Ketamine Combination Regimen Shows Promise For Long-term CRPS-1 Relief

Ketamine Combination Regimen Shows Promise For Long-term CRPS-1 Relief

Ketamine Combination Regimen Shows Promise For Long-term CRPS-1 Relief

womawithdoctors
Experts expect further refinement of treatment protocols for pain syndrome

by Gabriel Miller

Over the past 10 years, ketamine has emerged as a viable and potent treatment for patients with refractory complex regional pain syndrome type 1. In a new study, investigators show that combining epidural analgesia with inpatient ketamine infusion, followed by outpatient ketamine “boosters,” is an effective therapeutic protocol for this difficult-to-treat disease.
Ketamine was recognized as a potential treatment for complex regional pain syndrome type 1 (CRPS-1) in the United States approximately eight years ago. Since that time, two modalities have emerged: an “awake technique” in which subanesthetic ketamine is continuously infused, and a more dramatic protocol in which patients receive extremely high doses of ketamine while in a medically induced coma.

The high-dose method is currently not practiced in the United States, but a select group of centers has been using ketamine and studying the subanesthetic approach.
Advocates of ketamine for CRPS-1, previously known as reflex sympathetic dystrophy (RSD), say that the ketamine protocols first “turn off the pain” and then “reset the whole system” of pain transmission.
CRPS-1 appears to be caused by central sensitization and pain “wind-up,” a gradual, cumulative hyper-excitable neuronal response resulting from repeated painful stimulation of peripheral nerves. The N-methyl-d-aspartate (NMDA) receptor complex appears to play a major role in the development of this overall central sensitization; additionally, evidence shows that NMDA receptors are present in the peripheral nerves.

“Pain begets more pain,” said Robert Schwartzman, MD, professor and chairman of the Department of Neurology at Drexel University in Philadelphia. “When NMDA receptors are open, calcium enters the pain transmission neuron and initiates cascades that end up making pain transmission neurons more easily fired. This calcium entry causes something akin to long-term potentiation—it makes those cells more excitable—and that’s clearly one of the mechanisms in at least 80% of RSD patients.”

NMDA receptor antagonists, such as ketamine, have long been thought to be a viable treatment for both chronic pain conditions in general and CRPS-1 in particular.
“What [an NMDA receptor antagonist] does is block that mechanism of calcium entry into cells; once you’ve turned this system off, you’ve turned off the genetic transformation that occurs with persistent pain,” said Dr. Schwartzman, who has treated more than 500 patients with CRPS-1 using ketamine. “We are tuning back the hypersensitivity in the pain transmission neurons that is caused by pain.”
But psychomimetic effects, including hallucinations or paranoid delusions, and central nervous system (CNS) side effects have previously limited the therapeutic impact of the strongest-acting NMDA receptor antagonists, such as ketamine.

What’s more, in order to prevent the rapid re-sensitization of the CNS, the primary source of pain must also be controlled. Before beginning ketamine therapy for CRPS-1, a patient’s initial source of chronic pain, such as an improperly healed fracture, a neuroma or pressure on a nerve, must be identified and treated.
Thus, a typical ketamine protocol for CRPS-1 requires first treating any primary sources of pain, and then following with five to 10 days of inpatient low-dose, continuous ketamine infusion coupled with a high-dose benzodiazepine to minimize CNS side effects.

Finally, despite exceptional initial results—in prospective trials, between 80% and 100% of patients refractory to pharmacologic treatment for CRPS-1 report significant relief with ketamine—the treatment effect fades over time. To compensate, clinicians have now been using outpatient ketamine “boosters” in an attempt to extend the initial treatment effect.

Innovative Protocol
The current study is unique in that it also adds an additional epidural anesthetic during ketamine infusion, concomitantly blocking pain while the NMDA receptor complex is “reset” with ketamine. The new research was presented by lead study author Hai Nguyen, MD, an anethesiologist in Cleveland, Ohio, at the annual meeting of the American Society of Regional Anesthesia and Pain Medicine (ASRA) in San Antonio (abstract ID: 9).
Patients received a five-day inpatient, continuous IV ketamine infusion (0.6-0.8 mg/kg per hour; maximum, 60 mg/h) combined with continuous epidural analgesia (bupivacaine, dilaudid and clonidine) as well as 1 mg lorazepam every six hours. Patients were then given an outpatient, IV ketamine “booster” of 100 to 250 mg combined with 2 mg midazolam every two to four weeks for two months. The booster was given over a four-hour period on two consecutive days.

Forty-two patients were studied, and prior to ketamine treatment, 92.9% (39 of 42) had CRPS-1 involvement in all four extremities, 95.2% (40 of 42) experienced pain affecting the entire body and 100% had a numeric pain scale (NPS) rating of 10 on a 10-point scale.
At 12 weeks, 61.9% of patients reported moderate pain improvement, defined as a decrease of three or more points on the NPS. At 24 weeks, 30.9% reported continued moderate pain relief.
“The novel element [of the study] is combining the epidural component,” said Michael Goldberg, MD, professor and chief of anesthesiology at Cooper University Hospital in Camden, N.J., who uses continuous brachial plexus blocks as a peripheral anesthetic during his ketamine treatments.
“But the interesting thing to notice with this study, and all of our studies, [is that] we find that at about 12 weeks we have less significant pain relief. So it doesn’t stick and that’s the problem with the ketamine treatment for all of us,” Dr. Goldberg said.

With the somewhat complex interaction of drugs, side effects can be significant in ketamine protocols, particularly in the patients receiving moderate doses. These patients require more ketamine to control their CRPS-1 but not enough to necessitate a dose that requires deep sedation, Dr. Goldberg said.
In the 42 patients studied, significant side effects included nausea (64.3%), vomiting (38.1%), mild liver function test elevation (4.8%) and delirium (2.4%).
Overall, side effect risks associated with ketamine therapy have been overinflated, said Dr. Schwartzman, and in a population of patients with completely debilitating refractory pain, the risk for severe side effects is justified.
“[Side effects] have been grossly overexaggerated in the literature,” said Dr. Schwartzman. “Even in this study they didn’t use enough midazolam, but when you use [ketamine] properly, it’s a very safe drug. We’ve done it thousands of times.” Randomized controlled trials have further confirmed the efficacy and safety of ketamine therapy, said Dr. Schwartzman, who authored one such study (Pain 2009;147:107-115).
Anecdotally, he said, patients are willing to put up with side effects, even at a cost of as much as $10,000 for a treatment cycle.
“Insurance companies don’t pay for this,” he said. “When Americans are paying for stuff out of pocket, you know it has to work.”

Week of  July 7, 2015 Breaking Research Updates

Week of July 7, 2015 Breaking Research Updates

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Withdrawal from Acute Amphetamine Induces an Amygdala-Driven Attenuation of Dopamine Neuron Activity: Reversal by Ketamine.

P Belujon, NL Jakobowski, HK Dollish, AA Grace – … : official publication of the …, 2015

Drug addiction is a chronic disorder characterized by a cycle composed of drug seeking,

intoxication with drug taking and withdrawal associated with negative affect. Numerous

studies have examined withdrawal/negative affect after chronic use; however, very few

 

Enantioselective inhibition of D‐serine transport by (S)‐ketamine

NS Singh, M Bernier, S Camandola, MA Khadeer… – British Journal of …, 2015

Background and purpose Patients with major depressive disorder receiving racemic

ketamine,(R, S)-ketamine, experience transient increases in Clinician-Administered

Dissociative States Scale (CADDS) scores and coincident drop in plasma D-serine levels.

 

Pain Management with Low-Dose Ketamine Infusions

A Katz – Emergency Medicine News, 2015

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your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. The M 2 E Too! Blog by Larry Mellick,

 

Sedative medications outside the operating room and the pharmacology of sedatives

TG Hansen – Current Opinion in Anesthesiology, 2015

Ketamine. Ketamine is a unique phencyclidine derivate that differs from other sedatives in several

ways. Ketamine seems to induce a dissociative anesthetic state with functional and

electrophysiological separation between the limbic system and hypothalamus.

 

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

A Hadhimane, M Shankariah, KV Neswi – Journal of Maxillofacial and Oral Surgery, 2015

Purpose In this study we assessed the clinical efficacy of sub-mucosal injection of ketamine

at sub-anesthetic dose of 0.5 mg/kg on post-operative pain, swelling and trismus following

surgical extraction of impacted mandibular third molars. Methods Forty bilaterally

 

Fluorescence‐guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti‐CEA dylight 650 for tumor illumination

S Miwa, N De Magalhães, M Toneri, Y Zhang, W Cao… – Journal of Orthopaedic …, 2015

Tumor implantation Six to eight-week-old male mice were anesthetized by a ketamine mixture

(10 µL ketamine HCL, 7.6 Before resection of the metastatic tumor, mice were anesthetized with

the ketamine mixture (described above), and their limbs were sterilized with alcohol.

 

Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples

J Van Schoors, C Lens, K Maes, Y Michotte, I Smolders… – Journal of Chromatography …, 2015

Diazepam 10 mg/2 mL is purchased as Valium ® from Roche (Cenexi, Fontenay-sous-Bois,

France), ketamine 1000 mg/10 mL as Ketamine 1000 ® from Ceva (Libourne, France), Ketoprofen

1% as Ketofen ® from Merial (Toulouse, France) and NaCl 0.9% from Baxter (Lessines

 

Ultrasound-induced suppression of visually-evoked potentials: experience in nonhuman primates with a clinical transcranial MRI-guided focused ultrasound system

N McDannold, C Arvanitis, N Vykhodtseva… – Journal of Therapeutic …, 2015

650 kHz. Methods. The animal was deeply anesthetized using ketamine and

dexdormitor. First we targeted the LGN using MR temperature imaging, and then

we relocated the MRI table just outside the MRI. Visually-evoked

 

Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)

CM Parrula, J Mysore, H Burr, W Freebern, N Neef – Comparative Medicine, 2015

On day 4, a follow-up complete physical exam under ketamine sedation (10 mg/kg IM; ketamine

hydrochloride, Fort Dodge Animal Health, Fort Dodge, IA), showed diffuse, pale-red discoloration

in both inguinal regions, as noted previously, and multifocal pinpoint foci of

 

Estradiol protects female rats against sepsis induced by Enterococcus faecalis improving leukocyte bactericidal activity

RS Saia, FM Garcia, EC Cárnio – Steroids, 2015

0.5–1 × 10 10 CFU/animal) (time “zero” hour). At 6 and 24 h, rats were deeply

anesthetized (ketamine and xylazine at 55 and 10 mg/kg, respectively, ip) for sample

collection. As detailed in the subsequent sections, the blood

 

Hot Off the Press: Subdissociative‐dose Ketamine for Acute Pain in the Emergency Department

AB Drake, WK Milne, CR Carpenter – Academic Emergency Medicine, 2015

Social Media. Hot Off the Press: Subdissociative-dose Ketamine for Acute Pain in the Emergency

Department. How to Cite. Drake, AB, Milne, WK, Carpenter, CR (2015), Hot Off the Press:

Subdissociative-dose Ketamine for Acute Pain in the Emergency Department.

 

Optimization and application of an extraction procedure to determine drugs of abuse in solid environmental matrices of Turia River Basin

MJ Andres, R Alvarez, V Andreu, Y Pico – EGU General Assembly Conference …, 2015

Amphetamine, methamphetamine, ethylamphetamine, ecstasy, ethylone, bk-MMBDB and MBDB

belong to phenylethylamine group; codeine and ketamine belong to opioid and phencyclidine

group, respectively, and benzoylecgonine is the major excreted metabolite of the

 

Green spaces and cognitive growth in children

C Dieme – PNAS, 2015

AG. Previous Section. Neural mechanism of ketamine. Ketamine can produce rapid and

long-lasting antidepressant effects, but the drug’s potential for side effects and abuse limits its

widespread use, and the cellular mechanisms of ketamine’s effects are not yet known.

 

Increasing use of ‘party drugs’ in people living with HIV on antiretrovirals: a concern for patient safety

M Bracchi, D Stuart, R Castles, S Khoo, D Back… – AIDS, 2015

These substances are a combination of ‘club drugs’ (methylenedioxy- methamphetamine,

gamma-hydroxybutyrate, ketamine, benzodiazepine) and drugs that are more specifically used

in a sexualized context (methamphetamine, mephe- drone, poppers and erectile Ketamine

 

Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil …

BA MacDonald, KV Chakravarthy, BA Davidson… – Anesthesiology, 2015

The authors demonstrate that halothane mitigates the risk of SBP postflu through modulation

of the effects of type I interferon (IFN). METHODS: Mice (n = 6 to 15) were exposed to halothane

or ketamine and treated with influenza and Streptococcus pneumoniae.

 

[HTML]Airtraq® laryngoscope-assisted fiberoptic bronchoscope intubation in a child with Pierre-Robin sequence: a case report

S Zhang, M Yi – International Journal of Clinical and Experimental …, 2015

Sedation was achieved with IV dexmedetomidine 1 μg/kg and ketamine 1 mg/kg. We

opted to use dexmedetomidine and ketamine in this child because they provide

sedation and analgesia without compromising respiratory drive.

