Celebrity Chef, Catherine Ruehle, on Foods to Ease Rheumatoid Arthritis

Celebrity Chef, Catherine Ruehle, on Foods to Ease Rheumatoid Arthritis

by | May 4, 2015 | Uncategorized

What would you do if rheumatoid arthritis ended a thriving life as a star cake artist? Catherine Ruehle, a former contestant on “Food Network Challenge,” faced that situation. In this exclusive interview, she shares how her anti-inflammatory RA diet and lifestyle led to a new career…

Catherine Ruehle, 45, was known for creating one-of-a-kind cake masterpieces at her Sublime Bakery in Fort Worth, Texas.

So when the seasoned baker appeared on the reality show “Food Network Challenge” in 2010, her competitors were ready for a formidable opponent.

But Ruehle surprised everyone – including herself – when she had to withdraw from the show. The reason? Her hands stopped working as she was making a cake.

At first, she chalked up her symptoms to long hours in the bakery. But when her hand pain worsened, she saw a doctor. The diagnosis: rheumatoid arthritis (RA), a chronic autoimmune disease that causes joints to become inflamed and painful.

“I was shocked,” Ruehle tells Lifescript. “I was 41 at the time, and always believed RA was an elderly person’s disease.”

In fact, RA most commonly begins between ages 30 and 60 but can occur even earlier, according to the Arthritis Foundation. Its symptoms can build slowly or strike suddenly, as it did with Ruehle.

Still, she couldn’t just stop baking, so she “plodded along in denial,” she says.

“When I first started experiencing pain in my hands, it was Christmas – the busiest season at my bakery – and I couldn’t take time off,” Reuhle says. “It became hard to do everyday tasks, such as [screwing] the top off a water bottle or bending my elbows to brush my hair.”

Finally, she had to close her bakery in 2011. But Reuhle’s food career wasn’t over. She now has a business helping other people improve their health with diet and lifestyle changes.In this exclusive Lifescript interview, Ruehle reveals how she has learned to manage her condition through an anti-RA diet.

What symptoms led to your RA diagnosis?
I had pain and stiffness throughout my entire body – it started in my hands and spread to my elbows, ankles, legs and toes. The pain was so bad that I initially worried I might have bone cancer.

Is that what led you to see a doctor?
I procrastinated when it came to making a doctor’s appointment. It was the holiday season and I was swamped. I convinced myself that my body was just tired from spending long hours in the bakery.

What convinced you to see a doctor?
The [symptoms got worse, so] I went to see my doctor. I asked if there was a way to alleviate my pain so that I could enjoy Christmas with my family, and then return for testing.

He gave me a shot of prednisone [an anti-inflammatory steroid], which immediately eased my stiffness.

After the holidays, I went in for tests, which included blood work and a rheumatoid factor blood test. The tests indicated that I had RA.

[Editor’s note: No single test can confirm RA, so Ruehle’s doctor asked about her joint symptoms, how and when they started, how severe they were, and what, if anything, made them better or worse. She was also given a blood test that measured her inflammation levels and the rheumatoid factor blood test, which measures the antibody most common in RA. Although high levels of rheumatoid factor are associated with more severe rheumatoid disease, it can also be present in patients with other conditions such as lupus or hepatitus and in people who have family members with RA.]

What was your reaction to the RA diagnosis?
While I was glad I didn’t have bone cancer, I was shocked to learn I had RA. I lead an active lifestyle, and have always eaten healthfully – I felt as if my body was betraying me.

I also didn’t [know] how severely it would affect my life. I wondered if I would eventually have disfigured, arthritic hands.

I immediately began to read everything I could find out about RA so that I could weigh my treatment options.

What did you learn about the condition?
I was intrigued by evidence that RA is caused by an overactive immune system. I realized my immune system was angry and attacking my body.

I wanted to see if I could treat the cause with anti-RA diet and lifestyle changes. I discovered a functional medicine expert, Dr. Mark Hyman, and adopted his mantra as my own: “Treat the fire, not the smoke.”

How did your rheumatologist feel about this idea?
[He] told me diet had nothing to do with RA inflammation. But my gut told me that [what I ate] would have everything to do with my long-term health.

What dietary changes have you made?
I [now] describe my diet as a whole foods, mostly organic plan that’s also free of corn, gluten and dairy.

I discovered evidence that foods, such as vegetables and omega-3 [oils in] fish, can ease an overactive immune system. And I decided to load up on nutrient-dense plant foods and drink green juice daily.But I avoid nightshade vegetables (such as tomatoes, peppers and eggplants), because I found they set off my arthritis symptoms.

[Editor’s note: Some arthritis patients say these vegetables increase symptom flares; there’s little scientific proof that they cause inflammation].

While I enjoyed a couple glasses of wine for my recent birthday, I can’t drink it every night because it also exacerbates my condition.

With your anti-RA diet, was it hard to give up certain foods?
I’m a foodie, so it wasn’t easy. Rather than concentrate on foods I couldn’t have, I tried to focus on what I could eat.

What are some of your favorite healthy foods?
[In place of] cow’s milk, I now use coconut milk for cooking and in smoothies. It contains selenium, an important antioxidant that controls free radicals and has been shown to relieve the symptoms of arthritis.

[Editor’s note: Selenium-rich foods, which also include whole grains and shellfish, may be useful in preventing arthritis symptoms, according to the Arthritis Foundation.]

I also eat a lot of green, leafy vegetables. I had never eaten kale before [my diagnosis]; now I have it every day. I also eat hemp seeds, nuts such as walnuts and almonds, and cold-water fish including salmon and sardines – all inflammation-fighting foods.

What other lifestyle changes have you made?
I’ve started working to eliminate stress in my life, which has shown to be a cause of RA flare-ups.How do you combat stress?
I’ve become addicted to yoga and subscribe to an online service that streams yoga videos. I’ve found that practicing it daily not only strengthens the core and improves flexibility, it also helps me sleep better, feel more centered and clear-headed, and gives me more energy.

I went through a divorce this past year and lost my father, and I know doing yoga helped me cope better with the loss and stress.

Are you still working as a chef?
I closed my bakery shortly after my diagnosis, because [the business] involved long, unpredictable hours. I needed a schedule that was more manageable and less stressful.

How did your RA diagnosis lead to a career change?
In my quest to learn more about the effects of diet on health, I enrolled in a yearlong online study program through the Institute for Integrative Nutrition, where classes are taught by health experts, including Dr. Andrew Weil and Dr. Deepak Chopra.

I have a business, A Well-Nourished Life, where I create individualized wellness programs, including meal plans. My goal is to help [people with chronic illnesses] improve their symptoms and regain their health. I do custom meal planning and preparation for some clients.

And I just finished writing Gluten Free Cakes, a cookbook that will be published by Ten Speed Press [in September 2014].

Have you found any gadgets that make cooking easier?
One of my favorite tricks is using those nonstick squares that you place under rugs to open bottles. They make it so much easier! Oxo also makes a vegetable peeler with oversized rubber handles.

I also use a gel floor mat in the kitchen that can make it easier on your knees if you’re standing and cooking for long periods of time.

How’s your health today?
I’m doing great and continue to be primarily pain- and symptom-free – as long as I stick to my diet and exercise regimen.Here are three of Ruehle’s anti-RA recipes.

All recipes reprinted with permission from Catherine Ruehle’s A Well-Nourished Life.

Oven Roasted Beets & Brussels Over Kale with Raw Honey-Ginger Dressing

Serves: 2-4

Ingredients
2 medium beets, washed, peeled and cubed
3 cups whole Brussels sprouts, washed & halved
1 tablespoon extra virgin olive oil
1 head kale, washed and coarsely chopped
Pinch pink Himalayan sea salt (optional)
2 tablespoons pine nuts (optional)
1 tablespoon fresh ginger root, grated
1 tablespoon raw honey
1 lemon, juice only
1-2 teaspoons organic oil, such as toasted sesame or extra virgin olive oil
Salt & pepper to taste

Preparation
1. Preheat oven to 400 degrees.

2. Toss the beets and Brussels sprouts with the olive oil in a bowl to coat well. Spread out on a foil-lined baking sheet in a single layer.

3. Roast in the oven until tender and darkened at the edges, about 25 minutes, rotating the pan halfway through the cooking time.

4. While the veggies are roasting, combine the dressing ingredients in a small bowl and whisk together.

5. Toss the chopped kale with half the dressing and set aside while veggies roast.

6. Remove veggies from oven. Spread the kale on the serving plates. Place the hot veggies in the same bowl the kale was in and add the remaining dressing; toss to coat.

7. Layer the beets and Brussels sprouts over the kale on the serving plates. Top with the sea salt and pine nuts. Season with salt and pepper to taste.Zucchini & Herb Fritters with Mint-Yogurt Sauce

Ingredients
3 large zucchini, grated
1 teaspoon salt
1 shallot, diced
1 garlic clove, diced
2 eggs
1 tablespoon chopped fresh mint
1/2 cup crumbled feta cheese (optional)
1/4 cup gluten-free flour mix (I like Angel’s), or all-purpose flour if not gluten-free
Salt & pepper to taste
Olive oil for sautéing

For the Yogurt-Mint Sauce:
1 cup Greek yogurt (or nondairy yogurt like Amonde or So Delicious)
2 tablespoons chopped fresh mint
1 tablespoon chopped fresh dill
Juice of 1 lemon
Salt and pepper to taste

Preparation
1. Place the grated zucchini in a colander and sprinkle with the salt. Allow to sit for about 15 minutes while you chop your shallot and garlic.

2. Squeeze the excess moisture out of the zucchini then place in a large bowl.

3. Add shallot, garlic, eggs, mint, feta and flour to the zucchini. Combine and season with salt and pepper.

4. Add enough olive oil to your saute pan to coat the bottom of the pan and heat over medium. While pan heats, use your hands, two spoons, or an ice cream scoop, to form balls of zucchini mixture.

5. Place 3-4 balls into your hot pan, and press down to flatten to about 1 inch tall. Make sure you keep at least 2 inches between each fritter so they will brown nicely and not “steam” each other.

6. Cook on each side for about 2-3 minutes until golden. Remove to a paper towel to drain.

7. Combine all ingredients for the Yogurt-Mint Sauce.

8. Serve fritters warm or room temperature with sauce on top or on the side.

Note: Fritters will keep in the refrigerator for 3 days or in the freezer for 1 month. Sauce keeps in refrigerator for 3 days. Vegan Chocolate Pudding

Serves: 4

Ingredients
2 ripe avocados, peeled and pit removed
1 cup canned coconut milk, chilled overnight and liquid drained off
3/4 cup organic maple syrup
3/4 cup raw organic cacao powder
1 teaspoon pure vanilla extract
1 teaspoon ground cinnamon
Pinch fine sea salt

Preparation
1. Add all ingredients to a blender or food processor and blend until smooth.

Note: you want to use only the thick coconut “cream,” reserve the liquidy coconut water for another use such as smoothie. Don’t skip the chilling step or you may not be able to separate the cream from the water, resulting in a thin pudding.

Emerging Research

Emerging Research

by | Apr 30, 2015 | Uncategorized

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Rapid antidepressant Action and Restoration of Excitatory Synaptic Strength after Chronic Stress by Negative Modulators of alpha5-containing GABAA Receptors.

J Fischell, AM Van Dyke, MD Kvarta, TA LeGates… – … : official publication of the …, 2015

… The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but

has troubling side-effects. We hypothesized that negative allosteric modulators of

GABAA receptors would exert similar effects on brain activity …

 

Temporal evoltion on MRI of successful treatment of rabies

A Lu, P Shah, P Shen, P Lee, AE Nidecker… – Clinical Imaging, 2015

… Her treatment regimen came to be known as the “Milwaukee protocol” [1]. Briefly, the

protocol consists of using a sedative agent such as ketamine, midazolam, propofol, or

a combination to place the patient in a medically induced coma. …

 

[PDF] A Gelatin-Based Prophylactic Sealant for Bowel Wall Closure, Initial Evaluation in Mid-rectal Anastomosis in a Large Animal Model

Y Kopelman, Y Nir, Y Siman-Tov, B Person, O Zmora – J Gastrointest Dig Syst, 2015

… Preemptive analgesia (intramuscular Dipyron 1 gr) was given to all any amounts prior to surgery.

