Latest Research Updates

Latest Research Updates

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day! In an effort to help our patients stay up tochronic speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates. The title of each article below is a link to the full study report. If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

Concomitant Benzodiazepine Use Attenuates Ketamine Response: Implications for Large Scale Study Design and Clinical Development.

MA Frye, P Blier, SJ Tye – Journal of Clinical Psychopharmacology, 2015

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Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

PVM Steagall, M Aucoin, BP Monteiro, M Moreau… – Journal of the American …, 2015

Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine,

in cats anesthetized with isoflurane. The ketamine or saline solution bolus was administered

over 5 seconds, and the CRIs were started immediately afterward.

 

Asymmetric synthesis of (S)-and (R)-norketamine via Sharpless asymmetric dihydroxylation/Ritter amination sequence

M Biermann, G Zheng, M Hojahmat, NV Moskalev… – Tetrahedron Letters, 2015

Ketamine is a dissociative anesthetic drug marketed as Kenanest ® , Ketaset ® ,

and Ketalar ® . In addition, ketamine has been shown in clinical studies to have

long-lasting antidepressant effects with a rapid onset of action.

 

Possible role of afferent autonomic signals in abdominal organs in anorexic and cardiovascular responses to nicotine injection in rats.

S Yagi, M Tanida, J Satomi – NeuroReport, 2015

To measure BP in conscious rats, each rat was anesthe- tized with an intraperitoneal

injection of a mixture of ketamine (91 mg/kg body weight) and xylazine (9.1 mg/kg body

weight) and two catheters were inserted (femoral vein and artery).

 

[PDF] Stepwise tapering of remifentanil at the end of surgery decreased postoperative pain and the need of rescue analgesics after thyroidectomy

SS Han, SH Do, TH Kim, WJ Choi, JS Yun, JH Ryu – BMC Anesthesiology, 2015

Previous investigation of patients undergoing major abdominal surgery suggested hyperalgesia

after high dose remifentanil and preventive effect of ketamine for opioid-induced hyperalgesia

[3]. Patients with intraoperative high-dose remifentanil (0.4 μg/kg/min) showed larger

 

[HTML] The dexmedetomidine” augmented” sedato analgesic cocktail: An effective approach for sedation in prolonged endoscopic retrograde cholangio-pancreatography

S Mukhopadhyay, M Niyogi, J Sarkar… – Journal of Anaesthesiology …, 2015

Group 1 received propofol and midazolam, Group 2 received the sedato-analgesic cocktail

containing ketamine-propofol-midazolam-pentazocine, and the Group 3 received sedate-analgesic

cocktail plus dexmedetomidine infusion under monitoring of vital parameters and

 

Convergence of lemniscal and local excitatory inputs on large gabaergic tectothalamic neurons

T Ito, H Hioki, J Sohn, S Okamoto, T Kaneko, S Iino… – Journal of Comparative …, 2015

Viral injections. Rats were anesthetized with a ketamine & xylazine mixture (97.6 mg/kg & 2.4

mg/kg, im). rats were re-anesthetized with a ketamine & xylazine mixture and perfused

transcardially with 4% paraformaldehyde in 0.1 M phosphate buffer (pH 7.4).

 

CURRENT OPINION Postcaesarean section analgesia: are opioids still required?

AMJV Schyns-van den Berg, A Huisjes, RJ Stolker – Curr Opin Anesthesiol, 2015

Ketamine Ketamine, an anaesthetic that also acts as a N-methyl-D-aspartate (NMDA)

receptor antagonist, has shown significance in reducing opioid use in subanaesthetic

doses with minimal side-effects [31]. Furthermore, ketamine

 

Advances in Exotic Mammal Clinical Therapeutics

MG Hawkins – Veterinary Clinics of North America: Exotic Animal …, 2015

For example, patients can be premedicated with an opioid medication and a tranquilizer to

modulate pain and stress, ketamine used as a part of the induction protocol can reduce excitement,

local anesthetic blocks can be added to inhibit pain transmission, and nonsteroidal anti

 

