary radiofrequency ablation

N Musquer, E Ménager Tabourel, D Luet… – Gastrointestinal Endoscopy, 2015

We present the case of a 57-year-old woman with a history of hilar cholangiocarcinoma type

3A of the Bismuth classification. A right hepatectomy after right portal embolization was

planned. Finally, because peritoneal carcinomatosis was diagnosed during surgery, a

 

Ventricular premature depolarization ablation and reversal of nonischemic cardiomyopathy

RC Arroyo, S Maeda, BP Betensky, P Santangeli, D Lin… – Interventional Cardiology, 2015

4.4 cm. CM: Cardiomyopathy; LVDD: Left ventricular end-diastolic dimension; LVEF:

Left ventricular ejection fraction; RFA: Radiofrequency ablation; VPD: Ventricular

premature depolarization. Ventricular premature depolarization

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

Lumbar Plexus and Femoral Nerve Block. Traditional and Ultrasound Guided Techniques

D Jankovic, J Kessler, AT Gray – Regional Nerve Blocks in Anesthesia and Pain …, 2015

5. Arterial occlusive disease and poor perfusion in the lower extremities. 6. Complex regional

pain syndrome (CRPS) types I and II. 7. Postamputation pain. 8. 3. Prophylaxis against complex

regional pain syndrome (CRPS). Contraindications. Specific. 1.

 

Superior Cervical Ganglion Block

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Therapeutic [ 3 ]. 1. Migraine [ 4 ], cluster headache, and headaches of cervical origin. 2. Complex

regional pain syndrome (CRPS) in the head region. 3. Perfusion disturbances and vasospastic

diseases. 4. Central poststroke syndrome (contralateral block!). 5. Facial pain. 6.

 

Brachial Plexus Blocks Above the Clavicle Traditional Techniques

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

10–20 mL local anesthetic – eg, 0.2–0.375 % ropivacaine or 0.25 % bupivacaine (0.25 %

levobupivacaine) in post-herpetic neuralgia, vascular diseases and injuries, complex

regional pain syndrome (CRPS) types I and II, post-amputation pain.

 

Stellate Ganglion Block

A Bhatia, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

AACN Clin Issues. 2005;16:320–32.PubMedView Article; 25. Stanton-Hicks MD, Burton

AW, Bruehl SP, et al. An updated interdisciplinary clinical pathway for CRPS: report of

an expert panel. Pain Pract. 2002;2:1–16.PubMedView Article; 26.

 

[HTML] The efficacy of different doses of Midazolam added to Lidocaine for upper extremity Bier block on the sensory and motor block characteristics and postoperative pain

A Honarmand, M Safavi, K Nemati, P Oghab – Journal of Research in Pharmacy …, 2015

24. 25. Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): A

novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic

dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat.

 

Complications of Peripheral Nerve Blocks

D Xu, A Hadzic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post–ischemia pain (CPIP): a novel

animal model of complex regional pain syndrome–type I (CRPS–I; reflex sympathetic dystrophy)

produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain.

 

Functional neurological symptoms

A Carson, J Stone – Landmark Papers in Neurology, 2015

 

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Page 1. ifssh ezine CoNNeCTiNG ouR GloBAl HAND suRGeRy FAmily

www.ifssh.info volume 5 issue 3 aUgUSt 2015 WHAT Does THe PRACTiCe oF HAND

THeRAPy looK liKe iN iFsHT memBeR CouNTRies? CoNseRvATive

 

Preparation of polydimethylaminoethyl methacrylate grafted attapulgite via ceric ion‐induced redox polymerization

H Xu, H Yang, S Xue, J Pan, Q Ni, F Gong – Journal of Applied Polymer Science, 2015

interests.[10-12] Surface-initiated graft polymerizations of various monomers onto inorganic

nanoparticles have been reported by using UV-induced polymerization,[13] conventional radical

polymerizations,[14] and controlled/living radical polymerizations (CRPs).[15, 16] CRPs

 

