by admin | Dec 7, 2015 | Uncategorized
People born with a rare genetic mutation are unable to feel pain, but previous attempts to recreate this effect with drugs have had surprisingly little success. Using mice modified to carry the same mutation, UCL researchers funded by the MRC and Wellcome Trust have now discovered the recipe for painlessness.
‘Channels’ that allow messages to pass along nerve cell membranes are vital for electrical signalling in the nervous system. In 2006, it was shown that sodium channel Nav1.7 is particularly important for signalling in pain pathways and people born with non-functioning Nav1.7 do not feel pain. Drugs that block Nav1.7 have since been developed but they had disappointingly weak effects.
The new study, published in Nature Communications, reveals that mice and people who lack Nav1.7 also produce higher than normal levels of natural opioid peptides.
To examine if opioids were important for painlessness, the researchers gave naloxone, an opioid blocker, to mice lacking Nav1.7 and found that they became able to feel pain. They then gave naloxone to a 39-year-old woman with the rare mutation and she felt pain for the first time in her life.
“After a decade of rather disappointing drug trials, we now have confirmation that Nav1.7 really is a key element in human pain,” says senior author Professor John Wood (UCL Medicine). “The secret ingredient turned out to be good old-fashioned opioid peptides, and we have now filed a patent for combining low dose opioids with Nav1.7 blockers. This should replicate the painlessness experienced by people with rare mutations, and we have already successfully tested this approach in unmodified mice.”
Broad-spectrum sodium channel blockers are used as local anaesthetics, but they are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. By contrast, people born without working Nav1.7 still feel non-painful touch normally and the only known side-effect is the inability to smell.
Opioid painkillers such as morphine are highly effective at reducing pain, but long-term use can lead to dependence and tolerance. As the body becomes used to the drug it becomes less effective so higher doses are needed for the same effect, side effects become more severe, and eventually it stops working altogether.
“Used in combination with Nav1.7 blockers, the dose of opioid needed to prevent pain is very low,” explains Professor Wood. “People with non-functioning Nav1.7 produce low levels of opioids throughout their lives without developing tolerance or experiencing unpleasant side-effects. We hope to see our approach tested in human trials by 2017 and we can then start looking into drug combinations to help the millions of chronic pain patients around the world.”
The findings were made possible by the use of ‘transgenic’ mice, meaning they were modified to carry genetic material from another organism — in this case, the mutation that prevents humans from feeling pain. Precise physiological experiments showed that the nervous systems of the transgenic mice contained around twice the levels of naturally-produced opioids as unmodified mice from the same litter.
“Our results reaffirm the clinical relevance of transgenic mouse models for human diseases,” says Professor Wood. “Studying the mice showed us what was going on in the nervous system that led to painlessness and our findings were directly translatable to humans, as confirmed by the painless patient. Without the work in transgenic mice, none of this would have been possible and we still wouldn’t know how to replicate the effects to help people suffering from chronic pain.”
Story Source:
University College London. “Genetically modified mice reveal the secret to a painless life: Researchers have discovered the pharmaceutical recipe for painlessness.” ScienceDaily. ScienceDaily, 4 December 2015. <www.sciencedaily.com/releases/2015/12/151204090034.htm>
Journal Reference:
- Michael S. Minett, Vanessa Pereira, Shafaq Sikandar, Ayako Matsuyama, Stéphane Lolignier, Alexandros H. Kanellopoulos, Flavia Mancini, Gian D. Iannetti, Yury D. Bogdanov, Sonia Santana-Varela, Queensta Millet, Giorgios Baskozos, Raymond MacAllister, James J. Cox, Jing Zhao, John N. Wood. Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7. Nature Communications, 2015; 6: 8967 DOI: 10.1038/ncomms9967
by admin | Nov 5, 2015 | Uncategorized
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli
F Hu, G Ding, Z Zhang, LA Gatto, S Hawgood… – Innate Immunity, 2015
… UTI was induced as previously described, 30 with some modifications. In brief, mice were
anesthetized by ip injection with ketamine/xylazine (90 mg/kg ketamine and 10 mg/kg xylazine),
and were gently massaged and pushed down on the bladder to expel urine. …
[PDF] Comparison of propofol and ketofol in minor gynecologic interventions
Y Işık, Z Kurdoğlu, U Göktaş, İ Katı, D Sözen – J Clin Exp Invest www. jceionline. org …, 2015
… Propofol is administered as an infusion instead of in repeated doses, which prevents
dose-dependent respiratory and cardiovascular system depression and pro- vides controlled
sedation [1]. Ketamine is preferred for premedication, anesthesia induction and main- tenance …
Anesthesia Complications of Pediatric Radiotherapy
V Verma, AB Beethe, M LeRiger, RR Kulkarni, M Zhang… – Practical Radiation …, 2015
… While agents such as ketamine (complication rates approaching 23-24%) have been used
in the past, other agents such as propofol and volatile anesthetics have lower complication
rates due to improved drug side effect profiles (0.01-3.5%). …
[HTML] Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway
R Rajkumar, Y Wu, U Farooq, WH Tan, GS Dawe – Brain Research Bulletin, 2015
… Ketamine (Parnell Manufacturing Pty Ltd; Alexandria, NSW, Australia), xylazine (Ilium Xylazil,
Troy Laboratories Pty Ltd; Glendenning, NSW, Australia), enrofloxacin (Baytril 5%, Bayer Health
Care; Seoul, Korea) and carprofen (Carprieve, Norbrook Laboratories (GB), Ltd …
The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect
K Pytka, A Dziubina, K Młyniec, A Dziedziczak… – Pharmacological Reports, 2015
Depression is one of the most common mental disorders and social issue worldwide. Although
there are many antidepressants available, the effectiveness of the th.
[HTML] Communicating with mismatch and tension: treatment provision experiences of primary care doctors treating patients with overactive bladder in Hong Kong
JY Siu – BMC Family Practice, 2015
… [P6]. During the study period, the symptoms of OAB, particularly urinary frequency and
urinary incontinence, were identified by government antisubstance abuse public service
announcements as signs and consequences of ketamine abuse. …
Hydrogen sulfide (H 2 S) attenuates uranium-induced acute nephrotoxicity through oxidative stress and inflammatory response via Nrf2-NF-κB pathways
J Zheng, T Zhao, Y Yuan, N Hu, X Tang – Chemico-Biological Interactions, 2015
… sacrificed. After urine collection, rats were anesthetized by an ip injection of
ketamine-xylazine (50 mg/kg ketamine and 5 mg/kg xylazine), and blood samples
were obtained directly from the heart ventricle in anesthetized animals. …
[PDF] General discussion and future perspectives
SA Bouwense, M de Vries, LT Schreuder, SS Olesen… – PDF hosted at the Radboud …, 2015
… even if technically successful. If central nervous system pain processing is altered,
specific treatment targeting these changes should be instituted (eg gabapentinoids,
ketamine or tricyclic antidepressants). Suitable tools are …
Propofol target-controlled infusion for sedated gastrointestinal endoscopy: A comparison of propofol alone versus propofol–fentanyl–midazolam
CD Hsu, JM Huang, YP Chuang, HY Wei, YC Su… – The Kaohsiung Journal of …, 2015
… The currently used regimens include propofol, benzodiazepines (such as midazolam and
diazepam), opioids (such as fentanyl and remifentanil), ketamine, and de-dexmedetomidine
[3], [4], [5] and [6]. Among them propofol has become popular in developed countries, because …
[PDF] A Critical Case of Closed Cervix Pyometra in a Bitch
JK Agrawal, A Saxena, P Kumar, A Patel – International Journal of Livestock Research, 2015
… General anethesia was induced and maintained by a combination of ketamine hydrochloride @
5mg/kg and Xylazine @ 0.2mg/kg body weight intravenously following premedication with atropine
sulphate @ 0.04mg/kg body weight. Laparotomy was performed …
Radiofrequency Ablation (RFA)
Treatment of Neuroendocrine Liver Metastases
HA Farley, RF Pommier – Surgical Oncology Clinics of North America, 2015
… Treatment options: radiofrequency ablation. RFA is another technique used to treat
neuroendocrine metastases of the liver, but it has limitations. One can ablate a limited number
of lesions (generally up to 5), of limited size (generally <5 cm in diameter), provided they are …
[PDF] Ablative Techniques in Advanced Pancreatic Cancer: Do They Affect The Quality of Life?–Review
D Dimitrov, H Feradova, D Gincheva, L Dall’Olio – JOP. J Pancreas (Online), 2015
… Such ablative therapies are high-intensity focused ultrasound (HIFU), radiofrequency
ablation (RFA), irreversible electroporation (IRE), iodine-125, iodine-125–cryosurgery,
photodynamic therapy (PDT) and microwave ablation [8]. …
Minimally Invasive Techniques for Resection of Pancreatic Neuroendocrine Tumors
GGF Ranvier, D Shouhed, WB Inabnet – Surgical Oncology Clinics of North America, 2015
Please note that Internet Explorer version 8.x will not be supported as of January 1,
2016. Please refer to this blog post for more information. Close. …
[HTML] Colorectal Liver Metastasis, Primary Gallbladder Carcinoma and Myelofibrosis Present Simultaneously in a Liver Resection Specimen
SA Gray, MH Raber, E Provoost, GJ Toes, JM Klaase – Case Reports in …, 2015
… An elective operation was scheduled, and the surgeon performed a wedge resection of segments
5 and 7 of the liver, and a radiofrequency ablation was used to treat a lesion in segment 3.