The interactive effects of Ketamine and Magnesium on Brain-Derived Neurotrophic Factor (BDNF) and depressive-like behavior (P4. 080)

S Razmjou, D Litteljohn, S Hayley – Neurology, 2015

Objective: To evaluate the potential synergistic effect of ketmaine and magnesium treatment

on prefrontal cortex (PFC) and hippocampal BDNF expression and depressive-like behavior

in mice model. Background: Ketamine, an NMDA receptor antagonist with neuroplastic

 

Ketamine modulates TRH and TRH-like peptide turnover in brain and peripheral tissues of male rats

AE Pekary, A Sattin, RL Lloyd – Peptides, 2015

Abstract Major depression is the largest single healthcare burden with treatments of slow

onset and often limited efficacy. Ketamine, a NMDA antagonist used extensively as a

pediatric and veterinary anesthetic, has recently been shown to be a rapid acting

 

[PDF] A Label-Free Immunosensor for Ultrasensitive Detection of Ketamine Based on Quartz Crystal Microbalance

Y Yang, Y Tu, X Wang, J Pan, Y Ding – Sensors, 2015

Abstract: In this study, we have developed a label-free immunosensor with the variation of

resonance frequency (Δf) of a quartz crystal microbalance (QCM) as readout signal for

ultrasensitive detection of Ketamine (KT). An optimized strategy for immobilization of KT

 

[HTML] Coupling in the cortico-basal ganglia circuit Is aberrant in the ketamine model of schizophrenia

I Cordon, MJ Nicolás, S Arrieta, E Lopetegui… – European …, 2015

Abstract Recent studies have suggested the implication of the basal ganglia in the

pathogenesis of schizophrenia. To investigate this hypothesis, here we have used the

ketamine model of schizophrenia to determine the oscillatory abnormalities induced in the

 

Methoxetamine: An early report on the motivations for use, effect profile and prevalence of use in a UK clubbing sample

AR Winstock, W Lawn, P Deluca, R Borschmann – Drug and Alcohol Review, 2015

Keywords: novel psychoactive substance; methoxetamine; ketamine; monitoring system.

Prevalence of lifetime, last year and last month use, sourcing of the drugs, motivations for use,

and subjective effect and risk profile compared with that of ketamine were measured. Results.

 

[PDF] Ketofol for Procedural Sedation and Analgesia in Children with Acute Lymphoblastic Leukemia

AA Ibrahim Ahmed, G Mohamed Fathy… – J Anesth Clin Res, 2015

Objectives: The aim of this work is to study the effects, adverse effects and recovery time of IV

mixed propofol and ketamine (ketofol) in 3:1 ratio as a sedative analgesic in children with acute

lymphoblastic leukemia undergoing bone marrow aspiration Methods: This was a

 

Mechanisms of Drug Interaction

AM Manrique-Espinel, EA Sullivan, PK Sikka – Basic Clinical Anesthesia, 2015

 

Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling

KA Russo, JL La, SBZ Stephens, MC Poling… – Endocrinology, 2015

St. Louis, MO) using a ketamine cocktail (21 mg ketamine, 2.4 mg xylazine, and 0.3

mg acepromazine per ml injected ip at a dose of 0.25 ml per 100 g body mass) with

buprenorphrine for pre- and postoperative analgesia. This

 

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway

SI Bibli, I Andreadou, A Chatziananstasiou, C Tzimas… – Cardiovascular Research, 2015

Murine in Vivo Model of Ischemia-Reperfusion Injury The mice were anesthetized by

intraperitoneal injection (0.01 mL/g) with a combination of ketamine, xylazine and atropine (final

concentrations of ketamine, xylazine and atropine 100 mg/kg, 20 mg/kg and 0.6

 

[HTML] Anaesthetic management for drainage of frontoparietal abscess in a patient of uncorrected Tetralogy of Fallot

AS Wajekar, AN Shetty, SP Oak, RA Jain – Indian Journal of Anaesthesia, 2015

Hyperventilation without PEEP helps to decrease PVR. Ketamine for induction is avoided

for neurosurgery. [8] Combination of dexmedetomidine and ketamine has been used in two

patients of uncorrected TOF for surgeries under general anaesthesia.