 

[HTML]Transcutaneous electric acupoint stimulation alleviates remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial

Y Chen, Y Yao, Y Wu, D Dai, Q Zhao, L Qiu – International Journal of Clinical and …, 2015

Some medications, including ketamine, methadone, dextromethorphan, COX-2 inhibitors and

α 2 receptor agonists can modulate remifentanil-induced hyperalgesia [7]. Due to drug-related

side effects and longer duration of PACU stay, however, we have found these

 

Impact of Obesity on Endotoxin-Induced Disseminated Intravascular Coagulation.

T Duburcq, A Tournoys, G Viviane, T Hubert, V Gmyr… – Shock, 2015

animals). For the experiment, animals were premedicated with intramuscular injection of ketamine

(Ketamine 1000, 10 mg/kg of body weight; Virbac, Carros, France) and xylazine (Sedaxylan,

2.5 mg/kg of body weight; CEVA Santé Animale, Libourne, France). Then we

 

Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro …

RC Almada, CM Roncon, DH Elias-Filho, NC Coimbra – Neuroscience, 2015

The surgeries were performed under deep anesthesia with 100 mg/kg ketamine (Ketamine

Agener, União Química Farmacêutica Nacional, São Paulo, Brazil) and 10 mg/kg xylazine

(Calmiun, União Química Farmacêutica Nacional, São Paulo, Brazil).

 

ACUTE INHIBITION OF MONOAMINE OXIDASE AND ISCHEMIC PRECONDITIONING IN ISOLATED RAT HEARTS: INTERFERENCE WITH POSTISCHEMIC …

MD Dănilă, AI Privistirescu, SN Mirica, A Sturza… – Canadian Journal of …, 2015

Male (body weight 400-450 g) and female (body weight 250-300 g) Wistar rats were anesthetized

with ketamine (Vetased, 30 mg/kg) and xylazine (Xylazin, 10 mg/kg) Page 4 of 23 Page 5. 5

ketamine able to induce anesthesia was chosen in order to not interfere with the IPC-

 

 

Radiofrequency Ablation (RFA)

 

In vitro artefact assessment of a new MR-compatible microwave antenna and a standard MR-compatible radiofrequency ablation electrode for tumour ablation

R Hoffmann, H Rempp, F Eibofner, DE Keßler… – European Radiology, 2015

Objective To evaluate and compare artefact configuration and diameters in a magnetic

resonance (MR)-compatible prototype microwave (MW) applicator and a standard MR-

compatible radiofrequency (RF) applicator for MR-guided tumour ablation. Methods Both

 

Does Surgical Resection Provide Better Outcomes Than Radiofrequency Ablation in Patients With BCLC Very Early-stage Hepatocellular Carcinoma?.

C Li, TF Wen – Annals of Surgery, 2015

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your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. Skip Navigation Links Home >

 

Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry.

RJ Haidry, G Lipman, MR Banks, MA Butt, V Sehgal… – Endoscopy, 2015

Background and study aim: Mucosal neoplasia arising in Barrett’s esophagus can be

successfully treated with endoscopic mucosal resection (EMR) followed by radiofrequency

ablation (RFA). The aim of the study was to compare clinical outcomes of patients with

 

Effectiveness of focal vs. balloon radiofrequency ablation devices in the treatment of Barrett’s esophagus

J Brown, B Alsop, N Gupta, DC Buckles, MS Olyaee… – United European …, 2015

Abstract Background and aims The safety and efficacy of radiofrequency ablation (RFA) in

treatment of Barrett’s esophagus (BE)-associated dysplasia has been well established. The

effectiveness of focal and balloon RFA devices has not been compared. Therefore, the

 

Microwave Ablation: Comparison of Simultaneous and Sequential Activation of Multiple Antennas in Liver Model Systems

CM Harari, M Magagna, M Bedoya, FT Lee Jr… – Radiology, 2015

Although both methods have been used in clinical studies of radiofrequency (RF) and microwave

ablation, an optimal delivery method has not yet been determined (6–9). Comparison studies

of sequential and simultaneous RF ablation techniques have concluded that

 

Heparin Kinetics: The “Holy Grail” of Periprocedural Anticoagulation for ablation of atrial fibrillation

DF Briceno, A Natale, LD Biase – Pacing and Clinical Electrophysiology, 2015

anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from

a multicenter prospective registry. anticoagulation in patients undergoing radiofrequency ablation

for atrial fibrillation: results from a multicenter prospective registry.

 

Catheter Ablation of Atrial Fibrillation Should Be Offered as Primary Therapy: What’s Your Hurry?

EF Wedam, MCP Haigney – Cardiac Electrophysiology Clinics, 2015

medications. Radiofrequency ablation/cryoballoon ablation: a cure for atrial fibrillation?

Merriam-Webster’s unknown. Does early radiofrequency ablation/cryoballoon ablation

prevent progression to permanent atrial fibrillation? A major

 

OC-037 6 year disease durability outcomes on patients treated with endoscopic therapy for barrett’s related neoplasia from the uk registry

R Haidry, G Lipman, A Gupta, J Dunn, H Smart… – Gut, 2015

Introduction Endoscopic therapy with combined Endoscopic mucosal resection (EMR) followed

by Radiofrequency ablation (RFA) is now the recommended first line Thereafter patients underwent

RFA 3 monthly until all visible BE was ablated or cancer developed (endpoints).

 

[HTML]Hybrid atrial fibrillation ablations and the increasing importance of the hybrid cardiovascular laboratory operating room

WJ Schleifer, JF Beshai, H Ramakrishna – Annals of Cardiac Anaesthesia, 2015

the epicardium. [4] Moreover, endocardial catheters can check for the completeness

of the epicardial lesions and potentially identify gaps, which can then be addressed

with endocardial radiofrequency ablation. A similar approach

 

[PDF]Effects of Hepatitis B Virus Load on Hepatectomy

M Wang, W Peng, TF Wen, LH He, C Li – Clin Microbiol, 2015

MC: Milan Criteria; HR: Hepatic Resection; AFP: Alpha-Fetoprotein; OS: Overall Survival; RFS:

Recurrence-Free Survival; DNA: Deoxyribonucleic Acid; CT: Computed Tomography; MRI:

Magnetic Resonance Imaging; RFA: Radiofrequency Ablation; PEI: Percutaneous Ethanol

 

HEALTH-RELATED QUALITY OF LIFE AFTER PERCUTANEOUS RADIOFREQUENCY ABLATION OF COLD SOLID BENIGN THYROID NODULES: A 2-YEAR …

R Valcavi, P Tsamatropoulos – Endocrine practice: official journal of the American …, 2015

OBJECTIVE: We studied the impact of Radiofrequency ablation (RFA) on health-related

quality of life (HRQL) in patients with benign thyroid nodules (TN) in a 2-year follow-up.

METHODS: Forty patients (35 female and 5 men; age 54.9±14.3 years) with cold thyroid

 

Comparison of laparoscopic radiofrequency ablation versus open resection in the treatment of symptomatic-enlarging hepatic hemangiomas: a prospective study

X Zhang, L Yan, B Li, T Wen, W Wang, M Xu, Y Wei… – Surgical Endoscopy, 2015

Background Radiofrequency ablation (RFA) has been demonstrated to be a promising

therapy for symptomatic large hepatic hemangioma. However, there is a lack of studies to

demonstrate the benefits and disadvantages of RFA as compared with surgical resection

 

… mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett’s esophagus: results from the United States Radiofrequency Ablation

N Li, S Pasricha, WJ Bulsiewicz, RE Pruitt… – Diseases of the Esophagus, 2015

Summary The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and

safety of radiofrequency ablation (RFA) for treatment of nodular Barrett’s esophagus (BE) is

poorly understood. Prior studies have been limited to case series from individual tertiary

 

… MicroRNA-122 Expression is a Poor Prognostic Marker in Patients with Hepatitis B Virus-related Hepatocellular Carcinoma who undergo Radiofrequency Ablation

HJ Cho, JK Kim, JS Nam, HJ Wang, J hee Lee, SS Kim… – Clinical Biochemistry, 2015

Objectives: Aim of this study was to investigate the prognostic potential of plasma microRNA-

122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after

hepatic resection or radiofrequency ablation (RFA).

 

[HTML]… efficacy enough to prevent stroke in atrial fibrillation patient with high CHADS2 score during peri-procedural catheter radiofrequency ablation? A case report with …

XM Shi, FK Chen, Z Liang, J Li, K Lin, JP Guo, ZL Shan – International Journal of …, 2015

Abstract Atrial fibrillation (AF) is a major cause of thromboembolic (TE) events including

stroke and transient ischemic attacks, catheter radiofrequency ablation (CA) has been

demonstrated to effectively eliminate AF in majority of patients. During the peri-procedural

 

Right upper lobe lung cancer: Resection through left anterior mediastinotomy

M Sirois, WA Arab, E Turcotte, Y Poulin – Asian Cardiovascular and Thoracic Annals, 2015

evaluation revealed a forced expiratory volume in 1 s of 1.8 L with carbon dioxide diffusion

capacity of 48% and maximal uptake of oxygen 14 mL min −1 kg −1 . Treatment including

stereotactic body radiation therapy, radiofrequency ablation, and surgery were discussed.

 

Magnetic guidance versus manual control: comparison of radiofrequency lesion dimensions and evaluation of the effect of heart wall motion in a myocardial phantom

A Bhaskaran, MAT Barry, SI Al Raisi, W Chik… – Journal of Interventional …, 2015

Abbreviations MNS Magnetic navigation system MC Manual control 1 Introduction Magnetic

navigation system (MNS) allows remote guidance of ablation catheters during radiofrequency

ablation for cardi- ac arrhythmias. Page 3. 2.2 MNS versus MC radiofrequency ablation

 

Thermal necrosis induced by electrocauterization as a local adjuvant therapy in local aggressive bone tumors, what is the safe limit for surgical margins? An …

M Aydin, K Basarir, M Armangil, HY Yildiz, Y Saglik… – Archives of Orthopaedic and …, 2015

Majno PE, Mentha G, Mazzaferro V (2010) Partial hepatectomy versus radiofrequency ablation

for hepatocellular carcinoma: confirming the trial that will never be, and some comments on the

indications for liver resection. Hepatology 51(4):1116–1118PubMedView Article; 23.

 

Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation

K Hayashi, T Konno, H Tada, S Tani, L Liu, N Fujino… – Circulation: Arrhythmia and …, 2015

 

Endoscopic Management of Early Esophageal Cancer.

JA Barnes, FF Willingham – Journal of Clinical Gastroenterology, 2015

proportionately. In the past decade, radiofrequency ablation has become the standard

first-line therapy for high-grade dysplasia when found in the precursor lesion to

esophageal adenocarcinoma, Barrett’s esophagus. Success

 

Chronic Regional Pain Syndrome (CRPS/RSD)

 

V33. Functional imaging of somatosensory finger representation and intracortical inhibition modulation in complex regional pain syndrome

S Strauss, M Grothe, T Usichenko, W Byblow, M Lotze – Clinical Neurophysiology, 2015

Neurophysiological pathology in CRPS type I is characterized by somatosensory and motor deficits.

Transcranial magnetic stimulation (TMS) and functional MRI rev. Neurophysiological pathology

in CRPS type I is characterized by somatosensory and motor deficits.

 

Exploiting resistive cross-point array for compact design of physical unclonable function

PY Chen, R Fang, R Liu, C Chakrabarti, Y Cao, S Yu – Hardware Oriented Security …, 2015

primitive that leverages the inherent randomness in the physical systems (eg the semiconductor

manufacturing process) to produce a unique response (output) for a given challenge (input)

[1]. Depending on the number of possible challenge-response pairs (CRPs), PuFs can

 

Do psychological factors influence recovery from Complex Regional Pain Syndrome Type-1? A Prospective Study.

DJ Bean, MH Johnson, W Heiss-Dunlop, AC Leed… – PAIN, 2015

Conflicts of Interest: none declared. Running Head: “Psychological factors in the recovery from

CRPS-1” Number of Pages: 19 Number of Tables: 3 Number of Figures: 1 Summary: Amongst

patients with recently-onset CRPS-1, those with higher levels of pain-related

 

A comparison of linear and non-linear data assimilation methods using the NEMO ocean model

P Kirchgessner, J Tödter, L Nerger – EGU General Assembly Conference Abstracts, 2015

pdaf.awi.de), which ensures identical experimental conditions for both filters. To

account for the nonlinearity, the assimilation skill of the two methods is assessed

by using different statistical metrics, like CRPS and Histograms.

 

The total probabilities from high-resolution ensemble forecasting of floods

J Olav Skøien, K Bogner, P Salamon, P Smith… – EGU General Assembly …, 2015

Weather Rev., 135(4), 1386-1402, doi:10.1175/MWR3341.1, 2007. Gneiting, T., Raftery,

AE, Westveld, AH and Goldman, T.: Calibrated Probabilistic Forecasting Using Ensemble

Model Output Statistics and Minimum CRPS Estimation, Mon.