Total Elbow Arthroplasty for Distal Humerus Fractures

LS Harmer, J Sanchez-Sotelo – Hand Clinics, 2015

Mansat et al, 31 2013, 87, 80:7, Age: >65 Isolated #, —, A: 9 B: 8 C: 70, CM: 85 Lat: 1 Discovery:

1, 37.5 (6–106) (100%), 86 (45–100), 29–125/—, Hematoma: 5 CRPS: 2 Skin necrosis: 1 Neuro

injury: 7 Deep infection: 1 Stem #: 1 Stem loosening: 2 Elbow stiffness: 2 Peripros #: 1

 

Sacral roots stimulation in chronic pelvic pain

P Sokal, P Zieliński, M Harat – Neurologia i Neurochirurgia Polska, 2015

is not recommended because of long-term moderate effects and increased risk of major

complications [2]. The CPP with predominance of neuropathic pain can be the part of

failed-back-surgery syndrome (FBSS) or complex regional pain syndrome (CRPS) which are

 

[PDF] Probabilistic temperature forecasting based on an ensemble AR modification

A Möller, J Groß – arXiv preprint arXiv:1508.01397, 2015

Gneiting et al. (2005) propose to estimate the parameters by optimizing the continuous ranked

probability score (CRPS, Wilks, 2011) over the training data. EMOS AR-EMOS SLP MAE 2.042

2.036 1.969 CRPS 1.471 1.460 1.407 DSS 3.135 2.908 2.821

 

The value of SPECT/CT in carpal boss

U Bhure, U Hug, MW Huellner, H Grünig, A Zander… – European Journal of …, 2015

One patient was lost to follow-up after infiltration of CB. One patient had a complete response

to surgery initially but developed a CRPS (complex regional pain syndrome) some weeks after

surgery. Infiltration with complete response; surgery performed; CRPS during follow-up. 5.

 

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

G Littlejohn – Nature Reviews Rheumatology, 2015

fibromyalgia. Clinical features of CRPS. Neurogenic inflammation—comprising tissue

swelling, vasomotor changes and marked allodynia—also contributes substantially to

the clinical features of CRPS. 91. Neuropeptides in CRPS. Increased

 

[HTML] Memristive crypto primitive for building highly secure physical unclonable functions

Y Gao, DC Ranasinghe, SF Al-Sarawi, O Kavehei… – Scientific Reports, 2015

Our novel architecture demonstrates desirable characteristics of PUFs, including uniqueness,

reliability, and large number of challenge-response pairs (CRPs) and desirable characteristics

of strong PUFs. Number of CRPs. Figure 10: Number of CRPs.

 

Methods for Treating GI Syndrome and Graft versus Host Disease

JA Rotolo, RN Kolesnick – US Patent 20,150,216,971, 2015

Ceramide generated on the surface of endothelium coalesces to form ceramide-rich

platforms (CRPs) that transmit an apoptotic signal (Stancevic B., Kolesnick R.

Ceramide-rich platforms in transmembrane signaling. FEBS Lett.

 

Multivariate postprocessing techniques for probabilistic hydrological forecasting

S Hemri, D Lisniak, B Klein – Water Resources Research, 2015

river Lahn as these values lead to the best climatological forecasts in terms of the contin- uous

ranked probability score (CRPS, see equation (4)). The smaller the catchment, the of the EMOS

model are estimated by minimization of the CRPS over the training pe- riod.

 

Ambiguous anti‐fouling surfaces: Facile synthesis by light‐mediated radical polymerization

CW Pester, JE Poelma, B Narupai, SN Patel, GM Su… – Journal of Polymer Science …, 2015

the prevention of marine biofouling.[7, 8]. Controlled radical, surface-initiated

polymerizations (SI-CRPs) provide a robust and versatile strategy for the formation

of grafted polymer brushes. A variety of techniques have been

 

Fibromyalgia

 

Off-Label Trazodone Prescription: Evidence, Benefits and Risks

L Bossini, A Coluccia, I Casolaro, J Benbow… – Current Pharmaceutical …, 2015

depression, insomnia, anxiety (then Gen- eralized Anxiety Disorder, Post-Traumatic Stress