 

Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, …

M Chatterjee, R Verma, R Kumari, S Singh, AK Verma… – Pharmaceutical biology, 2015

Abstract Context: Schizophrenia is a chronic disabling psychiatric disorder affecting 1% of

the population worldwide. Due to the adverse effects of available antipsychotic medications,

recent investigations have focused on the search for well-tolerated, safe molecules from

 

Autotransplantation for the management of ketamine ureteritis

NTJ Raison, T O’Brien, D Game, J Olsburgh – BMJ Case Reports, 2015

Summary Ketamine-associated cystitis is a well-recognised syndrome; yet upper urinary

tract involvement remains poorly understood. We present the case of a 33-year-old man who

developed ketamine-associated cystitis and ureteritis. The patient’s severe bladder

 

… magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotube for the determination of methylamphetamine and ketamine in human urine and …

S Zhang, Y Cui, J Sun, Y Xi, C Zhang, J Tang – Analytical Methods, 2015

A sensitive and rapid magnetic solid-phase microextraction (MSPE) procedure based on

multi-walled carbon nanotubes (MWNTs), combined with gas chromatography-mass

spectrometry (GC-MS), was developed for the quantification of two illegal basic drugs of

 

[PDF] Dexmedetomedine-Ketamine versus Propofol-Ketamine as anaesthetic agents in paediatric cardiac catheterization

NP Ali, M Kanchi, S Singh, A Prasad, N Kanase – Journal of Armed Forces Medical …, 2015

Abstract Introduction: Anaesthesia for these patients undergoing for interventional

procedures in paediatric patients with congenital cardiac anomalies remains a challenge for

the anaesthesiologist. There are no specific techniques to follow and anaesthetic

 

Gonadal hormones do not alter the development of antinociceptive tolerance to delta-9-tetrahydrocannabinol in adult rats

AA Wakley, JL Wiley, RM Craft – Pharmacology Biochemistry and Behavior, 2015

Louis, MO) were injected sc; 15 min later, rats were anesthetized with ketamine plus xylazine

ip (90 mg/kg ketamine + 10 mg/kg xylazine in females, 100 mg/kg ketamine + 10 mg/kg xylazine

in males; Patterson Veterinary Supply Inc., Kansas City, MO).

 

[PDF] Topical and Intranasal Analgesic Therapy in a Woman with Refractory Postherpetic Neuralgia

KC Hohmeier, LM Almon – Case Reports in Medicine, 2015

The patient-specific, stepped approach resulted in clinically significant decreases in pain on visual

analog scale (VAS), with the use of intranasal ketamine 10% solution and topical gabapentin

6%, ketoprofen 10%, lidocaine 5%, and ketamine 10% cream. 1. Introduction.

 

Prehospital Pain and Analgesic Therapy in Elderly Patients with Hip Fractures

L Oberkircher, N Schubert, DA Eschbach, C Bliemel… – Pain Practice, 2015

Ketamine was used 5 times. Esketamine was preferred (N = 4, 2.6%, mean dosage = 27, SD =

23), but one patient did receive racemic ketamine (0.7%, dosage = 50). Ibuprofen, 1 (0.7), 800 (–),

98 (–), 3 (–), 60 (–). Ketamine, 1 (0.7), 50 (–), 62 (–), 3 (–), 104 (–). Sum, 43 (25)a,

 

[HTML] Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus

D Bing, SC Lee, D Campanelli, H Xiong, M Matsumoto… – Cellular Physiology and …, 2015

Since NMDA receptor antagonists, when systemically given, tend to have a number of negative

central nervous system side effects such as hallucinations or anesthesia (for which eg Ketamine

was originally developed), their clinical potential has been limited.

 

[PDF] Two-Stage Nerve Graft in Severe Scar: A Time-Course Study in a Rat Model

SA Zadegan, M Firouzi, MH Nabian, LO Zanjani… – The Archives of Bone and …, 2015

Surgical procedures An intraperitoneal (IP) injection of ketamine (100 mg/ kg ketamine

hydrochloride, Rotexmedica, Germany) was used to induce anesthesia. Anesthesia was induced

with ketamine (100mg/kg, IP, ketamine hydrochloride, Rotexmedica, Germany).