 

Efficacy of combined physical and occupational therapy in patients with conservatively treated distal radius fracture: randomized controlled trial

V Filipova, D Lonzarić, BJ Papež – Wiener klinische Wochenschrift, 2015

Two participants from group A and two from group B were suspected of having complex

regional pain syndrome (CRPS) type I yet were not excluded from the trial since there

was no significant deviation regarding the observed variables.

 

Combining Graph Analysis and Recurrence Plot on fMRI data

A Lombardi, P Guccione, L Mascolo, P Taurisano… – Medical Measurements and …, 2015

Even if a visual inspection of CRPs can reveal valuable information about the relationship between

the two systems, the quantification of the structures in CRPs through CRQA has been used for

making more objective the comparison between the time series. Page 3.

 

Improving Precipitation Forecasts by Generating Ensembles through Postprocessing

DL Shrestha, DE Robertson, JC Bennett, QJ Wang – Monthly Weather Review, 2015

In this study, the forecast 3 performance is characterized by evaluating the bias, the Continuous

Ranked Probability Score 4 (CRPS), reliability and Relative Operating Characteristics (ROC)

to assess different aspects of 5 forecast quality. 6 The mean CRPS (hereafter 16

 

The Forecast Skill Horizon

R Buizza, M Leutbecher – Quarterly Journal of the Royal Meteorological Society, 2015

theoretical tools are deemed to be impractical to use. We select the continuous ranked probability

score (CRPS, Brown 1974, Hersbach 2000) as metric to decide when the closer to the observed

CDF (bottom panel). The CRPS is equal to the mean squared error

 

Functional Outcomes Following Bridge Plate Fixation for Distal Radius Fractures

A Lauder, S Agnew, K Bakri, CH Allan, DP Hanel… – The Journal of Hand …, 2015

2/134 deep infection. 2/134 extensor tendon adhesions. 1/134 EPL rupture. DASH: N/A. Hanel

et al 13, IV: retrospective chart review, 62 pts via chart review, second metacarpal, No CRPS,

1/62 ECRL rupture, 1/62 hardware failure, 0/62 postoperative digit stiffness. DASH: N/A.

 

New findings implicated in Coronary calcification in Chronic phase Kawasaki disease

T Yahata, K Ikeda, A Hamaoka, C Suzuki, A Yoshioka… – Circulation, 2015

tomography. We measured %FMD as an endothelial function marker and hs-CRPs

as an inflammatory marker, serum hydroperoxide and urinary 8-OHdG as oxidative

stress markers, and the bone mineral density (BMD). Patients

 

[PDF]Evaluation of the Red Sea State Food Security Status 2007-2009

AAA Ahmed – 2015

nutrition monitoring using MUAC Since 2006 no nutrition survey conducted. However, EWS

started collecting the nutrition information using the Community Resource Persons (CRPs)

to follow up the nutrition situation in sentinel sites in RPS and Tokar.

 

Spatio-temporal circular models with non-separable covariance structure

G Mastrantonio, GJ Lasinio, AE Gelfand – TEST, 2015

Page 1. TEST DOI 10.1007/s11749-015-0458-y ORIGINAL PAPER Spatio-temporal

circular models with non-separable covariance structure Gianluca Mastrantonio1 ·

Giovanna Jona Lasinio2 · Alan E. Gelfand3 Received: 7

 

Predictors of Spinal Cord Stimulation Success

P De La Cruz, C Fama, S Roth, J Haller, M Wilock… – … : Technology at the Neural …, 2015

Failure, Success. CRPS, Complex Regional Pain Syndrome; FBSS, Failed Back Surgery

Syndrome. Age, Mean + Range, 47.8 + 25.0, 51.2 + 53. Gender, Male : Female, 3:7, 20:27. Hybrid

(%), 0, 8.1. Indication, FBSS (%), 60, 37.8. CRPS (%), 20, 37.8. Neuritis (%), 20, 24.3.

 

Physical Therapy Examination and Assessment

JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015

Why Are My Nerves So Sensitive? Neuroscience Education for Patients With CRPS

or RSD. Authors: Ariana Brutico, MSPT, PhD. AFFILIATION: Body Dynamic: Outpatient

Physical Therapy, Pilates, and Yoga Clarks Summit, PA.

 

Improved model output statistics of numerical weather prediction based irradiance forecasts for solar power applications

RA Verzijlbergh, PW Heijnen, SR de Roode, A Los… – Solar Energy, 2015

irradiance is zero. The evaluation of the probabilistic forecasts is carried out using

two metrics. The first is the continuous ranked probability score (CRPS): equation(9).

CRPS ( k ) = 1 T ∑ t = 1 T ∫ x F ̂ t + k | t ( x ) – H ( x – y t + k ) 2.

 

Thoracic sympathectomy: a review of current indications

M Hashmonai, AEP Cameron, PB Licht, C Hensman… – Surgical Endoscopy, 2015

However, because the role of the autonomous nervous system is obscure in the pathogenesis

of these disorders, the term “Complex regional pain syndrome” (CRPS) is preferred. There is

very little good evidence in the literature to guide treatment of CRPS.

 

NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.

CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015

image (contralateral) side [21]. This symptom has been observed in many clinical

pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid

arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror

 

Process Documentation Research and Impact of Community-Driven Development Grants Research in Rural India, Socioeconomics Discussion Paper Series 34

M Bhattarai, Y Mohan Rao, BL Varalakshmi, VD Duche… – 2015

Item Type: Socioeconomics Discussion Paper Series. Divisions: RP-Market Institutions

and Policies. CRPS: CGIAR Research Program on Policies, Institutions, and Markets.

Series Name: Socioeconomics Discussion Paper Series.

 

SCAMP: A new tool for an old problem

RH Rathod – Journal of Hospital Medicine, 2015

BWH, Brigham and Women’s Hospital; CRPS, complex regional pain syndrome; EPL, extensor

pollicis longus; PFL, Flexor pollicis longus; MRN, medical record number; N/A, not applicable;

OT, occupational therpay; PA, physician’s assistant. Download figure to PowerPoint.

 

Fibromyalgia

 

Results of an active neurodynamic mobilization program in patients with fibromyalgia syndrome: a randomized controlled clinical trial

JR Torres, IC Martos, IT Sánchez, AO Rubio… – Archives of Physical …, 2015

To examine the effects of an active neurodynamic mobilization program on pain, neurodynamics,

perceived health state and fatigue in patients with fibromyalgia s. Setting. A local Fibromyalgia

Association. Participants. 48 patients with fibromyalgia syndrome. Interventions.

 

The evaluation in terms of sarcopenia of patients with fibromyalgia syndrome

I Koca, E Savas, ZA Ozturk, A Boyaci, A Tutoglu… – Wiener klinische …, 2015

Background Fibromyalgia syndrome (FMS) is an extra-articular rheumatic illness,

characterized by widespread body pain and decreased muscle function. Generalized loss of

muscle mass and strength is named as sarcopenia. The objective of this study was to

 

Stigma, Unspeakable Dilemmas, and Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia

J Griffith, N Ryan – Meanings of ME: Interpersonal and Social Dimensions …, 2015

Chronic fatigue syndrome (CFS) and fibromyalgia are both illnesses for which suffering is

amplified by stigmatisation. People with these illnesses often feel judged, devalued,

marginalised, or discriminated against by employers, family members, friends and, most of

 

[PDF]Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia

DH Choi, HS Kim – Korean Journal of Internal Medicine, 2015

Background/Aims: Nailfold capillaroscopy (NFC) has been used to examine morphological

and functional microcirculation changes in connective tissue diseases. It has been

demonstrated that NFC patterns reflect abnormal microvascular dynamics, which may play

 

Fibromyalgia incidence among patients with hepatitis B infection

L Yazmalar, Ö Deveci, İ Batmaz, D İpek, T Çelepkolu… – International Journal of …, 2015

Aim The purpose of our investigation was to evaluate the incidence of fibromyalgia

syndrome (FMS) and identify FMS-related clinical symptoms in hepatitis B virus (HBV)

patients. Methods One hundred and eighteen HBV surface antigen (HbsAg)-positive

 

[PDF]Rheumatology: Current Research

EÖ Bulduk, B Biral – 2015

Page 1. Treatment Approaches of Juvenile Fibromyalgia Syndrome Abstract Juvenile

fibromyalgia syndrome (JFMS) is an idiopathic long-term health condition characterized

by widespread musculoskeletal pain in children and adolescents.

 

Meanings of ME: Interpersonal and Social Dimensions of Chronic Fatigue

CD Ward – 2015

10 11 12 13 14 The Challenge of CFS/ME in Primary Care Laura Saunders The Said and the

Unsaid: Ambivalence in CFS/ME Christopher D. Ward Stigma, Unspeakable Dilemmas, and

Somatic Symptoms–a Legacy of Suffering in CFS/ME and Fibromyalgia James Griffith and

 

AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome

P Bullon, E Alcocer-Gómez, AM Carrión… – Antioxidants and Redox …, 2015

Deficient AMPK activation and over-activation of NLRP3-inflammasome axis was also observed

in blood cells from patients with Fibromyalgia (FM), a prevalent human some pain conditions as

neuropathic pain, fibromyalgia (FM), and complex regional pain syndrome (6,15,16).

 

Is Chronic Pain a Disease in Its Own Right? Discussions from a Pre-OMERACT 2014 Workshop on Chronic Pain

AM Taylor, K Phillips, JO Taylor, JA Singh… – The Journal of …, 2015

In a review of functional disorders36, various mechanisms were proposed to explain the cause

of conditions such as irritable bowel syndrome, fibromyalgia, temporomandibular joint disorder,

and inter- stitial cystitis, including enhanced pain perception, altered brain activation

 

Compendium for the Antenatal Care of High-Risk Pregnancies

H Narayan – 2015

AB1222-HPR Hypervigilance to Emotional Subliminal Images in Patients with Fibromyalgia

I Peláez, F Mercado, P Barjola, S Cardoso – Annals of the Rheumatic Diseases, 2015

Background Fibromyalgia (FM) is a chronic condition characterized by the presence of pain,

fatigue and cognitive dysfunction, among other symptoms. Previous research (Duschek et

al., 2014) also indicated that patients show an hypervigilance pattern to pain and negative

 

[HTML]Temporal analysis of pain responders and common adverse events: when do these first appear following treatment with pregabalin

J Fink, B Emir, B Parsons, A Clair – Journal of Pain Research, 2015

Clair Pfizer, New York, NY, USA Background: Pregabalin is an α2δ ligand indicated in the USA

for treatment of a number of chronic pain conditions, including diabetic peripheral neuropathy,

postherpetic neuralgia, pain associated with spinal cord injury, and fibromyalgia.

 

SP0133 Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Diseases

T Avcin – Annals of the Rheumatic Diseases, 2015

The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.

Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12

JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford.

 

Neuropathic pain as part of chronic widespread pain: environmental and genetic influences.

SK Momi, SM Fabiane, G Lachance, G Livshits… – Pain, 2015

frances.williams@kcl.ac.uk; +44 (0) 20 7188 6765 Keywords: chronic widespread pain;

neuropathic pain; genetic; fibromyalgia; twin ACCEPTED ABSTRACT Chronic widespread pain

(CWP) has complex aetiology and forms part of the fibromyalgia syndrome.

 

SP0130 C5A and its Receptor in Anca-Associated Vasculitis

MH Zhao – Annals of the Rheumatic Diseases, 2015

The clinical trials of CCX168, a small molecule antagonist of human C5aR, in human is underway.

Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.6705 FRIDAY, 12

JUNE 2015 WIN session 5 SP0131 FIBROMYALGIA: WHAT IS NEW LJ Crofford.

 

The spectrum of noncoeliac gluten sensitivity

I Aziz, M Hadjivassiliou, DS Sanders – Nature Reviews Gastroenterology & …, 2015

with NCGS is described as well as the symptom manifestations commonly reported after gluten

exposure, which include intestinal symptoms consistent with IBS, and extraintestinal symptoms

such as neurological dysfunction, psychological disturbances, fibromyalgia and skin

 

Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice

M Schedlowski, P Enck, W Rief, U Bingel – Pharmacological Reviews, 2015

 

Health-related quality of life improvements among women with chronic pain: comparison of two multidisciplinary interventions

SV Björnsdóttir, M Arnljótsdóttir, G Tómasson, J Triebel… – Disability & Rehabilitation, 2015

18,19]. Recently published systematic reviews on multidisciplinary programs for

people with chronic pain [19], chronic low back pain [20] or fibromyalgia syndrome

[21] agree on recommended content in such programs. This

 

NGF-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.