Although the suspicion of gallbladder carcinoma at the time of surgery was low, the …
Nontraumatic Cervical Spine for Primary Care Providers
CR Hemmer – The Journal for Nurse Practitioners, 2015
… physical therapy, a home traction unit, transcutaneous electrical nerve stimulation, epidural steroid
injections, selective nerve root blocks (transforaminal injections), botulinum toxin type A injections,
medication management, radiofrequency ablation, and surgical correction. …
Surgical Management of Adrenocortical Carcinoma: An Evidence-Based Approach
J Datta, RE Roses – Surgical Oncology Clinics of North America, 2015
Please note that Internet Explorer version 8.x will not be supported as of January 1,
2016. Please refer to this blog post for more information. Close. …
SYSTEM AND METHOD FOR RECONSTRUCTING CARDIAC SIGNALS ASSOCIATED WITH A COMPLEX RHYTHM DISORDER
S Narayan, R Sehra – US Patent 20,150,289,807, 2015
… For instance, ablation success for atrial tachycardias (a ‘simple’ disorder) may be as low as 70%. …
Thus, ablating the cause of a heart rhythm disorder can be challenging, and even experienced
practitioners may require hours to ablate certain ‘simple’ rhythm disorders …
[HTML] RADIONUCLIDE IMAGING AND THERAPY OF NEUROENDOCRINE TUMOURS
S Navalkissoor, G Gnanasegaran – Journal of Cancer & Allied Specialties, 2015
… These include surgical debulking, chemotherapy, molecular targeted therapies (eg sunitinib
and everolimus), interferon, somatostatin analogues, local therapies (eg radiofrequency ablation
or embolisation) and peptide receptor radionuclide therapy (PRRT). …
[PDF] Successful Radiofrequency Pulmonary Vein Isolation In A Patient With Pneumonectomy
F Kilicaslan, EE Gul, C Erol
… Circumferential radiofrequency ablation of ipsilateral PVs was done (30-35 W, 17
mL/min) with irrigated catheter (Sprinklr, Medtronic, Minneapolis, USA) and both,
entrance and exit blocks were achieved after the ablation. Interestingly …
[PDF] Ablation Is A Treatment Option Without Permanent Pacemaker Implantation For Bradycardia With Persistent Atrial Fibrillation
W Yamada, K Tanimoto, M Yamada, K Inagawa…
… Page 5. Rotational Atriography Of Left Atrium – A Imaging Technique Used To Support Left Atrial
Radiofrequency Ablation: A Comparison Of Anatomical Data Of Left Atrium F. Lehar, Z. Starek,
J. Jez, J. Wolf, T. Kulik, A. Zbankova, M. Novak Department of Cardiology, ICRC/St. …
Complex Regional Pain Syndrome (CRPS/RSD)
[PDF] Do insiders trade on mispricing after earnings announcements?
JP Fidrmuc, J Novák, H Contreras – 2015
Page 1. Do insiders trade on mispricing after earnings announcements? Jana P.
Fidrmuc∗ Warwick Business School Jirı Novák† Charles University Harold Contreras‡
Warwick Business School October 21, 2015 Abstract This …
[PDF] A predictive framework for evaluating models of semantic organization in free recall
NW Morton, SM Polyn – Journal of Memory and Language, 2015
Research in free recall has demonstrated that semantic associations reliably influence the
organization of search through episodic memory. However, the specific.
6-, 7-, OR 8-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
GW Muller, H Man – US Patent 20,150,291,555, 2015
… Examples of diseases or disorders include, but are not limited to, cancer, disorders associated
with angiogenesis, pain including, but not limited to, Complex Regional Pain Syndrome (“CRPS”),
Macular Degeneration (“MD”) and related syndromes, skin diseases, pulmonary …
[PDF] Psychological distress and stressful life events in pediatric complex regional pain syndrome
MD Hannah Brehmer, MD Boris Zernikow
… Complex regional pain syndrome (CRPS) is increasingly recog- nized as a serious pain
disorder in children and adolescents. … Specifically, it is not known which factors precipitate
CRPS and which result from the ongoing painful disease. …
[PDF] In the High Court of New Zealand Wellington Registry
L SEALES, SAOFL SEALES
… Pain News 11 (1) 2013 pages 30-33. Safarfashandi Z, Munglani R, Safarfashandi L, Sadheura
J, Jenner C “The incidence of complex regional pain syndrome (CRPS) post trauma and the
possible role of tight plaster of Paris in the aetiology of CRPS“. …
[PDF] Assessment Report
CO Onyango, Y Suwa, Y Pinto
… directory ….. 18 – Table 5: List of ASTI publications in Phase II 3 ….. 20 Table 6: Summary of
ex-post impact assessments by CGIAR Centres, CRPs and SPIA ….. 29 …
[PDF] Hereditary Immunity against Infectious Diseases
IA Shabarov, ZI Urmancheeva, SN Rumyantsev…
Page 1. 1 Innovative Immunology | www.austinpublishinggroup.com/ebooks Copyright
© Rumyantsev SN.This book chapter is open access distributed under the Creative
Commons Attribu- tion 4.0 International License, which …
Encyclopedia of Exploration Geophysics
M this Chapter
Page 1. U1-1 Abstract To produce a reliable image of the subsur- face, we must use
a depth-migration scheme that requires a detailed model of the parameter fields for
use by migration. Obtaining reliable values of all parameters …
Fibromyalgia
[PDF] Does “Multiple Labeling” Benefit or Harm in Fibromyalgia Patients
E Trallero, C Alegre – Fibrom open, 2015
A systematic review showed that there is no evidence an accurate diagnosis of fibromyalgia
per se could worsen prognosis in patients with this condition [1]. Indeed, it could be useful to
reduce healthcare utilization by patients. Nevertheless, social and individual long-term …
[PDF] Comparison between Depression Levels of Women with Knee Osteoarthritis, Rheumatoid Arthritis, and Fibromyalgia Syndrome: A Controlled Study
D Karşılaştırılması, BK Çalışma – 2015
DOI: 10.5152/tftrd.2015.87894 Turk J Phys Med Rehab 2015;61:197-202 Türk Fiz Tıp Rehab
Derg 2015;61:197-202 … Comparison between Depression Levels of Women with … Diz
Osteoartrit, Romatoid Artrit ve Fibromiyalji Sendromlu Kadınlarda Depresyon …
NOVEL BIPHENYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR …
CH Lee, K Lee – US Patent 20,150,291,509, 2015
… group consisting of dermatitis, allergy, atopy, conjunctivitis, periodontitis, rhinitis, tympanitis,
pharyngolaryngitis, tonsillitis, pneumonia, gastric ulcer, gastritis, Crohn’s disease, colitis, irritable
colitis, hemorrhoids, gout, ankylosing spondylitis, lupus, fibromyalgia, psoriasis, arthritis …
[PDF] Recent advances in massage therapy–a review
SL LIU, W Qi, H Li, YF WANG, XF YANG, ZM LI, Q Lu… – Eur Rev Med Pharmacol Sci, 2015
… in animal models. In a randomized trial conducted by Ekici et al13, application of
MLD to women with fibromyalgia resulted in improvements regarding pain, health
status, and health-related quality of life. Lancaster and Crow14 …
Immediate Effect of Basic Body Awareness Therapy on Heart Rate Variability
AM Mantovani, CEPT Fregonesi, RMR Lorençoni… – … Therapies in Clinical …, 2015
To determine the immediate effect of a Basic Body Awareness Therapy (BAT) session on
measures of heart rate variability (HRV) in healthy young people.13 healthy.