 

Quantifying progression and regression of thrombotic risk in experimental atherosclerosis

RU Palekar, AP Jallouk, MJ Goette, J Chen… – The FASEB Journal, 2015

Following 2 hours of in vivo NP circulation, mice were anes- thetized with a cocktail of ketamine

and xylazine (87 mg/kg and 37 mg/kg, respectively) and subjected to photochemical injury

of the carotid artery (13–15) to determine time to vessel occlusion.

 

Radiofrequency Ablation (RFA)

 

Irreversible electroporation of malignant lesions: An institution experience

BJ Bates, M Hellan, S Kauffman, J Ouellette – Journal of Solid Tumors, 2015

malignant. Three cases involved margin accentuation prior to resection. One treated

the IVC margin of a radiofrequency ablation site. Twenty-four procedures attempted

complete ablation. Lesions ranged from 1.0 cm to 6.0 cm.

 

[PDF] Clinical outcomes of patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective study of routine clinical practice in multi-institutions

SH Lee, IH Song, R Noh, HY Kang, SB Kim, SY Ko… – 2015

outcomes are generally poor [1,2]. Although potentially curable at an early stage, only 30-40%

of patients with HCC at the time of diagnosis are eligible for curative treatments such as liver

transplantation, tumor resection, or percutaneous radiofrequency ablation (RFA), and the

 

[HTML] Trichoepithelioma and Spiradenoma Collision Tumor

AF Marsch, JB Shackelton, DM Elston – Am J Orthop, 2015

Head Neck Pathol. 2014;8:88-109. « Back To: Landing. Did you miss this content? Cutaneous

Burn Caused by Radiofrequency Ablation Probe During Shoulder Arthroscopy. > more

Soft-Tissue articles. More From The American Journal of Orthopedics

 

Interventional CMR: Clinical Applications and Future Directions

T Rogers, RJ Lederman – Current Cardiology Reports, 2015

Conductive wires can resonate and heat during radiofrequency excitation for MRI [42], which

is a potential challenge for both passive and active devices and is determined by the total length

of If gaps in ablation lines can be visualized, then they can be ablated [67, 68

 

[PDF] Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

D Wu, ZY Shen, YM Zhang, J Wang, H Zheng, YL Deng… – BMC Cancer, 2015

liver transplantation [3]. Other methods including local ablation (eg, ethanol injection, microwave

coagulation, and radiofrequency ablation [RFA]) and transcatheter arterial chemoembolization

(TACE) have proved effective only in a small number of cases [6]. Local treatment

 

[PDF] Radiofrequency electric-field heating behaviors of highly enriched semiconducting and metallic single-walled carbon nanotubes

SJ Corr, M Raoof, BT Cisneros, AW Orbaek… – 2015

Clin Cancer Res 2010, 16, 5712-5721. [5] Glazer, ES; Curley, SA Non-invasive

radiofrequency ablation of malignancies mediated by quantum dots, gold

nanoparticles and carbon nanotubes. Ther Deliv 2011, 2, 1325-1330.

 

Systems and Methods of Radiometrically Determining a Hot-Spot Temperature of Tissue Being Treated

D Panescu, JV Koblish, JF Mccarthy, RC Allison – US Patent 20,150,105,765, 2015

having to repeat the ablation procedure as such, the clinician may ablate a series to assist the

clinician in determining whether any of those ablated regions are Radiofrequency ablation

techniques have developed a substantial following in the medical community, even though

 

[PDF] A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9

JACM Goos, VMH Coupé, MA van de Wiel, B Diosdado… – Towards molecular imaging …, 2015

with colorectal cancer (CRC) die as a consequence of advanced disease 1. The majority of CRC

metastases localize to the liver and resection of the affected liver tissue, often combined with

radiofrequency ablation (RFA), is the sole curative treatment option 2. Selection of

 

