by admin | May 21, 2015 | Uncategorized
First randomized clinical trial shows efficacy of intravenous ketamine for treating Posttraumatic Stress Disorder
A team of researchers put intravenous (IV) ketamine therapy to the test in forty-one patients with chronic Posttraumatic Stress Disorder (PTSD). Their results were published in the Journal of the American Medical Association Psychiatry (JAMA Psychiatry). This was the first randomized clinical study of its kind, pinning IV ketamine against an active placebo, IV midazolam. The primary outcome measure of the study was change in PTSD symptom severity. To this end, ketamine was associated with “significant and rapid reduction in PTSD symptom severity, compared with midazolam”. Interestingly, ketamine was also associated with a reduction in comorbid depressive symptoms and an improvement in overall clinical presentation, a novel finding in these difficult to treat patients.
Further, the authors found intravenous ketamine in this cohort of patients to be well tolerated without clinically significant persistent dissociative symptoms. This study provides the first evidence for the rapid treatment of PTSD using intravenous ketamine—a finding that will hopefully support novel approaches to the pharmacologic treatment of patients with this disabling condition.
Dr. Ashraf Hanna, M.D. and his team of expert clinicians at the Florida Spine Institute utilize IV ketamine infusion therapy to treat a myriad of diseases. To find out if IV ketamine might be right for you, please make an appointment with Dr. Hanna.
Full Article: Feder A, Parides MK, Murrough JW, et al. Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2014;71(6):681-688. doi:10.1001/jamapsychiatry.2014.62.
by admin | May 14, 2015 | Uncategorized
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
[PDF] Transscalene Brachial Plexu Approach for Brachial Plexus
SR Totawar – Age, 2015
… tchy action of the block, the block was converted to general anesthesia. If in case surg e effect
of the block wore off, rescue analgesia with intravenous ketamine given. … In the circumstance
of nesthesia. If in case surgery was unduly us ketamine given. …
Giuseppe D’Agostino1, 2*, Claudia Cristiano1, 2, 3, David J. Lyons2, Rita Citraro4, Emilio Russo4
C Avagliano, R Russo, GM Raso, R Meli, G De Sarro… – 2015
… pharmacological PPAR-α agonist treatment in mice improves behavior in a pharmacological
model of ketamine-induced behavioral dysinhibition and repetitive behavior in BTBR T+ tf/J mice. …
Keywords: lipids; nuclear receptor; ketamine; memory; neurodevelopmental disorders; …
[PDF] Efficacy conventional intersc approach Vs novel transscal of brachial plexus block
SR Totawar – 2015
… In the circumstance of inad anaesthesia. If in case surgery was undu intravenous
ketamine given. … If in case surgery was unduly prolonged and the effect of the block
wore off, rescue analgesia with intravenous ketamine given. …
Radiofrequency Ablation of the Pancreas: Protective Effect of Local Cooling Techniques
A Geranios, E Pikoulis, A Papalois, M Kontos… – The American Surgeon, 2015
… 1). Surgical Procedure The animals were anesthetized with ketamine (15–20 mg/kg) and
midazolam (0.5 mg/kg) in- tramuscularly and then intubated. The maintenance of anesthesia
was achieved by thiopental (3.5 mg/kg/hr) and fentanyl (15 mg/kg/hr). …
[HTML] Original Study Enhancement of Acute Tendon Repair Using Chitosan Matrix
E Melamed, BG Beutel, D Robinson – Am J Orthop, 2015
… Tikva, Israel. The rats were anesthetized with ketamine 90 mg/kg and xylazine 10
mg/kg, both administered intramuscularly, and anesthesia was prolonged as needed
with 2% isoflurane, administered by nose cone. The skin …
[PDF] Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia
HCS Abeysinghe, L Bokhari, GJ Dusting, C Roulston – J Neurol Neurophysiol, 2015
… food and water. Rats were anaesthetized using a mixture of Ketamine/Xylazine
(75 mg/kg: 10 mg/kg respectively ip) and maintained throughout surgery by inhalation
of isoflurane (95% oxygen and 5% isoflurane). A 23-gauge …
Antiseizure medications
S Sanders – Seizures in Dogs and Cats
… felbamate (FBM); ketamine (KET); lacosamide (LCM). Summary. … The uncommon drugs include
felbamate (FBM), ketamine (KET), lacosamide (LCM), and propofol (PRO). Some of the rarely
used drugs are carbamazepine, ethosuximide, and valproic acid. Get PDF (344K). …
Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline …
M Grobman, A Graham, H Outi, JR Dodam, CR Reinero – Journal of Feline Medicine …, 2015
… 23 Briefly, ketamine (30 mg IV) was used as a premedicant, propofol was used for induction
(6 mg/kg) and maintenance (0.3 mg/kg/min), and cisatracurium (0.1 mg/kg IV of with additional
doses of 0.01–0.02mg/kg titrated to effect) was administered for neuromuscular blockade. …
[PDF] Evaluation of Anti-inflammatory and Analgesic Activities of Cymbopogon citratus in vivo-Polyphenols Contribution
R Garcia, JP Ferreira, G Costa, T Santos, F Branco… – Research Journal of …, 2015
… Ketamine (Ketalar, 7.7 mg kgG )1 was purchased from Parke-Davis, Pfizer (Seixal,
Portugal) Chlorpromazine (Largatil, 2.3 mg kgG )1 was purchased from
Rhône-Poulenc Rores, Laboratório Vitória SA (Amadora, Portugal). …
Acute neurokinin-1 receptor antagonism fails to dampen airflow limitation or airway eosinophilia in an experimental model of feline asthma
M Grobman, S Krumme, H Outi, JR Dodam… – Journal of Feline Medicine …, 2015