CF Cheng, JK Cheng, CY Chen, RH Rau, YC Chang… – Pain, 2015

image (contralateral) side [21]. This symptom has been observed in many clinical

pain conditions, such as complex regional pain syndrome (CRPS) [23], rheumatoid

arthritis [35], fibromyalgia [4], and neuropathic pain [27]. Mirror

 

Physical Therapy Examination and Assessment

JM David, C OCS, M Ariana Brutico – journal of orthopaedic & sports physical therapy, 2015

and nerve sensitivity. It is one of several manuals written by the primary author, all

of which discuss concurrent topics involving pain and recovery from injury, including

whiplash, headaches, and fibromyalgia. The manual begins

Clinical Study Shows IV Ketamine is Efficacious in the Treatment of CRPS

Clinical Study Shows IV Ketamine is Efficacious in the Treatment of CRPS

A clinical study conducted by researchers at the Leiden University Medical Center in The Netherlands evaluated the efficacy of a multi-day infusion regimen of intravenous ketamine for the treatment of Chronic Regional Pain Syndrome Type 1.  This double blind, placebo-controlled study validated intravenous ketamine as a treatment for CRPS-1, which historically responds poorly to standard pain treatment.  Sixty CRPS-1 patients were randomized into groups to undergo infusion therapy for 4.2 days with intravenous ketamine or placebo.  The researchers measured pain levels in these patients using a numerical pain score assessment.  They found that pain scores over the 12 week study period in patients receiving ketamine were significantly lower compared to those that received placebo (P<0.001).  Importantly, after the 12th week, statistical significance between the two groups was lost, indicating that the infusion regimen that the researchers used is not a permanent fix for CRPS-1.  Nonetheless, it did provide relatively long lasting relief in a patient population that is desperate for more effective therapies.  Intravenous ketamine could be the answer that they’re looking for.

Future studies should focus on the optimal dose of intravenous ketamine and possible synergistic combination drugs to enhance the efficacy of this treatment option for the treatment of chronic pain conditions, like CRPS.  A new combination ketamine infusion therapy is offered at the Florida Spine Institute that might just be the answer for long lasting analgesic efficacy.  To find out if this procedure is right for your chronic pain, please make an appointment to see Dr. Ashraf Hanna, an expert pain management doctor with significant experience using intravenous ketamine.  It is our goal at the Florida Spine Institute to conduct the cutting edge research necessary to eradicate CRPS once and for all.

Full Citation: 

Sigtermans, M.J., van Hilten, J.J., Bauer, M.C., Arbous, M.S., Marinus, J., Sarton, E.Y., Dahan, A., 2009. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain 145, 304-311.

Weekly Breaking Research Updates, June 22, 2015

Weekly Breaking Research Updates, June 22, 2015

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Ketamine and Phencyclidine: the good, the bad and the unexpected

D Lodge, MS Mercier – British Journal of Pharmacology, 2015

ABSTRACT: The history of ketamine and phencyclidine from their development as potential

clinical anaesthetics, through drugs of abuse and animal models of schizophrenia to

potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA

 

Intra‐and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

R Minoshima, S Kosugi, D Nishimura, N Ihara, H Seki… – Acta Anaesthesiologica …, 2015

Background In this randomized controlled trial, we examined whether intra-and

postoperative infusion of low-dose ketamine decreased postoperative morphine

requirement and morphine-related adverse effects as nausea and vomiting after scoliosis

 

Period Prevalence of Ketamine-Propofol Admixture “Ketofol” in the Operating Room among Anesthesia Providers at an Academic Medical Center

AN Olson, WR Rao, ME Marienau, NJ Smischney – Medical Science Monitor, 2015

BACKGROUND: The primary aim of this study was to determine the period prevalence of the

single-syringe ketamine-propofol admixture used for sedation and induction among

anesthesia providers during a 5-year period before and after educational sessions

 

Electrochemiluminescence immunosensor for ketamine detection based on polyamidoamine-coated carbon dot film

Q Li, W Tang, Y Wang, J Di, J Yang, Y Wu – Journal of Solid State Electrochemistry, 2015

Abstract In this work, we reported the synthesis of water-soluble carbon dots (CDs) by a one-

step hydrothermal synthetic route using polyamidoamine (PAMAM) as platform and

passivant, where the formation of CDs capped with PAMAM and the surface passivation

 

Letter to the editor: When what you see might not be what you get: prudent considerations of anesthetics for murine echocardiography

J Wu, J You, S Wang, Y Ye, X Wang, J Jia, Y Zou – American Journal of Physiology- …, 2015

In their well- designed experiments, the authors compared four popular an- esthetic regimens

(ketamine-xylazine, ketamine alone, avertin, and isoflurane) used in mice during

echocardiographic mea- surement, with conscious state as a reference.

 

Ketamine promotes inflammation through increasing TLR4 expression in RAW264. 7 cells

C Meng, Z Liu, G Liu, L Fu, M Zhang, Z Zhang, H Xia… – Journal of Huazhong …, 2015

Summery Ketamine (KTM), a N-methyl-D-aspartate (NMDA) receptor antagonist, was found

to has an anti-inflammatory effect, but some patients suffered from exacerbated pro-

inflammatory reactions after anesthesia with KTM. The present study was aimed to

 

The effect of NMDA receptor antagonists and antidepressants on resting state in major depressive disorder

A Dutta – 2015

fMRI ; major depressive disorder ; resting state ; antidepressant ; lanicemine ; ketamine ; citalopram

; anterior cingulate cortex ; NMDA ; glutamate. Ketamine and other NMDA antagonists have

improved MDD symptoms within 24 hours though the effects are short lasting.

 

Assessing Measures of Suicidal Ideation in Clinical Trials with a Rapid-Acting Antidepressant

ED Ballard, DA Luckenbaugh, EM Richards, TL Walls… – Journal of Psychiatric …, 2015

Received 22 April 2015, Revised 21 May 2015, Accepted 5 June 2015, Available online 16 June

2015. Highlights. • Clinical trials of ketamine and suicide will require appropriate measurement. •

We compared several suicide assessment measures in ketamine clinical trials. •

 

d-Cycloserine

AR Durrant, U Heresco-Levy – Encyclopedia of Psychopharmacology, 2015

of this concept became evident during the last decade when robust antidepressant effects

emerging within 2–4 h and lasting up to more than 2 weeks were obtained and replicated fol-

lowing intravenous administration of single sub-anesthetic doses of ketamine (Krystal et al.

 

Depression: Response and Remission

SD Østergaard, GI Papakostas, M Fava – Encyclopedia of Psychopharmacology, 2015

of this concept became evident during the last decade when robust antidepressant effects

emerging within 2–4 h and lasting up to more than 2 weeks were obtained and replicated fol-

lowing intravenous administration of single sub-anesthetic doses of ketamine (Krystal et al.

 

Is pre-emptive administration of ketamine a significant adjunction to intravenous morphine analgesia for controlling postoperative pain? A randomized, double-blind, …

A Fiorelli, A Mazzella, B Passavanti, P Sansone… – … and Thoracic Surgery, 2015

OBJECTIVES To evaluate if the pre-emptive administration of ketamine would potentiate the

effect of intravenous morphine analgesia in the management of post-thoracotomy pain.

METHODS This was a unicentre, double-blind, placebo-controlled, parallel-group,

 

Kappa-Opioid Agonists

E Opioid – 2015

It is considered a precancerous condition. Ketamine Synonyms Ketalar; Ketaset Definition

Ketamine is an FDA-approved medication for induction and maintenance of anesthesia

in adults. It is a phencyclidine derivative first synthetized in 1962.

 

Investigation of the effects of stress on some liver enzymes (AST, ALT, ALP) in rats.

YG Gencer, A Çınar, B Comba – Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2015

was applied intraperitoneally (ip) to the experimental group. After 3 h, blood samples

were collected from both groups under ketamine anaesthesia, using appropriate

techniques. The control group serum AST, ALT, ALP values

 

Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy?

RM Hoffman – Gene Therapy of Solid Cancers, 2015

7. Anesthetic reagents (ketamine, xylazine, acepromazine maleate). 8. Kanamycin. 9. Nair. 10.

1. Four-week-old female mice were anesthetized by a ketamine mixture (10 μl ketamine HCL,

7.6 μl xylazine, 2.4 μl acepromazine maleate, and 10 μl H 2 O) via sc injection.

 

[PDF] The Protective Effect of Melatonin vs. Vitamin E in the Ischemic/Reperfused Skeletal Muscle in the Adult Male Rat Model

EA Mohamed – J Cytol Histol S, 2015

All surgical procedures were performed under anesthesia with IP injection of

Ketamine hydrochloride (Ketame, Egyptian Int. Co. After 2 hours of reperfusion, the

rats were sacrificed by Ketamine hydrochloride (100 mg/kg) [10].

 

[PDF] CORM2 protects from myocardial ischemia reperfusion injury via modulation of the inflammatory response and apoptosis

NR Hadi, FG Al-Amran, KA Muhsin, A Taher – Journal of Advanced Pharmacy …, 2015

2% vials (RompunTM, Bayer AG, Leverkusen, Germany), ketamine (Hikma, Jordan), ethanol

(Fluka, Switzerland) and normal saline (KSA). Rat (IL-1β), (IL- Surgical LAD ligation The rats were

anesthetized by intraperitoneal injection with a mixture of ketamine and xylazine in a

 

[HTML] Long-term correlation of the electrocorticogram as a bioindicator of brain exposure to ionizing radiation

LAA Aguiar, IMS Silva, TS Fernandes, RA Nogueira – Brazilian Journal of Medical and …, 2015

The irradiation was carried out with the animals anesthetized with 10 mg/kg xylazine and 75

mg/kg ketamine administered intraperitoneally. To record the ECoG, animals were anesthetized

with 10 mg/kg xylazine and 75 mg/kg ketamine administered intraperitoneally.

 

[HTML] The Anti-Tumor Effects of Adipose Tissue Mesenchymal Stem Cell Transduced with HSV-Tk Gene on U-87-Driven Brain Tumor

SM de Melo, S Bittencourt, EG Ferrazoli, CS da Silva… – PLOS ONE, 2015

The animals were anesthetized via the ip injection of a ketamine (100 mg/kg) and xylazine

(10 mg/kg) solution (Syntec, 1356009 and 1720407) and fastened to a stereotaxic

instrument (David Kopf) equipped with a mouse adapter (Enlaup).

 

[HTML] Intrarectal Lidocaine-Diltiazem-Meperidine Gel for Transrectal Ultrasound Guided Prostate Biopsy

F Imani, Y Moghaddam, RS Moharari, F Etezadi… – Anesthesiology and Pain …, 2015

4, 6) or bupivacaine as a single agent (7). These latter studies have suggested that rectal

administration of lidocaine gel is a safe, simple modality, without any discomfort for patients (8).

Not only local anesthetic agents but also intravenous anesthetic drugs (ketamine) (9) or

 

[PDF] Alcohol Withdrawal Syndrome: Improving Outcomes Through Early Identification And Aggressive Treatment Strategies

AF Pizon – 2015

Page 1. June 2015 Volume 17, Number 6 Authors Joseph H. Yanta, MD Medical

Toxicology Fellow, Division of Medical Toxicology, Dept. of Emer- gency Medicine,

University of Pittsburgh Medical Center, Pittsburgh, PA Greg

 

Radiofrequency Ablation (RFA)

 

Use of Contact Force Sensing Technology During Radiofrequency Ablation Reduces Recurrence of Atrial Fibrillation: A Systematic Review and Meta-Analysis

MR Afzal, J Chatta, A Samanta, S Waheed… – Heart Rhythm, 2015

ScienceDirect is phasing out support for older versions of Internet Explorer on Jan 12, 2016.

For the best product experience, we recommend you upgrade to a newer version of IE or

use a different browser: Firefox or Chrome. For additional information please see the

 

Comparison of Surgical Resection and Radiofrequency Ablation for Hepatocellular Carcinoma: Take Care Not to Neglect Radiofrequency Technic and Device.

A Hocquelet, M Montaudon, P Balageas, N Frulio… – Annals of Surgery, 2015

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining

your privacy and will not share your personal information without your express consent. For more

information, please refer to our Privacy Policy. Skip Navigation Links Home >

 

Effect of different ablation settings on acute complications using the novel irrigated multipolar radiofrequency ablation catheter (nMARQ)

T Deneke, P Müller, P Halbfaß, A Szöllösi, M Roos… – Journal of Cardiovascular …, 2015

Background: Single-shot ablation devices for pulmonary vein isolation (PVI) in patients with

symptomatic atrial fibrillation (AF) have been increasingly used in clinical practice. Objective:

A novel mapping-system integrated irrigated multipolar circular ablation catheter (nMARQ)

 

Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and Neuron Remodeling in Target Atrial Tissues in a Canine Model

X Wang, M Zhang, Y Zhang, X Xie, W Wang, Z Li… – Circulation: Arrhythmia and …, 2015

Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and

Neuron Remodeling in Target Atrial Tissues in a Canine Model. Atrial electrophysiological

characteristics were examined before ablation, immediately and continuously after ablation.

 

… to Letter From Bisbal et al Regarding,“Repeat Left Atrial Catheter Ablation: Cardiac Magnetic Resonance Prediction of Endocardial Voltage and Gaps in Ablation

JL Harrison, C Sohns, NW Linton, R Karim, SE Williams… – Circulation: Arrhythmia and …, 2015

Tolosana JM,; Arbelo E,; de Caralt TM,; Perea RJ,; Brugada J,; Mont L. CMR-guided

approach to localize and ablate gaps in repeat AF ablation procedure. JACC Cardiovasc

Imaging . 2014;7:653–663. doi: 10.1016/j.jcmg.2014.01.014.