[PDF] Radial shock wave therapy in the treatment of lateral epicondylitis
JD Rompe, J Decking, C Schoellner, C Theis…
… P009-e Gait analysis: An objective measurement for subgrouping fibromyalgia patients B. Auvinet
a,*, D. Chaleil b, J. Cabane c, A. Dumolard d, P. Hatron e, R. Juvin d, M. Lanteri-minet f, Y. Mainguy
g, L. Negre-pages h, F. Pillard i, D. Riviere i, Y. Maugars j a Clinique, 8, rue des …
2-OXO-2, 3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS
D Brunner, J Malberg, BG Shankar, S Kolczewski… – US Patent 20,150,284,386, 2015
… Fibromyalgia, which is a syndrome characterized by chronic generalized pain associated with
different somatic symptoms, such as sleep disturbances, fatigue, stiffness, balance problems,
hypersensitivity to physical and psychological environmental stimuli, depression and …
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
JE Campbell, P Jones – US Patent 20,150,291,626, 2015
… affective disorder, seasonal affective disorder, obsessive-compulsive disorder, attention deficit
disorder, attention deficit hyperactivity disorder, vertigo, pain, neuropathic pain, sensitization
accompanying neuropathic pain, inflammatory pain, fibromyalgia, migraine, cognitive …
[PDF] How is Qigong Conducive to Women’s Health
FK Cheng – Int J Complement Alt Med, 2015
… Likewise, Tai Chi is beneficial for treating fibromyalgia, achieving better symptomatology,
aerobic capacity, dynamic balance, body strength, and walking distance [112]. Psychological
health: Studies inform the effects of Baduanjin on mental well-being. …
[HTML] Recommendations to the primary care practitioners and the patients for managing pelvic pain, especially in painful bladder syndrome for early and better prognosis
KJ Chung, ANY Han, KH Kim – Journal of Exercise Rehabilitation, 2015
… Scholar]. Nickel JC., Tripp DA., Pontari M., Moldwin R., Mayer R., Carr LK., Doggweiler R., Yang
CC., Mishra N., Nordling J. Interstitial cystitis/painful bladder syndrome and associated medical
conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic …
by admin | Oct 1, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
Ketamine Derivatives
JW Sleigh, WA Denny, J Jose, SA Gamage, MG Harvey… – US Patent 20,150,259,277, 2015
Abstract: The present invention relates to ketamine derivatives of the formula (I),
pharmaceutical compositions comprising them, and methods for treating pain comprising
administering them, and their use in the manufacture of medicaments for treating pain. …
Comparing the hemodynamic parameters and seizure duration between ketamine and thiopental during Electroconvulsive therapy in patients with Major depressive …
M Mohseni, A Ghanbari, MA Motazedi Ghajar… – Anesthesiology and Pain, 2015
Aim and Background: Today the effect of Electroconvulsive therapy (ECT) in cure of Major
depressive disease (MDD), and psychiatric patients is well accepted and usage of this
method is developed every day. In this regard, selecting the most effective hypnotic drugs …
The antinociceptive efficacy of morphine-ketamine-magnesium combination is influenced by the order of medication administration.
SM Vučkovič, VKR Savič, DP Srebro, BM Medič… – European review for …, 2015
OBJECTIVE: Ketamine and magnesium, both N-methyl-D-aspartate (NMDA) receptor
antagonists, enhance the antinociceptive effects of opioid analgesics in different animal
models of pain, as well as in humans. This study aimed at evaluating whether magnesium …
[HTML] Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
S Klein, CB Herath, R Schierwagen, J Grace… – PLOS ONE, 2015
… Cholestatic model. BDL was performed in 40 rats (180g) after anesthesia with ketamine/xylazine
(78mg/kg and 10mg/kg body weight) as previously described [12]. … Briefly rats were anesthetized
with ketamine/xylazine (78mg/kg and 10mg/kg body weight), respectively. …
[HTML] Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction
AL Leblond, K Klinkert, K Martin, EC Turner, AH Kumar… – PLOS ONE, 2015
… Procedures were performed under anesthesia induced by ketamine (90mg/kg), xylazine
(10mg/kg) and urethane (1.25mg/kg) and analgesia by ip delivery of carprofen (5 mg/Kg). … Mice
were anesthetized with ketamine (90mg/kg), xylazine (10mg/kg) and urethane (1.25mg/kg). …
Morphological Pulmonary Diffusion Capacity for Oxygen of Burmese Pythons (Python molurus): a Comparison of Animals in Healthy Condition and with Different …
JM Starck, I Weimer, H Aupperle, K Müller… – Journal of Comparative …, 2015
… Snakes were anaesthetized (1 mg/kg diazepam intramuscularly [i/m]; Faustan; Temmler Pharma,
Marburg, Germany, followed by 40 mg/kg ketamine hydrochloride i/m; Ketavet; Pfizer Pharma,
Berlin, Germany) and placed in the CT scanner (Brilliance CT 6; Philips, Hamburg …
[PDF] Articles in PresS. Am J Physiol Lung Cell Mol Physiol (March 27, 2015). doi: 10.1152/ajplung. 00291.2014
BA MacKenzie, I Henneke, S Hezel, D Al Alam… – 2015
… Mice were genotyped as described previously (3, 12, 34). 148 149 Bleomycin administration
150 10–14 week-old female mice were anaesthetized with a mixture of 0.6 µl/g Ketamine 10%
151 (100 mg/ml) and 0.3 µl/g Dormitor 10% (0.5 mg/ml) dissolved in 0.7% saline. …
Anesthesia for Endoscopy
M Asakawa – Veterinary Clinics of North America: Small Animal …, 2015
… 26 Another study found that a combination of acepromazine and butorphanol followed by induction
with propofol had minimal effect on splenic volume, whereas medetomidine and butorphanol
as premedicants followed by ketamine and diazepam for induction were associated …
[HTML] Generation and Characterization of Live Attenuated Influenza A (H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation
S Shcherbik, N Pearce, A Balish, J Jones, S Thor… – PLOS ONE, 2015
… replication in multiple organs. Anesthesia occurred through an intramuscular injection
of a ketamine-xylazine-atropine cocktail (25 mg/kg ketamine, 2 mg/kg xylazine,
and 0.05 mg/kg of atropine). For euthanasia, ferrets were …
[HTML] Standardized surgical approaches to ear surgery in rats
P Li, D Ding, K Gao, R Salvi – Journal of Otology, 2015
… studies using rats. 2. Anesthesia and pre-operative preparation. Health SD rats
weighing about 250 g were selected and anesthetized with intraperitoneal ketamine
(100 mg/kg) and chlorpromazine (5 mg/kg). The skin around …
Radiofrequency Ablation (RFA)
Is radiofrequency ablation of lung metastases the most radical treatment?