… 19 Briefly, ketamine (30 mg IV) was used as a premedicant, propofol was used for induction
(6 mg/kg) and maintenance (0.3 mg/kg/min), and cisatracurium (0.1mg/kg IV, with additional doses
of 0.01–0.02 mg/kg titrated to effect) was administered for neuromuscular blockade. …
Radiofrequency Ablation (RFA)
Radiofrequency Ablation of the Pancreas: Protective Effect of Local Cooling Techniques
A Geranios, E Pikoulis, A Papalois, M Kontos… – The American Surgeon, 2015
Pancreatic carcinoma is one of the commonest malignant diseases today and the majority of
patients are suitable for palliative treatment only. Radiofrequency ablation (RFA) has been
used extensively for the treatment of solid organ tumors but little is known on the efficacy …
Effects of renal denervation from the intima and the adventitia of renal arteries on renal sympathetic nerve activity in dogs: a comparative study
M Bai, C Yang, C Gao, X Wang, H Liu, Y Zhang, J Liu… – Cardiology, 2015
… A cardiac radiofrequency ablation catheter was then applied to ablate the adventitia from the
outside, also of 8 W or less and lasting up to 2 min each to obtain up to six ablations separated
both longitudinally and rotationally, which was the same as the ablation of renal …
[PDF] Laryngopharyngeal Reflux: a Syndrome that Mimics Asthma
M Merchant – Proceedings of UCLA Healthcare, 2015
… Surgical options include minimally invasive procedures such as radiofrequency ablation of the
lower esophageal sphincter as well as endoscopic Nissen Fundoplication, a procedure where
the surgeon wraps the stomach around the distal esophagus to create a tight valve. …
Helical DeNervation Ablation Catheter Apparatus
J Mogul – US Patent 20,150,126,992, 2015
… sympathetic nerves which run through the adventitia of the renal arteries using radiofrequency
(RF) energy … The catheter’s RF-ablation electrode(s) will then be deployed by movement of the
slider … the endoluminal, or inner arterial, surface of the artery in order to ablate the renal …
Method and Apparatus for Tissue Ablation
VK Sharma, H Jabs – US Patent 20,150,126,990, 2015
… can use one or more sources of infrared, electromagnetic, acoustic or radiofrequency energy
to … anal canal; engaging the targeted hemorrhoid by suctioning the hemorrhoid into the ablation
device; and, delivering the ablative agent to the hemorrhoid to ablate the hemorrhoid …
[PDF] N. Ayez1, EP van der Stok1, DJ Grünhagen1, J. Rothbarth1, E. van Meerten2, AM Eggermont3, C. 5 Verhoef1 6 7
DJ Grünhagen – 2015
… Local treatment was performed in 122 170 patients (47%) (surgery, radiofrequency ablation,
stereotactic radiotherapy), 112 patients (43%) had 171 palliative chemotherapy and 29 patients
(11%) received neither chemotherapy nor local treatment. 172 …
METHOD AND SYSTEM FOR SKIN TREATMENT
M Jurna, JA Palero, MR Horton – US Patent 20,150,126,913, 2015
… The modifier is configured to decrease the electrical impedance for the radiofrequency energy,
in particular … exploited concurrent with and/or directly subsequent to the burning and/or ablation
step and … as the aforementioned 70° C., and/or the laser is used to ablate skin portions …
Operative Techniques in Thoracic and Esophageal Surgery
M Hawn – 2015
Apparatus and Methods Related to Constrained Deployment of Cryogenic Balloons for Limited Cryogenic Abiation of Vessel Walls
B Kelly, J Kelly, G Kelly, B Mullins – US Patent 20,150,126,986, 2015
… As compared to ablation lesions formed via radiofrequency energy, cryotherapy typically utilizes
much less power … vessel wall and thus results in a smaller nominal treatment area/ablation pattern
than … In another embodiment (not shown), if it is desired to ablate more than half of …
[PDF] Long-term efficacy of radiofrequency ablation compared to surgical resection for the treatment of small hepatocellular carcinoma
X Bu, Z Ge, J Ma, S Guo, Y Wang, J Liu
Xiangyang Bu1,2*, Zhong Ge3*, Jian Ma4, Shanyuan Guo5, Yi Wang3, Jun Liu6 1Department
of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250021, China; 2Department
of Hepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao 266011, China; …
Complex Regional Pain Syndrome (CRPS/RSD)
Evolving Chinese Restaurant Processes for Modeling Evolutionary Traces in Temporal Data
P Wang, C Zhou, P Zhang, W Feng, L Guo, B Fang – Advances in Knowledge …, 2015
… To model cluster branching over time, ECRP lets each cluster in current epoch form a Chinese
Restaurant Process (CRP) and uses the combination of cluster-specific CRPs as the prior for
clusters in the next epoch. … where ωt−1,k and ωt,O are the weights of CRPs. …
Practical Problems With Clinical Guidelines for Breast Cancer Prevention Based on Remaining Lifetime Risk
AS Quante, AS Whittemore, T Shriver, JL Hopper… – Journal of the National …, 2015
… To evaluate discrimination, we computed the overall AUC and we plotted case risk
percentiles (CRPs, also called standardized placement values) (21) for the subjects who
developed breast cancer within 10 years of recruitment (case patients). …
PIPERIDINE COMPOUND AND ITS USE IN PEST CONTROL
S Arimori – US Patent 20,150,126,516, 2015
… A01N43/58. Related US Applications: 20040209906, Composition comprising
ketanserin AND AN ALKANOYL L-CARNITINE FOR THE TREATMENT OF CRPS,
October, 2004, Cavazza et al. 20070249732, USE OF CERTAIN …
[PDF] News from the Patient Liaison Committee: The brave new world ‘How are pain services evolving–the impact on patients?’