The animals were anesthetized with a combination of Ketamine 22 mg/mL and Xylazine injection

(Apectrum Chemicals and Laboratory Products, Gardena, California) 1 mg/kg IM. …

 

[PDF] The optimal fitting model for aging-related receptive field size curve of macaque V1 neurons

J Cui, H Ding, L Wang, J Qiang – … on Mechatronics, Electronic, Industrial and Control …, 2015

… of 28 years. An initial ophthalmological examination was performed under ketamine

(100 mg/kg im, Ketalar, Parke-Davis, Morris Plains, NJ, USA) anesthesia to screen

for monkeys with ocular pathology. B. Visual Stimulation …

 

[PDF] Preventing Testicular Damage in Genital Burns With Cooling: An Experimental Study

AE Abalı, H Özdemir

… The sham group (S group) consisted of 10 healthy testes. In this group, rats were anesthetized

with an intraperitoneal injection of 100 mg/kg ketamine hydrochloride (Alfamine 10%, Alfasan,

Holland) and 10 mg/kg … Animals were killed by high-dose ketamine HCl. …

 

[PDF] JAMES A. McNAMARA, JR., DDS, Ph. DT

T KURODA

… Page 2. Ketamine & Phencyclidine . . . … Dosage, prepared according to levels

recommended by other investigators-fit10:11 was as fol- lows: phencyclidine HCl,

1.5 ngkg. of body weight (intramuscular); ketamine HCI, 25 mgjkg. …

 

Fine-scale genetic structure of the ringtail (Bassariscus astutus) in a Sky Island mountain range

RC Lonsinger, RM Schweizer, JP Pollinger, RK Wayne… – Journal of Mammalogy, 2015

… Traps were baited with dry cat food and either loganberry paste or sardines. Captured ringtails

were anesthetized using a mixture of medetomidine hydrochloride (50 µg/kg) and ketamine

hydrochloride (5mg/kg) injected intramuscularly (Orion Corporation, Espoo, Finland). …

 

[PDF] Evaluation of the Effect of Alfalfa Extract on Breast Cancer

F Nabatchian, SMH Aghoosi, A Mordadi, F Khodaverdi – J. Appl. Environ. Biol. Sci, 2015

… normal saline. In the solution, the tumor was cut into 3 mm2 pieces. Then, the mice

in the first and second groups were anesthetized with intraperitoneal injection of

ketamine (10 mg/kg) and xylene (5 mg/kg). The tumor pieces …

 

Effects of light pollution on seasonal estrus and daily rhythms in a nocturnal primate

T LeTallec, M Théry, M Perret – Journal of Mammalogy, 2015

… Ltd, Saint-Paul, Minnesota) previously implanted in the visceral cavity under general anesthesia

and under veterinary supervision (Diazepam-Valium: 1mg/100g, subcutaneous injection; Ketamine

hydrochloride-Imalgen: 10mg/100g, intraperitoneal injection; postoperative …

 

[PDF] Evaluation of Cissampelos pareira root for antifertility activity

J Samanta, S Bhattacharya, AC Rana – Journal of Pharmacy Research Vol, 2015

… from D1 pregnancy. On day 12th day (D12) all the rats of control and treated group

were anaesthetized with normal dose of ketamine-xylazine anaesthesia15 and

laparotomized to count the no. of implants of each rat. 2.3.6. Effectsof …

 

 

Radiofrequency Ablation (RFA)

 

[HTML] Transcatheter embolization therapy in liver cancer: an update of clinical evidences

YXJ Wáng, T De Baere, JM Idée, S Ballet – Chinese Journal of Cancer Research, 2015

… 2-4). For the treatment of early stage HCC, curative therapies including liver transplantation,

hepatic resection, and radiofrequency ablation (RFA) are … coagulative necrosis of both the tumor

and a rim of surrounding parenchymal tissue producing a margin of ablated non-tumoral …

 

CATHETER WITH ATRAUMATIC TIP

ES Olson, JV Kauphusman, LK Nemec, TT Tegg – US Patent 20,150,112,331, 2015

… According to at least one medical study (See, eg, Ikeda et al., Radiofrequency Ablation Catheter

with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine

Heart, Conference Proceedings of the Hearth Rhythm Society, May 2008 and …

 

ELECTRICAL STIMULATION OF THE CAROTID ARTERY

I Gillbe – US Patent 20,150,112,359, 2015

… or bodies without heating the tissues to a temperature at which they are ablated such that … the

RF energy delivered is of a non-thermal nature, so that ablation and possible … As previously

described, pulsed radiofrequency is employed for this purpose; comprising short bursts of …

 

METHOD TO REDUCE SENSE OF TASTE AND FOOD INTAKE

H Li – US Patent 20,150,112,326, 2015

… To ablate the subsurface tissue without ablating the surface tissue of the mouth, a room … During

a heat induced ablation with fluid cooling, ablation head and the tissue surface in … delivered into

it from an energy source such as ultrasound, microwave, and radiofrequency current. …

 

MODULATION OF NERVES INNERVATING THE LIVER

BR Azamian, JA Coe, SB Vafai – US Patent 20,150,112,332, 2015

… In some embodiments, the neuromodulation catheter is a radiofrequency (RF) ablation catheter

comprising … about substantially 180 degrees of the vessel circumference to ablate in a … In some

embodiments, other patterns of ablation electrode movement (regardless of inherent …

 

BALLOON CATHETERS WITH FLEXIBLE CONDUCTING WIRES AND RELATED METHODS OF USE AND MANUFACTURE

MR Willard, DC Sutermeister, KR Larson, TA Ostroot… – US Patent 20,150,112,328, 2015

… Sympathetic nerve ablation device 12 may be used to ablate nerves (eg, renal nerves) disposed

adjacent to the kidney K (eg, renal nerves … Sympathetic nerve modulation device 12 may be

configured to deliver ablation energy, for example, radiofrequency energy, to a target …

 

Current Control Methods and Systems

H Cadouri – US Patent 20,150,112,321, 2015

… an energy field to a target site in the renal artery (eg, via radiofrequency ablation) have been … above

45° C. (or above 60° C. in other cases) may induce thermal ablation of the … In some patients, it

may be desirable to achieve temperatures that thermally ablate the target neural …

 

DIAPHRAGM ENTRY FOR POSTERIOR SURGICAL ACCESS

SD Fleischman, R Neubert, EW Rogers – US Patent 20,150,112,145, 2015

… Atrial fibrillation surgery involving radiofrequency, DC, microwave, ultrasound, laser or other

modes of thermal … of focusing energy into local areas spaced at known distances from the ablation

device (in … tissue in the ventricles from the diaphragm) are used to ablate the imaged …

 

[PDF] ASRA/ESRA/INS/AAPM/WIP/NANS guidelines for interventional spine and pain procedures in patients on antiplatelets and anticoagulants

S Narouze, HT Benzon, D Provenzano, A Buvanendran…

… C, cervical; T, thoracic; L, lumbar; S, sacral; MBNB, medial branch nerve block; RFA,

radiofrequency ablation *Patients with high risk for bleeding undergoing low or intermediate

risk procedures should be treated as internmediate or high risk repectively. …

 

SYSTEM AND METHOD FOR TREATING URINARY TRACT DISORDERS

U Eshel – US Patent 20,150,112,413, 2015

… transurethral microwave thermotherapy (temperatures over 46 degrees Celsius that cause tissue

ablation to exposed … that the higher level of heat in the surrounding non-ablated tissue either … It

includes a catheter with a sheathed radiofrequency antenna, surrounded by a flow of …

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

What is the maximum safe tourniquet time in elective upper limb surgery?

N Sawant, GEB Giddins – Journal of Hand Surgery (European Volume), 2015

… Two patients developed chronic regional pain syndrome type 1 (CRPS 1). In one patient this

was noticed 4 weeks following complex rheumatoid surgery. The tourniquet time was 2 hours

4 minutes and there was no immediate post-operative pain or distal paraesthesia. …

 

RODENT RUN

MJ Dixon, PM Taylor, B Dixon – US Patent 20,150,107,525, 2015

… [2] Millecamps, Laferrière, Ragavendran, Stone, Coderre: “Role of peripheral endothelin receptors

in an animal model of complex regional pain syndrome type 1 (CRPS-I)” J Pain, volume 151

(2010) pages 174-183; [3] Ugo Basile Leaflet for Von Frey Hairs (with grid) Cat. No. …

 

Using Computing with Words for Managing Non-cooperative Behaviors in Large Scale Group Decision Making

FJ Quesada, I Palomares, L Martínez – Granular Computing and Decision-Making, 2015

… sufficiently to reach the solution made. In order to overcome this drawback, Consensus

Reaching Processes (CRPs) were introduced as an additional phase in the resolution

process for GDM problems [17]. In a CRP, experts try …

 

The Parturient With Implanted Spinal Cord Stimulator: Management and Review of the Literature

AC Young, TR Lubenow, A Buvanendran – Regional Anesthesia and Pain Medicine, 2015

… Complex regional pain syndrome (CRPS) is neuropathic pain syndrome that is more common

in women, with some studies showing a higher prevalence among women aged 25 to 50

years. … Patient 3 suffered from CRPS of the right upper extremity. …

 

Decision Makers’ Opinions Changing Attitude-Driven Consensus Model under Linguistic Environment and Its Application in Dynamic MAGDM Problems

B Dutta, D Guha – Granular Computing and Decision-Making, 2015

… Based on the concept of soft consensus, vari- ous consensus reaching processes

(CRPs) have been designed in the literature [22]. The existing CRPs for solving GDM

problems can be classified in two categories: static consensus …

 

Peripheral Nerve Stimulationperipheral nerve stimulation

AS Hanna – Anatomy and Exposures of Spinal Nerves, 2015

… Download Chapter (482 KB). Abstract. Peripheral nerve stimulation is an off-label use of spinal

cord stimulators. It is used for intractable pain in a peripheral nerve distribution, refractory to

medical management, especially with complex regional pain syndrome (CRPS ). …

 

[HTML] External Fixation and Adjuvant Pins Versus Volar Locking Plate Fixation in Unstable Distal Radius Fractures: A Randomized, Controlled Study With a 5-Year Follow- …

JH Williksen, T Husby, JC Hellund, HD Kvernmo… – The Journal of Hand …, 2015

… At the 5-year follow-up, 3 patients had died, 1 (with an extensor pollicis longus rupture) had moved

abroad, and 2 (1 patient with complex regional pain syndrome [CRPS]) withdrew from the study. …

Carpal tunnel syndrome, 2, 1. CRPS, 0, 1. Extensor tendon synovitis, 0, 5. …

 

Complex regional pain syndrome type I: a comprehensive review

M Bussa, D Guttilla, M Lucia, A Mascaro, S Rinaldi – Acta Anaesthesiologica …, 2015

… Background. Complex regional pain syndrome type I (CRPS I), formerly known as reflex

sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a

minor injury to a limb. … Pathophysiological mechanisms of CRPS I. …

 

Phenotype-Specific Diagnosis of Functional (Psychogenic) Movement Disorders

AJ Espay, AE Lang – Current Neurology and Neuroscience Reports, 2015

Page 1. MOVEMENT DISORDERS (M OKUN, SECTION EDITOR) Phenotype-Specific

Diagnosis of Functional (Psychogenic) Movement Disorders Alberto J. Espay1,3 & Anthony

E. Lang2 © Springer Science+Business Media New York 2015 …

 

[PDF] Time-consistent calibration of short-term regional wind power ensemble forecasts

S SPäTH, L VON BREMEN, C JUNk, D HEINEMANN – 2015

… For minimum score esti- mation, we use the continuous ranked probability score (crps). … For

a forecast cumulative distribution function (cdf) Fp(x) and the verifying obser- vation y, the crps

can be calculated as: crps(Fp,y) = ∞ ∫ − Fp(x) − Θ(x − y) ]2 dx (4.4) …

 

Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization

S Tomisawa, Y Sato, M Kamiya, Y Kumaki, T Kikukawa… – Protein Expression and …, 2015

… The mouse Paneth cell α-defensins, termed cryptdins (Crps) 1 , are secreted into the lumen of

the small intestinal crypts in response to exposure to bacteria or bacterial antigens [6]. Among

the known isoforms, cryptdin-4 (Crp4) has the most potent antimicrobial activity [7 …

 

[PDF] Erythrocyte Sedimentation Rate, C-Reactive Protein and Procalcitonin in Infections of the Spine and Infections in Spinal Cord Injury Patients

JAL Buensalido, MP Reyes – Open Infectious Diseases Journal, 2015

… One study reported a mean CRP of 3 mg/L in paraplegics, while a mixed paraplegia/tetraplegia

study that excluded patients with CRPs >10 mg/L, also showed a mean of 3 mg/L. Another group

noted that mean CRP level was 38 mg/L, or 27% higher, in SCI versus non-SCI …

 

Fibromyalgia

 

The role of sleep in pain and fibromyalgia.

EH Choy – Nature reviews. Rheumatology, 2015

Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced

pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common

symptoms include nonrestorative sleep, fatigue, cognitive dysfunction, stiffness and mood …

 

Nonpharmacological Treatments of Insomnia for Long-Term Painful Conditions: A Systematic Review and Meta-analysis of Patient-Reported Outcomes in …

NK Tang, ST Lereya, H Boulton, MA Miller, D Wolke… – Sleep, 2015

… This study evaluated the effect of nonpharmacological sleep treatments on

patient-reported sleep quality, pain, and well-being in people with long-term cancer

and non-cancer (eg, back pain, arthritis, fibromyalgia) pain conditions. …

 

COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY

S Hoffman – US Patent 20,150,111,878, 2015

… Abstract: The present invention provides methods, compositions, and kits for treating intestinal

hyperpermeability in a subject in need thereof, including underlying diseases such as diabetes,

autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease …

 

American College of Lifestyle Medicine Expert Panel Discussion Treat the Cause: Evidence-Based Practice*

JM Rippe, M Greger, DL Katz, JH Kelly, M Moore… – American Journal of …, 2015

… Following this strategy, I am fostering clinical evaluation of coaching for fibromyalgia,

for which there is no good treatment other than exercise. However, it has taken 10

years to get to the place where we have enough coaches …

 

Whole body vibration training in patients with COPD A systematic review

R Gloeckl, I Heinzelmann, K Kenn – Chronic Respiratory Disease, 2015

… Abstract. In recent years, several studies have shown that whole body vibration training (WBVT)

may be a beneficial training mode in a variety of chronic diseases and conditions such as

osteoporosis, fibromyalgia, multiple sclerosis, or chronic low back pain. …

 

[PDF] Fibromyalgia Syndrome AmongIraqi Patients with Systemic Lupus Erythematosus: A Case Control Study

ZS Al-Rawi, HAJ Badran, FI Gorial

Abstract: Objective: To determine the prevalence of fibromyalgia syndrome (FMS) among

Iraqi patients with systemic lupus erythematosus (SLE) and its association with disease

activity. Patients and methods: This case control study included 100 patients with SLE and …

 

[PDF] Quality of life, sense of coherence and experiences with three different treatments in patients with psychological distress in primary care: a mixed-methods study

T Arvidsdotter, C Taft, B Marklund, S Kylén – BMC Complementary and Alternative …, 2015

… More detailed data on the procedure are reported elsewhere [48]. The patients had a primary

diagnosis of depression, anxiety or panic disorders, severe stress, somatic symptoms/pain

(including irritable bowel syndrome, fibromyalgia, migraine, fatigue) or sleep disorders. …

 

SULFUR-CONTAINING BICYCLIC COMPOUND

N Shiraishi, H Hoshii, W Hamaguchi, E Honjo… – US Patent 20,150,111,876, 2015

… containing bicyclic compound having a PAM action of GABA B , and it use for preventing

and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum

disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot …

 

TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY

R Aung-din – US Patent 20,150,111,930, 2015

… respective receptors. They are indicated for such diverse and seemingly different

conditions as: focal onset seizures, post-herpetic neuralgia, diabetic peripheral

neuropathy, fibromyalgia, anxiety, and drug withdrawal syndromes. The …

 

Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

YH Lee, SC Bae, SJ Choi, JD Ji, GG Song – Lupus, 2015

 

[HTML] Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia

B Regland, S Forsmark, L Halaouate, M Matousek… – 2015

Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue

syndrome) may respond most favorably to frequent vitamin B12 injections, in vital

combination with oral folic acid. However, there is no established algorithm for …

 

Cardiovascular control in women with fibromyalgia syndrome: do casual methods provide non redundant information compared to more traditional approaches?