M Zielinski, R Zaimi, P Sabatier, P Bagan – European Journal of Surgical Oncology, 2015
We read with interest the article on long term results of radiofrequency ablation (RFA) to lung
metastases from colorectal cancer 1. This article is an interesting retrospective analysis on
long term survival in patients with lung metastases from colorectal cancer treated with this …
Uninterrupted new oral anticoagulants compared to uninterrupted Vitamin K antagonists in ablation of atrial fibrillation. A Meta-analysis
R Nairooz, K Ayoub, P Sardar, J Payne, A Almomani… – Canadian Journal of …, 2015
… NOAC= new oral anticoagulant, VKA=vitamin K antagonist, N/A=not available, TEE=
trans-esophageal echocardiogram, ICE= intra-cardiac echocardiogram, UFH=
unfractionated heparin, s= seconds, RFA= radiofrequency ablation. …
Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome
P Gal, NF Marrouche – European Heart Journal, 2015
… Post-ablation DE-MRI allows for assessment of the total scar burden, complete encirclement
of pulmonary veins, and the assessment of residual fibrosis, which were all reported to
be strong predictors of arrhythmia recurrences post-ablation. …
Imaging Hepatocellular Carcinoma with Dynamic CT Before and After Transarterial Chemoembolization: Optimal Scan Timing of Arterial Phase
M Saake, MM Lell, A Eller, W Wuest, M Heinz, M Uder… – Academic Radiology, 2015
… In eight patients previous TACE and in five patients previous radiofrequency ablation had been
performed and follow-up imaging had demonstrated HCC recurrence. … First, in a part of our cohort
the HCCs had been treated previously by TACE or radiofrequency ablation. …
Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial
K Kaitani, K Inoue, A Kobori, Y Nakazawa, T Ozawa… – European Heart Journal, 2015
… fasttrack ★ Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation
for Atrial Fibrillation (EAST-AF) trial. Kazuaki Kaitani, Koichi Inoue, Atsushi Kobori,
Yuko Nakazawa, Tomoya Ozawa, Toshiya Kurotobi, Itsuro …
PAEDIATRIC CT EXPOSURE PRACTICE IN THE COUNTY OF RIO DE JANEIRO: THE NEED TO ESTABLISH DIAGNOSTIC REFERENCE LEVELS
FM de Jesus, LAG Magalhães, S Kodlulovich – Radiation Protection Dosimetry, 2015
… are essential for the diagnosis and monitoring of patients with complex cardiovascular disease
(2–4) , for the diagnosis of pulmonary embolism (5) and for guiding interventional procedures,
such as radiofrequency ablation, biopsy, abscess drainage and nephrostomy (6) . In …
Substrate Mapping for Unstable Ventricular Tachycardia
P Santangeli, FE Marchlinski – Heart Rhythm, 2015
… Scar dechanneling, linear ablation through sites matching VT with pacing and the core isolation
approach focus on more discrete … and/or inducible arrhythmias by means of physiological
maneuvers, although this does not necessarily translate in less radiofrequency lesions to …
[HTML] Evaluation and management of chronic coccygodynia: Fluoroscopic guided injection, local injection, conservative therapy and surgery in non-oncological pain
A Galhom, M al-Shatouri, SA El-Fadl – The Egyptian Journal of Radiology and …, 2015
… 23). The beneficial effect was retained with repeated injections (21). Radiofrequency
ablation using two needles achieved a pain reduction of >50% for an average duration
of 2.2 months, in a series of 13 patients (24). Another …
[HTML] Assessment of prognosis of patients with stage II colon cancer
S Martins, P Martins – Journal of Coloproctology, 2015
… Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined
resection/ablation for colorectal liver metastases. Ann. Surg., 239 (2004), pp. 818–825 discussion
825–27. 9; K. Lang, JR Korn, DW Lee, LM Lines, CC Earle, J. Menzin; …
Energy delivery systems and uses thereof
DW van der Weide, PF Laeseke, FT Lee, CL Brace – US Patent 9,119,649, 2015
… tissue for a wide variety of applications, including medical procedures (eg, tissue ablation,
resection, cautery … the device is configured to deliver a sufficient amount of energy to ablate the
tissue … In some embodiments, the energy is microwave energy and/or radiofrequency energy …
Chronic Regional Pain Syndrome (CRPS/RSD)
Side-Channel Assisted Modeling Attacks on Feed-Forward Arbiter PUFs Using Silicon Data
R Kumar, W Burleson – … : 11th International Workshop, RFIDsec 2015, New …, 2015
… However, the performance of modeling attacks is impacted by the presence of
error-prone CRPs in the training set. To that extent … error-prone CRPs. The terms
“error-prone” and “error- inflicted” refer to the same set of CRPs. …
Making Invisible Intersectionality Visible Through Theater of the Oppressed in Teacher Education
B Powers, PB Duffy – Journal of Teacher Education, 2015
… Thank you! We ended there on the first day. Day 2. After initial warm-ups, the students broke up
into four groups. Each group, of about five to six students, was asked to create two to three
tableaux that explored their positions within schools as it relates to the course of CRPs. …
Energy geographies: thinking critically about energy issues in the classroom
E Delgado – Journal of Geography in Higher Education, 2015
Analysis of suicide attempts and completions at the South Texas Veterans Health Care System: a retrospective review
R Oliveira, TA Moore, CA Gutierrez – Mental Health Clinician, 2015
… Additional information collected included psychiatric medications used during the review period,
including psychiatric MPRs for 6 months before the suicide attempt. The MPRs were calculated
manually using the prescription refill history available in CRPS. …
[PDF] Cadmium toxicity in diazotrophic Anabaena spp. adjudged by hasty up-accumulation of transporter and signaling and severe down-accumulation of nitrogen …
S Rai, S Singh, LC Rai – 2015
… Percentage of total protein variability explained in PC1 and PC2 is given in parenthesis.
Protein spots in red color represent variables whereas text in blue color indicates time points.
Fig. 5. Cluster analysis of Cd responsive (CRPs) in Anabaena spp. …
[PDF] The migraine brain in transition: girls vs boys
V Fariaa, N Erpeldinga, A Lebela, A Johnsona… – 2015
Page 1. NUMBER 1 OF 1 AUTHOR QUERIES DATE 7/25/2015 JOB NAME PAIN ARTICLE
PAIN-D-14-13318 QUERIES FOR AUTHORS V. Faria et al. THIS QUERY FORM MUST
BE RETURNED WITH ALL PROOFS FOR CORRECTIONS …
Structure-function relationships in mammalian Histidine-Proline-Rich Glycoprotein
F Ronca, A Raggi – Biochimie, 2015
Histidine-proline-rich glycoprotein (HPRG), or histidine-rich glycoprotein (HRG), is a serum
protein that is synthesized in the liver and is actively internalis.
Fibromyalgia
[PDF] Adult attention-deficit and hyperactivity disorder and fibromyalgia: a case-control study
A Golimstok, MC Fernandez, MM Garcia Basalo – Neuro Open J, 2015
ABSTRACT Introduction: Fibromyalgia syndrome (FMS) is a disorder characterized by
widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues.
An association between attention deficit and fibromyalgia was reported. However, to our …
Fasting and rheumatic diseases (ahead of publication)
MH Jokar – Journal of Fasting and Health, 2015
… Predicting chronic symptoms after an acute “stressor”—lessons learned from 3 medical conditions.
Med Hypotheses 2004;63:653-8. 17-Chervin RD, Teodorescu M, Kushwaha R, et al. Objective
measures of disordered sleep in fibromyalgia. J Rheumatol 2009;36:2009-16. …
… —With treatment approaches for fibromyalgia evolving over the course of modern medicine, many clinicians are reviewing the Diagnosing and Treating Fibromyalgia: …
C Palsy, CPCLE Row
The pathophysiology of fibromyalgia includes central sensitization (amplification of pain in
the spinal cord via spontaneous nerve activity, expanded receptive fields, and augmented
stimulus responses), abnormalities of descending inhibitory pain pathways (dysfunction in …
[HTML] Select a Site
V Promise, VO Heritage, B Areas, L Diabetes…
Neuroscience covers both mental disorder and pain manifestations. Mental disorder covers Bipolar
Disorder, Schizophrenia,Depression and General Anxiety Disorder while pain includes Diabetic
neuropathy, Fibromyalgia and chronic pain. … 54th ed. Lange; 2015. Fibromyalgia. …
The measurement of bridging social capital in population health research
E Villalonga-Olives, I Kawachi – Health & Place, 2015
… capital (a combination of social resources that can be beneficial to a person’s physical health
and well-being), personal coping strategies, and additional personal and disease-related factors,
contribute to the functioning and quality of life (QoL) of fibromyalgia (FM) patients. …
Therapeutic Effects of the Mineral Waters from Copahue Spa
AM Monasterio, F Armijo, F Maraver – Copahue Volcano, 2015
… and chondrolysis, Fioravanti et al. (2011) reported: • A reduction in the levels of
circulating pros- taglandins E2 (PGE-2) and leukotriene B4 (LT-B4) in patients with
osteoarthritis or fibromyalgia. • Reductions in tumour necrosis …
Seven Steps to Choosing Joy!: Discover the Power of Your Inner Wisdom
L Ackles – 2015
DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING
IR Vlahov, CP Leamon – US Patent 20,150,258,203, 2015
… any one of the preceding embodiments wherein the disease is selected from the group consisting
of arthritis, including rheumatoid arthritis and osteoarthritis, glomerulonephritis, proliferative
retinopathy, restenosis, ulcerative colitis, Crohn’s disease, fibromyalgia, psoriasis and ..