A Chuter – Reltebon® Oxycodone Prolonged-release Tablets, 2015
Page 16. March 2015 Vol 13 No 1 l Pain News 13 Pain News 2015, Vol 13 (1)
13–14 © The British Pain Society 2015 News After months of planning by Geraldine
Granath, Colin Preece, Liz Killick, Austin Leach and Antony Chuter …
SYSTEMS AND METHODS FOR COMPOUND MOTOR ACTION POTENTIAL MONITORING WITH NEUROMODULATION OF THE PELVIS AND OTHER BODY …
KD Benson, VR Lucente, JR Miklos – US Patent 20,150,126,894, 2015
… Neuromodulation has also been used safely and effectively to help relieve chronic back pain,
pain from cancer and other nerve injuries, and pain from Complex Regional Pain Syndrome
(CRPS) and Reflex Sympathetic Dystrophy (RSD), greatly improving the quality of life for …
[PDF] EXPLORATION OF FACTORS ASSOCIATED WITH PATIENT ADHERENCE IN UPPER EXTREMITY REHABILITATION: A MIXED-METHODS EMBEDDED DESIGN
EV Smith-Forbes – 2015
… Multi-joint Fracture Multiple 0.0% 0.0% 0.0% 2.0% CRPS 0.0% 0.0% 0.0% 1.6% Nerve Injury
0.0% 0.0% 0.0% 1.2% … MCID= minimal clinical important difference, DRUJ= distal radio-ulnar
joint, CRPS = complex regional pain syndrome, ROC = receiver operator characteristics …
[PDF] Temperature Dependent Dielectric Model at 1.4 GHz for an Agricultural Soil Thawed and Frozen
VL Mironov, AY Karavaysky
… 0.513 The results of validation measurements for the soil CRPs are displayed in
Fig. … range. To obtain the error of the developed model, we correlated the predicted
CRPs with the ones especially measured for validation. In Fig. …
[PDF] A Bayesian A Bayesian Beta Markov Random Beta Markov Random Field Calibration of the Term structure of implied risk neutral densities densities
R Casarin, FR Casarin, F Leisen, GMGMG Molina…
Page 1. A Bayesian A Bayesian Beta Markov Random Beta Markov Random Field Calibration
of the Term structure of implied risk neutral densities densities Roberto Casarin, Fabrizio Roberto
Casarin, Fabrizio Leisen, German Molina German Molina German Molina, …
Fibromyalgia
[PDF] Heart rate turbulence analysis in female patients with fibromyalgia
O Solak, H ToktasIV – 2015
OBJECTIVE: Fibromyalgia is characterized by diffuse musculoskeletal pain and discomfort.