Disorder, Obses- sive-Compulsive Disorder and Panic Disorder), off-label uses (then bulimia,

benzodiazepine abuse, alcohol withdrawal, fibromyalgia, dementia, schizophrenia and

 

[PDF] Purification of A1PI from Human Plasma-an Improved Process to Achieve Therapeutic Grade Purity

NA Kumar, KL Rao, Z Chakraborthy, A Giri, KU Devi – J Chromatogr Sep Tech, 2015

due to congenital A1PI deficiency but as evident from the available literature, due to the multiple

biological activities of A1PI, it has been associated with other lung diseases (cystic fibrosis) and

many non-pulmonary diseases like vasculitis, fibromyalgia, asthma, pancreatitis

 

[PDF] Clinical features of musculoskeletal disorders due to hand-held devices

D Sharan – Proceedings 19th Triennial Congress of the IEA, 2015

Associated Disorder n % Myofascial pain syndrome of neck and upper back 48 69

Thoracic outlet syndrome 34 49 Fibromyalgia syndrome 07 10 Hypothyroidism 02 2.9

Extensor wrist tendinosis 04 5.7 De Quervain’s tenosynovitis 02 2.9

 

[PDF] Outcome of treatment of work related musculoskeletal disorders in on-site clinics in information technology companies)

DSMMR Ranganathan – Proceedings 19th Triennial Congress of the IEA, 2015

Common diagnosis made were Myofascial Pain Syndrome (49.20%), Fibromyalgia (8.5%),

Thoracic Outlet Syndrome (25.02%), Cubital Tunnel Syndrome (0.16%), Chronic Regional

Pain Syndrome (0.20%), and Wrist Tendinities (3.70%).

 

COMPLEX PHYSIOTHERAPEUTIC PROGRAM FOR IMPACT ON INDIVIDUALS WITH CHRONIC PAIN IN THE BACK AND LOW BACK.

YV Pashkunova – Activities in Physical Education & Sport, 2015

mechanical back pain associated with the work done are charac teristic for men.

Polymyalgia rheumatic, fibromyalgia, osteoporosis and diseases of parathyroid glands

are characteristic for women (Borenstein, 1998). Generally

 

[HTML] Animal-Assisted Therapy for People with Chronic Pain

MOT Kristen Counts

In 2013, a follow-up study was done with fibromyalgia patients (3) . Fibromyalgia is a disorder

characterized by widespread muscle pain that is accompanied by fatigue, sleep, memory, and

mood issues. Of course, the exercise further decreased my fibromyalgia symptoms.

 

[PDF] The barrier of hidden disabilities

Ε Βαβουράκη, Γ Παναγιάρης, Κ Σφλώμος – 2015

hyperactivity disorder(AD/HD), asthma and allergies, bipolar disorder, psychiatric disorders,

depression, anxiety, cancer, cardiac or respiratory conditions, chronic fatigue syndrome, colour

blindness, cystic fibrosis, diabetes, epilepsy, seizure disorders, fibromyalgia, HIV/AIDS

 

Superior Cervical Ganglion Block

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

number of patients. These observations principally concern patients with

pain-associated depression in chronic pain conditions (various types of headache,

migraines, facial pain, post-nucleotomy pain, fibromyalgia, etc.). In the

 

[HTML] Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot

S Wang, J Zhou, X Wei, P Li, K Li, O Wang, F Wei… – Rheumatology: Current …, 2015

Arthritis Res Ther 10: R117. Schmechel DE, Edwards CL (2012) Fibromyalgia, mood disorders,

and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology

33: 1454-1472. Goldring MB, Goldring SR (2007) Osteoarthritis.

 

[PDF] Examining the relationship between childhood victimization, health risk behaviors, and adult physical health outcomes among women on probation and parole.

TR Renn – 2015

Chartier, Walker & Naimark (2009) Female & Male Obesity OR=1.61 Rohde et al. (2008)

Female Adjusted for age and race Obesity OR=1.84 Alexander et al (1998) Fibromyalgia

Heitkemper et al (2001) Irritable bowel syndrome Rich-Edwards, et al.