AR Zamunér, A Porta, CP Andrade, A Marchi, M Forti… – American Journal of …, 2015

Abstract The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have

been widely studied in FMS patients through the computation of linear indices of

spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However, …

 

Aberrant Analgesic Response to Medial Branch Blocks in Patients With Characteristics of Fibromyalgia

CM Brummett, AG Lohse, A Tsodikov, SE Moser… – Regional Anesthesia and …, 2015

Abstract Background and Objectives: Facet interventions for spine pain have high failure

rates, and preprocedural prediction of response is nearly impossible. A potential explanation

may be aberrant central pain processing as that existing in conditions like fibromyalgia. To …

 

[HTML] Effects of Whole-Body Vibration Therapy in Patients with Fibromyalgia: A Systematic Literature Review

D Collado-Mateo, JC Adsuar, PR Olivares… – … -Based Complementary and …, 2015

Objective. To review the literature on the effects of whole-body vibration therapy in patients

with fibromyalgia. Design. Systematic literature review. Patients. Patients with fibromyalgia.

Methods. An electronic search of the literature in four medical databases was performed to …

 

Six Syndromes with Surprising Psychotherapy Solutions

T Rodriguez, V Stern – Scientific American Mind, 2015

… These links to content published by NPG are automatically generated. Cognitive behavioral

therapy for fibromyalgia. … Utility of cognitive behavioral therapy as a treatment for insomnia in

patients with fibromyalgia. Nature Clinical Practice Rheumatology (01 Apr 2006). …

 

Comorbid Conditions Do Not Differ in Children and Young Adults with Functional Disorders with or without Postural Tachycardia Syndrome

G Chelimsky, K Kovacic, M Nugent, A Mueller… – The Journal of Pediatrics, 2015

… All patients underwent formal autonomic testing, Beighton scores assessment for joint

hypermobility (0-9), and fibromyalgia tender points (0-18) (43 subjects). Results. … All subjects with

fibromyalgia by tender point-examination had a Beighton score ≥4 (P = .002). Conclusions. …

 

Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias

S Regauer, B Eberz, C Beham‐Schmid – APMIS, 2015

… Similar to other chronic pain syndromes among which are chronic pelvic and bladder pain,

fibromyalgia, and atopic dermatitis morphological correlates are hyperinnervation and increased

infiltrates of mast cells [3-5]. Activated mast cells release pre-stored or rapidly produced …

 

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study

E Generaal, N Vogelzangs, GJ Macfarlane, R Geenen… – Annals of the Rheumatic …, 2015

… Previous studies mostly defined chronic widespread pain, a cardinal symptom of the fibromyalgia

syndrome, as axial and bilateral pain above and below the waist.41 With this somewhat ‘less

stringent’ definition, we may have included some patients with milder pain. …

 

Speed, science and optimal pain relief

RA Moore – International Journal of Clinical Practice, 2015

… For example, a retrospective analysis of patients with chronic back pain or fibromyalgia revealed

that patients rated their treatment as successful if their pain was reduced by 50–70%, from a level

of 5–10 on a visual analogue scale (total score 10) to below three (no more than …

 

[PDF] An Insight of D 鄄 Ribose Metabolic Imbalance in Type 2 Diabetes Mellitus

T SU, RQ HE – Progress in Biochemistry and Biophysics, 2015

… 14-15]. Ribose is often marked as a supplement for bodybuilders with a common

recommended daily dose of 5g or more and has also been used to reduce fatigue

in fibromyalgia and chronic fatigue syndrome [2,16]. Ribose …

Fibromyalgia Syndrome: Your Questions Answered

Fibromyalgia Syndrome: Your Questions Answered

by | Apr 28, 2015 | Uncategorized

Fibromyalgia Syndrome: Your Questions Answered

Fibromyalgia  syndrome is a common and chronic disorder characterized by widespread pain, diffuse tenderness and many other symptoms. So what do sufferers really need to know? Find out now…

Although fibromyalgia is often considered an arthritis-related condition, it’s not truly a form of arthritis (a disease of the joints) because it doesn’t cause inflammation or damage to the joints, muscles or other tissues.

But like arthritis, fibromyalgia can cause significant pain and fatigue that can interfere with a person’s daily activities. Also like arthritis, fibromyalgia is considered rheumatic, a medical condition that impairs the joints and/or soft tissues and causes chronic pain.

People with fibromyalgia may experience a variety of other symptoms, including:

  • Cognitive and memory problems (sometimes referred to as “fibro fog”)
  • Sleep disturbances
  • Morning stiffness
  • Headaches
  • Irritable bowel syndrome
  • Painful menstrual periods
  • Numbness or tingling of the extremities
  • Restless legs syndrome
  • Temperature sensitivity
  • Sensitivity to loud noises or bright lights

Fibromyalgia isn’t a disease, but a syndrome: a collection of signs, symptoms and medical problems that tend to occur together but are not related to a specific, identifiable cause. A disease, on the other hand, has a specific cause or causes and recognizable signs and symptoms.

Who Gets Fibromyalgia?
Scientists estimate that fibromyalgia affects 5 million Americans age 18 or older. For unknown reasons, between 80% and 90% are women; however, men and children also can be affected. Most people are diagnosed during middle age, although the symptoms often become present earlier in life.

People with certain rheumatic diseases – such as rheumatoid arthritis, systemic lupus erythematosus (commonly called lupus) or ankylosing spondylitis (spinal arthritis) – may be more likely to have fibromyalgia too.

Several studies indicate that women with a family member with fibromyalgia are more likely to have the condition themselves, but the reason for this – whether it be heredity, shared environmental factors or both – is unknown.What Causes Fibromyalgia?
The causes of fibromyalgia are unknown, but there are probably several factors involved. Many people associate the development of fibromyalgia with a physically or emotionally stressful or traumatic event, such as an automobile accident. Some connect it to repetitive injuries. Others link it to an illness. For others, fibromyalgia seems to occur spontaneously.

Many researchers are examining other causes, including problems with how the central nervous system (the brain and spinal cord) processes pain.

Some scientists speculate that a person’s genes may regulate the way his or her body processes painful stimuli. According to this theory, people with fibromyalgia may have a gene or genes that cause them to react strongly to stimuli that most people would not perceive as painful. There have already been several genes identified that occur more commonly in fibromyalgia patients, and NIAMS-supported researchers are currently looking at other possibilities.

How Is Fibromyalgia Diagnosed?
Research shows that people with fibromyalgia typically see many doctors before receiving the diagnosis. One reason for this may be that pain and fatigue, the main symptoms of fibromyalgia, overlap with those of many other conditions. Therefore, doctors often have to rule out other potential causes of these symptoms before making a fibromyalgia diagnosis.

Also, there are currently no diagnostic laboratory tests for fibromyalgia; standard laboratory tests fail to reveal a physiologic reason for pain. Because there is no generally accepted, objective test for fibromyalgia, some doctors unfortunately may conclude a patient’s pain is not real, or they may say there’s little they can do.

A doctor familiar with fibromyalgia, however, can make a diagnosis based on criteria established by the American College of Rheumatology (ACR): a history of widespread pain lasting more than 3 months, and other general physical symptoms including fatigue, waking unrefreshed, and cognitive (memory or thought) problems.Pain is considered to be widespread when it affects all four quadrants of the body, meaning it must be felt on both the left and right sides as well as above and below the waist. ACR also has designated 18 sites on the body as possible tender points. To meet the strict criteria for a fibromyalgia diagnosis, a person must have 11 or more tender points, but often patients with fibromyalgia will not always be this tender, especially men. People who have fibromyalgia certainly may feel pain at other sites too, but those 18 standard possible sites on the body are the criteria used for classification.

How Is Fibromyalgia Treated?
Fibromyalgia can be difficult to treat. Not all doctors are familiar with fibromyalgia and its treatment, so it is important to find a doctor who is. Many family physicians, general internists or rheumatologists (doctors who specialize in arthritis and other conditions that affect the joints or soft tissues) can treat fibromyalgia.

Fibromyalgia treatment often requires a team approach – with your doctor, a physical therapist, possibly other health professionals and, most importantly, yourself all playing an active role.

It can be hard to assemble this team, and you may struggle to find the right professionals to treat you. When you do, however, the combined expertise of these professionals can help you improve the quality of your life.

You may find several members of the treatment team at pain and rheumatology clinics that specialize in arthritis and other rheumatic diseases, including fibromyalgia.Only three medications – duloxetine, milnacipran and pregabalin – are approved by the U.S. Food and Drug Administration (FDA) for fibromyalgia treatment.

Duloxetine was originally developed for and is still used to treat depression. Milnacipran is similar to a drug used to treat depression but is FDA-approved only for fibromyalgia. Pregabalin is a medication developed to treat neuropathic pain (chronic pain caused by damage to the nervous system).

The following are some of the most commonly used categories of drugs for fibromyalgia:

Analgesics: Analgesics are painkillers. They range from over-the-counter acetaminophen to prescription medicines, such as tramadol and even stronger narcotic preparations. For some people with fibromyalgia, narcotic medications are prescribed for severe muscle pain.

However, there is no solid evidence showing that narcotics actually work to treat the chronic pain of fibromyalgia, and most doctors hesitate to prescribe them for long-term use because of the potential of physical or psychological dependency.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): As their name implies, nonsteroidal anti-inflammatory drugs – including aspirin, ibuprofen and naproxen sodium – treat inflammation. Although inflammation is not a fibromyalgia symptom, NSAIDs also relieve pain. The drugs inhibit substances in the body called prostaglandins, which play a role in pain and inflammation. These medications, some of which are available without a prescription, may help ease the muscle aches of fibromyalgia. They may also relieve menstrual cramps and the headaches often associated with fibromyalgia.Complementary and Alternative Therapies: Many people with fibromyalgia also report varying degrees of success with complementary and alternative therapies, including massage, movement therapies (such as Pilates and the Feldenkrais method), chiropractic treatments, acupuncture, and various herbs and dietary supplements for different fibromyalgia symptoms.

Although some of these supplements are being studied for fibromyalgia, there is little, if any, scientific proof yet that they help. The FDA doesn’t regulate the sale of dietary supplements, so information about side effects, proper dosage and the amount of a preparation’s active ingredient may not be well known.

If you’re using or would like to try a complementary or alternative therapy, you should first speak with your doctor, who may know more about the therapy’s effectiveness, as well as whether it’s safe to try in combination with your medications.

What Can I Do to Try to Feel Better?
Besides taking medicine prescribed by your doctor, there are many things you can do to minimize the impact of fibromyalgia on your life. These include:

Getting better sleep. Getting enough sleep and the right kind of sleep can help ease the pain and fatigue of fibromyalgia. Even so, many people with fibromyalgia have problems such as pain, restless legs syndrome, or brainwave irregularities that interfere with restful sleep. It’s important to discuss any sleep problems with your doctor, who can prescribe or recommend treatment for them.Here are some tips for a better night’s sleep:

 

  • Keep regular sleep habits. Try to get to bed at the same time and get up at the same time every day – even on weekends and vacations.
  • Avoid caffeine and alcohol in the late afternoon and evening. If consumed too close to bedtime, the caffeine in coffee, soft drinks, chocolate and some medications can keep you from sleeping or sleeping soundly. Even though it can make you feel sleepy, drinking alcohol around bedtime also can disturb sleep.
  • Time your exercise. Regular daytime exercise can improve nighttime sleep. But avoid exercising within 3 hours of bedtime, which actually can be stimulating, keeping you awake.
  • Avoid daytime naps. Sleeping in the afternoon can interfere with nighttime sleep. If you feel you can’t get by without a nap, set an alarm for 1 hour. When it goes off, get up and start moving.
  • Reserve your bed for sleeping. Watching the late news, reading a suspense novel, or working on your laptop in bed can stimulate you, making it hard to sleep.
  • Keep your bedroom dark, quiet and cool.
  • Avoid liquids and spicy meals before bed. Heartburn and late-night trips to the bathroom aren’t conducive to good sleep.
  • Wind down before bed. Avoid working right up to bedtime. Do relaxing activities, such as listening to soft music or taking a warm bath, that get you ready to sleep. (A warm bath also may soothe aching muscles.)

Exercising. Although pain and fatigue may make exercise and daily activities difficult, it’s crucial to be as physically active as possible. Research has repeatedly shown that regular exercise is one of the most effective treatments for fibromyalgia. People who have too much pain or fatigue to do vigorous exercise should begin with walking or other gentle exercise, and build endurance and intensity slowly.