There are several reports regarding autonomic nervous system dysfunction in patients with
fibromyalgia. Heart rate turbulence is expressed as ventriculophasic sinus arrhythmia and …
[HTML] FIBROMYALGIA: CURABLE
ME Platt – Alternative Medicine, 2015
Abstract From a survival standpoint, the body always wants to make sure the brain has
enough fuel.[…] any time the body detects a low amount of fuel in the brain, it releases
adrenaline to raise sugar levels.[…] use of these methods often leads to a cure for …
[PDF] Association of Impaired Sleep Quality in Patients With Burning Mouth Syndrome: A Case-Control Study
F Arbabi-Kalati, NM Bakhshani, B Tahmtan… – 2015
… deprivation. Sleep deprivation can also lead to mood changes, insomnia and fatigue,
affecting pain sensation (2). Patients with known fibromyalgia have a lower noc- turnal
sleep quality compared to controls and have more insomnia …
Dizziness, Lightheadedness, and Syncope in a Patient with Type 2 Diabetes
S Paturi, JL Gilden, F FCP – Diabetes Case Studies: Real Problems, Practical …, 2015
Vagally mediated heart rate variability in headache patients—a systematic review and meta-analysis
J Koenig, DWP Williams, AH Kemp, JF Thayer – Cephalalgia, 2015
… capabilities (21). Lower vmHRV is reported in a variety of chronic painful conditions,
such as chronic neck pain (22), chronic pelvic pain (23), complex regional pain (24),
fibromyalgia (25,26) and irritable bowel syndrome (27). In …
Novel Therapeutic Uses of Mu-Opiate Receptor Peptides
TE Maione – US Patent 20,150,126,455, 2015
… pain. 16. The method, according to claim 1, used to reduce chronic noncancer pain
selected from pain associated with arthritis, neuropathy, low back pain, osteoarthritis,
fibromyalgia, headache, and diabetic neuropathy. 17. …
Brain-gut axis: gastroenterology-IBS
J Wright – The Specialist Forum, 2015
… to controls. Interestingly, this hypoalgesia was even greater in patients with concomitant
fibromyalgia, suggesting a commonality between these two symptom-driven diagnoses.
Anticipatory factors may also play a part. In experiments …
[PDF] A Pilot Study Measuring Outcomes of Managing Fascial Health for Individuals With Fibromyalgia
KB Segarra
Abstract This article examines the outcomes of managing fascial health for persons
diagnosed with fibromyalgia based on the protocol developed by the author, Dr. Kirstie
Bender Segarra, and implemented in a pilot study of five clients. The protocol was …
[PDF] The Somatosensory Amplification in Vitiligo and Chronic Urticaria Patients: A Controlled Study
M Sukan, F Maner – J Neurol Disord, 2015
… Amplification may be a pathogenic mechanism in certain specific amplification
disorders such as fibromyalgia and irritable bowel syndrome [9]. Some individuals
are generally more sensitive to bodily sensation than others. …
Psychotherapy and mental health as a psychological science discipline
HU Wittchen, S Härtling, J Hoyer – Verhaltenstherapie, 2015
… which behavioural factors play a significant role in the initiation, maintenance and rehabilitation,
such as cancer (eg [Fors et al., 2011]), cardiovascular disease (eg [Gulliksson et al., 2011]),
metabolic disease and obesity (eg [Grilo et al., 2012]), and fibromyalgia [Kashikar-Zuck et …
by admin | May 8, 2015 | Uncategorized
Neuropathic pain is often very difficult to treat with current Food and Drug Administration (FDA)-approved analgesics. The most commonly prescribed medication to treat these chronic pain conditions is opioids. Opioids have very limited efficacy in patients with chronic neuropathic pain conditions. This has sparked research into new targets for the treatment of these patients. Promising research by investigators at the Cleveland Clinic demonstrated that microglial inflammation is a common pathway for neuropathic pain and other treatment-resistant neuroinflammatory conditions, such as Alzheimer’s disease (AD).
“Microglial inflammation is a mechanism of many CNS disorder – neuropathic pain, Alzheimer’s disease, multiple sclerosis, parkinsonism, you name it,” said lead researcher Mohamad Naguid, MD, of Cleveland Clinic’s Anesthesiology Institute, Department of Pain Management.
Subsequently, this team of researchers has synthesized a molecule called MDA7, which is a cannabinoid type 2 (CB2) receptor-selective agonist. Preliminary studies with this new drug candidate have shown that it can inhibit microglial activation and recruitment, which is fundamental to microglial inflammation and neuropathic pain.
Thus far, their research is in the preclinical phase. They have shown efficacy in a rodent model of Chemotherapy-induced neuropathic pain1, CRPS (not yet published), and some promising results in an animal model of Alzheimer’s disease2. They hope to test MDA7 in humans as a next step. The team is very hopeful that their preclinical results translate well to the clinic. Only time will tell.
References:
1. Naguib, M., Xu, J.J., Diaz, P., Brown, D.L., Cogdell, D., Bie, B., Hu, J., Craig, S., Hittelman, W.N., 2012. Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system. Anesthesia and analgesia 114, 1104-1120.
2. Bie, B., Wu, J., Yang, H., Xu, J.J., Brown, D.L., Naguib, M., 2014. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Nature neuroscience 17, 223-231.
by admin | May 5, 2015 | Uncategorized
Many Americans live with chronic pain in one form or another. About 52.5 million Americans report having been diagnosed with some illness that causes chronic pain, like arthritis, rheumatoid arthritis, lupus, gout, or fibromyalgia. The symptoms of chronic pain can be very severe and can dramatically affect a person’s quality of life. Finding relief of pain due to chronic pain syndromes can be tough, but according to Harvard Medical School, tai chi could help.
Tai chi is a martial art that began as a form of defensive techniques but has evolved into a method of relaxation and active meditation. Movements are slow and fluid, and people participating in tai chi breathe naturally and deeply while focusing on an area of the body just below the navel, which is said, in the practice, to store the body’s “chi.”