by admin | Aug 13, 2015 | Uncategorized
Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
[HTML] Which Sedation is more Appropriate during Spinal Anesthesia: Propofol or Ketamine-Propofol Combination
H Güleç, ZB Tutal, M Şahap, M Babayiğit, H İnceöz… – Anaesth Pain & Intensive …, 2015
ABSTRACT Background and objective: Spinal anesthesia is a preferred method in daily
practice as it provides muscle relaxation and maintains spontaneous respiration during
surgical procedures. Opiods, midazolam, ketamine, propofol and dexmedetomidine are …
[PDF] Evaluation of Use of Ketamine Hydrochloride for Induction of Anaesthesia in Rabbits with Experimentally Induced Unilateral Ureteral Obstruction
RI Udegbunam, KC Ogbanya, SO Udegbunam… – 2015
ABSTRACT This study investigated the anaesthetic characteristics of ketamine
hydrochloride in rabbits with Unilateral Ureteral Obstruction (UUO). Two groups of rabbits (B
and C) were anaesthetized with 30 mg kgG1 ketamine intravenously (IV) on days 7 and …
Case 62: What Are the Safety Data for This Formulation?
JG Brock-Utne – Clinical Research, 2015
… Discussion We were faced with this problem when we wanted to use ketamine intrathecally. …
References 1. Brock-Utne JG, Mankowitz E, Kallichurum S, Downing JW. Effects of intrathecal
saline and ketamine with or without preservatives on the spinal nerve roots of monkeys. …
[HTML] Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology
W Tong, M Maira, M Gagnon, HU Saragovi – PLOS ONE, 2015
… For pharmacological inhibition, the Src kinase inhibitor PP2 (20 μM) (Enzo Life Science),
NMDA-R antagonist ketamine (Bioniche Animal Health) (20 μM) or the PKA inhibitor H-89 (Sigma)
(20 ng/ml) were added to the resting cells 30 minutes before the indicated treatments. …
[PDF] Development of Certified Reference Materials of Drug Abuse (Heroin, Etc) for Elimination of Measurement Error in Forensic Drugs
F Su, X Dai, H Li – Pharm Anal Acta, 2015
… For the first time, we developed 9 illicit drug CRMs, including methamphetamine, heroin,
ketamine and others. … CRMs Column Mobile phase Acetonitrile:water Flow Rate (mL/min)
Injection volume(uL) DAD (nm) Ketamine hydrochloride a 40:60* 1.5 20 210 …
[HTML] AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates
M Jeyanathan, Z Shao, X Yu, R Harkness, R Jiang, J Li… – PLOS ONE, 2015
… Animals were euthanized first by anesthesia with ketamine (im 10 mg/kg) and then by a lethal
dose injection of sodium pentobarbital (iv 100 mg/kg). Experimental animals and handling. …
Animals were anesthetized with ketamine (10 mg/kg) before handling. …
The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction.
ME Chua, J Mendoza, IV See, E Esmena, D Aguila… – Canadian Urological …, 2015
… Under sedation with isoflurane inhalation, all rats were subsequently anesthetized with
intraperitoneal (IP) ketamine (100 mg/kg) plus xylazine (15 mg/kg) after being preopera- tively
hydrated by subcutaneous injection of 5 cc saline mixed with indigo carmine (5,5 …
P-193TRACHEAL RESECTION WITH PATIENT UNDER LOCAL ANAESTHESIA AND SEDATION
FP Caronia, D Loizzi, A Fiorelli – Interactive CardioVascular and Thoracic Surgery, 2015
… During the procedure the patient remained awake in conscious sedation achieved by bolus
of ketamine and midazolam. … During the entire procedure the patient remained awake in
conscious sedation achieved by bolus of ketamine and midazolam. …
[HTML] Neural Resolution of Formant Frequencies in the Primary Auditory Cortex of Rats
C Honey, J Schnupp – PLOS ONE, 2015
… Anesthesia was induced by intraperitoneal injection of ketamine (Ketaset; Fort Dodge Animal
Health, Overland Park, Kansas, USA) and medetomidine (Domitor, Pfizer, Walton Oaks, Surrey,
UK), and maintained with intraperitoneal infusions of ketamine, medetomidine and …
Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR
GS Masson, AR Nair, PPS Soares, LC Michelini… – American Journal of …, 2015
… Analysis of Cardiovascular Parameters and Baroreflex Function 135 At the end of the protocols,
rats were anaesthetized (ketamine, 80 mg.kg−1 plus 136 … calculated as BrS = –(P2×P3)/4. 152
After the physiologic measurements, animals were anesthetized (ketamine, 80 153 …
Combination of intravenous S-ketamine and oral tranylcypromine in treatment-resistant depression: A case report
L Bartova, SE Vogl, M Stamenkovic… – European …, 2015
Abstract Ketamine, a rapid-acting antidepressant and anti-suicidal agent, is thought to
increase brain monoamine levels by enhancing monoamine release or inhibiting
presynaptic monoamine-reuptake. Here we present two female inpatients suffering from …
Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.
JW Wang, V Kivovich, L Gordon – Pediatric Emergency Care, 2015
Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain
subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,
leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical …
Ketamine Abuse Syndrome
JW Wang, V Kivovich, L Gordon – 2015
Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain
subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,
leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical …
Ondasetron Is More Likely Than Ketamine to Cause Ventricular Tachycardia
P Marzuillo, I Rabach, E Barbi – Pediatric Emergency Care, 2015
We read with interest the article published in the October 2014 issue of Pediatric Emergency
Care entitled “Ventricular tachycardia after ketamine sedation for fracture reduction.” Stukus
et al 1 described a 10-year-old female patient who experienced asymptomatic ventricular …
The development of paper microfluidic devices for presumptive drug detection.
G Musile, L Wang, J Bottoms, F Tagliaro, B McCord – Analytical Methods, 2015
… different lanes. A different colorimetric reaction occurs within each lane, permitting
the multiplexed detection of a variety of different compounds, including cocaine,
opiates, ketamine, and various phenethyl amines. Furthermore …
[PDF] GLP-1 increases pre-ovulatory LH source and the number of mature follicles, as well as synchronizing the onset of puberty in female rats
V Outeiriño-Iglesias, M Romaní-Pérez… – Endocrinology, 2015
… bregma. Cannulation was performed under ketamine/xylazine anesthesia (50
mg/kg and 5 mg/kg, respectively) and the correct placement of the cannula was
confirmed by postmortem injection of trypan- blue 0.5% (Sigma, St. …
[HTML] Bispectral index-guided induction of anesthesia by ketofol infusion provides the same cardiovascular stability like that of etomidate infusion
HF Soliman – Ain-Shams Journal of Anaesthesiology, 2015
… Get Permissions. Abstract, Introduction Various techniques have been tried to maintain
cardiovascular stability with anesthesia induction. This study compares the cardiovascular effects
of propofol-ketamine mixture versus etomidate during the induction of anesthesia. …
[PDF] Anti-osteoporotic activity of ethanol extract of Terminalia arjuna (Roxb.) Wight & Arn. on ovariectomized rats
A Trivedi, HR Katti, MH Shalavadi, A Ramkishan… – Indian Journal of Natural …, 2015
… Estrogen and Ketamine obtained from Neon Laboratories Ltd. Mumbai, India. … After seven days
of acclimation, the rats were ovariectomized or Sham operated and then anesthetized with
Ketamine HCL (50 mg/kg, ip); the ovaries were removed bilaterally. …
[HTML] Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles
W Cao, L Li, S Mii, Y Amoh, F Liu, RM Hoffman – PloS one, 2015
… Animals were anesthetized by intramuscular injection of a 0.02 ml solution of 20 mg/kg
ketamine, 15.2 mg/kg xylazine, and 0.48 mg/kg acepromazine maleate. … Non-transgenic nude
mice were anesthetized with a ketamine mixture (described above). …
Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin
KA Wunderlich, N Tanimoto, A Grosche, E Zrenner… – The FASEB Journal, 2015
… Mice were dark- adapted (DA) overnight before the experiments and anesthetized with a
subcutaneous injection of a mixture of ketamine, xylazine, and physiologic saline. Ketamine
and xylazine were given at 66.7 and 11.7 mg/kg body weight, respectively. …
Radiofrequency Ablation (RFA)
[PDF] Electrophysiological Bases of Torsion and Suction in the Continuous Cardiac Band Model
J Trainini, B Elencwajg, N López-Cabanillas… – Anat Physiol, 2015
… early diastolic filling by the suction effect. We investigated the electrophysiological
basis of this mechanism, by electroanatomical left ventricular endoepicardial mapping
(EEM) in five patients, during radiofrequency ablation. …
Uninterrupted Apixaban Safe and Effective in AF Ablation
EH Nichols – MD Conference Express, 2015
… Summary. According to a multicenter, prospective registry study, uninterrupted apixaban used
in the periprocedural setting of radiofrequency catheter ablation in patients with atrial fibrillation
does not increase the risk of bleeding compared with uninterrupted warfarin. …
Lateral Femoral Cutaneous Nerve Block
P Tumber, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… Pain Pract. 2011;11(3):302–8.PubMedView Article; 15. Fowler IM, Tucker AA, Mendez RJ.