Making changes at work. Most people with fibromyalgia continue to work, but they may have to make big changes to do so. For example, some people cut down the number of hours they work, switch to a less demanding job, or adapt a current job. If you face obstacles at work, such as an uncomfortable desk chair that leaves your back aching or difficulty lifting heavy boxes or files, your employer may make adaptations that will enable you to keep your job. An occupational therapist can help you design a more comfortable workstation or find more efficient and less painful ways to lift.

Eating well. Although some people with fibromyalgia report feeling better when they eat or avoid certain foods, no specific diet has been proven to influence fibromyalgia. Of course, it’s important to have a healthy, balanced diet. Not only will proper nutrition give you more energy and make you generally feel better, it will also help you avoid other health problems.

From the National Institutes of Health
Published May 15, 2014
Fibromyalgia Syndrome: Mystery Pain Explained

Fibromyalgia Syndrome: Mystery Pain Explained

by | Apr 24, 2015 | Uncategorized

Fibromyalgia Syndrome: Mystery Pain Explained

Painful and puzzling, fibromyalgia syndrome primarily strikes women. Why? Researchers don’t know. And with details scarce about its cause and treatment, dealing with the condition can be maddening. We have answers to 10 common questions about fibromyalgia in women…

1. What causes fibromyalgia syndrome?
Genetics may play a role in developing fibromyalgia. But no one really knows what causes the syndrome and there are no known risk factors.

The most prevalent theory is that fibromyalgia results from a disturbance in the central nervous system called central sensitization, which may intensify pain signals.

Linked to that theory is the notion that patients have higher amounts of a compound called substance P in their spinal fluid, which increases their sensitivity to pain.

Another theory: There may be two types of fibromyalgia: “primary” fibromyalgia, which occurs spontaneously, and “secondary” fibromyalgia, which may be triggered by trauma – such as a car accident – or by certain infections, such as Lyme disease and hepatitis C.Some researchers think that the primary type is caused by a sleep disturbance, but it’s also possible that the sleep disturbance is a symptom of fibromyalgia.

2. I often hear fibromyalgia, chronic fatigue syndrome and lupus mentioned together. Are they similar?
Although the three are separate conditions, symptoms of fibromyalgia and chronic fatigue syndrome overlap. And fibromyalgia and lupus both involve the muscle and bone network in our bodies, which can cause confusion between the two illnesses.

Fibromyalgia is characterized by many symptoms including muscle pain, fatigue, sleep disturbances, irritable bowel syndrome and, in some people, depression.

Despite its consistent general characteristics, it can be tough to diagnose because symptoms vary from patient to patient.The main symptoms of chronic fatigue syndrome (CFS) include:

  • Overwhelming fatigue
  • Memory loss
  • Muscle soreness
  • Sore throat
  • Swollen glands

Symptoms can coincide or come and go in individual cycles. Doctors usually diagnose CFS through a process of elimination: They rule out other potential causes of long-term fatigue.

Lupus is an autoimmune disease in which the body attacks itself. It may start with joint pains, which patients can confuse with the muscle pains of fibromyalgia.

Diagnosed by blood tests that show a high level of certain antibodies, lupus can be progressive and cause serious illness throughout the body.

People with lupus appear more prone to develop fibromyalgia and chronic fatigue, although researchers don’t know why.
3. Why do more women than men get fibromyalgia syndrome?
The majority of people with fibromyalgia (80%-90%) are women, as is the case with lupus and CFS.

No one knows why women are affected more often than men.

4. Is it age-related?
Fibromyalgia occurs most commonly in people between 20 and 55 years old, although it may arrive at any age, including childhood.

5. Is it an autoimmune disease or a form of arthritis?
Neither. In fact, unlike inflammatory arthritis and autoimmune disease, which cause joint destruction and inflammation, fibromyalgia causes neither, despite symptoms of joint and muscle pain.

6. What are warning signs or symptoms of fibromyalgia?
Alas, the symptoms of fibromyalgia arrive without warning. They can, as mentioned earlier, include muscle and joint soreness, fatigue, sleep problems, irritable bowel symptoms, morning stiffness, depression and brain fog.

7. How is it diagnosed?
Unfortunately, it’s not uncommon to be misdiagnosed or have to see several doctors before a diagnosis is made.

Your best bet is to see a rheumatologist, a doctor who specializes in conditions affecting muscles and joints.

He or she will look for symptoms and physical findings that meet a specific definition of fibromyalgia established by the American College of Rheumatology.For example, a patient must have 11 out of 18 specific tender points on her body (neck, shoulders, back, hips, and upper and lower extremities), and she must have had widespread pain in her muscles and joints lasting for three months or more without explanation.

The doctor will also work to rule out other diseases that have similar symptoms, such as lupus and polymyalgia rheumatica (another autoimmune disease).

8. What lifestyle changes can I make to help alleviate the symptoms?
Get plenty of gentle aerobic exercise (like swimming or walking briskly), working up to at least 30 minutes most days of the week.

Weight gain commonly accompanies fibromyalgia (thanks to the fatigue, muscle pain and poor sleep).

Regular exercise will give you more energy, boost your mood, lower your weight and help you sleep better.

Eating a healthy diet with lots of vegetables, fruits, whole grains, lean meats and dairyalso will energize you, lower your weight and improve your overall health as you battle fibromyalgia.You can also try eliminating the following foods, which appear to bother some people with fibromyalgia:

  • Food additives like MSG and nitrates (the preservative in hot dogs and bacon)
  • Aspartame (NutraSweet)
  • Sugar
  • Caffeine drinks


But remember, what works for one person may not work for another.

9. What are the latest fibromyalgia treatments?
Pregabalin (Lyrica) was the first to be approved by the Food and Drug Administration (FDA) for fibromyalgia [in 2007]. Studies suggest that it prevents pain and improves sleep by slowing the release of chemicals associated with pain. [Duloxetine (Cymbalta) was approved in 2008 and Milnacipran (Savella) in 2009.]

Older standbys can help too. Anti-inflammatories such as ibuprofen and muscle relaxers can relieve pain. Antidepressants – especially tricyclics (amitriptyline or Elavil) – boost mood as well as lessen pain and improve sleep.Supplements such as 5-HTP and SAM-e (S-adenosylmethionine) may also be useful. An amino acid, 5-HTP, converts to serotonin, a feel-good neurotransmitter that helps boost mood and sleep. SAM-e is an enzyme already present in the body that affects mood and lessens pain.

D-Ribose, a simple sugar in powder form, may lessen pain and fatigue when dissolved in water and taken 2-3 times daily.

Cognitive behavioral therapy, acupuncture, hypnotherapy and biofeedback may also be worth trying.

10. What is the long-term outlook for a woman with fibromyalgia?
The good news is that fibromyalgia does not cause damage to muscles and joints that can lead to debilitation, immobility or joint replacement.

The bad news is that the symptoms typically don’t resolve. Many women simply must learn to live with fibromyalgia.
The key is finding individual or combination therapies that help. Not all treatments help all patients with fibromyalgia; discovering which help you is a matter of trial and error. But scientists continue to work on finding the cause of fibromyalgia and, ultimately, a cure or effective treatment.

How Much Do You Know About Fibromyalgia?
Described by Hippocrates in ancient Greece, fibromyalgia is one of the world’s oldest medical mysteries. The disease – a complex illness marked by chronic muscle, tendon and ligament pain, fatigue and multiple tender points on the body – affects about 2% percent of Americans, most of them women.

By Robin H. Miller, M.D. and Janet Horn, M.D., Lifescript Women’s Health Experts
Published April 16, 2015
Latest Research Updates

Latest Research Updates

by | Apr 23, 2015 | Uncategorized

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day! In an effort to help our patients stay up tochronic speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Concomitant Benzodiazepine Use Attenuates Ketamine Response: Implications for Large Scale Study Design and Clinical Development.

MA Frye, P Blier, SJ Tye – Journal of Clinical Psychopharmacology, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. … Skip Navigation Links Home > …

 

Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

PVM Steagall, M Aucoin, BP Monteiro, M Moreau… – Journal of the American …, 2015

… Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine,

in cats anesthetized with isoflurane. … The ketamine or saline solution bolus was administered

over 5 seconds, and the CRIs were started immediately afterward. …

 

Asymmetric synthesis of (S)-and (R)-norketamine via Sharpless asymmetric dihydroxylation/Ritter amination sequence

M Biermann, G Zheng, M Hojahmat, NV Moskalev… – Tetrahedron Letters, 2015

… Ketamine is a dissociative anesthetic drug marketed as Kenanest ® , Ketaset ® ,

and Ketalar ® . … In addition, ketamine has been shown in clinical studies to have

long-lasting antidepressant effects with a rapid onset of action. …

 

Possible role of afferent autonomic signals in abdominal organs in anorexic and cardiovascular responses to nicotine injection in rats.

S Yagi, M Tanida, J Satomi – NeuroReport, 2015

… To measure BP in conscious rats, each rat was anesthe- tized with an intraperitoneal

injection of a mixture of ketamine (91 mg/kg body weight) and xylazine (9.1 mg/kg body

weight) and two catheters were inserted (femoral vein and artery). …

 

[PDF] Stepwise tapering of remifentanil at the end of surgery decreased postoperative pain and the need of rescue analgesics after thyroidectomy

SS Han, SH Do, TH Kim, WJ Choi, JS Yun, JH Ryu – BMC Anesthesiology, 2015

… Previous investigation of patients undergoing major abdominal surgery suggested hyperalgesia

after high dose remifentanil and preventive effect of ketamine for opioid-induced hyperalgesia

[3]. Patients with intraoperative high-dose remifentanil (0.4 μg/kg/min) showed larger …

 

[HTML] The dexmedetomidine” augmented” sedato analgesic cocktail: An effective approach for sedation in prolonged endoscopic retrograde cholangio-pancreatography

S Mukhopadhyay, M Niyogi, J Sarkar… – Journal of Anaesthesiology …, 2015

… Group 1 received propofol and midazolam, Group 2 received the sedato-analgesic cocktail

containing ketamine-propofol-midazolam-pentazocine, and the Group 3 received sedate-analgesic

cocktail plus dexmedetomidine infusion under monitoring of vital parameters and …

 

Convergence of lemniscal and local excitatory inputs on large gabaergic tectothalamic neurons

T Ito, H Hioki, J Sohn, S Okamoto, T Kaneko, S Iino… – Journal of Comparative …, 2015

… Viral injections. Rats were anesthetized with a ketamine & xylazine mixture (97.6 mg/kg & 2.4

mg/kg, im). … rats were re-anesthetized with a ketamine & xylazine mixture and perfused

transcardially with 4% paraformaldehyde in 0.1 M phosphate buffer (pH 7.4). …

 

CURRENT OPINION Postcaesarean section analgesia: are opioids still required?

AMJV Schyns-van den Berg, A Huisjes, RJ Stolker – Curr Opin Anesthesiol, 2015

… Ketamine Ketamine, an anaesthetic that also acts as a N-methyl-D-aspartate (NMDA)

receptor antagonist, has shown significance in reducing opioid use in subanaesthetic

doses with minimal side-effects [31]. Furthermore, ketamine …

 

Advances in Exotic Mammal Clinical Therapeutics

MG Hawkins – Veterinary Clinics of North America: Exotic Animal …, 2015

… For example, patients can be premedicated with an opioid medication and a tranquilizer to

modulate pain and stress, ketamine used as a part of the induction protocol can reduce excitement,

local anesthetic blocks can be added to inhibit pain transmission, and nonsteroidal anti …

 

The interactive effects of Ketamine and Magnesium on Brain-Derived Neurotrophic Factor (BDNF) and depressive-like behavior (P4. 080)

S Razmjou, D Litteljohn, S Hayley – Neurology, 2015

Objective: To evaluate the potential synergistic effect of ketmaine and magnesium treatment

on prefrontal cortex (PFC) and hippocampal BDNF expression and depressive-like behavior

in mice model. Background: Ketamine, an NMDA receptor antagonist with neuroplastic …

 

Ketamine modulates TRH and TRH-like peptide turnover in brain and peripheral tissues of male rats

AE Pekary, A Sattin, RL Lloyd – Peptides, 2015

Abstract Major depression is the largest single healthcare burden with treatments of slow

onset and often limited efficacy. Ketamine, a NMDA antagonist used extensively as a

pediatric and veterinary anesthetic, has recently been shown to be a rapid acting …

 

[PDF] A Label-Free Immunosensor for Ultrasensitive Detection of Ketamine Based on Quartz Crystal Microbalance

Y Yang, Y Tu, X Wang, J Pan, Y Ding – Sensors, 2015

Abstract: In this study, we have developed a label-free immunosensor with the variation of

resonance frequency (Δf) of a quartz crystal microbalance (QCM) as readout signal for

ultrasensitive detection of Ketamine (KT). An optimized strategy for immobilization of KT …

 

[HTML] Coupling in the cortico-basal ganglia circuit Is aberrant in the ketamine model of schizophrenia

I Cordon, MJ Nicolás, S Arrieta, E Lopetegui… – European …, 2015

Abstract Recent studies have suggested the implication of the basal ganglia in the

pathogenesis of schizophrenia. To investigate this hypothesis, here we have used the

ketamine model of schizophrenia to determine the oscillatory abnormalities induced in the …

 

Methoxetamine: An early report on the motivations for use, effect profile and prevalence of use in a UK clubbing sample

AR Winstock, W Lawn, P Deluca, R Borschmann – Drug and Alcohol Review, 2015

… Keywords: novel psychoactive substance; methoxetamine; ketamine; monitoring system. …

Prevalence of lifetime, last year and last month use, sourcing of the drugs, motivations for use,

and subjective effect and risk profile compared with that of ketamine were measured. Results. …

 

[PDF] Ketofol for Procedural Sedation and Analgesia in Children with Acute Lymphoblastic Leukemia