According to a study published in the New England Journal of Medicine, tai chi can actually help some chronic pain patients. There are a number of different chronic pain medications and procedures like nerve blocks, minimally invasive surgeries, and the use of ketamine to treat pain, but tai chi could be a good supplement to any of these, not to mention a way to keep active through the symptoms of chronic pain. Compared to a control group, a group of fibromyalgia patients reported less pain, depression, and more sleep after six weeks of tai chi.
In a survey that asked participants about the four most common types of pain, respondents said that back pain was the most common (27%), followed by severe headache and neck pain — both at (15%), and facial pain (4%). Americans spend about $86 billion each year on back pain alone, so finding effective methods is helpful for those who haven’t found relief any other way.
It can be hard, but staying active through chronic pain can actually help relieve it, and tai chi is an easy and low-impact way of doing it. It’s usually practiced in classes where participants learn the moves and exercises, and then do them alone at home.
by admin | May 5, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
One of the most fascinating drugs in the anesthesiologist’s armament is ketamine, an N-
methyl-D-aspartate receptor antagonist with a myriad of uses. The drug is a dissociative
anesthetic and has been used more often as an analgesic in numerous hospital units, …
Acute administration of ketamine inhibited stress induced pro-inflammatory cytokines in hippocampus of rats
G Unal, G Terzioglu, C Sahin, GY Demirel, F Aricioglu – Bulletin of Clinical …, 2015
Objective: Major depression is a complex and devastating disease which one-third of
patients still do not respond to current treatments. It has been demonstrated that there is a
correlation between high levels of plasma cytokines such as IL-1β, IL-6, IL-18 and TNF-α …
The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.
GS Aylan, N Sarper, U Demirsoy, E Zengin, E Çakmak – Turkish journal of …, 2015
OBJECTIVE: The aim of this study is to investigate the efficacy and safety of sedoanalgesia
performed outside the operating room by pediatricians trained in advanced airway
management and life support. MATERIALS AND METHODS: Midazolam and ketamine …
[HTML] Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and …
GS Vasconcelos, NC Ximenes, CNS de Sousa… – Schizophrenia Research, 2015
Abstract Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid
(ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied
the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of …
Low Dose Ketamine Infusion For Managing Acute Pain
M Yetim, S Tekindur, Y Emrah Eyi – The American Journal of Emergency Medicine, 2015
Dear Editor, We read with great interest the article “Short (low-dose) ketamine infusion for
managing acute pain in the ED: case-report series” written by Goltser et al (1). We believe
that this original study provides a new and insightful approach to pain management in …
[PDF] Symptomatic remission and hippocampus volume in schizophrenia
PT Chang, JF Lirng, YH Chou – Bulletin of Clinical Psychopharmacology, 2015
… 1):S146-S7 [Abstract:0577] Neuroimaging in psychiatry Alterations in resting state electrocortical
network oscillations, schizophrenia-like symptoms and their relationships induced with the
administration of the NMDA receptor antagonist ketamine in human volunteers …
G535 (P) The development and implementation of a policy promoting parental (patient) involvement in escalation of clinical care
MA Webster, C Haines, J Fraser – Archives of Disease in Childhood, 2015
… www.midstaffspublicinquiry.com/report (accessed 28 Nov 2014) G536(P) THE CHALLENGES
OF SETTING UP A KETAMINE SEDATION SERVICE IN THE PAEDIATRIC ED – LEARNING
LESSONS AND EFFECTING CHANGE 1E Dewhirst, 1C Whitehouse, 2T Waterfield. …
[PDF] Eyes tell the psychopathology: preliminary findings
H Balibey, C Basoglu, A Ates, A Algul, R Tutuncu… – Bulletin of Clinical …, 2015
… On the other hand, the behavioral and pharmacological effects of the noncompetitive
N-methyl-D-aspartate (NMDA) receptor antagonist ketamine have been used to study
important aspects of psychotomimetic action in humans. …
Adjunctive Use of Ceftriaxone and Sodium Valproate in the Management of Tetanus: A Case Report and Literature Review
S Oriaifo, N Oriaifo, M Oriaifo, E Okogbenin, E Omogbai – Journal of Biology, …, 2015
… immune globulin. Control of spasms was mainly by the use of the GABAergic-
enhancing drugs diazepam and sodium valproate combined with the use of the
anti-excitotoxics magnesium sulphate and ketamine. The introduction …
PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines
T Arai, K Tsuchiya, E Matsumura – Organic Letters, 2015
… adduct (27%, 80% ee). The formation of the chiral N,O-acetal inspired us to optimize
the reaction conditions for the addition of methanol to an isatin-derived
N-Boc-ketamine (1a), as shown in Table 1. Table 1. Optimization of …
Radiofrequency Ablation (RFA)