Treatment of meralgia paresthetica with ultrasound-guided pulsed radiofrequency ablation of
the lateral femoral cutaneous nerve. Pain Pract. 2012;12(5):394–8.PubMedView Article. …
Sacroiliac Joint
PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… Am J Phys Med Rehabil. 2006;85:997–1006.PubMedView Article; 6. Roberts S, Burnham R,
Ravichandiran K, Agur A, Loh E. Cadaveric study of sacroiliac joint innervation: implications
for diagnostic blocks and radiofrequency ablation. Reg Anesth Pain Med. …
Ilioinguinal, Iliohypogastric, and Genitofemoral Nerve Blocks
D Bugada, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… 2014;2014:371703. doi:10. 1155/ 2014/ 371703.PubMed CentralPubMed; 47. Terkawi AS,
Romdhane K. Ultrasound-guided pulsed radiofrequency ablation of the genital branch of the
genitofemoral nerve for treatment of intractable orchalgia. Saudi J Anaesth. …
[HTML] Neoplastic disease after liver transplantation: focus on de novo neoplasms
P Burra, KI Rodríguez-Castro – World J Gastroenterol, 2015
… Prognosis seems dismal according to reported cases, despite tapering of
immunosuppression, transarterial chemoembolization, radiofrequency ablation, hepatic
resection, or retransplantation. Strategies for preventing this neoplasm …
Pediatric Nuclear Medicine
PJ Koo, FD Grant – Nuclear Medicine and PET/CT Cases, 2015
European Heart Rhythm Society, EHRA EUROPACE-CARDIOSTIM2015
RP Giugliano, S Bansilal, MP Bonaca, M Cavender… – MD Conference Express, 2015
… Two registry studies examined the use of non–vitamin K antagonist oral anticoagulant
use in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation
(RFA). The first determined that AF patients can safely …
[HTML] Propensity Score Matching Analysis of Changes in Alpha-Fetoprotein Levels after Combined Radiotherapy and Transarterial Chemoembolization for Hepatocellular …
Y Jeong, SM Yoon, S Han, JH Shim, KM Kim, YS Lim… – PLOS ONE, 2015
Advertisement. …
Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy
N Lee, D Yoo, D Ling, MH Cho, T Hyeon, J Cheon – Chemical Reviews, 2015
… When a resonant radiofrequency is irradiated, the nucleus absorbs the energy and the
number of the spins with a higher-energy state increases. … During the relaxation process,
the excited nuclei emit a weak radiofrequency that can be detected. …
… Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency …
D Hyun, SK Cho, SW Shin, KB Park, HS Park… – CardioVascular and …, 2015
Purpose To report the results of combined therapy with transarterial chemoembolization
(TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC)
considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE …
The procedure outcome of laparoscopic resection for’small’hepatocellular carcinoma is comparable to vlaparoscopic radiofrequency ablation
M Casaccia, G Santori, G Bottino, P Diviacco… – 2015
Background: The aim of this study was to compare the effectiveness of laparoscopic liver
resection (LLR) and laparoscopic radiofrequency ablation (LRFA) in the treatment of small
nodular hepatocellular carcinoma (HCC). Patients And Methods: We enrolled 50 cirrhotic …
PTH-177 Radiofrequency ablation for complicated barrett’s oesophagus: experience of a tertiary centre in northern ireland at 5 years
P Hall, O Reed, I Mainie – Gut, 2015
Abstract Introduction The 2013 British Society of Gastroenterology (BSG) guideline supports
first line use of endoscopic therapy in patients with dysplastic Barrett’s oesophagus or
intramucosal carcinoma (IMC). 1 Endoscopic mucosal resection (EMR) and …
Observations on Attenuation of Local Electrogram Amplitude and Circuit Impedance During Atrial Radiofrequency Ablation: An In vivo Investigation Using a Novel …
A Bhaskaran, W Chik, C Nalliah, J Pouliopoulos… – Journal of Cardiovascular …, 2015
Aims To define the temporal characteristics of atrial lesion growth (lesion surface area), local
electrogram amplitude attenuation and circuit impedance decrement during in vivo Radio
Frequency (RF) ablation with direct endocardial visualization (DEV).
[HTML] Intraductal Radiofrequency Ablation Followed by Locoregional Tumor Treatments for Treating Occluded Biliary Stents in Non-Resectable Malignant Biliary Obstruction …
XH Duan, YL Wang, XW Han, JZ Ren, TF Li, JH Zhang… – PloS one, 2015
Objectives To determine the safety and feasibility of intraductal radiofrequency ablation
(RFA) followed by locoregional tumor treatments in patients with non-resectable malignant
biliary obstruction and stent re-occlusion. Methods Fourteen patients with malignant biliary …
Sorafenib combined with radiofrequency ablation in the treatment of a patient with renal cell carcinoma plus primary hepatocellular carcinoma
G Gang, Y Hongkai, Z Xu – 2015
The combination of renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) is
extremely rare, and the prognosis for patients with these two cancers is poor. In the past
decade, molecular targeted therapy and radiofrequency ablation (RFA) have emerged …
RADIOFREQUENCY ABLATION FOR BENIGN THYROID NODULES-A LOOK TOWARDS THE FUTURE OF INTERVENTIONAL THYROIDOLOGY
MA Lupo – Endocrine Practice, 2015
Welcome to the new Endocrine Practice website. Click HERE to access your account and reset
your password if this is your first visit. The IP ranges for your institution have already been added
to your account. You may wish to review this information under the Institutional …
[PDF] Clinical Effect of Percutaneous Radiofrequency Ablation for Residual Lung Metastases from Breast Cancer After Systemic Chemotherapy
Y Wang, X Lu, Y Wang, J Zhou – Journal of the College of Physicians and Surgeons …, 2015
Breast Cancer (BC) is the most common malignant tumor in women and it is the leading cause
of death in women.1 The earliest and most frequent site of BC metastasis is the lungs and
bones, and no more than 5 – 20% of cases have only liver metastases.2 Metastatic BC …
Recanalization of obstructed metallic uncovered biliary stent using endobiliary radiofrequency ablation
N Musquer, E Ménager Tabourel, D Luet… – Gastrointestinal Endoscopy, 2015
We present the case of a 57-year-old woman with a history of hilar cholangiocarcinoma type
3A of the Bismuth classification. A right hepatectomy after right portal embolization was
planned. Finally, because peritoneal carcinomatosis was diagnosed during surgery, a …
Ventricular premature depolarization ablation and reversal of nonischemic cardiomyopathy
RC Arroyo, S Maeda, BP Betensky, P Santangeli, D Lin… – Interventional Cardiology, 2015
… 4.4 cm. CM: Cardiomyopathy; LVDD: Left ventricular end-diastolic dimension; LVEF:
Left ventricular ejection fraction; RFA: Radiofrequency ablation; VPD: Ventricular
premature depolarization. Ventricular premature depolarization …
Complex Regional Pain Syndrome (CRPS/RSD)
Lumbar Plexus and Femoral Nerve Block. Traditional and Ultrasound Guided Techniques
D Jankovic, J Kessler, AT Gray – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… 5. Arterial occlusive disease and poor perfusion in the lower extremities. 6. Complex regional
pain syndrome (CRPS) types I and II. 7. Postamputation pain. 8. … 3. Prophylaxis against complex
regional pain syndrome (CRPS). Contraindications. Specific. 1. …
Superior Cervical Ganglion Block
D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… Therapeutic [ 3 ]. 1. Migraine [ 4 ], cluster headache, and headaches of cervical origin. 2. Complex
regional pain syndrome (CRPS) in the head region. 3. Perfusion disturbances and vasospastic
diseases. 4. Central poststroke syndrome (contralateral block!). 5. Facial pain. 6. …