AA Ibrahim Ahmed, G Mohamed Fathy… – J Anesth Clin Res, 2015

… Objectives: The aim of this work is to study the effects, adverse effects and recovery time of IV

mixed propofol and ketamine (ketofol) in 3:1 ratio as a sedative analgesic in children with acute

lymphoblastic leukemia undergoing bone marrow aspiration Methods: This was a …

 

Mechanisms of Drug Interaction

AM Manrique-Espinel, EA Sullivan, PK Sikka – Basic Clinical Anesthesia, 2015

 

Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling

KA Russo, JL La, SBZ Stephens, MC Poling… – Endocrinology, 2015

… St. Louis, MO) using a ketamine cocktail (21 mg ketamine, 2.4 mg xylazine, and 0.3

mg acepromazine per ml injected ip at a dose of 0.25 ml per 100 g body mass) with

buprenorphrine for pre- and postoperative analgesia. This …

 

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway

SI Bibli, I Andreadou, A Chatziananstasiou, C Tzimas… – Cardiovascular Research, 2015

… Murine in Vivo Model of Ischemia-Reperfusion Injury The mice were anesthetized by

intraperitoneal injection (0.01 mL/g) with a combination of ketamine, xylazine and atropine (final

concentrations of ketamine, xylazine and atropine 100 mg/kg, 20 mg/kg and 0.6 …

 

[HTML] Anaesthetic management for drainage of frontoparietal abscess in a patient of uncorrected Tetralogy of Fallot

AS Wajekar, AN Shetty, SP Oak, RA Jain – Indian Journal of Anaesthesia, 2015

… Hyperventilation without PEEP helps to decrease PVR. Ketamine for induction is avoided

for neurosurgery. … [8] Combination of dexmedetomidine and ketamine has been used in two

patients of uncorrected TOF for surgeries under general anaesthesia. …

 

Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, …

M Chatterjee, R Verma, R Kumari, S Singh, AK Verma… – Pharmaceutical biology, 2015

Abstract Context: Schizophrenia is a chronic disabling psychiatric disorder affecting 1% of

the population worldwide. Due to the adverse effects of available antipsychotic medications,

recent investigations have focused on the search for well-tolerated, safe molecules from …

 

Autotransplantation for the management of ketamine ureteritis

NTJ Raison, T O’Brien, D Game, J Olsburgh – BMJ Case Reports, 2015

Summary Ketamine-associated cystitis is a well-recognised syndrome; yet upper urinary

tract involvement remains poorly understood. We present the case of a 33-year-old man who

developed ketamine-associated cystitis and ureteritis. The patient’s severe bladder …

 

… magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotube for the determination of methylamphetamine and ketamine in human urine and …

S Zhang, Y Cui, J Sun, Y Xi, C Zhang, J Tang – Analytical Methods, 2015

A sensitive and rapid magnetic solid-phase microextraction (MSPE) procedure based on

multi-walled carbon nanotubes (MWNTs), combined with gas chromatography-mass

spectrometry (GC-MS), was developed for the quantification of two illegal basic drugs of …

 

[PDF] Dexmedetomedine-Ketamine versus Propofol-Ketamine as anaesthetic agents in paediatric cardiac catheterization

NP Ali, M Kanchi, S Singh, A Prasad, N Kanase – Journal of Armed Forces Medical …, 2015

Abstract Introduction: Anaesthesia for these patients undergoing for interventional

procedures in paediatric patients with congenital cardiac anomalies remains a challenge for

the anaesthesiologist. There are no specific techniques to follow and anaesthetic …

 

Gonadal hormones do not alter the development of antinociceptive tolerance to delta-9-tetrahydrocannabinol in adult rats

AA Wakley, JL Wiley, RM Craft – Pharmacology Biochemistry and Behavior, 2015

… Louis, MO) were injected sc; 15 min later, rats were anesthetized with ketamine plus xylazine

ip (90 mg/kg ketamine + 10 mg/kg xylazine in females, 100 mg/kg ketamine + 10 mg/kg xylazine

in males; Patterson Veterinary Supply Inc., Kansas City, MO). …

 

[PDF] Topical and Intranasal Analgesic Therapy in a Woman with Refractory Postherpetic Neuralgia

KC Hohmeier, LM Almon – Case Reports in Medicine, 2015

… The patient-specific, stepped approach resulted in clinically significant decreases in pain on visual

analog scale (VAS), with the use of intranasal ketamine 10% solution and topical gabapentin

6%, ketoprofen 10%, lidocaine 5%, and ketamine 10% cream. 1. Introduction. …

 

Prehospital Pain and Analgesic Therapy in Elderly Patients with Hip Fractures

L Oberkircher, N Schubert, DA Eschbach, C Bliemel… – Pain Practice, 2015

… Ketamine was used 5 times. Esketamine was preferred (N = 4, 2.6%, mean dosage = 27, SD =

23), but one patient did receive racemic ketamine (0.7%, dosage = 50). … Ibuprofen, 1 (0.7), 800 (–),

98 (–), 3 (–), 60 (–). Ketamine, 1 (0.7), 50 (–), 62 (–), 3 (–), 104 (–). Sum, 43 (25)a, …

 

[HTML] Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus

D Bing, SC Lee, D Campanelli, H Xiong, M Matsumoto… – Cellular Physiology and …, 2015

… Since NMDA receptor antagonists, when systemically given, tend to have a number of negative

central nervous system side effects such as hallucinations or anesthesia (for which eg Ketamine

was originally developed), their clinical potential has been limited. …

 

[PDF] Two-Stage Nerve Graft in Severe Scar: A Time-Course Study in a Rat Model

SA Zadegan, M Firouzi, MH Nabian, LO Zanjani… – The Archives of Bone and …, 2015

… Surgical procedures An intraperitoneal (IP) injection of ketamine (100 mg/ kg ketamine

hydrochloride, Rotexmedica, Germany) was used to induce anesthesia. … Anesthesia was induced

with ketamine (100mg/kg, IP, ketamine hydrochloride, Rotexmedica, Germany). …

 

Quantifying progression and regression of thrombotic risk in experimental atherosclerosis

RU Palekar, AP Jallouk, MJ Goette, J Chen… – The FASEB Journal, 2015

… Following 2 hours of in vivo NP circulation, mice were anes- thetized with a cocktail of ketamine

and xylazine (87 mg/kg and 37 mg/kg, respectively) and subjected to photochemical injury

of the carotid artery (13–15) to determine time to vessel occlusion. …

 

Radiofrequency Ablation (RFA)

 

Irreversible electroporation of malignant lesions: An institution experience

BJ Bates, M Hellan, S Kauffman, J Ouellette – Journal of Solid Tumors, 2015

… malignant. Three cases involved margin accentuation prior to resection. One treated

the IVC margin of a radiofrequency ablation site. Twenty-four procedures attempted

complete ablation. Lesions ranged from 1.0 cm to 6.0 cm. …

 

[PDF] Clinical outcomes of patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective study of routine clinical practice in multi-institutions

SH Lee, IH Song, R Noh, HY Kang, SB Kim, SY Ko… – 2015

… outcomes are generally poor [1,2]. Although potentially curable at an early stage, only 30-40%

of patients with HCC at the time of diagnosis are eligible for curative treatments such as liver

transplantation, tumor resection, or percutaneous radiofrequency ablation (RFA), and the …

 

[HTML] Trichoepithelioma and Spiradenoma Collision Tumor

AF Marsch, JB Shackelton, DM Elston – Am J Orthop, 2015

… Head Neck Pathol. 2014;8:88-109. « Back To: Landing. Did you miss this content? Cutaneous

Burn Caused by Radiofrequency Ablation Probe During Shoulder Arthroscopy. > more

Soft-Tissue articles. More From The American Journal of Orthopedics …

 

Interventional CMR: Clinical Applications and Future Directions

T Rogers, RJ Lederman – Current Cardiology Reports, 2015

… Conductive wires can resonate and heat during radiofrequency excitation for MRI [42], which

is a potential challenge for both passive and active devices and is determined by the total length

of … If gaps in ablation lines can be visualized, then they can be ablated [67, 68 …

 

[PDF] Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

D Wu, ZY Shen, YM Zhang, J Wang, H Zheng, YL Deng… – BMC Cancer, 2015

… liver transplantation [3]. Other methods including local ablation (eg, ethanol injection, microwave

coagulation, and radiofrequency ablation [RFA]) and transcatheter arterial chemoembolization

(TACE) have proved effective only in a small number of cases [6]. Local treatment …

 

[PDF] Radiofrequency electric-field heating behaviors of highly enriched semiconducting and metallic single-walled carbon nanotubes

SJ Corr, M Raoof, BT Cisneros, AW Orbaek… – 2015

… Clin Cancer Res 2010, 16, 5712-5721. [5] Glazer, ES; Curley, SA Non-invasive

radiofrequency ablation of malignancies mediated by quantum dots, gold

nanoparticles and carbon nanotubes. Ther Deliv 2011, 2, 1325-1330. …

 

Systems and Methods of Radiometrically Determining a Hot-Spot Temperature of Tissue Being Treated

D Panescu, JV Koblish, JF Mccarthy, RC Allison – US Patent 20,150,105,765, 2015

… having to repeat the ablation procedure as such, the clinician may ablate a series … to assist the

clinician in determining whether any of those ablated regions are … Radiofrequency ablation

techniques have developed a substantial following in the medical community, even though …

 

[PDF] A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9

JACM Goos, VMH Coupé, MA van de Wiel, B Diosdado… – Towards molecular imaging …, 2015

… with colorectal cancer (CRC) die as a consequence of advanced disease 1. The majority of CRC

metastases localize to the liver and resection of the affected liver tissue, often combined with

radiofrequency ablation (RFA), is the sole curative treatment option 2. Selection of …

 

[HTML] What Is Your Diagnosis? New World Cutaneous Leishmaniasis

C Hennings, K Bloch, J Miller, J Zwerner – Am J Orthop, 2015

The American Journal of Orthopedics is an Index Medicus publication that is valued by orthopedic

surgeons for its peer-reviewed, practice-oriented clinical information. Most articles are written

by specialists at leading teaching institutions and help incorporate the latest technology …

 

RADIOFREQUENCY AMPLIFIER IMPEDANCE OPTIMIZATION

JH Johnson, JA Gilbert – US Patent 20,150,105,766, 2015

… The present disclosure relates to radiofrequency amplifiers that use phase-shifted full bridge

resonant inverters … high radio frequency electrical current to a surgical site to cut, ablate, coagulate

or … cycle sinusoidal waveform in cut mode, which is best suited for ablating, fusing and …

 

[HTML] Pulmonary vein orientation assessment: Is it necessary in patients undergoing contact force sensing guided radiofrequency catheter ablation of atrial fibrillation

P Gal, JFW Ooms, JP Ottervanger, JJJ Smit… – IJC Heart & Vasculature, 2015

Purpose We hypothesized pulmonary vein (PV) orientation influences tissue contact of the

contact force (CF) sensing radiofrequency ablation catheter (CFC) and therefore atrial

fibrillation (AF) free survival after pulmonary vein isolation (PVI). The aim of this study was …

 

Switching Bipolar Hepatic Radiofrequency Ablation Using Internally Cooled-wet Electrodes: Comparison with Consecutive Monopolar and Switching Monopolar …

JH Yoon, JM Lee, S Woo, EJ Hwang, I Hwang, W Choi… – The British Journal of …, 2015

Objective: To evaluate whether switching bipolar radiofrequency ablation (SB-RFA) using

three internally cooled-wet (ICW) electrodes can induce coagulations> 5 cm in porcine livers

with better efficiency than consecutive monopolar (CM) or switching monopolar (SM) …

 

One-year follow-up after irrigated multi-electrode radiofrequency ablation of persistent atrial fibrillation

N Pavlović, C Sticherling, S Knecht, T Reichlin, A Mühl… – Europace, 2015

Aims Irrigated multi-electrode ablation (IMEA) is a novel tool to perform pulmonary vein

isolation (PVI). The aim was to compare IMEA with point-by-point radiofrequency (RF)

ablation in patients with persistent atrial fibrillation (AF) undergoing PVI.

 

Radiofrequency Ablation in the Treatment of Unresectable Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-Analysis

K Han, HK Ko, KW Kim, HJ Won, YM Shin, PN Kim – Journal of Vascular and …, 2015

Abstract The purpose of this study was to perform a meta-analysis and systematic review of

the clinical efficacy and safety of radiofrequency (RF) ablation in the treatment of intrahepatic

cholangiocarcinoma (ICC). A comprehensive literature search of Ovid MEDLINE and …

 

Safety profile of multielectrode-phased radiofrequency pulmonary vein ablation catheter and irrigated radiofrequency catheter

K Wasmer, P Foraita, P Leitz, F Güner, C Pott… – Europace, 2015

Background Silent cerebral lesions with the multielectrode-phased radiofrequency (RF)

pulmonary vein ablation catheter (PVAC®) have recently been investigated. However,

comparative data on safety in relation to irrigated RF ablation are missing.

 

Hepatic radiofrequency ablation: in vivo and ex vivo comparison of 15-gauge (G) and 17-G internally cooled electrode

KD Song, MW Lee, HJ Park, DI Cha, TW Kang, J Lee… – The British Journal of …, 2015

Objectives: To compare the performance of the 15-gauge (G) internally cooled electrode

with that of the conventional 17-G internally cooled electrode. Methods: A total of 40 (20 for

each electrode) and 20 ablation zones (ten for each electrode) were made in extracted …

 

[HTML] Suppression of postsurgical recurrence of hepatocellular carcinoma treated with autologous formalin‐fixed tumor vaccine, with special reference to glypican‐3

I Kawashima, Y Kawashima, Y Matsuoka, K Fujise… – Clinical Case Reports, 2015

… Once HCC is detected, patients experience repeated recurrence, despite the fact that a variety

of HCC treatment methods have been developed, such as anti-viral agents, surgical treatment,

percutaneous ethanol injection (PEIT), radiofrequency ablation (RFA), trans-catheter …

 

Role of Sarcoplasmic Reticulum Calcium in Development of Secondary Calcium Rise and Early Afterdepolarizations in Long QT Syndrome Rabbit Model.