Radiofrequency Ablation for Atrial Fibrillation: Trends in Patients, Clinical Outcomes, and Resources Among Medicare Beneficiaries from Fiscal Year 2010 to Fiscal …
MR Reynolds, AD Kugelmass, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
Abstract Introduction: The objective of this analysis was to report four year trends among
Medicare beneficiaries (MB) undergoing Radiofrequency Ablation (RFA) to treat Atrial
Fibrillation (AF). Methods: This retrospective study examined both the Medicare Provider …
Systematic review and meta-analysis of perinatal outcomes following radiofrequency ablation and bipolar cord occlusion in monochorionic pregnancies
K Gaerty, RM Greer, S Kumar – American Journal of Obstetrics and Gynecology, 2015
Objective The aim of this study was to analyse perinatal outcomes following selective
reduction in monochorionic pregnancies using either radiofrequency ablation (RFA) or
bipolar cord occlusion (BCO). Study Design This was a systematic review and meta- …
Sublobar Resection, Radiofrequency Ablation or Radiotherapy in Stage I Non-Small Cell Lung Cancer
S Safi, G Rauch, J Kunz, T Schneider, M Bischof… – Respiration, 2015
Background: The best therapy for patients with stage I non-small cell lung cancer (NSCLC)
who are medically unfit for lobectomy or prefer not to undergo surgery has not yet been
demonstrated. Objectives: We analyzed data from our prospective database to evaluate …
The efficacy of radio-frequency ablation for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage …
Y Naya, T Nakamura, M Oishi, T Ueda, H Nakanishi… – International Journal of …, 2015
… Okuma et al. [14] reported that tumors under 20 mm in size can be completely ablated in lung
tumor. … Cancer 3:1409–1419 7. Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation
of unresectable primary and metastatic hepatic malignancies. Results in 123 patients. …
Metastastectomy for metachronous pulmonary and hepatic metastases from nasopharyngeal carcinoma: Report of 6 cases and review of the literature
SJM Lim, NG Iyer, LL Ooi, HN Koong, A Chung, HK Tan… – Head & Neck, 2015
… not prevent disease progression in the long term. Surgery and radiofrequency ablation have … ten
patients who underwent radiofrequency ablation +/- adjuvant chemotherapy had a median survival
period of 77.1 months compared to 32.4 months in another ten patients who only …
[HTML] Lobulated Enhancement Evaluation in the Follow-Up of Liver Metastases Treated by Stereotactic Body Radiation Therapy
H Jarraya, P Borde, X Mirabel, O Ernst, T Boulanger… – International Journal of …, 2015
… have limitations for the evaluation of targeted therapies; for example, imatinib for gastrointestinal
stromal tumors (GIST) and bevacizumab for colorectal liver metastasis 8, 9 and 10 or other local
treatments, such as lung tumor SBRT (11), liver radiofrequency ablation (12), and …
Percutaneous microwave ablation of thyroid nodules: effects on thyroid function and antibodies
K Heck, C Happel, F Grünwald, H Korkusuz – International Journal of Hyperthermia, 2015
… The results demonstrated that in all 30 sessions the complete volume of the 34
nodules could be ablated. The treatment … al. Radiofrequency ablation of benign thyroid
nodules: Safety and imaging follow-up in 236 patients. Eur …
Current state of the treatment of perforating veins
ED Dillavou, M Harlander-Locke, N Labropoulos… – Journal of Vascular Surgery: …, 2015
… Table II. Technical success of radiofrequency ablation (RFA), endovenous laser ablation (EVLA),
and ultrasound-guided foam sclerotherapy (UGFS). Primary author (year), Perforator treatment
modality, No. … 14, 15, 18 and 26. Radiofrequency ablation (RFA). …
Irreversible Electroporation of the Pancreas Is Feasible and Safe in a Porcine Survival Model.
S Fritz, CM Sommer, D Vollherbst, MF Wachter… – Pancreas, 2015
… From a histopathological point of view, the ablated area was character- ized by cellular eosinophila …
The ability of IRE to ablate undesirable tissue near large blood vessels and damageable … of the
electric field to which the tissue is exposed.13 Radiofrequency ablation has been …
An Analysis of Patients Transferred to a Tertiary Oncological Intensive Care Unit for Defined Procedures
S Kamat, S Chawla, P Rajendram, SM Pastores… – American Journal of Critical …, 2015
Skip to main page content. …
Complex Regional Pain Syndrome (CRPS/RSD)
Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS
AS Won, CA Tataru, CM Cojocaru, EJ Krane… – Pain Medicine, 2015
… Letter to the Editor. Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. … How
to Cite. Won, AS, Tataru, CA, Cojocaru, CM, Krane, EJ, Bailenson, JN, Niswonger, S. and Golianu,
B. (2015), Two Virtual Reality Pilot Studies for the Treatment of Pediatric CRPS. …
A dynamic PUF anti-aging authentication system based on restrict race code
B Li, S Chen – Science China Information Sciences, 2015
… Based on the CRP mechanism, the PUF circuit can produce chip-unique responses when
challenges are applied to it and stored in the database by the way of CRPs. (2) Authentication. …
The expected data in the database are called CRPs in paper. …
Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?