[HTML] What Is Your Diagnosis? New World Cutaneous Leishmaniasis

C Hennings, K Bloch, J Miller, J Zwerner – Am J Orthop, 2015

The American Journal of Orthopedics is an Index Medicus publication that is valued by orthopedic

surgeons for its peer-reviewed, practice-oriented clinical information. Most articles are written

by specialists at leading teaching institutions and help incorporate the latest technology

 

RADIOFREQUENCY AMPLIFIER IMPEDANCE OPTIMIZATION

JH Johnson, JA Gilbert – US Patent 20,150,105,766, 2015

The present disclosure relates to radiofrequency amplifiers that use phase-shifted full bridge

resonant inverters high radio frequency electrical current to a surgical site to cut, ablate, coagulate

or cycle sinusoidal waveform in cut mode, which is best suited for ablating, fusing and

 

[HTML] Pulmonary vein orientation assessment: Is it necessary in patients undergoing contact force sensing guided radiofrequency catheter ablation of atrial fibrillation

P Gal, JFW Ooms, JP Ottervanger, JJJ Smit… – IJC Heart & Vasculature, 2015

Purpose We hypothesized pulmonary vein (PV) orientation influences tissue contact of the

contact force (CF) sensing radiofrequency ablation catheter (CFC) and therefore atrial

fibrillation (AF) free survival after pulmonary vein isolation (PVI). The aim of this study was

 

Switching Bipolar Hepatic Radiofrequency Ablation Using Internally Cooled-wet Electrodes: Comparison with Consecutive Monopolar and Switching Monopolar …

JH Yoon, JM Lee, S Woo, EJ Hwang, I Hwang, W Choi… – The British Journal of …, 2015

Objective: To evaluate whether switching bipolar radiofrequency ablation (SB-RFA) using

three internally cooled-wet (ICW) electrodes can induce coagulations> 5 cm in porcine livers

with better efficiency than consecutive monopolar (CM) or switching monopolar (SM)

 

One-year follow-up after irrigated multi-electrode radiofrequency ablation of persistent atrial fibrillation

N Pavlović, C Sticherling, S Knecht, T Reichlin, A Mühl… – Europace, 2015

Aims Irrigated multi-electrode ablation (IMEA) is a novel tool to perform pulmonary vein

isolation (PVI). The aim was to compare IMEA with point-by-point radiofrequency (RF)

ablation in patients with persistent atrial fibrillation (AF) undergoing PVI.

 

Radiofrequency Ablation in the Treatment of Unresectable Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-Analysis

K Han, HK Ko, KW Kim, HJ Won, YM Shin, PN Kim – Journal of Vascular and …, 2015

Abstract The purpose of this study was to perform a meta-analysis and systematic review of

the clinical efficacy and safety of radiofrequency (RF) ablation in the treatment of intrahepatic

cholangiocarcinoma (ICC). A comprehensive literature search of Ovid MEDLINE and

 

Safety profile of multielectrode-phased radiofrequency pulmonary vein ablation catheter and irrigated radiofrequency catheter

K Wasmer, P Foraita, P Leitz, F Güner, C Pott… – Europace, 2015

Background Silent cerebral lesions with the multielectrode-phased radiofrequency (RF)

pulmonary vein ablation catheter (PVAC®) have recently been investigated. However,

comparative data on safety in relation to irrigated RF ablation are missing.

 

Hepatic radiofrequency ablation: in vivo and ex vivo comparison of 15-gauge (G) and 17-G internally cooled electrode

KD Song, MW Lee, HJ Park, DI Cha, TW Kang, J Lee… – The British Journal of …, 2015

Objectives: To compare the performance of the 15-gauge (G) internally cooled electrode

with that of the conventional 17-G internally cooled electrode. Methods: A total of 40 (20 for

each electrode) and 20 ablation zones (ten for each electrode) were made in extracted

 

[HTML] Suppression of postsurgical recurrence of hepatocellular carcinoma treated with autologous formalin‐fixed tumor vaccine, with special reference to glypican‐3

I Kawashima, Y Kawashima, Y Matsuoka, K Fujise… – Clinical Case Reports, 2015

Once HCC is detected, patients experience repeated recurrence, despite the fact that a variety

of HCC treatment methods have been developed, such as anti-viral agents, surgical treatment,

percutaneous ethanol injection (PEIT), radiofrequency ablation (RFA), trans-catheter

 

Role of Sarcoplasmic Reticulum Calcium in Development of Secondary Calcium Rise and Early Afterdepolarizations in Long QT Syndrome Rabbit Model.