PC Chang, HT Wo, HL Lee, SF Lin, MS Wen, Y Chu… – PloS one, 2015

… Atrioventricular block (AVB) was created by radiofrequency ablation. After baseline studies,

E4031, SR Ca2+ cycling inhibitors (ryanodine plus thapsigargin) and nifedipine were then

administrated subsequently, and the protocols were repeated. …

 

CURRENT OPINION Management of lymphatic malformations in children

N Bagrodia, AM DefnetÃ, JJ Kandel – Curr Opin Pediatr, 2015

… Recent findings Current treatment options include nonoperative management, surgery,

sclerotherapy, radiofrequency ablation, and laser therapy. … Grimmer JF, Mulliken JB, Burrows PE,

Rahbar R. Radiofrequency ablation of microcystic lymphatic malformation in the oral cavity. …

 

[PDF] Long-term complete response of advanced hepatocellular carcinoma treated with multidisciplinary therapy including reduced dose of sorafenib: case report and …

M Shinoda, N Kishida, O Itano, S Ei, A Ueno, M Kitago… – World Journal of Surgical …, 2015

… condition. Thus, transcatheter arterial chemoembolization and radiofrequency

ablation of the tumors were performed. Three months later, residual tumor of the

larger lesion and multiple pulmonary metastases were detected. …

 

Quantitative Analysis of Localized Sources Identified by Focal Impulse and Roter Modulation Mapping in Atrial Fibrillation

P Benharash, E Buch, P Frank, M Share, R Tung… – Circulation: Arrhythmia and …, 2015

… Abstract. Background—New approaches to ablation of atrial fibrillation (AF) include

focal impulse and rotor modulation (FIRM) mapping, and initial results reported with

this technique have been favorable. We sought to independently …

 

Characteristics of VT Ablation in Patients with Continuous Flow Left Ventricular Assist Devices

F Sacher, T Reichlin, ES Zado, ME Field… – Circulation: Arrhythmia and …, 2015

… Original Article. Characteristics of VT Ablation in Patients with Continuous Flow Left

Ventricular Assist Devices. … This study describes VA characteristics and ablation in

patients implanted with a Heart Mate 2 (HM2) device. Methods …

 

Catheter Ablation of Ventricular Tachycardia and Mortality in Patients with Nonischemic Dilated Cardiomyopathy: Can Noninducibility after Ablation be a Predictor for …

B Dinov, A Arya, A Schratter, V Schirripa, L Fiedler… – Circulation: Arrhythmia and …, 2015

… Original Article. Catheter Ablation of Ventricular Tachycardia and Mortality in Patients with

Nonischemic Dilated Cardiomyopathy: Can Noninducibility after Ablation be a Predictor for

Reduced Mortality? … Related Collections. Ablation/ICD/surgery. Social Bookmarking. …

 

Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective

N Sengupta, GA Ketwaroo, DM Bak, V Kedar… – Gastrointestinal Endoscopy, 2015

Background Radiofrequency ablation (RFA) is an effective treatment for Barrett’s esophagus

(BE) dysplasia. For patients with dysplasia refractory to RFA, data are limited regarding

efficacy of endoscopic therapy. Objective To assess the efficacy and safety of cryotherapy …

 

A novel microwave catheter can perform noncontact circumferential endocardial ablation in a model of pulmonary vein isolation

P Qian, MA Barry, T Nguyen, D Ross, P Kovoor… – Journal of Cardiovascular …, 2015

… Second, we were able to ablate at high power without limitations from catheter … Haemmerich,

Contribution of direct heating, thermal conduction and perfusion during radiofrequency and

microwave … ablation were equivalent whether one pair of radials were orientated in the plane …

 

Selective reduction in complicated monochorionic twins: Prediction of obstetric outcome and comparison of techniques

Y Yinon, E Ashwal, B Weisz, B Chayen, E Schiff… – Ultrasound in Obstetrics & …, 2015

… Keywords: Monochorionic twins; selective reduction; bipolar cord coagulation; radiofrequency

ablation; selective intra-uterine growth restriction … All rights reserved Abstract Objective: To

compare the outcome of radiofrequency ablation (RFA) and bipolar …

 

Hypertensive crisis during hemostasis of adrenal bleeding using a soft‐coagulation device

T Kawai, M Suzuki, M Otsuka, S Nakazono, Y Tanaka… – International Journal of …, 2015

… Fransson et al. reported hypertensive crisis during radiofrequency ablation of normal

adrenal tissue in dogs. The … SA. Hemodynamic changes during laparoscopic

radiofrequency ablation of normal adrenal tissue in dogs. Vet. Surg. …

 

[HTML] Contrast-Enhanced Subharmonic and Harmonic Ultrasound of Renal Masses Undergoing Percutaneous Cryoablation

JR Eisenbrey, CM Shaw, A Lyshchik, P Machado… – Academic Radiology, 2015

… CT guidance during the session. Cryoablation is also significantly less painful than

heat-based techniques such as microwave and radiofrequency ablation, thereby

avoiding the use of general anesthesia in many patients (6). …

 

Rare Endocrine Tumors of the Pancreas: Evidence of Management

JT Li, SY Peng, DF Hong – Pancreatic Cancer, Cystic Neoplasms and Endocrine …, 2015

… Medical treatment such as a somatostatin analogue and/or other interventional modality

such as radiofrequency ablation or hepatic artery embolization can allow these patients

long survival times. Get PDF (2762K). More content like this. …

 

New Treatment Modalities for Hepatocellular Cancer

K Mauer, R O’Kelley, N Podda, S Flanagan, S Gadani – Current Gastroenterology …, 2015

… These include microwave ablation (MWA), which achieves higher temperatures more rapidly,

and irreversible electroporation (IRE … higher in energy than RFA (ranging from 900 to 2400 MHz,

while radiofrequency is typically around 400 kHz) to thermally ablate the tumor …

 

[HTML] Distribution of abnormal potentials in chronic myocardial infarction using a real time magnetic resonance guided electrophysiology system

SO Oduneye, M Pop, M Shurrab, L Biswas, V Ramanan… – Journal of Cardiovascular …, 2015

… Further- more, linear radiofrequency ablation lesions designed to transect these channels of

slow conduction have been shown to be on average longer in length by several centimeters when

the isthmus has not been effectively identified and only voltage maps are known (eg …

 

Evaluation of transforaminal endoscopic lumbar discectomy in the treatment of lumbar disc herniation

K Wang, X Hong, BY Zhou, JP Bao, XH Xie, F Wang… – International Orthopaedics, 2015

… Last, elderly patients usually suffer from LDH for more years and have more severe vertebral

degeneration than younger pa- tients; thus, the clinical outcomes of elderly patients were not

good when the radiofrequency ablation for annuloplasty was performed. …

 

[PDF] Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency Ablation for Lumbar Facet Syndrome

ZL McCormick, B Marshall, J Walker, R McCarthy… – Int J Anesthetic Anesthesiol, 2015

Abstract Objective: Radiofrequency ablation (RFA) of the medial branch nerves for facet-

mediated low back pain demonstrates clinical benefit for 6-12 months and possibly up to 2

years. This study investigated function, pain, and medication use outcomes of RFA for …

 

Effect of Irrigant Characteristics on Lesion Formation after Radiofrequency Energy Delivery Using Ablation Catheters with Actively Cooled Tips

DT Nguyen, M Olson, L Zheng, W Barham, JD Moss… – Journal of Cardiovascular …, 2015

Background The delivery of radiofrequency (RF) energy through irrigated ablation catheters

may be affected by irrigant osmolarity and by catheter position. We sought to characterize

lesion formation characteristics using different irrigants in both open and closed irrigated …

 

Efficacy and Safety of Radiofrequency Ablation for Treatment of Locally Recurrent Thyroid Cancers Smaller than 2 cm

J Kim, WS Yoo, YJ Park, DJ Park, TJ Yun, SH Choi… – Radiology, 2015

Purpose To evaluate the efficacy and safety of radiofrequency ablation (RFA) for localized

small recurrent thyroid cancers less than 2 cm by comparing them with those at repeat

surgery. Materials and Methods This retrospective study was institutional review board– …

 

Long‐term local disease control in a recurrent soft‐tissue sarcoma of the thigh treated by radiofrequency ablation

MD Belfiore, P Maria, MD Ronza, M Francesco… – Journal of Surgical …, 2015

Locally recurrent soft-tissue sarcoma without distant metastases occurs in nearly 20% of

patients [1]. However, in these patients treatment options may be limited because of

previous limb-sparing surgery and radiation therapy, frequently resulting in a …

 

Real Time Atrial Wall Imaging during Radiofrequency Ablation in a Porcine Model

M Granier, PF Winum, M Granier, P Liaud, G Cayla… – Heart Rhythm, 2015

Objective We used intravascular ultrasound (IVUS) to describe atrial wall changes during RF

ablation, and assess the extent of RF-induced lesions. Methods In nine piglets, RF and IVUS

catheters were coupled and introduced into the right atrium (RA). RF applications were …

 

Efficacy of Computed Tomography Guided Radiofrequency Ablation for Osteoid Osteomas in 31 Patients

J Kim, JM Ahn, JW Lee, GY Lee, E Lee, JH Oh, HS Cho… – Journal of the Korean …, 2015

Purpose To present the clinical outcome of computed tomography (CT) guided

radiofrequency ablation (RFA) for osteoid osteoma. Materials and Methods Thirty-one

patients (M: F= 23: 8, mean age: 20 years, range: 4-54 years) who underwent RFA for …

 

SPINAL DISK HERNIATION REPOSITIONING AND RADIOFREQUENCY ABLATION (RFA) DEVICE AND METHOD FOR TREATING VERTEBRAL DISC HERNIATION

H Wang, J Wang – US Patent 20,150,100,052, 2015

Abstract: Devices, components, apparatus, and/or methods for using and making a

combination spinal disk herniation repositioning and radiofrequency apparatus (RFA) or

device that uses one or more repositioning probes and one or more needles/electrodes, …

 

[HTML] Radiofrequency ablation (RFA) for palliative treatment of painful non‐small cell lung cancer (NSCLC) rib metastasis: Experience in 12 patients

M Hu, X Zhi, J Zhang – Thoracic Cancer, 2015

Background Painful rib metastasis is common in non-small cell lung cancer (NSCLC). Pain

is often partially or totally refractory to analgesic medications or the side effects of medication

are unacceptable. We report the safety and efficacy of a new method: radiofrequency …

 

[PDF] Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European

KN Phoa, RE Pouw, IR Bisschops, O Pech, K Ragunath… – surgery, 2015

… 11 Jayan Mannath,4 CA Seldenrijk,12 Mike Visser,13 Toni Lerut,2 Stefan Seewald,14 Fiebo

J ten Kate,13 Christian EII,3 Horst Neuhaus,6 Jacques JGHM Bergman1 ABSTRACT Objective

Focal endoscopic resection (ER) followed by radiofrequency ablation (RFA) safely and …

 

A National Analysis of the Complications, Cost, and Mortality of Percutaneous Lung Ablation

BT Welch, W Brinjikji, GD Schmit, MR Callstrom… – Journal of Vascular and …, 2015

… Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology,

243 (2007), pp. 268–275. … Primary non-small cell lung cancer: review of frequency, location, and

time of recurrence after radiofrequency ablation. Radiology, 254 (2010), pp. 301–307. …

 

 Complex Regional Pain Syndrome (CRPS/RSD)

 

Substituted imidazolium compounds for treating disease

H Tabuteau – US Patent 9,006,279, 2015

… In some embodiments, a subject compound may be administered to relieve complex regional

pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex regional

pain syndrome type II (CRPS-II), CRPS-NOS, or another type of CRPS. …

 

CURRENT OPINION Improving the outcome of bacterial meningitis in newborn infants in Africa: reflections on recent progress

EM Molyneux, Q Dube, L Newberry – Curr Opin Infect Dis, 2015

… C-REACTIVE PROTEIN Only 35–65% of serum CRPs are positive at the beginning of the illness

[14]. Serial CRPs 24–48h after the onset of symptoms are more helpful and if two tests, 24 h apart

are less than 10 mg/l, the nega- tive predictive value for sepsis is 99% [15]. …

 

Well‐Defined High Molecular Weight Polystyrene with High Rates and High Livingness Synthesized via Two‐Stage RAFT Emulsion Polymerization

K Yan, X Gao, Y Luo – Macromolecular Rapid Communications, 2015

… in dead chains has long been pursued since it provides a powerful tool for synthesizing

well-defined nanostructured functional materials with precisely controlled chain microstructures

and complex architectures.[1] Controlled radical polymerizations (CRPs), which show some …

 

Iatrogenic lesions of peripheral nerves

WN Löscher, J Wanschitz, S Iglseder, A Vass… – Acta Neurologica …, 2015

… In addition to pain, patients may develop weakness or sensory, respectively, trophic disturbances.

Rarely, neuropathic pain without weakness occurs. In half of the cases, trophic disturbances

and a chronic regional pain syndrome (CRPS) develop [68, 70]. …

 

A survey on memristor modeling and security applications

MT Arafin, C Dunbar, G Qu, N McDonald, L Yan – Quality Electronic Design (ISQED), …, 2015

… the discrepancy from the expected delay or the instable power-on states of the memory cells,

to generate chip-dependent PUF data that can be used as secret keys or as seeds of random

number generators, and/or to create challenge response pairs (CRPs) for authentication …

 

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

JS Gewandter, RH Dworkin, DC Turk, JT Farrar… – PAIN, 2015

… recovery (SNR); (4) chronic post-surgical pain (IG); (5) postherpetic neuralgia (RHD); (6) painful

diabetic peripheral neuropathy (DZ); (7) HIV and chemotherapy-associated peripheral

neuropathies (MJP); (8) complex regional pain syndrome (CRPS) type 1 (ALO); (9) …

 

Surgical Management of Posttraumatic Midfoot Deformity and Arthritis.