RG Boles, EA Zaki, JR Kerr, K Das, S Biswas… – Mitochondrion, 2015
… Herein, we tested for these variants in chronic fatigue, CRPS, SIDS and depression. … CVS = cyclic
vomiting syndrome, Fxn abd pain = functional abdominal pain (a common pediatric functional
syndrome), IBS = irritable bowel syndrome, CRPS = complex regional pain syndrome. …
[HTML] TURAN and EVAN Mediate Pollen Tube Reception in Arabidopsis Synergids through Protein Glycosylation
H Lindner, SA Kessler, LM Müller, H Shimosato-Asano… – 2015
… Abbreviations:: ConA, Concanavalin A; CRPs, cysteine-rich polypeptides; CrRLK1L, Catharanthus
roseus receptor-like kinase 1-like subfamily; DAE, days after emasculation; DAP, days after
pollination; DAPI, 4′,6-diamidino-2-phenylindole; DEFL, defensin-like protein; Dol-P …
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to post-fracture nociceptive sensitization.
X Shi, T Guo, T Wei, W Li, DJ Clark, WS Kingery – PAIN, 2015
… neuropeptide-dependent nociceptive and inflammatory changes in the hindlimbs of rats similar
to those seen in complex regional pain syndrome (CRPS). Inflammatory changes … inflammatory
mediators contributing to nociceptive sensitization in a rodent fracture model of CRPS. …
Ketamine-A Narrative Review of Its Uses in Medicine.
BM Radvansky, S Puri, AN Sifonios, JD Eloy, V Le – American Journal of Therapeutics, 2015
… pain clinics, and in the prehospital realm. It has been used to treat postoperative pain, chronic
pain, complex regional pain syndrome (CRPS), phantom limb pain (PLP), and other neuropathic
conditions requiring anal- gesia. … CRPS has remained a difficult-to-treat entity. …
Trends in Coronary Revascularization Procedures among Medicare Beneficiaries between Fiscal Years 2010 and 2013
A Kugelmass, MR Reynolds, DJ Cohen, PP Brown… – … : Cardiovascular Quality and …, 2015
… Mortality rates were highest and increasing for MBs presenting with STEMI across all procedures.
Conclusions: The overall volume of CRPs among MBs is declining and more MBs are presenting
with an AMI, and overall mortality rates are increasing year over year. …
CORD STIMULATIONS IN PATIENTS WITH COMPLEX REGIONAL PAIN SYNDROME: A RANDOMIZED PLACEBO CONTROLLED TRIAL
N Kriek, J Groeneweg, D Stronks, F Huygen
… N. Kriek, J. Groeneweg, D. Stronks, F. Huygen Center for pain management, Erasmus MC,
Rotterdam, The Netherlands Objectives: Spinal cord stimulation (SCS) is an effective invasive
therapy to treat neuropathic pain states including complex regional pain syndrome (CRPS). …
[HTML] Diagnostic value of C-reactive protein to rule out infectious complications after major abdominal surgery: a systematic review and meta-analysis
SL Gans, JJ Atema, S van Dieren, BG Koerkamp… – International Journal of …, 2015
… The posttest odds were calculated by multiplying the pretest odds with the positive and
negative LR. Posttest probabilities for a high and a low CRPs were calculated and presented
in a graph for pretest probabilities across the range of 0 to 100 %. …
[HTML] World congress comes to you 7: Yes we can (control chronic pain)
V Bellan
… If you want more information on CRPS you might find what we know about CRPS helpful as
well as these resources by the Royal College of Physicians. You can also read recent research
published by the team and browse through our CRPS blog articles. …
Fibromyalgia
Factors Associated With Time to Diagnosis in Fibromyalgia
G Chodick, D Weitzman, Y Bar-On, V Shalev, H Amital – Journal of Patient-Centered …, 2015
Background/Aims: The diagnosis of fibromyalgia, a chronic debilitating disorder, is
complicated and affected by various factors of the patient and the caregiver. The objectives
of this study were to investigate the time passing from initial complaints to diagnosis and to …
[PDF] Central Sensitization Syndrome and the Initial Evaluation of a Patient with Fibromyalgia: A Review
KC Fleming, MM Volcheck – Rambam Maimonides Med J, 2015
ABSTRACT In both primary care and consultative practices, patients presenting with
fibromyalgia (FM) often have other medically unexplained somatic symptoms and are
ultimately diagnosed as having central sensitization (CS). Central sensitization …
Does low bone density influence symptoms and functional status in patients with fibromyalgia? Observations from rural South India
AS Babu, FM Ikbal, MS Noone, AN Joseph, D Danda – International Journal of …, 2015
Results Low BMD was seen in 81.6%(129/158) of the persons screened. FMS was seen in
37/158 persons, of which 31/37 (83.7%) had low BMD. Conclusion FMS with low bone
density leads to higher levels of pain and a poorer QoL compared to those without FMS. …
[PDF] Walking as physical exercise in Fibromyalgia: An elicitation study from the Theory of Planned Behavior
MÁ Pastor, S López-Roig, Y Sanz, C Peñacoba – anales de psicología, 2015
Abstract: This study is the first phase of the formative research recommended in the Theory
of Planned Behavior for the development of an intervention. Our aims are to identify modal
beliefs about the performance of an exercise pattern in people with fibromyalgia, to test …