 

Pulmonary vein stenosis after pulmonary vein isolation using duty-cycled unipolar/bipolar radiofrequency ablation guided by intracardiac echocardiography

S Asbach, F Schluermann, L Trolese, M Langer… – Journal of Interventional …, 2015

Purpose Concerning rates of pulmonary vein (PV) stenosis were reported following PV

isolation (PVI) with a circular pulmonary vein ablation catheter (PVAC). As this may depend

on intraprocedural imaging, we evaluated the incidence of PV stenosis in patients

 

Atrioventricular Block During Slow Pathway Ablation Entirely Preventable?

H Chen, M Shehata, W Ma, J Xu, J Cao, E Cingolani… – Circulation: Arrhythmia and …, 2015

In a small percentage of cases of AVNRT, it may be necessary to ablate within the CS

with larger atrial potentials, however, ablation at the roof of the proximal CS carries

a high risk of AV nodal block during radiofrequency application.

 

Is There Still a Role for CFAE Ablation in Addition to Pulmonary Vein Isolation in Patients with Paroxysmal and Persistent Atrial Fibrillation? A Meta-Analysis of 1,415 …

R Providência, PD Lambiase, N Srinivasan, GG Babu… – Circulation: Arrhythmia and …, 2015

Is There Still a Role for CFAE Ablation in Addition to Pulmonary Vein Isolation in Patients with

Paroxysmal and Persistent Atrial Fibrillation? We aimed to assess the impact of CFAE ablation

in addition to pulmonary vein isolation (PVI) in patients undergoing ablation for AF.

 

Real-Time Contact Force Measurement A Key Parameter for Controlling Lesion Creation With Radiofrequency Energy

DC Shah, M Namdar – Circulation: Arrhythmia and Electrophysiology, 2015

Low CF values are also advisable in the vicinity of already ablated sites, where the for the

acquisition of reliable mapping information and achievement of stable ablation lesions 183 gs)

as area under curve (red hatched zone) during short duration of radiofrequency (RF) energy

 

Atrioventricular Nodal Block With Atrioventricular Nodal Reentrant Tachycardia Ablation

SJ Asirvatham, WG Stevenson – Circulation: Arrhythmia and Electrophysiology, 2015

a relatively slow stable, junctional rhythm with consistent stable retrograde atrial conduction during

radiofrequency application. of energy delivery, junctional rhythm may not be seen despite adequate

slow pathway ablation, and the operator may be inclined to ablate at more

 

[HTML] Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial …

RP Singh-Moon, CC Marboe, CP Hendon – Biomedical Optics Express, 2015

Abstract Effects of radiofrequency ablation (RFA) treatment of atrial fibrillation can be limited

by the ability to characterize the tissue in contact. Parameters obtained by conventional

catheters, such as impedance and temperature can be insufficient in providing

 

A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular …

CJ Breitbach, A Moon, J Burke, TH Hwang, DH Kirn – Gene Therapy of Solid Cancers, 2015

Download Protocol (725 KB). Abstract. Primary liver cancer (hepatocellular carcinoma; HCC)

in patients not eligible for surgery or transplant is currently treated by locoregional therapeutic

approaches, including trans-arterial chemoembolization and radiofrequency ablation.

 

[PDF] Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

CM Huang, MY Huang, JY Tang, SC Chen, LY Wang… – World Journal of Surgical …, 2015

Several other treatment modalities for patients with unresectable HCC, including percutaneous

ethanol injection (PEI), radiofrequency ablation (RFA), and transcatheter arterial

chemoembolization (TACE), seem to be more effective in smaller tumors and are contraindicated

 

The Wolf-Parkinson-White ECG Pattern-Assessing the Mortality Risk

E Posan – Journal of Insurance Medicine, 2015

32. MANAGEMENT. Radiofrequency Ablation Therapy With pacing maneuvers, the accessory

pathway properties are defined, potential tachycardias are induced, accurate mapping (localization)

of the accessory pathway is achieved and radiofrequency ablation is employed.

 

[HTML] Congenital (in growing) osteoma skull in 20-day-old neonate

PG Devi, TS Venkatachalam, YV Sharma, MP Kumar – CHRISMED Journal of …, 2015

6. 7. Virayavanich W, Singh R, O’Donnell RJ, Horvai AE, Goldsby RE, Link TM. Osteoid osteoma

of the femur in a 7-month-old infant treated with radiofrequency ablation. Skeletal Radiol

2010;39:1145-9. Back to cited text no. 7. 8. McHugh JB, Mukherji SK, Lucas DR.

 

[PDF] Simulating and Optimizing the Response of a Sine Wave Finite state Machine with Timestamp Simulation Using Simulink

M Kalpna, MA Varma – International Journal of Research, 2015

[5.] Dagmara M. Dołęga, Jerzy Barglik, (2012) “Computer modeling and simulation of

radiofrequency thermal ablation“, COMPEL – The international journal for computation and

mathematics in electrical and electronic engineering, Vol. 31 Iss: 4, pp.1087 – 1095

 

[PDF] Coexistence of permanent junctional reciprocating tachycardia with rheumatic valvular disease; a case sucessfully treated with radiofrequency ablation

M Aydın, A Yıldız, M Yüksel, Y İslamoğlu

Abstract A seventeen years old female had presented with palpitation. On the

electrocardiography (ECG), long RP, narrow QRS tachycardia, inverted P waves in leads

D2, D3 and aVF were noticed. On transthoracic echocardiography, rheumatic mitral

 

[PDF] Macrophage Inflammatory Protein Derivative ECI301

T Radiotherapy

inhibition by ECI301 was not attributable to radiation alone but also shown to other factors such

as the heat generated from high-frequency alter- nating current, namely radiofrequency ablation

(RFA; ref. 5B), significant differences were ablated by the anti- HMGB1 antibody.

 

[PDF] Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. J Stem Cells Res

D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015

back or neck pain refractory to physical therapy, trigger point injections, medial branch blocks,

or radio- frequency ablation. There is scarce evidence supporting less commonly performed

non-surgical treatments for lumbar radiculopathy including pulsed radiofrequency to the

 

[HTML] Modern medicine-morcellation

SC Olmstead

abandoned as a surgical procedure? What about noninvasive treatment options that

leave the presumed fibroid inside the body, such as uterine artery embolization,

MRI-guided focused ultrasound, and radiofrequency ablation?

 

Chronic Regional Pain Syndrome (CRPS/RSD)

 

What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature

S Grieve, L Jones, N Walsh, C McCabe – European Journal of Pain, 2015

Background and objective. Complex Regional Pain Syndrome (CRPS) is a chronic pain condition,

often triggered by trauma to a limb and characterized by sensory, motor, autonomic and trophic

changes within the affected limb. 2.4 Classification of CRPS clinical trials.

 

[PDF] MIRROR THERAPY: A REVIEW OF EVIDENCES

A Najiha, J Alagesan, VJ Rathod, P Paranthaman – Int J Physiother Res, 2015

Three particular conditions that have been studied the most are stroke, CRPS and phantom

limb pain. MT was used in conditions like stroke, cerebral palsy (CP), complex regional pain

syndrome (CRPS), phantom limb pain (PL) and fracture rehabilitation.

 

Physical Therapy Treatment for Patients Diagnosed with Complex Regional Pain Syndrome

J Connole – 2015

Abstract. This case study and evidence-based research analyzes the effects of physical

therapy interventions on a patient diagnosed with type 1 complex regional pain

syndrome (CRPS) to determine the most beneficial treatments.

 

Hybrid short-term freeway speed prediction methods based on periodic analysis

Y Zou, X Hua, Y Zhang, Y Wang – Canadian Journal of Civil Engineering, 2015

Page 1. Hybrid short-term freeway speed prediction methods based on periodic

analysis By Yajie Zou, Ph.D. Research associate 133B More Hall, Box 352700

Department of Civil and Environmental Engineering University of

 

[HTML] Japanese MD Develops Nutritional Protocols for Gardasil/Cervarix HPV Vaccine Injury

LC Botha – 2015

subacute sclerosing panencephalitis; CRPS: Complex regional pain syndrome; POTS:

Postural orthostatic tachycardia syndrome; Anti-phospholipid antibody syndrome;

SLE: systemic lupus erythematosus; Rheumatoid arthritis;

 

The social behavior of children adopted from Russian Federation: a controlled study

C Caprin, L Ballarin, L Benedan, A Castelli – Psicologia clinica dello sviluppo, 2015

Nonostante nella ricerca si sia utilizzata la forma estesa per genitori dello strumento

(CRPS-R:L; Conners, validazione Italiana a cura di Nobile, Alberti e Zuddas, 2007), composta

da 80 item (valori di a com- presi fra 0.57 e 0.91 per i maschi e 0.58 e 0.89 per le femmine), in

 

A Review of the Use of Stellate Ganglion Block in the Treatment of PTSD

E Lipov, EC Ritchie – Current Psychiatry Reports, 2015

14. Lipov EG, Joshi JR, et al. A unifying theory linking the prolonged efficacy of the stellate

ganglion block for the treatment of chronic regional pain syndrome (CRPS), hot flashes,

and posttraumatic stress disorder (PTSD). Med Hypotheses.

 

Addiction Recovery in Services and Policy: An International Overview

A Laudet, D Best – Textbook of Addiction Treatment: International …, 2015

model is growing in popularity nationwide: in the past decade, growing concerns about substance

use on campus and federal agencies’ focus on building a community-based continuum of care

system for youths have fueled a fivefold increase in the number of CRPs, from four

 

[HTML] Related Products

R Frank

43. Canalith Repositioning Procedures. The recommended treatment for BPPV is a canalith

repositioning procedure (CRP). There are several CRPs described in the literature; the most

studied and used in the United States was first described by Epley in 1992.

 

Central habituation and distraction alter C‐fibre‐mediated laser‐evoked potential amplitudes

P Hüllemann, YQ Shao, G Manthey, A Binder, R Baron – European Journal of Pain, 2015

Skip to Main Content. Wiley Online Library. Log in / Register. Log In E-Mail

Address Password Forgotten Password? Remember Me.

 

Nuclear Medicine Imaging of Sport Injuries of the Wrist, Hand and Fingers

M Sathekge, FE Suleman, MD Velleman, R Clauss – Nuclear Medicine and …, 2015

Abductor pollicis longus. CRPS: Chronic regional pain syndrome. 1997 ). 24.7 Complex Regional

Pain Syndrome (Reflex Sympathetic Dystrophy, Sudeck’s Dystrophy). Complex regional pain

syndrome (CRPS) is one of the most challenging chronic pain conditions of the limbs.

 

The Child with a Painful Limp

J Robb – Paediatric Orthopaedic Diagnosis, 2015

There may be symptoms of psychological distress and further specialist evaluation may

reveal an underlying cause. Complex Regional Pain Syndrome (CRPS). Children with

CRPS type 1 affecting the lower limb often limp (Wilder et al. 1992 ).

 

Complex regional pain syndrome type I. An analysis of 7 cases in children

VP Stalla, CM Olaso, VK Almada, GG Rabelino – Neurología (English Edition), 2015

Complex regional pain syndrome (CRPS) is characterised by the presence of pain accompanied

by sensory, autonomic and motor symptoms, usually preceded by a lesio.

 

Vitamin C, Extremity Trauma and Surgery

N Shibuya, MR Agarwal, DC Jupiter – 2015

987 Abstract Complex regional pain syndrome (CRPS) is a devastating condition often seen

after extrem- ity injury and surgery. Efficacy and safety of vitamin C used to prevent CRPS are

discussed. List of Abbreviations CRPS Complex regional pain syndrome Introduction

 

Psychological Factors as Outcome Predictors for Spinal Cord Stimulation

T Bendinger, N Plunkett, D Poole, D Turnbull – Neuromodulation: Technology at the …, 2015

SCS trials were offered for the following indications: failed back surgery syndrome (FBSS),

refractory radiculopathy or peripheral neuropathy, complex regional pain syndrome (CRPS),

and refractory angina (at the beginning of observed period—since 2008, this indication is not

 

[PDF] The Role of Transitional Justice and Access to Justice in Conflict Resolution and Democratic Advancement

MF Moscati – 2015

year mandate. The Community Reconciliation Processes (CRPs) of Timor-Leste were created

with the specific aim of dealing with disputes between perpetrators into their communities. The

possibility of recourse to CRPs was established by the United Nations Transitional

 

Complex Regional Pain Syndrome in Children: a Multidisciplinary Approach and Invasive Techniques for the Management of Nonresponders

MJ Rodriguez‐Lopez, M Fernandez‐Baena, A Barroso… – Pain Practice, 2015

Complex regional pain syndrome (CRPS) is multifactorial condition with complex

pathogenesis characterized by spontaneous or stimulus-induced pain that is

disproportionate to the inciting event. It is also commonly accompanied

 

Analgesic response to intravenous ketamine is linked to a circulating microRNA signature in female complex regional pain syndrome patients

SR Douglas, BB Shenoda, RA Qureshi, A Sacan… – The Journal of Pain, 2015

Although ketamine is beneficial in treating complex regional pain syndrome (CRPS), a subset

of patients respond poorly to therapy. We investigated treatment-ind. Highlights. • We studied

ketamine treatment induced miRNA alterations in blood from CRPS patients. •

 

Peptide signalling during the pollen tube journey and double fertilization

LJ Qu, L Li, Z Lan, T Dresselhaus – Journal of Experimental Botany, 2015

In general, plant peptides can be categorized into two classes: secreted peptides and

non-secreted peptides. Secreted peptides can be further divided into two major classes:

cysteine-rich peptides (CRPs) and non-CRPs (NCRPs). CRPs are significantly larger peptides.