JD Seybold, JC Coetzee – Techniques in Foot & Ankle Surgery, 2015

… Kuo et al4 echoed these results, with neuritis, metatarsalgia, and malunion noted

as the most common complications in their series. One superficial infection, 1

asymptomatic nonunion, and 1 case of CRPS were also reported. …

 

Using Augmented Reality in the Treatment of CRPS Patients

L Knudsen, HP Hansen, D Baskarada, N Nedergaard…

Background Mirror Visual Feedback (MVF) is an important part of therapeutic treatment of

Complex Regional Pain Syndrome (CRPS). Unfortunately mirror boxes (MB) are not

compatible with meaningful activities. Recently it was shown that Virtual Reality (VR) as …

 

Development of a Clinical Framework for Mirror Therapy in Patients with Phantom Limb Pain: An Evidence‐based Practice Approach

A Rothgangel, S Braun, L Witte, A Beurskens… – Pain Practice, 2015

… Only one protocol [41] specifically addressed patients with PLP. Two protocols [39, 42] were

applied in a mixed pain population and one protocol [40] mainly focused on patients with complex

regional pain syndrome (CRPS) but also provided some basic information on PLP. …

 

Techniquesformonitoring, imaging, and pain relief

S Dhir, R Sharma, S Ganapathy – Trauma Anesthesia, 2015

 

Skin Hyperpigmentation in Complex Regional Pain Syndrome (CRPS)(P3. 315)

R Knobler – Neurology, 2015

OBJECTIVE: To characterize hyperpigmented skin changes which appear as a

manifestation in limbs affected by CRPS. BACKGROUND: CRPS is a neuropathic, often

treatment resistant, non-malignant pain syndrome. Early diagnosis is essential for a good …

 

Chronic Regional Pain Syndrome: A Preliminary report on molecular mechanisms and structural correlates (S10. 005)

B Murinson, Z Ghersin, E Peled – Neurology, 2015

… Abstract. OBJECTIVE: Complex Regional Pain Syndrome (CRPS) is a painful neurological

condition that is highly resistant to treatment. As the disease pathophysiology is not

definitively characterized, case studies may offer valuable insights. …

 

[PDF] Towards an integrated probabilistic nowcasting system (En-INCA)

M Suklitsch, A Kann, B Bica – Advances in Science and Research, 2015

… The two plots in the right column of Fig. 4 illustrate the Continuous Ranked Probability Score

(CRPS) and the per- centage of outliers. … The CRPS compares a full distribution of ensemble

predictions with observations, both represented as cumula- tive distribution functions. …

 

Role of magnetic resonance imaging in the diagnosis of the painful unicompartmental knee arthroplasty

CN Park, HA Zuiderbaan, A Chang, S Khamaisy… – The Knee, 2015

… then the patient underwent MRI. Patients who presented with other obvious causes

of pain (eg lumbar spine stenosis, hip osteoarthritis, complex regional pain syndrome

(CRPS)) were excluded. The final study group consisted …

 

New experimental hosts of Barley yellow dwarf virus among wild grasses with implications for grassland habitats

LL Ingwell, NA Bosque‐Pérez – Plant Pathology, 2015

… virus reservoirs in the environment (Borer et al., 2007). Understanding the ability of BYDV to infect

grass species including those present in prairies and CRPs, and the suitability of these Page

5. Accepted Article This article is protected by copyright. All rights reserved. …

 

[PDF] Evaluation of the CGIAR Research Program on Aquatic Agricultural Systems (AAS)

R Birner, R Bhujel, EM Rathgeber, J Sumberg… – 2015

Page 1. ! ! ! ! Fund%Council% ! 13th%Meeting%(FC13)—Bogor,%Indonesia%

April%28?29,%2015% % % ! ! WORKING(DOCUMENT( % % % % Evaluation!of!the!!

CGIAR!Research!Program!on!! Aquatic!Agricultural!Systems!(AAS)!! ! % Submitted!by:!! …

 

[PDF] Evaluation of the CGIAR Research Program on Wheat

W Beversdorf, S Brouder, PP Sachdeva, R Sulaiman – 2015

… Regarding research on sustainable intensification, the Team sees need for greater lateral learning

that spans across CRPs and crops and greater use of synthesis reviews and meta-analysis to

enhance the international public gods nature of the xii Page 17. cgiar.iea.org …

 

[PDF] Evaluation of the CGIAR Research Program “Policies, Institutions and Markets”(PIM)

K Andersson, C Gerrard, W Meyers, F Nankhuni… – 2015

… its funders and partners in making decisions with respect to the continuation, expansion, and

structuring of PIM during the extension phase of 2015–16; • to inform decisions on the program

in response to the call of the Fund Council for the second round of CRPs in 2016; • to …

 

[HTML] Elucidating the Pathophysiology of Peripheral Neuropathies: A Conversation With Claudia Sommer

N Andrews – 2015

… Uçeyler N, Zeller D, Kahn AK, Kewenig S, Kittel-Schneider S, Schmid A, Casanova-Molla J,

Reiners K, Sommer C. Brain. 2013 Jun; 136(Pt 6):1857-67. Anti-autonomic nervous system

antibodies in CRPS. Sommer C. Pain. 2011 Dec; 152(12):2675-6. Epub 2011 Jul 30. …

 

Secondary Dystonia

P Kanovsky, D Dressler, K Menšíková – Dystonia and Dystonic Syndromes, 2015

… Eur J Neurol. 2010;17:649–60.CrossRefPubMed. 38. Schott GD. Peripherally-triggered CRPS

and dystonia. Pain. 2007;130:203–7.CrossRefPubMed. 39. van Hilten JJ, Geraedts EJ, Marinus

J. Peripheral trauma and movement disorders. Parkinsonism Relat Disord. …

 

[PDF] COMPLEX REGIONAL PAIN SYNDROME IN PEDIATRIC SPORTS: A CASE SERIES OF THREE YOUNG ATHLETES.

BAMDEP RICO

… Patients: Three adolescent young female athletes who developed clinical findings compatible

with Complex Regional Pain Syndrome (CRPS) after lower extremity trauma. … Conclusion: CRPS

is a challenging disease that may affect young active and athletic patients. …

 

[PDF] Successful Treatment of a Nine—Year Case of Complex Regional Pain Syndrome Type-l (Reflex Sympathetic Dystrophy) Wlth

WAAF Patient

… introduction Complat Pain Syndrome (CRPS) is a pain— ful and debilitating mopadtic

pain disorder. CRPS is classified into two types [1]. Both types appear to occur after

a traumatic event. With type-I. which is more common. …

 

Pain Management

RK Naidu, TM Pham – Basic Clinical Anesthesia, 2015

 

[PDF] Nuclear Data Development Related to Th-U Fuel Cycle in India

S Ganesan

… 7. The IAEA Co-ordinated Research Projects (CRPs). … International collaborations with CERN

n_TOF under BARC MOU, Korea, IAEA CRPs • Identification of faculty & support for formation

of useful local neutron data centres in Indian universities and institutes. …

 

Appendix of Management Algorithms For Certain Clinical Conditions

M ABCs, C Intralipid – Basic Clinical Anesthesia

Page 660. 675 PK Sikka et al.(eds.), Basic Clinical Anesthesia, DOI 10.1007/978-

1-4939-1737-2,© Springer Science+ Business Media New York 2015 Appendix

of Management Algorithms For Certain Clinical Conditions A1. …

 

Spinal Cord Stimulation for the Treatment of Neuropathic Pain Associated With Leprosy: A Case Report

NJ Brandmeir, MD Sather – Neuromodulation: Technology at the Neural Interface, 2015

… Background. Leprosy is a major source of nerve damage and may lead to neuropathic pain as

well as complex regional pain syndrome (CRPS). Spinal cord stimulation is an effective treatment

for CRPS, but there are no reports of this treatment in a patient with leprosy. …

 

Evaluating the skill of NMME seasonal precipitation ensemble predictions for 17 hydroclimatic regions in continental China

F Ma, A Ye, X Deng, Z Zhou, X Liu, Q Duan, J Xu… – International Journal of …, 2015

… (7). where FracErr is the mean fractional error, which is not biassed by the number of bins. The

continuous ranked probability score (CRPS) applies to probabilistic forecasts that exhibit

predictive cumulative distribution functions. … The CRPS is defined as. (8). …

 

Reconfigurable physical unclonable function based on probabilistic switching of RRAM

A Chen – Electronics Letters, 2015

… bit strings. These challenge–response pairs (CRPs) can be utilised as security

primitives. Ideally … Most of these PUF designs are static with unalterable CRPs after

the fabrication of the underlying physical systems. The so-called …

 

Burst Spinal Cord Stimulation in a Patient with Complex Regional Pain Syndrome: A 2‐year Follow‐Up

N Kriek, G Groeneweg, FJPM Huygen – Pain Practice, 2015

… Spinal cord stimulation (SCS) is an effective therapy to treat most patients with complex

regional pain syndrome (CRPS); however, the effect is not always maintained over

time. We present a case report of a patient successfully …

 

[PDF] Covariance models on the surface of a sphere: when does it matter?

J Jeong, M Jun – arXiv preprint arXiv:1504.01985, 2015

… as well as the two popular scoring rules (Gneiting and Raftery, 2007), the mean absolute

error (MAE) and the continuous ranked probability score (CRPS). … Figures 2(a)-(d) present

MAE and CRPS from the two models, the exponential models using …

 

A novel modeling attack resistant PUF design based on non-linear voltage transfer characteristics

A Vijayakumar, S Kundu – Proceedings of the 2015 Design, Automation & Test in …, 2015

… In addition, layout techniqu metallization and routing of interconnects can further increase the

resistance to such invasive PUF circuits can be widely classified as strong PUF based on their

physical implemen PUFs such as SRAM PUFs have limited ch pairs (CRPs). …

 

Assimilation of stream discharge for flood forecasting: Updating a semidistributed model with an integrated data assimilation scheme

Y Li, D Ryu, AW Western, QJ Wang – Water Resources Research, 2015

Page 1. Assimilation of stream discharge for flood forecasting: Updating a

semi-distributed model with an integrated data assimilation scheme Yuan

Li1,2,3, Dongryeol Ryu1, Andrew W. Western1, QJ Wang2 1 Department of …

 

Exploitation of complement regulatory proteins by Borrelia and Francisella

M Madar, E Bencurova, P Mlynarcik, AM Almeida… – Molecular BioSystems, 2015

… university of veterinary medicine and pharmacy, Komenskeho – 73, Kosice, Slovakia Running

title: Exploitation of CRPs by Borrelia and Francisella … binding to the host complement regulatory

proteins (CRPs) on their surface or expression of the CRP mimicking molecules. …

 

Efficient attacks on robust ring oscillator PUF with enhanced challenge-response set

PH Nguyen, DP Sahoo, RS Chakraborty… – Proceedings of the 2015 …, 2015

… The CRPs are generated by applying a log2 m–bit challenge, selecting (de- pending

on the applied challenge) a unique pair of ROs from the available set, and comparing

the oscillation frequencies of the two ROs in the pair. …

 

A spatial hybrid approach for downscaling of extreme precipitation fields

A Bechler, M Vrac, L Bel – Journal of Geophysical Research: Atmospheres, 2015

… ity Score (CRPS) and the 95% Quantile Score (QS95) [Gneiting and Raftery, 2007], the

multivariate energy score (ES), which generalizes the CRPS [Gneiting et al., 2008], is … It appears

that concerning the marginal distribution (ie, CRPS, QS, KS and CVM …

 

Fibromyalgia

 

Concomitance of fibromyalgia syndrome and cervical disc herniation

M Güler, T Aydın, E Akgöl, Ö Taşpınar – Journal of Physical Therapy Science, 2015

[Purpose] Fibromyalgia syndrome (FMS) and cervical disc herniation (CDH) are a common

diseases commonly encountered in physical therapy clinics. There are also patients who

have both of these diseases. In this study we aim to investigated whether FMS is a risk …

 

[PDF] Evaluation of Depression in Women Affected by Fibromyalgia Syndrome

A Vespa, C Meloni, MV Giulietti, M Ottaviani… – J Depress Anxiety, 2015

Objective: In this paper, we explored the association between the clinical course of Fibromyalgia

Syndrome (FMS) and patient’s response to emotional stress in terms of depression. …

Method: All participants (n=57 women with Fibromyalgia Sindrome (FMS); control group ( …

 

Scientific Controversy and its Relationship to the Media

K Perleberg – 2015

… environmental, and health-related issues. Some examples of this phenomenon include

global climate change, the effects of hydraulic fracturing (fracking) on the environment,

and what fibromyalgia is exactly. While the media has …

 

Osteomalacia, Severe Thoracic Deformities and Respiratory Failure in a Young Woman with Anorexia Nervosa

D Watanabe, M Hotta, A Ichihara – Internal Medicine, 2015

… She worked indoors in part- time and had a body weight of 32 kg. In the summer of year X-3,

at 19 years of age, she complained of generalized pain, and her family physician suspected

fibromyalgia. … However, the patient’s family physician diagnosed her with fibromyalgia. …

 

[PDF] Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?