 

Thalamic Mechanisms Underlying Alpha-Delta Sleep with Implications for Fibromyalgia

S Vijayan, EB Klerman, GK Adler, N Kopell – Journal of Neurophysiology, 2015

Abstract Alpha-delta sleep is the abnormal intrusion of alpha activity (8-13 Hz oscillations)

into the delta activity (1-4 Hz oscillations) that defines slow wave sleep. Alpha-delta sleep is

especially prevalent in fibromyalgia patients and there is evidence suggesting that the

 

SP0131 Fibromyalgia: What is New

LJ Crofford – Annals of the Rheumatic Diseases, 2015

Abstract Further clarification of the impact of FM classification criteria has emerged with a

higher prevalence and greater proportion of men identified with the modified 2010 criteria.

This together with ongoing epidemiologic studies has confirmed the relationships

 

Pelvic Floor and Urinary Distress in Women with Fibromyalgia

KD Jones, C Maxwell, SD Mist, V King, MA Denman… – Pain Management Nursing, 2015

Abstract Fibromyalgia (FM) patients were recently found to have more symptom burden from

bothersome pelvic pain syndromes that women seeking care for pelvic floor disease at a

urogynecology clinic. We sought to further characterize pelvic floor symptoms in a larger

 

[PDF] Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

DJ Engen, SJ McAllister, MO Whipple, SS Cha, LJ Dion… – J Integr Med, 2015

ABSTRACT BACKGROUND: Fibromyalgia is a syndrome characterized by chronic pain,

fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies

have reported decreased intracellular magnesium levels in patients with fibromyalgia and

 

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

G Littlejohn – Nature Reviews Rheumatology, 2015

Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical

phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in

each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both

 

Validation of fibromyalgia survey questionnaire and polysymptomatic distress scale in a Persian population

A Bidari, B Ghavidel-Parsa, AA Maafi, A Montazeri… – Rheumatology International, 2015

Abstract The aim of this study was to assess validity of the fibromyalgia survey questionnaire

(FSQ) and polysymptomatic distress scale (PSD) in an Iranian population. We also sought to

classify the severity levels of fibromyalgia (FM) symptoms according to the PSD scale.

 

Health anxiety and depression in patients with fibromyalgia syndrome

M Uçar, Ü Sarp, Ö Karaaslan, AI Gül, N Tanik, HO Arik – Journal of International …, 2015

Methods Patients with FMS and healthy control subjects were recruited. All participants

completed the Health Anxiety Inventory Short Form (HAI-SF) and Beck Depression Inventory

(BDI). Pain was assessed in patients with FMS using the Fibromyalgia Impact

 

Subgroups of fibromyalgia patients using the 1990 American College of Rheumatology criteria and the modified 2010 preliminary diagnostic criteria: the al-Ándalus …

V Segura-Jiménez, A Soriano-Maldonado… – Clinical and experimental …, 2015

OBJECTIVES: We aimed to investigate the symptom profiles in subsets of fibromyalgia

patients according to the subgroups created from the satisfaction of the 1990 American

College of Rheumatology (ACR) diagnostic criteria (1990c) and/or the modified 2010 ACR

 

Effects of music on pain in patients with fibromyalgia

GB Alparslan, B Babadağ, A Özkaraman, P Yıldız… – Clinical Rheumatology, 2015

Abstract Fibromyalgia syndrome (FMS) is a chronic syndrome characterized by diffuse

musculoskeletal system pain and painful tender points in certain areas of the body. The aim

of the investigation was to determine the effects of music on pain in fibromyalgia patients.

 

[HTML] Oral Burning With Dysphagia and Weight Loss

TM Seccia, G Rossitto, LA Calò, GP Rossi – Medicine, 2015

Accepted June 22, 2015. Collapse Box Abstract. Abstract: Fibromyalgia is a disorder characterized

by an abnormal pain regulation. We report on the case of a patient with fibromyalgia, who

presented with dysphagia, odynophagia, and glossodynia as prevalent symptoms.

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