 

[HTML] Overexpression of the Arabidopsis thaliana signalling peptide TAXIMIN1 affects lateral organ development

J Colling, T Tohge, R De Clercq, G Brunoud, T Vernoux… – Journal of Experimental …, 2015

Two distinct classes of secreted peptides can be distinguished in plants: small post-translationally

modified peptides such as the CLAVATA3/ENDOSPERM SURROUNDING REGION (CLE) family,

and cysteine-rich peptides (CRPs), exemplified by the EPIDERMAL

 

METHODS OF MODULATING DRUG PLASMA LEVELS USING ERYTHROHYDROXYBUPROPION

H Tabuteau – US Patent 20,150,157,582, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type 11 (CRPS-II

 

METHODS FOR THE SAFE ADMINISTRATION OF IMIDAZOLE OR IMIDAZOLIUM COMPOUNDS

H Tabuteau – US Patent 20,150,157,564, 2015

embodiments, an osteoclast inhibitor, such as a nitrogen-containing bisphosphonate, eg

zoledronic acid, ibandronic acid or minodronic acid, may be administered to relieve complex

regional pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex

 

Fibromyalgia

 

The Use of Polysymptomatic Distress Categories in the Evaluation of Fibromyalgia (FM) and FM Severity

F Wolfe, BT Walitt, JJ Rasker, RS Katz, W Häuser – The Journal of Rheumatology, 2015

Objective The polysymptomatic distress (PSD) scale is derived from variables used in the

2010 American College of Rheumatology (ACR) fibromyalgia (FM) criteria modified for

survey and clinical research. The scale is useful in measuring the effect of PSD over the

 

Association of different levels of depressive symptoms with symptomatology, overall disease severity, and quality of life in women with fibromyalgia

A Soriano-Maldonado, K Amris, FB Ortega… – Quality of Life Research, 2015

Purpose This study examined the associations of different levels of depression with pain,

sleep quality, fatigue, functional exercise capacity, overall fibromyalgia (FM) severity, and

health-related quality of life (HRQoL) in women with FM. Methods A total of 451 women

 

Fibromyalgia: Clinical Guidelines and Treatments

E Lawson, M Wallace – 2015

 

Major Classes of Medication for Treatment of Fibromyalgia

AM Kelly, K Mauer – Fibromyalgia: Clinical Guidelines and Treatments, 2015

 

Implications of proposed fibromyalgia criteria across other functional pain syndromes

N Egloff, R von Känel, V Müller, UT Egle… – Scandinavian Journal of …, 2015

Objectives: In 2010, the American College of Rheumatology (ACR) proposed new criteria for

the diagnosis of fibromyalgia (FM) in the context of objections to components of the criteria of

1990. The new criteria consider the Widespread Pain Index (WPI) and the Symptom

 

Omar I. Halawa and David A. Edwards

DA Edwards – Fibromyalgia: Clinical Guidelines and Treatments, 2015

 

Psychophysiological Methods

RH McAllister-Williams – Encyclopedia of Psychopharmacology, 2015

potential. Tramadol reduces pain substantially in osteoarthritis and fibromyalgia

(Bennett et al. 2003). Methadone below). There is evidence of a mild degree of benefit

in low back pain, fibromyalgia, and headaches. Anticonvulsant

 

PTSD and Fibromyalgia Syndrome: Focus on Prevalence, Mechanisms, and Impact

W Häusera, J Ablinb, B Walittc – 2015

Abstract The association between fibromyalgia syndrome (FMS) and posttraumatic stress

disorder (PTSD) is of growing interest in psychosocial research. The mechanisms by which

both disorders are interconnected are not well understood. The article presents an

 

Conditioned Pain Modulation: Neurophysiological, Cognitive, And Pharmacological Aspects

RR Nir, D Yarnitsky – Topics in Pain Management, 2015

The relevance of modulatory pain mechanisms in the clinical arena is represented through

cumulative research reporting impaired pain inhibition associated with pain disorders, particularly

fibromyalgia, irritable bowel syndrome, migraine, tension-type headache

 

Ryan D. McConn and Magdalena Anitescu

RD McConn – Fibromyalgia: Clinical Guidelines and Treatments, 2015

 

[HTML] Another dimension of pain

TH Khan – Anaesth Pain & Intensive Care, 2015

Pain Manag Nurs. 2013 Dec;14(4):368-78. [PubMed] doi: 10.1016/j.pmn.2011.08.001. Menzies

V, Taylor AG, Bourguignon C. Effects of guided imagery on outcomes of pain, functional status,

and self-efficacy in persons diagnosed with fibromyalgia. J Altern Complement Med.

 

[HTML] Pattern of irritable bowel syndrome and its impact on quality of life: A tertiary hospital based study from Kolkata on newly diagnosed patients of irritable bowel …

U Sinharoy, K Sinharoy, P Mukhopadhyay… – CHRISMED Journal of …, 2015

[6],[7],[8],[9] IBS can coexist with other functional disorders, most notably fibromyalgia, chronic

fatigue syndrome 10. 11. Aaron LA, Burke MM, Buchwald D. Overlapping conditions among

patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.

 

[PDF] Disability Status, Disability Type, and Training as Predictors of Job Placement

J Stahl – 2015

Deafness Hearing, Communicating Deafness Neurological Memory, Speaking TBI, Multiple

Sclerosis, Fibromyalgia Developmental Reading, Writing, Speaking Autism, Williams Syndrome

Mental Neurological Memory, Speaking TBI, Multiple Sclerosis, Fibromyalgia

 

[HTML] Pilates for Fibromyalgia

DPT Tom Lavosky, C MDT

By Gabrielle Shirer As originally seen in the Fall 2006 edition of the Pilates Coreterly

According to the National Fibromyalgia Association, Fibromyalgia Syndrome (FMS) is an

increasingly recognized chronic pain illness characterized by widespread

 

New study by guidelines author dismisses risk of chronic Lyme disease

D Cameron

In addition, these patients were not more prone to developing fibromyalgia and/or chronic fatigue,

according to two additional papers by Dr. Wormser. [1]. And previous studies report there’s a

high risk of developing fibromyalgia after having Lyme disease.

 

[HTML] Evolution of Skin Temperature after the Application of Compressive Forces on Tendon, Muscle and Myofascial Trigger Point

MF Magalhães, AV Dibai-Filho, EC de Oliveira Guirro… – PLOS ONE, 2015

of musculoskeletal, tendon or nervous injuries in the upper limb, history of fracture in the upper

limb, use of painkillers, anti-inflammatory drugs or muscle relaxants during the previous week,

presence of systemic or neuromuscular diseases, and medical diagnosis of fibromyalgia

 

[HTML] Rejuvenate With Stem Cells

R Schilling – 2015

literature. This combination (laser activated, intravenous mesenchymal injection) has

the potential for being useful for a multitude of chronic illnesses like fibromyalgia,

MS, generalized arthritis, just to mention a few. Mesenchymal

 

[PDF] Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. J Stem Cells Res

D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015

Positive results for Prolotherapy have been published for a variety of conditions including lateral

epicondylosis [21], osteoarthritis [22], sacroiliac joint pain [23], chondromalacia patellae [24],

fibromyalgia [25], chronic groin pain [26] and Osgood-Schlatter disease [27].

 

[PDF] APPROVAL SHEET

M Holman – 2015

Page 14. Effect of US and Graston on Muscle Contraction 11 plantar fasciitis,

patellofemoral disorders, fibromyalgia, scar tissue, and trigger finger. 13 The Graston

Technique allows for controlled application of friction massage to the

 

[HTML] Blueg rass Doctors of Physical Therapy, PLLC Physical Therapy Care Provider in the Louisville, Kentucky We provide EXPERT CARE for YOUR Health!

N Patient, C Forms

There are many symptoms that can lead the person with fibromyalgia syndrome (FMS)

and/or chronic myofascial pain (CMP) to your office. Research indicates that fibromyalgia

may increase the risk of cardiovascular disease (Curtis, O’Keefe Jr 2002).

Weekly Breaking Research Updates, May 22, 2015

Weekly Breaking Research Updates, May 22, 2015

Weekly Breaking Research Updates, May 22, 2015

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

[HTML] Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome

X Feng, M Maze, LG Koch, SL Britton, J Hellman – 2015

All procedures were performed under ketamine and xylazine anesthesia, and all efforts

were made to minimize suffering. Animals. The edema. At 48 h, the rats were sacrificed

under deep anesthesia provided by ketamine/xylazine.

 

Drugs that Target the Glutamate Synapse: Implications for the Glutamate Hypothesis of Schizophrenia

CA MIELNIK, A RAMSEY – Drug Discovery for Schizophrenia, 2015

In addition to the ligand bind- ing domains, NMDA receptors have modulatory sites for

zinc and spermine, and a modulatory site within the channel that binds the

non-competitive inhibitors phencyclidine (PCP), dizocilpine, and ketamine.

 

EVALUATION OF ANTHELMINTIC FISHMEAL POLYMER BAITS FOR THE CONTROL OF BAYLISASCARIS PROCYONIS IN FREE-RANGING RACCOONS ( …

TJ Smyser, SR Johnson, MD Stallard, AK McGrew… – Journal of Wildlife Diseases, 2015

lactating were released at the capture location. We anesthe- tized captured raccoons

with ketamine/xyla- zine (10 mg/kg ketamine and 2 mg/kg xylazine, intramuscularly

[Fowler 2009]). Upon induc- tion, animals were weighed

 

[PDF] Intra-ventral tegmental HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

J Zhu, NM Midde, AM Gomez, W Sun, SB Harrod – Name: Frontiers in Microbiology, 2015

session 29 (Fig 1A). 30 Briefly, rats were anesthetized using a mixture of ketamine

hydrochloride and xylazine 31 by intraperitoneal (IP) injection (7.5 mg ketamine/100

g b.wt. and 30 mg xylazine/100 g b.wt.). 32 Rats were then

 

Autonomic remodeling: How atrial fibrillation begets atrial

L Zhang, SS Po, HW PhD&, BJ Scherlag, HL PhD&… – 2015

13 Fifty-two male adult New Zealand white rabbits, weighing 2.0–2.5 kg, were 14 premedicated

with ketamine/xylazine ( 35mg/5mg/kg ),and restrained in the 15 supine position. Anesthesia

was also maintained by intra-peritoneal injection of 16 20% urethane 5 ml as needed.

 

Protein Interactions with Dopamine Receptors as Potential New Drug Targets for Treating Schizophrenia

P SUa, AHC WONG, F LIU – Drug Discovery for Schizophrenia, 2015

Page 222. Chapter 9 208 antagonist, ketamine, or PCP-induced cognitive deficits with an

inverted U-shaped dose response curve. 52 Conversely, there is less ketamine-induced

behavioral activation in D1R knockout mice than in wild-type mice.

 

Plasma arginine metabolites reflect airway dysfunction

H Grasemann, JA Scott, ML North, M Rafii, H Huang… – J Appl Physiol, 2015

On day 21, 24 h after the final aerosol challenge, mice were anesthetized (ketamine/xylazine)

for tracheal and jugular venous cannulations for ventilator-based measurement of respiratory

function and infusion of the stable L-arginine isotopomer cocktail, respectively.

 

[PDF] Histological and Histomorphometric Evaluation of Pharmacological Action of the Essential Oil of Melaleuca Alternifolia on Healing of Infected Alveolitis in Experimental …

WS Abdel-fattah, MM Dahaba, AA Ahmed… – J Interdiscipl Med Dent Sci, 2015

Materials and Methods Chemicals Tea tree oil was purchased from (SIGMA-ALDRICH

Chemie GmbH RiedstrasseUSA), vancomycin hydrochloride and ketamine were

obtained from the local pharmaceutical market. Bacterial infection

 

[PDF] Clinical Evaluation of Caudal Clonidine as an Adjuvant to Bupivacaine in Pediatric Patients Undergoing Sub Umbilical Surgeries

S Dalal – 2015

Prolongation of caudal analgesia using a single-shot technique has been achieved by addition

of various adjuvants, such as epinephrine, opioid, ketamine, and alpha 2 agonists [9]. Clonidine,

an alpha 2 agonist has extensively been used in neuraxial blocks [10- 13] and

 

The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats

E Taslidere, N Vardi, M Esrefoglu, B Ates, C Taskapan… – Human & Experimental …, 2015

kg body weight for 20 days. At the end of the experiment, rats were killed by ketamine

anesthesia. After blood samples were collected from tail vein, livers were removed

and divided into two portions. One sample was used for

 

[PDF] Assessment of the effect of ketamine on cytochrome P450 isoforms activity in rats by cocktail method

F Lin, Y He, L Zhang, M Zhang, Y Zhang, C Wen – Int J Clin Exp Med, 2015

Abstract: Cocktail method was used to evaluate the influence of ketamine on the activities of

CYP450 isoforms CYP1A2, CYP2D6, CYP3A4, CYP2C19, CYP2C9 and CYP2B6, which

were reflected by the changes of pharmacokinetic parameters of six specific probe drugs

 

Ketamine and suicidal ideation in depression: Jumping the gun?