Brachial Plexus Blocks Above the Clavicle Traditional Techniques
D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… 10–20 mL local anesthetic – eg, 0.2–0.375 % ropivacaine or 0.25 % bupivacaine (0.25 %
levobupivacaine) in post-herpetic neuralgia, vascular diseases and injuries, complex
regional pain syndrome (CRPS) types I and II, post-amputation pain. …
Stellate Ganglion Block
A Bhatia, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… AACN Clin Issues. 2005;16:320–32.PubMedView Article; 25. Stanton-Hicks MD, Burton
AW, Bruehl SP, et al. An updated interdisciplinary clinical pathway for CRPS: report of
an expert panel. Pain Pract. 2002;2:1–16.PubMedView Article; 26. …
[HTML] The efficacy of different doses of Midazolam added to Lidocaine for upper extremity Bier block on the sensory and motor block characteristics and postoperative pain
A Honarmand, M Safavi, K Nemati, P Oghab – Journal of Research in Pharmacy …, 2015
… 24. 25. Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): A
novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic
dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. …
Complications of Peripheral Nerve Blocks
D Xu, A Hadzic – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post–ischemia pain (CPIP): a novel
animal model of complex regional pain syndrome–type I (CRPS–I; reflex sympathetic dystrophy)
produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain. …
Functional neurological symptoms
A Carson, J Stone – Landmark Papers in Neurology, 2015
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H THeRAPy looK liKe iN, C TReATmeNT
Page 1. ifssh ezine CoNNeCTiNG ouR GloBAl HAND suRGeRy FAmily
www.ifssh.info volume 5 issue 3 aUgUSt 2015 WHAT Does THe PRACTiCe oF HAND
THeRAPy looK liKe iN iFsHT memBeR CouNTRies? CoNseRvATive …
Preparation of polydimethylaminoethyl methacrylate grafted attapulgite via ceric ion‐induced redox polymerization
H Xu, H Yang, S Xue, J Pan, Q Ni, F Gong – Journal of Applied Polymer Science, 2015
… interests.[10-12] Surface-initiated graft polymerizations of various monomers onto inorganic
nanoparticles have been reported by using UV-induced polymerization,[13] conventional radical
polymerizations,[14] and controlled/living radical polymerizations (CRPs).[15, 16] CRPs …
Total Elbow Arthroplasty for Distal Humerus Fractures
LS Harmer, J Sanchez-Sotelo – Hand Clinics, 2015
… Mansat et al, 31 2013, 87, 80:7, Age: >65 Isolated #, —, A: 9 B: 8 C: 70, CM: 85 Lat: 1 Discovery:
1, 37.5 (6–106) (100%), 86 (45–100), 29–125/—, Hematoma: 5 CRPS: 2 Skin necrosis: 1 Neuro
injury: 7 Deep infection: 1 Stem #: 1 Stem loosening: 2 Elbow stiffness: 2 Peripros #: 1 …
Sacral roots stimulation in chronic pelvic pain
P Sokal, P Zieliński, M Harat – Neurologia i Neurochirurgia Polska, 2015
… is not recommended because of long-term moderate effects and increased risk of major
complications [2]. The CPP with predominance of neuropathic pain can be the part of
failed-back-surgery syndrome (FBSS) or complex regional pain syndrome (CRPS) which are …
[PDF] Probabilistic temperature forecasting based on an ensemble AR modification
A Möller, J Groß – arXiv preprint arXiv:1508.01397, 2015
… Gneiting et al. (2005) propose to estimate the parameters by optimizing the continuous ranked
probability score (CRPS, Wilks, 2011) over the training data. … EMOS AR-EMOS SLP MAE 2.042
2.036 1.969 CRPS 1.471 1.460 1.407 DSS 3.135 2.908 2.821 …
The value of SPECT/CT in carpal boss
U Bhure, U Hug, MW Huellner, H Grünig, A Zander… – European Journal of …, 2015
… One patient was lost to follow-up after infiltration of CB. One patient had a complete response
to surgery initially but developed a CRPS (complex regional pain syndrome) some weeks after
surgery. … Infiltration with complete response; surgery performed; CRPS during follow-up. 5. …
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome
G Littlejohn – Nature Reviews Rheumatology, 2015
… fibromyalgia. Clinical features of CRPS. Neurogenic inflammation—comprising tissue
swelling, vasomotor changes and marked allodynia—also contributes substantially to
the clinical features of CRPS. … 91. Neuropeptides in CRPS. Increased …
[HTML] Memristive crypto primitive for building highly secure physical unclonable functions
Y Gao, DC Ranasinghe, SF Al-Sarawi, O Kavehei… – Scientific Reports, 2015
… Our novel architecture demonstrates desirable characteristics of PUFs, including uniqueness,
reliability, and large number of challenge-response pairs (CRPs) and desirable characteristics
of strong PUFs. … Number of CRPs. Figure 10: Number of CRPs. …
Methods for Treating GI Syndrome and Graft versus Host Disease
JA Rotolo, RN Kolesnick – US Patent 20,150,216,971, 2015
… Ceramide generated on the surface of endothelium coalesces to form ceramide-rich
platforms (CRPs) that transmit an apoptotic signal (Stancevic B., Kolesnick R.
Ceramide-rich platforms in transmembrane signaling. FEBS Lett. …
Multivariate postprocessing techniques for probabilistic hydrological forecasting
S Hemri, D Lisniak, B Klein – Water Resources Research, 2015
… river Lahn as these values lead to the best climatological forecasts in terms of the contin- uous
ranked probability score (CRPS, see equation (4)). The smaller the catchment, the … of the EMOS
model are estimated by minimization of the CRPS over the training pe- riod. …
Ambiguous anti‐fouling surfaces: Facile synthesis by light‐mediated radical polymerization
CW Pester, JE Poelma, B Narupai, SN Patel, GM Su… – Journal of Polymer Science …, 2015
… the prevention of marine biofouling.[7, 8]. Controlled radical, surface-initiated
polymerizations (SI-CRPs) provide a robust and versatile strategy for the formation
of grafted polymer brushes. A variety of techniques have been …
Fibromyalgia
Off-Label Trazodone Prescription: Evidence, Benefits and Risks
L Bossini, A Coluccia, I Casolaro, J Benbow… – Current Pharmaceutical …, 2015
… depression, insomnia, anxiety (then Gen- eralized Anxiety Disorder, Post-Traumatic Stress
Disorder, Obses- sive-Compulsive Disorder and Panic Disorder), off-label uses (then bulimia,
benzodiazepine abuse, alcohol withdrawal, fibromyalgia, dementia, schizophrenia and …
[PDF] Purification of A1PI from Human Plasma-an Improved Process to Achieve Therapeutic Grade Purity
NA Kumar, KL Rao, Z Chakraborthy, A Giri, KU Devi – J Chromatogr Sep Tech, 2015
… due to congenital A1PI deficiency but as evident from the available literature, due to the multiple
biological activities of A1PI, it has been associated with other lung diseases (cystic fibrosis) and
many non-pulmonary diseases like vasculitis, fibromyalgia, asthma, pancreatitis …
[PDF] Clinical features of musculoskeletal disorders due to hand-held devices
D Sharan – Proceedings 19th Triennial Congress of the IEA, 2015
… Associated Disorder n % Myofascial pain syndrome of neck and upper back 48 69
Thoracic outlet syndrome 34 49 Fibromyalgia syndrome 07 10 Hypothyroidism 02 2.9
Extensor wrist tendinosis 04 5.7 De Quervain’s tenosynovitis 02 2.9 …
[PDF] Outcome of treatment of work related musculoskeletal disorders in on-site clinics in information technology companies)
DSMMR Ranganathan – Proceedings 19th Triennial Congress of the IEA, 2015
… Common diagnosis made were Myofascial Pain Syndrome (49.20%), Fibromyalgia (8.5%),
Thoracic Outlet Syndrome (25.02%), Cubital Tunnel Syndrome (0.16%), Chronic Regional
Pain Syndrome (0.20%), and Wrist Tendinities (3.70%). …
COMPLEX PHYSIOTHERAPEUTIC PROGRAM FOR IMPACT ON INDIVIDUALS WITH CHRONIC PAIN IN THE BACK AND LOW BACK.