Y Khayyat, S Attar – Oman Medical Journal, 2015

… It is no doubt a questionable fact whether vitamin D deficiency could be taken into account as

a causative factor relating to the pathogenic aetiology in the development of IBS as in the case

of vitamin deficiency induced fibromyalgia cases.14 The present study has shown …

 

PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND AN ANALGESIC AGENT

S Gullapalli, PK Gupta, MN Gandhi, S Mandadi – US Patent 20,150,105,406, 2015

… The method according to claim 19, wherein the neuropathic pain comprises peripheral neuropathy,

diabetic peripheral neuropathy (DPN), post herpetic neuralgia, spinal-cord injury pain, fibromyalgia,

multiple sclerosis pain, ischemic pain, chronic musculoskeletal pain …

 

Evaluation of Pain in Humans

DB Ross – US Patent 20,150,105,688, 2015

… There has been a clear link established between fibromyalgia and psychiatric disorders. … Each

of these inputs is selective for different pathophysiologic phenomena. Palpation is often

applied for myofascial type pain syndromes (such as fibromyalgia). …

 

[PDF] TENS for pain relief

T Can – 2015

… As far as we can tell, the TENS machine can be used for all pain conditions, providing there

is no health reason preventing its use. However, it can be difficult if you have many pain

sites or more widespread pain, such as fibromyalgia syndrome. …

 

[PDF] Metformin and caloric restriction induce an AMPK-dependent 2 restoration of mitochondrial dysfunction in fibroblasts from 3 Fibromyalgia patients

M Battino, MD Cordero

50 Mitochondria are essential organelles present in virtually all eukary-51 otic cells. One of

the primary functions of mitochondria is ATP produc-52 tion via the oxidative

phosphorylation (OXPHOS) pathway. Moreover, 53 they play crucial roles in many other …

 

[PDF] REVISTA BRASILEIRA DE REUMATOLOGIA

KF Salvato, JPM Santos, DAA Pires-Oliveira… – rev bras reumatol, 2015

… The criteria for exclusion were individuals with full or partial prosthetics in any of the joints being

evaluated, with concomitant diagnosis of other osteoarticular/muscle dis- eases, such as

rheumatoid arthritis, fibromyalgia, systemic lupus erythematosus and other rheumatic …

 

[PDF] Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unitary’hypothesis

S Pejovic, BH Natelson, M Basta… – BMC Neurology, 2015

Background Since chronic fatigue syndrome (CFS) and fibromyalgia (FM) often co-exist,

some believe they reflect the same process, somatization. Against that hypothesis are data

suggesting FM but not CFS was common in patients with sleep-disordered breathing ( …

 

Fibromyalgia Syndrome: Considerations for Dental Hygienists

A Walters, SL Tolle, GM McCombs – American Dental Hygienists Association, 2015

Purpose: Fibromyalgia syndrome (FMS) is a neurosensory disorder characterized by

widespread musculoskeletal pain. Typically persistent fatigue, depression, limb stiffness,

non-refreshing sleep and cognitive deficiencies are also experienced. Oral symptoms and …

 

Physical Trauma and Infection as Precipitating Factors in Patients with Fibromyalgia.

J Jiao, A Vincent, SS Cha, CA Luedtke, CH Kim, TH Oh – American Journal of …, 2015

Objective: The objective of this study was to evaluate both precipitating factors in patients

with fibromyalgia and any differences in clinical presentation, symptom severity, and quality-

of-life between those with and without precipitating physical trauma or infection.

 

[PDF] The prevalence of severe fatigue in rheumatic diseases: an international study

CL Overman, MB Kool, JAP Da Silva, R Geenen… – Fatigue and functioning in …, 2015

… Severe fatigue was least prevalent in patients with osteoarthritis (35%) and most

prevalent in patients with fibromyalgia (82%). In logistic regression analysis, severe

fatigue was predicted by having fibromyalgia, having multiple …

 

Attention and Working Memory in Female Adolescents with Chronic Pain and Healthy Pain Free Female Adolescents: A Preliminary Pilot Study.

K Mifflin, J Chorney, B Dick – The Clinical Journal of Pain, 2015

… in adults with chronic pain. In one study, adults with different types of chronic pain (fibromyalgia,

rheumatoid arthritis, and musculoskeletal pain) were found to perform … found that patients with

chronic pain due to fibromyalgia had hypoactivation in overlapping areas commonly …

 

Vulvar Vestibulodynia: Strategies to Meet the Challenge

A Bonham – Obstetrical & Gynecological Survey, 2015

Advertisement. Close Window. Close Window. Enter your Email address: Wolters Kluwer Health

may email you for journal alerts and information, but is committed to maintaining your privacy

and will not share your personal information without your express consent. …

 

The head says yes but the heart says no: what is non-cardiac chest pain and how is it managed?

JB Chambers, EM Marks, MS Hunter – Heart, 2015

… psychologist. It is likely that patients seen by a cardiologist with NCCP resemble those

referred to a rheumatologist with fibromyalgia and perhaps those seen first by a

gastroenterologist, but comparative data do not exist. Symptoms …

 

[HTML] Internet-based interventions for pain management: A systematic review of randomised controlled trial (RCTs) conducted from 2010 to 2014

A El-Metwally – Journal of Public Health and Epidemiology, 2015

… Description of participants. Most studies targeted patients with chronic pain syndrome including

low back pain, migraine, fibromyalgia and musculoskeletal pain (Table 1). Wide age range used

in these studies captures adults, elderly and children between 3 years and above. …

 

Conditioned Pain Modulation in Patients with Acute and Chronic Low Back Pain.

S Mlekusch, AY Neziri, A Limacher, P Jüni… – The Clinical Journal of Pain, 2015

… 8. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and

heterotopic noxious conditioning stimulation (hncs) in fibromyalgia patients and healthy subjects. …

Julien N, Goffaux P, Arsenault P,et al. Widespread pain in fibromyalgia is related to a …

 

Manual Therapy, Therapeutic Patient Education, and Therapeutic Exercise, an Effective Multimodal Treatment of Nonspecific Chronic Neck Pain

H Beltran-Alacreu, I López-de-Uralde-Villanueva… – American Journal of …, 2015

… associated with whiplash in- juries, medical red flag history (ie, tumor, fracture, metabolic diseases,

rheumatoid arthritis, and oste- oporosis), neck pain with cervical radiculopathy, neck pain

associated with externalized cervical disc herniation, fibromyalgia syndrome, previous …

 

Pain Characteristics do not Distinguish Fibromyalgia Patients with Abnormal Skin Biopsy (P5. 069)

V Lawson, J Grewal, K Hackshaw, P Mongiovi – Neurology, 2015

OBJECTIVE: To determine whether pain characteristics can distinguish between

fibromyalgia patients who have abnormal skin biopsy and/or SNAP amplitudes.

BACKGROUND: Patients (n= 165) with fibromyalgia were assessed for differences in pain …

 

Effects of functional training on pain, leg strength and balance in women with fibromyalgia

PÁ Latorre Román, MP Santos e Campos… – Modern Rheumatology, 2015

Abstract Aim: The aim of this study was to analyze the effect of 18-week functional training

(FT) program consisting in two sessions a week of in-water exercise and one of on-land

exercise on pain, strength and balance in women with Fibromyalgia. Methods: A total …

 

[HTML] Elucidating the Pathophysiology of Peripheral Neuropathies: A Conversation With Claudia Sommer

N Andrews – 2015

… She is active in the development of national and international guidelines on treatment

of peripheral neuropathies, on nerve and skin biopsies, and on treatment of

fibromyalgia and neuropathic and facial pain. Sommer spoke …

 

Alterations in Brain Gray Matter Volume are Associated with Reduced Evoked-Pain Connectivity following Acute Pregabalin Administration (S10. 003)

T Puiu, A Kairys, L Pauer, T Schmidt-Wilcke, E Ichesco… – Neurology, 2015

… Preclinical studies indicate that PGB may potentially down-regulate glutamate release in the

synapse. DESIGN/METHODS: Sixteen female fibromyalgia patients completed a randomized

double-blind two-period cross-over study of PGB versus placebo (PBO). …

 

Clinical and molecular profiling of muscle pain in myotonic dystrophy type 2 (S10. 002)

V Palada, R Moshourab, S Kempa, M Boschmann… – Neurology, 2015

… CONCLUSIONS: Our data show that DM2 related myalgias are primarily of muscular origin

but some patients also develop additional central pain. The results may also help to understand

other more common reasons for muscle pain such as fibromyalgia. …

 

[HTML] Complementary and alternative medicine in chronic neurological pain

SK Mishra, B Trikamji, E Togneri – Indian Journal of Pain, 2015

… [68] Biomagnetic therapy has also been used in treating chronic pain, particularly related to tissue

ischemia and fibromyalgia with low frequency and low intensity magnetic energy. … Pioro-Boisset

M, Esdaile JM, Fitzcharles MA. Alternative medicine use in fibromyalgia syndrome. …

 

[DOC] Nociception at the diabetic foot, an uncharted territory

EA Chantelau – World J Diabetes, 2015

… Although this protocol had primarily been devised for examining hyperalgesia in non-nociceptive

pain syndromes like fibromyalgia, or neuropathic pains, and not for assessing hypoalgesia [18] ,

the author (Chantelau EA) believes that parts of it may well be applied for studying …

 

[HTML] Need of Indian protocol in pain management

R Gurumurthi, G Das – Indian Journal of Pain, 2015

… for responsible opioid prescribing in chronic noncancer pain and spine intervention procedures,

World Institute of Pain guidelines for interventional pain procedures, WHO ladder for cancer pain

management, American College of Rheumatology criteria for fibromyalgia and so …

 

[PDF] The Effects of Coffee and Korean Red Ginseng with Body Wrap Steam Bathing on Stress Markers and Lipid Profiles

SY Park, SP Lee – Journal of Food and Nutrition Research, 2015

… [4] Buskila, D., Abu-Shakra, M., Neumann, L., “Balneotherapy for fibromyalgia at the

Dead Sea,” Rheumatology International, 20, 105-108, 2001. [5] Neumann, L., Sukenik,

S., Bolotin, A., Abu-Shakra, M., Amir, M., Flusser, D., Buskila …

 

An Innovative Nursing Approach to Caring for an Obstetric Patient With Rape Trauma Syndrome (RTS)

C Parker – Journal of Obstetric, Gynecologic, & Neonatal Nursing, 2015

… Many survivors have a history of panic attacks, phobias, self-mutilation, personality disorders,

depression, anxiety, substance abuse, asthma, irritable bowel syndrome, chronic pain,

fibromyalgia, obesity, sleep disturbances, and migraines to name a few (Burian, 1995; Hobbins …

 

Herpes Simplex Virus Type 1 Dorsal Root Ganglionitis in a 34 Year Old Male With Occipital Neuralgia Refractory to Medical and Radiofrequency Ablation Therapies: …

J Rathore, K Slavin, R Rathore, A Rakic, T Valyi-Nagy – Neurology, 2015

… RESULTS: A 34 year old Caucasian homosexual male with past medical history of fibromyalgia,

post-traumatic stress disorder and bilateral occipital headaches that started 15 years ago after

a motor vehicle accident presented with a five week history of significantly worsened …

 

Placebo-Controlled, Double-Blind, Randomized Pilot Study to Evaluate the Effects of Low-Dose Naltrexone on Quality of Life and Fatigue in Newly Diagnosed High- …

K Peters, M Affronti, S Woodring, E Lipp, P Healy… – Neurology, 2015

… Naltrexone, an orally semisynthetic opiate antagonist, is FDA- approved for treatment of heroin/

alcohol addiction, but there have been observations that low dose naltrexone (LDN) can mitigate

fatigue and stress in fibromyalgia and multiple sclerosis patients. …

 

Diagnosis at work–On sick leave in Sweden

L Eriksson – Social Theory & Health, 2015

… The article explores how understandings of patients with symptom diagnoses, notably fibromyalgia,

are shaped by the introduction of a new medical decision-making support tool used to assess

patients’ ‘work capacity’, together with a revision of the Swedish social insurance. …

 

[HTML] Pressure pain threshold and pain perception in temporomandibular disorder patients: is there any correlation?

J Stuginski-Barbosa, RS Silva, CO Cunha… – Revista Dor, 2015

… in accordance with the RDC/TMD. Exclusion criteria included patients with systemic

disease like fibromyalgia or rheumatic conditions, odontogenic or neuropathic pain

and history of TMJ surgery. Patients on ongoing use of …

 

Current Topical and Systemic Therapies for Itch

TA Leslie, MW Greaves, G Yosipovitch – Pharmacology of Itch, 2015

… chronic kidney disease, cholestasis, myeloproliferative disorders and hyperthyroidism),

neuropathic (notalgia paresthetica, brachioradial pruritus and postherpetic neuralgia itch) and

psychogenic (obsessive-compulsive disorders, depression and fibromyalgia) (Yosipovitch and …

 

Common Co-morbidities and Fibromyalgia

D Marcus, A Deodhar

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The portal can access those files and use them to remember the user’s data, such as their

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[DOC] WHAT IS LYME DISEASE Named after the small town of Lyme, Connecticut, where the disease was first identified in 1975, Lyme disease is a bacterial illness …

T Der-Ohanian

… In later stages, Lyme disease can become chronic and trigger serious conditions such as

rheumatoid arthritis, multiple sclerosis, AlzheimerÆs disease, chronic fatigue syndrome,

fibromyalgia, ParkinsonÆs disease, and a host of other illnesses. …

 

[HTML] Chaga Mushroom Powder (1 lb)

ZNFSM Life

Wild, non-GMO Chaga Mushroom Powder- antioxidant & polysaccharide rich-

supports a healthy immune system. Fresh Chaga Powder.

 

The Dual-Dialectical Conceptualization in Psychotherapy

S Navon – American Journal of Psychotherapy, 2015

… The American Journal of Family Therapy, 33, 103-116. Navon, S. (2005b). Listening to

illness/non-illness motifs: A case of fibromyalgia. Families Systems & Health, 23, 358-361. Navon, S. (2014). The illness/non-illness model: Hypnotherapy for Physically Ill Patients. …

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