R Rajkumar, J Fam, EYM Yeo, GS Dawe – Pharmacological Research, 2015

Abstract Depression and suicide are known to be intricately entwined but the

neurobiological basis underlying this association is yet to be understood. Ketamine is an N-

methyl D-aspartate (NMDA) receptor antagonist used for induction and maintenance of

 

Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid- …

X Zhu, P Li, X Hao, K Wei, S Min, J Luo, F Xie, J Jin – Neuroscience Letters, 2015

Abstract Electroconvulsive therapy (ECT) is an effective treatment for depression, but can

result in memory deficits. This study aimed to determine whether ketamine could alleviate

electroconvulsive shock (ECS, an analogue of ECT in animals)-induced memory

 

D-AMPHETAMINE withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treament with ketamine

JJL Fuller, RC Murray, KA Horner – Neuropharmacology, 2015

Abstract Withdrawal from chronic D-amphetamine (D-AMPH) can induce negative emotional

states, which may contribute to relapse and the maintenance of addiction. Diminished levels

of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus has been

 

Management of acute pain in patients on treatment with opioids

J De Andres, G Fabregat-Cid, JM Asensio-Samper… – Pain Management, 2015

In fact, the use of NMDA receptor antagonists such as ketamine inhibits the development of

tolerance in test animals [15]. Inhibition of tolerance has been demonstrated in test animals with

the use of noncompetitive antagonists of NMDA receptors such as ketamine [48].

 

DrugScan

T Ha, L Abbott, J Booth, M Morrow, M Rawlins… – 2015

Emerg Med J 2014; 31: 706–13. Ketamine and Intraocular Pressure in Children This prospective

observational study sought to examine the potential increase in the intraocular pressure following

ketamine administration for paediatric procedural seda- tion.

 

Multimodal Analgesic Protocol and Postanesthesia Respiratory Depression During Phase I Recovery After Total Joint Arthroplasty.

TN Weingarten, AK Jacob, CW Njathi, GA Wilson… – Regional Anesthesia and …, 2015

Procedural sedation during block placement was with incremental dosing of intravenous midazo-

lam, fentanyl, and ketamine. Use of ketamine as a sedative for nerve blockade or analgesia was

at the discretion of the attending anesthesiologist and not part of the protocol.

 

Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis

X Ma, J Qin, B Song, C Shi, R Zhang, X Liu, Y Ji, W Ji… – Neurological Sciences, 2015

CAMARADES) [10]: peer- reviewed publication; statement of control of tem- perature; random

allocation to treatment or control; blinded induction; blinded assessment of outcome; use of

anesthetic without significant intrinsic neuroprotec- tive activity (such as ketamine); use of

 

Anatomical organization of the visual dorsal ventricular ridge in the chick (Gallus Gallus): Layers and columns in the avian pallium

P Ahumada‐Galleguillos, M Fernandez, GJ Marin… – Journal of Comparative …, 2015

Deposits of biocytin in vital slices. Forty chicks (P1-P5) were deeply anesthetized with a mixture

(3:1) of 1% Ketamine and 2% Xylazine, and then decapitated. Deposits of DiI in fixed slices. Ten

chicks were deeply anesthetized using the Ketamine/Xilazine mixture and perfused

 

[PDF] Alterations in molecular pathways in the retina of early experimental glaucoma eyes

L Cao, L Wang, G Cull, A Zhou – Int J Physiol Pathophysiol Pharmacol, 2015

in one eye of each animal under ketamine and xyla- zine anesthesia. One hundred follow-

up. During each test, IOP was measured by a rebound tonometer (Tonopen XL, Reichert

Inc) under ketamine and xylazine anesthesia. The peripapillary

 

Radiofrequency Ablation (RFA)

 

… K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A …

G Santarpia, S De Rosa, A Polimeni, S Giampà… – PloS one, 2015

BACKGROUND: Use of the non-vitamin K antagonist oral anticoagulants (NOACs) is

endorsed by current guidelines for stroke prevention in patients with atrial fibrillation (AF).

However efficacy and safety of NOACs in patients undergoing catheter ablation (RFCA) of

 

Treatment of Renal Cell Carcinomas

SN Kurukkal, SS Al-Busaidy – Urological Cancer Management, 2015

cavitational ultrasound (PCU). However, only two ablation therapies are recommended

by expert panels for the treatment of renal tumours: cryoablation and radiofrequency

ablation. hilum. 16.3.1 Radiofrequency Ablation (RFA). It is

 

[PDF] Metastatic Colorectal Cancer: Review of Diagnosis and Treatment Options

M Palaghia, CC Prelipcean, E Cotea, N Vlad… – Journal of Surgery [Jurnalul …, 2015

Liver Metastases: Addition of new, multidisciplinary techniques and therapies like systemic or

local chemotherapy, radiofrequency ablation (RFA), cryotherapy and radiotherapy improves the

rate of liver metastases resectability but currently there is no gold standard concerning

 

ть е рыв ж ть

H Takeuchi – 2015

transplantation and as a radiofrequency ablation for AF [3]. Sixty-four-slice multidetector CT

(64-MDCT) becomes an option to evaluate coronary artery stenosis. pulmonary venous stenosis

following radiofrequency ablation. Respiratory Care 2004; 49:1525-7.

 

[PDF] The natural product sulforaphane inhibits breast cancer stem cell targets in triple negative and trastuzumab-resistant breast cancers

J Burnett – 2015

metastasis (1). Substantial progress has been made with respect to the treatment of primary

tumors using surgery, chemotherapy, radiation therapy, and radiofrequency ablation. However,

the advancement of cancer to an invasive or metastatic stage is

 

[HTML] Multidisciplinary management of advanced lung neuroendocrine tumors

PL Filosso, P Ferolla, F Guerrera, E Ruffini, WD Travis… – Journal of Thoracic Disease, 2015

In the absence of hormonal control, many patients may benefit of SSA or Interferon,

associated with loco-regional therapies (liver palliative surgery, radiofrequency metastasis

ablation or trans arterial chemoembolization). Low-grade NETs.

 

[PDF] Minimally-invasive Therapy in Thyroid Practice

L Hegedüs

Ethanol ablation (PEI) • Laser ablation (ILP) • Radiofrequency ablation (RFA • Laszlo Hegedüs •

Enrico Papini (Rome, Italy) • Jung Hwan Baek (Seoul) Ford T Maserati Quatroporte Proto Spirra

Radiofrequency Ablation (RFA) Page 21. 5/13/2015 21 P < 0,0001 RFA Obs.

 

[PDF] 0915-0940 TBD 0940-1000 Coffee break/Poster viewing

M Kudo, G Abou-Alfa, O Baatarkhuu, RN Chien… – Surgery

Prof Ho Yeong Lim (Korea) 1535-1555 Novel techniques: ablation Dr Shuichiro

Shiina (Japan) Circulating biomarkers Dr Wei Tang (Japan) 1555-1615 Surgery

vs. ablation: a new balance in the era of new technologies?

 

Urological Cancer Management

SA Al-Mamari, SS Al-Busaidy

time PSM Positive surgical margins PTH-rP Parathormone-related peptide pTNM Pathological

TNM QoL Quality of life RALP Robotic assisted laparoscopic radical prostatectomy RC Radical

cystectomy RCC Renal cell carcinoma RFA Radiofrequency ablation RN Radical

 

[DOC] Deliverable 11

B Plan

Introduction. Ablatech Inc. is a novel company developing a direct current (DC) Ablation device

for the treatment of fibroadenomas and lipomas. Note: The DC Ablation generator is indicated

for use with Ablatech’s A2500 series of delivery needles, which are sold separately.

 

Radiofrequency ablation for treatment of hereditary hemorrhagic telangiectasia lesions:“How I do it”

B Rotenberg, S Noyek, CJ Chin – American Journal of Rhinology & Allergy, 2015

Introduction: Hereditary hemorrhagic telangiectasia (HHT) can cause significant epistaxis for

those that suffer from it. Traditaional surgical treatments are ablative and can cause thermal

damage. Radiofrequency (RF) energy can potentially be used to ablate HHT plaques at a

 

Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients

A Facciorusso, V Del Prete, N Crucinio, N Muscatiello… – Journal of Gastroenterology …, 2015

Methods Data on 153 patients were reviewed. The study population was classified into three

groups: 73 (47.8%) patients who received neither angiotensin converting enzyme inhibitors

nor sartans (Group 1), 49 (32%) patients treated with angiotensin converting enzyme

 

Ablative therapies: Advantages and disadvantages of radiofrequency, cryotherapy, microwave and electroporation methods, or how to choose the right method for an …

O Seror – Diagnostic and Interventional Imaging, 2015

It is important, however, to understand that each of the ablated regions created remains as possible

the functional liver parenchyma which implies to not ablate too large No touch multibipolar

radiofrequency ablation for single liver metastases: a: axial computed tomography at

 

Pulmonary Vein Stenosis After Minimally Invasive Stand‐alone Surgical Ablation of Atrial Fibrillation

E Abo‐salem, J Munjal, S Kapur – Journal of Cardiac Surgery, 2015

vein. In our case, several rounds of cryoablation alternating with radiofrequency ablation

were also applied to confirm a transmural block. An extensive ablation strategy may

have contributed to the development of stenosis. Aggressive

 

[PDF] Comparative study between conventional chemo-embolization and chemo-embolization using drug eluting beads as alternative methods for treatment of …

RS Elshahat, HA Ahmed, OI Saleh, EEA Ibrahim… – Life Science Journal, 2015

Although preliminary screening and diagnosis have allowed HCC patients to benefit from radical

resection, transplantation, or radiofrequency ablation, tumors in some patients still progress rapidly

because of local spreading or metastases, particularly in those with background

 

Treatment of hepatocellular carcinomas by thermal ablation and hepatic transarterial chemoembolization

P Chevallier, G Baudin, R Anty, A Guibal, M Chassang… – … and Interventional Imaging, 2015

It has now been shown for monopolar radiofrequency ablation that this therapy

alone is sufficient to effectively treat single HCCs < 3 cm in diameter provided that

liver micrometastases are not present. If the HCC is >3 cm in

 

The “Duality” of Idiopathic Ventricular Arrhythmias from the Left Ventricular Ostium

DJ Callans, P Santangeli – Pacing and Clinical Electrophysiology, 2015

LBBB, the other RBBB which were ablated from a single region. These patients were identified

from a series of 247 patients with idiopathic outflow tract PVCs. The methods included

electroanatomic mapping, irrigated radiofrequency ablation and site verification

 

nonsystemic treAtment of Liver metAstAses from neuroendocrine tumor

D Putzer, G Widmann, D Waitz, W Jaschke, IJ Virgolini – … Analogues: From Research …, 2015

274 NONsYsTEMIC TREATMENT Of LIVER METAsTAsEs RfA radiofrequency ablation RILD

radiation‐induced liver disease sIRT selective internal radiation therapy sPECT single photon

emission computed tomography TACE transarterial chemoembolization Us ultrasound

 

Interventional oncology for liver and lung metastases from colorectal cancer: The current state of the art

T de Baere, L Tselikas, E Pearson, S Yevitch, V Boige… – … and Interventional Imaging, 2015

tissue causes cooling through convention, which is responsible for the “heat sink effect”, and

causes difficulties in ablating tissue close to The hepatic recurrence rate in 6025 patients

undergoing surgery with or without radiofrequency ablation for malignant liver metastases from

 

One Year Incidence of Atrial Septal Defect After PV Isolation: A Comparison Between Conventional Radiofrequency and Cryoballoon Ablation

G Mugnai, J Sieira, G Ciconte, MS Hervas, G Irfan… – Pacing and Clinical …, 2015

Background: Transseptal (TS) catheterization is needed to access the left heart during

pulmonary vein isolation (PVI) procedures. In the radiofrequency (RF) ablation procedure,

left atrial access is commonly achieved with a double TS puncture; cryoballoon (CB)

 

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

[PDF] Topics on estimation, prediction and bounding risk for multivariate extremes

RA Yuen – 2015

17 2.3 CRPS M-estimation for max-stable models . . . . . 20 2.4 Simulation . . . . . 141

A.1 Code for fitting max-linear models via CRPS . . . . . 142 A.2 Code for fitting a

Tawn-Molchanov max-stable model . . . . 144 BIBLIOGRAPHY . . . . .

 

[PDF] A NOVEL APPROACH TO THE MANAGEMENT OF PARSONAGE-TURNER SYNDROME

DK Garas, MD Rano Faltas, ER Viscusi

refractory CRPS, and has been found to be particularly efficacious6. • In a study

of 25 patients with refractory CRPS who underwent surgery, IV ketamine

exacerbations or spread of their CRPS at their 3 month evaluation6, 13.