… advances in spinal cord and brainstem fMRI provide an unprecedented view of human pain processing and alterations to pain mechanisms in fibromyalgia
R Bosma – 2015
Abstract: Functional MRI of the human spinal cord and brainstem has tremendous potential
to enhance our basic understanding of healthy subcortical function, and impact our ability to
accurately diagnose and treat injury and disease. Despite this potential, there are many …
Understanding High Blood Pressure
S Aziz – 2015
Overcoming Low Self-Esteem with Mindfulness
D Ward – 2015
[HTML] Efficacy and processes of change in acceptance and commitment therapy for chronic pain
M Kemani – 2015
… The first trial utilized a wait-list control condition and included women with fibromyalgia (Study
I). Assessments were done pre- and post-treatment and at 3-month follow-up. … Acceptance and
commitment therapy for fibromyalgia: A randomized controlled trial. …
[PDF] Evaluation of psychiatry consultations requested for inpatients in a university hospital
H Mayda, HI Guzel, Y Gorucu, E Bagcioglu – Bulletin of Clinical Psychopharmacology, 2015
… [Abstract:0282] Psychosomatic disorders Metacognitive evaluation in patients with fibromyalgia
syndrome … In this study, we tested the assumption that patients with Fibromyalgia Syndrome (FMS)
experience more metacognitive thoughts compared to healthy individuals. …
[PDF] Investigation of state and trait anxiety levels among pharmacy students in TRNC
YH Balcıoglu, E Duran – Bulletin of Clinical Psychopharmacology, 2015
… Bulletin of Clinical Psychopharmacology 2015;25(Suppl. 1):S93-S4 [Abstract:0452] Anxiety,
stress, and adjustment disorders Angiotensin-converting enzyme and
methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome …
by admin | May 4, 2015 | Uncategorized
Nocturnal leg cramps are sudden contractions of the lower leg and foot muscles. They often awaken you from sleep. The calf muscles are most often involved. The cramps are harmless. They do not mean that you have a serious disease.
The specific cause of nocturnal leg cramps is unknown. These cramps may be related to imbalances in local muscle chemistry. Many activities and diseases are associated with nocturnal leg cramps:
- Overexertion of the muscles
- Standing on hard surfaces
- Prolonged sitting
- Certain leg positions while inactive
- Dehydration
- Diseases
- Diabetes
- Parkinson’s disease
- Hypoglycemia
- Hormone disorders (eg, thyroid imbalance )
- Chemical imbalances (eg, calcium, potassium, magnesium)
- Certain medications
- Blood pressure medicines
- Statins (that lower cholesterol)
- Morphine
- Lithium
The following factors increase your chance of developing nocturnal leg cramps:
- Age over 50
- Overexertion
- Pregnancy
- Staying in certain positions for a long time
- Flat feet or other foot or ankle deformities
- Alcoholism
- Neurologic diseases
- Certain medicines
- Diabetes
- Parkinson’s disease
- Hypoglycemia
- Hormone disorders (eg, thyroid imbalance )
- Chemical imbalances (eg, calcium, potassium, magnesium)
- Sudden nighttime calf (or foot) cramps
Your doctor will ask about your symptoms and medical history. A physical exam will be done.
Tests may include the following:
- Blood tests
- Checking your foot pulses for good circulation
Talk with your doctor about the best plan for you. If no specific cause can be found, treatment options include the following:
- When cramps occur, pull against them with your leg muscles. Also, grab your foot (feet) and pull up.
- Standing on the affected leg often stops the cramping.
- Massage and hot or cold treatments to help the muscles relax.
None of these medicines has earned full approval for either safety or efficacy. Quinine , while often effective for reducing the frequency and intensity of cramps, has a significant risk of major allergic reactions. The other prescription medications carry risks as well. So, they are not generally recommended. They are most often used in only severe cases.
- Diphenhydramine hydrochloride (Benadryl)
- Calcium
- Quinine sulfate
- Simple muscle relaxants (eg, meprobamate , Equanil, Robaxin )
- Verapamil hydrochloride (Calan, Isoptin, Verelan)
- Chloroquine phosphate (Aralen)
- Hydroxychloroquine sulfate (Plaquenil)
- Carbamazepine (Tegretol)
- Phenytoin (Dilantin)
To reduce your chance of getting nocturnal leg cramps, take the following steps:
- Stretch three times a day and just before going to bed.
- Face a wall and put your hands on the wall and keep them there. Step backward. Keep your knees locked. Keep your heels on the floor until you feel a strong pull in your calves. Hold that position for 10 seconds. Repeat two or three times.
- Exercise feet and legs regularly.
- Drink plenty of liquids.
- Eat plenty of potassium-rich foods. This includes bananas, tomatoes, potatoes, broccoli, cantaloupe, oranges, and grapefruit.
- Wear comfortable, supportive shoes.
- Sleep with toes up, not pointed downward.
The College of Family Physicians of Canada
http://www.cfpc.ca/
Women’s Health Matters
http://www.womenshealthmatters.ca/