YV Pashkunova – Activities in Physical Education & Sport, 2015
… mechanical back pain associated with the work done are charac teristic for men.
Polymyalgia rheumatic, fibromyalgia, osteoporosis and diseases of parathyroid glands
are characteristic for women (Borenstein, 1998). Generally …
[HTML] Animal-Assisted Therapy for People with Chronic Pain
MOT Kristen Counts
… In 2013, a follow-up study was done with fibromyalgia patients (3) . Fibromyalgia is a disorder
characterized by widespread muscle pain that is accompanied by fatigue, sleep, memory, and
mood issues. … Of course, the exercise further decreased my fibromyalgia symptoms. …
[PDF] The barrier of hidden disabilities
Ε Βαβουράκη, Γ Παναγιάρης, Κ Σφλώμος – 2015
… hyperactivity disorder(AD/HD), asthma and allergies, bipolar disorder, psychiatric disorders,
depression, anxiety, cancer, cardiac or respiratory conditions, chronic fatigue syndrome, colour
blindness, cystic fibrosis, diabetes, epilepsy, seizure disorders, fibromyalgia, HIV/AIDS …
Superior Cervical Ganglion Block
D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015
… number of patients. These observations principally concern patients with
pain-associated depression in chronic pain conditions (various types of headache,
migraines, facial pain, post-nucleotomy pain, fibromyalgia, etc.). In the …
[HTML] Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot
S Wang, J Zhou, X Wei, P Li, K Li, O Wang, F Wei… – Rheumatology: Current …, 2015
… Arthritis Res Ther 10: R117. Schmechel DE, Edwards CL (2012) Fibromyalgia, mood disorders,
and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology
33: 1454-1472. Goldring MB, Goldring SR (2007) Osteoarthritis. …
[PDF] Examining the relationship between childhood victimization, health risk behaviors, and adult physical health outcomes among women on probation and parole.
TR Renn – 2015
… Chartier, Walker & Naimark (2009) Female & Male Obesity OR=1.61 Rohde et al. (2008)
Female Adjusted for age and race Obesity OR=1.84 Alexander et al (1998) Fibromyalgia
Heitkemper et al (2001) Irritable bowel syndrome Rich-Edwards, et al. …
Thalamic Mechanisms Underlying Alpha-Delta Sleep with Implications for Fibromyalgia
S Vijayan, EB Klerman, GK Adler, N Kopell – Journal of Neurophysiology, 2015
Abstract Alpha-delta sleep is the abnormal intrusion of alpha activity (8-13 Hz oscillations)
into the delta activity (1-4 Hz oscillations) that defines slow wave sleep. Alpha-delta sleep is
especially prevalent in fibromyalgia patients and there is evidence suggesting that the …
SP0131 Fibromyalgia: What is New
LJ Crofford – Annals of the Rheumatic Diseases, 2015
Abstract Further clarification of the impact of FM classification criteria has emerged with a
higher prevalence and greater proportion of men identified with the modified 2010 criteria.
This together with ongoing epidemiologic studies has confirmed the relationships …
Pelvic Floor and Urinary Distress in Women with Fibromyalgia
KD Jones, C Maxwell, SD Mist, V King, MA Denman… – Pain Management Nursing, 2015
Abstract Fibromyalgia (FM) patients were recently found to have more symptom burden from
bothersome pelvic pain syndromes that women seeking care for pelvic floor disease at a
urogynecology clinic. We sought to further characterize pelvic floor symptoms in a larger …
[PDF] Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study
DJ Engen, SJ McAllister, MO Whipple, SS Cha, LJ Dion… – J Integr Med, 2015
ABSTRACT BACKGROUND: Fibromyalgia is a syndrome characterized by chronic pain,
fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies
have reported decreased intracellular magnesium levels in patients with fibromyalgia and …
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome
G Littlejohn – Nature Reviews Rheumatology, 2015
Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical
phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in
each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both …
Validation of fibromyalgia survey questionnaire and polysymptomatic distress scale in a Persian population
A Bidari, B Ghavidel-Parsa, AA Maafi, A Montazeri… – Rheumatology International, 2015
Abstract The aim of this study was to assess validity of the fibromyalgia survey questionnaire
(FSQ) and polysymptomatic distress scale (PSD) in an Iranian population. We also sought to
classify the severity levels of fibromyalgia (FM) symptoms according to the PSD scale. …
Health anxiety and depression in patients with fibromyalgia syndrome
M Uçar, Ü Sarp, Ö Karaaslan, AI Gül, N Tanik, HO Arik – Journal of International …, 2015
Methods Patients with FMS and healthy control subjects were recruited. All participants
completed the Health Anxiety Inventory Short Form (HAI-SF) and Beck Depression Inventory
(BDI). Pain was assessed in patients with FMS using the Fibromyalgia Impact …
Subgroups of fibromyalgia patients using the 1990 American College of Rheumatology criteria and the modified 2010 preliminary diagnostic criteria: the al-Ándalus …
V Segura-Jiménez, A Soriano-Maldonado… – Clinical and experimental …, 2015
OBJECTIVES: We aimed to investigate the symptom profiles in subsets of fibromyalgia
patients according to the subgroups created from the satisfaction of the 1990 American
College of Rheumatology (ACR) diagnostic criteria (1990c) and/or the modified 2010 ACR …
Effects of music on pain in patients with fibromyalgia
GB Alparslan, B Babadağ, A Özkaraman, P Yıldız… – Clinical Rheumatology, 2015
Abstract Fibromyalgia syndrome (FMS) is a chronic syndrome characterized by diffuse
musculoskeletal system pain and painful tender points in certain areas of the body. The aim
of the investigation was to determine the effects of music on pain in fibromyalgia patients. …
[HTML] Oral Burning With Dysphagia and Weight Loss
TM Seccia, G Rossitto, LA Calò, GP Rossi – Medicine, 2015
… Accepted June 22, 2015. Collapse Box Abstract. Abstract: Fibromyalgia is a disorder characterized
by an abnormal pain regulation. … We report on the case of a patient with fibromyalgia, who
presented with dysphagia, odynophagia, and glossodynia as prevalent symptoms. …
by admin | Jun 30, 2015 | Uncategorized
A clinical study conducted by researchers at the Leiden University Medical Center in The Netherlands evaluated the efficacy of a multi-day infusion regimen of intravenous ketamine for the treatment of Chronic Regional Pain Syndrome Type 1. This double blind, placebo-controlled study validated intravenous ketamine as a treatment for CRPS-1, which historically responds poorly to standard pain treatment. Sixty CRPS-1 patients were randomized into groups to undergo infusion therapy for 4.2 days with intravenous ketamine or placebo. The researchers measured pain levels in these patients using a numerical pain score assessment. They found that pain scores over the 12 week study period in patients receiving ketamine were significantly lower compared to those that received placebo (P<0.001). Importantly, after the 12th week, statistical significance between the two groups was lost, indicating that the infusion regimen that the researchers used is not a permanent fix for CRPS-1. Nonetheless, it did provide relatively long lasting relief in a patient population that is desperate for more effective therapies. Intravenous ketamine could be the answer that they’re looking for.
Future studies should focus on the optimal dose of intravenous ketamine and possible synergistic combination drugs to enhance the efficacy of this treatment option for the treatment of chronic pain conditions, like CRPS. A new combination ketamine infusion therapy is offered at the Florida Spine Institute that might just be the answer for long lasting analgesic efficacy. To find out if this procedure is right for your chronic pain, please make an appointment to see Dr. Ashraf Hanna, an expert pain management doctor with significant experience using intravenous ketamine. It is our goal at the Florida Spine Institute to conduct the cutting edge research necessary to eradicate CRPS once and for all.
Full Citation:
Sigtermans, M.J., van Hilten, J.J., Bauer, M.C., Arbous, M.S., Marinus, J., Sarton, E.Y., Dahan, A., 2009. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain 145, 304-311.