 

[PDF] Preliminary Port Recovery Plan Schedule 2: Regional Coastal Environment Plan for the Canterbury Region (RCEP) Provisions-Specific Changes Sought (or wording …

L Port, P Page – policy

for by policies, rules and other methods set out in the RCEP. These changes sought are consistent

with the CRPS as set in Schedule 1. These changes sought are consistent with the CRPS as set

out in Schedule 1. Amendments sought to Action 7 are Insert a new policy:

 

Organisational Complaint Management

S Garding, A Bruns – Complaint Management and Channel Choice, 2015

2013). Garnefeld et al. (2013) even recommend companies to consider “building CRPs

into social media campaigns to take advantage 6 1 Organisational Complaint

Management Page 7. of the increasing social commerce opportunities”.

 

[PDF] Reverse total shoulder arthroplasty for complex proximal humeral fractures in the elderly: How to improve outcomes and avoid complications

RPDM UCT, F Ortho, UCT MMed Orth, BVM Zim, F Orth… – pain

139 (90–180) – 27 (0–45) 1 (VAS) 10% 1 patient with CRPS, DVT, and GT resorption, 1 patient

with GT malunion, 1 patient with Grade 1 notching ASES 78 T a b le I: R esu lts o RTSA 9

133(±20) 41 (±19) 1 (±1) 1/9 CRPS (recovered) ASES 80 (±11) T a b le II: R esu lts fo r stu

 

[PDF] Syringomyelia & Spinal Cord Stimulation

RB Pitkanen, DL James

found to be successfully used in the treatment of several neuropathic pain syndromes

such as radiculopathy, failed back surgery syndrome, CRPS, post-herpetic neuralgia,

as well as to a lesser extent for chronic migraine, refractory

 

[PDF] Neuropsychology of Chronic Pain

EM Desensitization

For example, com- plex regional pain syndrome (CRPS) is caused by a disturbance of the

sympathetic nervous system— the network of nerves located along the spinal cord that controls

bodily functions such as the opening and closing of blood vessels and sweat glands.

 

Stefan Garding Andrea Bruns

SBIN BUSINESS

2013). Garnefeld et al. (2013) even recommend companies to consider “building CRPs

into social media campaigns to take advantage 6 1 Organisational Complaint Management

Page 19. of the increasing social commerce opportunities”.

 

” What I really needed was the truth”. Exploring the information needs of people with Complex Regional Pain Syndrome

S Grieve, C McCabe, J Adams – Musculoskeletal Care, 2015

Download (52Kb) | Request a copy: Description/Abstract. Background United Kingdom

guidelines indicate individuals with Complex Regional Pain Syndrome (CRPS) require

information and education to support self management.

 

Reprogramming of in situ spinal cord stimulator for covering newly developed postthoracotomy pain

NN Knezevic, MV Rana, P Czarnocki… – Journal of Clinical …, 2015

Postthoracotomy pain; Spinal cord stimulation. 1. Introduction. Spinal cord stimulation has become

increasingly successful in the treatment of pain syndromes, especially neuropathic pain, ranging

from failed back surgery syndrome to complex regional pain syndrome (CRPS).

 

Late Amputation May Not Reduce Complications or Improve Mental Health in Combat-Related, Lower Extremity Limb Salvage Patients

CA Krueger, JC Rivera, DJ Tennent, AJ Sheean… – Injury, 2015

Table 2. Documented reasons of why the limb salvage patients wanted a late amputation. CRPS:

Chronic Regional Pain Syndrome. Reasons for Desired Late Amputation, (n, %), Lack of joint

motion, 6, 13%. Lack of strength, 4, 9%. Skin coverage or flap failure, 2, 5%. CRPS, 1, 2%

 

Community-Based Review of Research Across Diverse Community Contexts: Key Characteristics, Critical Issues, and Future Directions

N Shore, A Ford, E Wat, M Brayboy, ML Isaacs, A Park… – American Journal of Public …, 2015

These community-based research review processes (CRPs) can provide individual and

community-level ethics protections, enhance the cul- tural relevance of study de- signs and

competence of re- searchers, build community and academic research capac- ity, and shape

 

Bayesian Model Averaging with Stratified Sampling for Probabilistic Quantitative Precipitation Forecasting in Northern China during Summer 2010

J Zhu, F Kong, L Ran, H Lei – Monthly Weather Review, 2015

Page 1. Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of

the author-produced manuscript that has been peer-reviewed and accepted for publication.

Since it is being posted so soon after acceptance, it has not yet been

 

COMPOSITIONS AND METHODS OF USING THREOHYDROXYBUPROPION FOR THERAPEUTIC PURPOSES

H Tabuteau – US Patent 20,150,133,485, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type II (CRPS-II

 

BUPROPION AS A MODULATOR OF DRUG ACTIVITY

H Tabuteau – US Patent 20,150,133,486, 2015

In some embodiments, a combination of dextromethorphan and an antidepressant, such as

bupropion, may be administered to relieve complex regional pain syndrome, such as complex

regional pain syndrome type I (CRPS-I), complex regional pain syndrome type II (CRPS-II

 

Osteoclast Inhibitors for Knee Conditions

H Tabuteau, G Jones – US Patent 20,150,133,403, 2015

embodiments, an osteoclast inhibitor, such as a nitrogen-containing bisphosphonate, eg

zoledronic acid, ibandronic acid or minodronic acid, may be administered to relieve complex

regional pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex

 

Neuroimaging-based biomarker discovery and validation.

CW Woo, TD Wager, CW Woo – PAIN, 2015

Neuroimage 2008;40(2):788-795. [11] Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish

TB, Apkarian AV. The brain in chronic CRPS pain: abnormal gray-white matter interactions

in emotional and autonomic regions. Neuron 2008;60(4):570-581.

 

[PDF] IASP Interprofessional Pain Curriculum Outline

N Kariuki, J Miró, L Niemi-Murola, G Ochoa…

Primary Lesion Peripheral • degenerative disc disease with radiculopathy in neck and low back •

peripheral neuropathies (diabetes, cancer, alcohol, HIV) • post herpetic neuralgia • acute disc

herniation with radiculopathy • complex regional pain syndrome II (CRPS II) (causalgia

 

Fibromyalgia

 

Inflammatory Allied Conditions

MA Oliveira, A Ciechomska – Musculoskeletal Ultrasonography in Rheumatic …, 2015

biopsies. Whereas in fibromyalgia, there are conflicting data about the utility of US,

and if used, it is mainly to exclude other causes of pain. XXXIX. Sonographic assessment

of hip in fibromyalgia patients. Clin Exp Rheumatol 30: pp.

 

Childhood adversity and illness progression in bipolar disorder

J Bücker, M Kauer-Sant’Anna, LN Yatham – Neuroprogression and Staging in Bipolar …, 2015

BD patients with a history of childhood adversity also seem to report comorbidity with numerous

medical conditions, including allergies, arthritis, asthma, chronic fatigue syndrome, chronic

menstrual irregularities, fibromyalgia, head injury, hypotension, irrit- able bowel syndrome

 

The Use of Motivational Interviewing in Physical Therapy Education and Practice: Empowering Patients Through Effective Self-Management

RM Pignataro, PT James Huddleston – Journal of Physical Therapy Education, 2015

been successfully employed in promoting adherence to a walking program in patients receiving

chemotherapy for breast cancer,42 in improving health promotion behaviors among people with

coronary risk factors,42 and in promoting exercise in patients with fibromyalgia.39 In

 

[PDF] Temporomandibular Joint Dysfunction

J Poduval – JMR, 2015

J Craniomandib Disord 1992, 6:301-355. 4. Truta MP, Santucci ET, Donlon WC. Head

and Neck fibromyalgia and temporomandibular arthralgia. In: Jacobson AL, Donlon WC,

(Eds). Headache and Facial Pain. New York: Raven, 1990:141.

 

From the Desk of Dr. Karl ROS Johnson, DC…..

ROS Karl

Intentional musings of a unique Shelby Township Michigan Chiropractic Physician dedicated

to helping people find solutions to improving their health by rooting out causes to chronic

conditions such as fibromyalgia, thyroid disorder symptoms, balance disorders, migraines

 

Ankylosing Spondylitis

M Backhaus, Y El Miedany – Musculoskeletal Ultrasonography in Rheumatic …, 2015

Beside spondyloarthritis patients, enthesitis have been reported among athletes

as a consequence of traumatic injuries. Distinguishing fibromyalgia tender points

from enthesitis is another important challenge to be considered.

 

[HTML] Development of a Learning-Oriented Computer Assisted Instruction Designed to Improve Skills in the Clinical Assessment of the Nutritional Status: A Pilot Evaluation

LG de Diego, M Cuervo, JA Martínez – 2015

Advertisement.

 

[PDF] P1. Community-Clinical Linkages in the WISEWOMAN Program

K Ahmed, I Vaid, D May, D Manheim – JOURNAL OF WOMEN’S HEALTH, 2015

this study. Of the women patients, 361 reported a history of hysterectomy. A

comparison group consisted of 361 patients with a primary diagnosis of headache

or fibromyalgia without history of hysterectomy. Patients completed

 

[HTML] The Hot Sauce: Peppers and Fat Loss

VR Prisk

Aside from deterrence of muggers and bets between friends, there are many therapeutic

applications of capsaicin. Capsaicin creams, which desensitize nerves over time, are used

to treat neuropathy, shingles, psoriasis, arthritis pain and fibromyalgia.

 

[PDF] TEMPORALITY AND INFORMATION WORK IN BONE MARROW TRANSPLANT

AG Büyüktür – 2015

al., 2010; Hubbard et al., 2010), motor neuron disease (eg Locock et al., 2009), chronic fatigue

syndrome and fibromyalgia (eg Asbring, 2001), HIV infection (eg Anderson et al., 2010; Wilson,

2007), and multiple sclerosis (eg Green et al., 2007), among others.

 

34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand?

JN Ablin, D Buskila – Vaccines and Autoimmunity, 2015

 

Gender and psychosocial context as determinants of fibromyalgia symptoms (fibromyalgia research criteria) in young adults from the general population

S Lourenço, L Costa, AM Rodrigues, F Carnide… – Rheumatology, 2015

Objective. To quantify the prevalence of FM (FM research criteria), to describe its

components—symptom severity score (SSS) and widespread pain index (WPI)—and to

identify biopsychosocial predictors of the severity of SSS as well as WPI using a

 

Fibromyalgia and the Risk of a Subsequent Motor Vehicle Crash

DA Redelmeier, JD Zung, D Thiruchelvam… – The Journal of …, 2015

Objective Motor vehicle crashes are a widespread contributor to mortality and morbidity,

sometimes related to medically unfit motorists. We tested whether patients diagnosed with

fibromyalgia (FM) have an increased risk of a subsequent serious motor vehicle crash.

 

Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis

J Ahmad, H Blumen, CE Tagoe – Rheumatology International, 2015

Abstract To investigate how autoimmune thyroiditis (ATD) affects the clinical presentation of

established rheumatoid arthritis (RA) with particular reference to fibromyalgia and chronic

widespread pain (CWP). A cohort of 204 patients with RA for whom the presence or

 

Association between fibromyalgia and thyroid autoimmunity

N Shirzad, S Movassaghi, H Karmostaji, F Esfahanian… – 2015

Fibromyalgia is a disorder characterised by fatigue, generalised body pain and cognitive

symptoms, and the aetiology has not been clearly described. Because similar symptoms are

frequently found in Hashimoto’s thyroiditis and there is not an optimal response to the

 

COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESTLESS LEG SYNDROME AND FIBROMYALGIA

M Kandula – US Patent 20,150,133,408, 2015

Abstract: The invention relates to the compounds of formula I or its pharmaceutical

acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates

thereof. The pharmaceutical compositions comprising an effective amount of compounds

 

[PDF] REVISTA BRASILEIRA DE REUMATOLOGIA

SB de Lorena, MCC de Lima, A Ranzolin, ÂLBP Duarte – rev bras reumatol, 2015

Review article Effects of muscle stretching exercises in the treatment of fibromyalgia: a systematic

review articleinfo Article history: Received 16 March 2014 Accepted 17 August 2014 Available

online 6 January 2015 Keywords: Fibromyalgia Stretching Physiotherapy abstract

 

36 Infections, Vaccinations, and Chronic Fatigue Syndrome

H Mahagna, N Mahroum, H Amital – Vaccines and Autoimmunity, 2015

 

COMPOSITIONS AND METHODS FOR INDUCING MYOBLAST DIFFERENTIATION AND MYOTUBE FORMATION

MP Czech, M Wang – US Patent 20,150,133,520, 2015

12. The method of claim 11, wherein the muscle disorder is selected from the group consisting

of: muscle atrophy, muscle weakness, myopathy, chronic fatigue syndrome, fibromyalgia, muscular

dystrophy, fatigue fibromyalgia, spinal muscle atrophy, distal muscular dystrophy

 

27 Aluminum Particle Biopersistence, Systemic Transport, and Long-Term Safety: Macrophagic Myofasciitis and Beyond

RK Gherardi, J Cadusseau, FJ Authier – Vaccines and Autoimmunity, 2015

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