PC Chang, HT Wo, HL Lee, SF Lin, MS Wen, Y Chu… – PloS one, 2015

Atrioventricular block (AVB) was created by radiofrequency ablation. After baseline studies,

E4031, SR Ca2+ cycling inhibitors (ryanodine plus thapsigargin) and nifedipine were then

administrated subsequently, and the protocols were repeated.

 

CURRENT OPINION Management of lymphatic malformations in children

N Bagrodia, AM DefnetÃ, JJ Kandel – Curr Opin Pediatr, 2015

Recent findings Current treatment options include nonoperative management, surgery,

sclerotherapy, radiofrequency ablation, and laser therapy. Grimmer JF, Mulliken JB, Burrows PE,

Rahbar R. Radiofrequency ablation of microcystic lymphatic malformation in the oral cavity.

 

[PDF] Long-term complete response of advanced hepatocellular carcinoma treated with multidisciplinary therapy including reduced dose of sorafenib: case report and …

M Shinoda, N Kishida, O Itano, S Ei, A Ueno, M Kitago… – World Journal of Surgical …, 2015

condition. Thus, transcatheter arterial chemoembolization and radiofrequency

ablation of the tumors were performed. Three months later, residual tumor of the

larger lesion and multiple pulmonary metastases were detected.

 

Quantitative Analysis of Localized Sources Identified by Focal Impulse and Roter Modulation Mapping in Atrial Fibrillation

P Benharash, E Buch, P Frank, M Share, R Tung… – Circulation: Arrhythmia and …, 2015

Abstract. Background—New approaches to ablation of atrial fibrillation (AF) include

focal impulse and rotor modulation (FIRM) mapping, and initial results reported with

this technique have been favorable. We sought to independently

 

Characteristics of VT Ablation in Patients with Continuous Flow Left Ventricular Assist Devices

F Sacher, T Reichlin, ES Zado, ME Field… – Circulation: Arrhythmia and …, 2015

Original Article. Characteristics of VT Ablation in Patients with Continuous Flow Left

Ventricular Assist Devices. This study describes VA characteristics and ablation in

patients implanted with a Heart Mate 2 (HM2) device. Methods

 

Catheter Ablation of Ventricular Tachycardia and Mortality in Patients with Nonischemic Dilated Cardiomyopathy: Can Noninducibility after Ablation be a Predictor for …

B Dinov, A Arya, A Schratter, V Schirripa, L Fiedler… – Circulation: Arrhythmia and …, 2015

Original Article. Catheter Ablation of Ventricular Tachycardia and Mortality in Patients with

Nonischemic Dilated Cardiomyopathy: Can Noninducibility after Ablation be a Predictor for

Reduced Mortality? Related Collections. Ablation/ICD/surgery. Social Bookmarking.

 

Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective

N Sengupta, GA Ketwaroo, DM Bak, V Kedar… – Gastrointestinal Endoscopy, 2015

Background Radiofrequency ablation (RFA) is an effective treatment for Barrett’s esophagus

(BE) dysplasia. For patients with dysplasia refractory to RFA, data are limited regarding

efficacy of endoscopic therapy. Objective To assess the efficacy and safety of cryotherapy

 

A novel microwave catheter can perform noncontact circumferential endocardial ablation in a model of pulmonary vein isolation

P Qian, MA Barry, T Nguyen, D Ross, P Kovoor… – Journal of Cardiovascular …, 2015

Second, we were able to ablate at high power without limitations from catheter Haemmerich,

Contribution of direct heating, thermal conduction and perfusion during radiofrequency and

microwave ablation were equivalent whether one pair of radials were orientated in the plane

 

Selective reduction in complicated monochorionic twins: Prediction of obstetric outcome and comparison of techniques

Y Yinon, E Ashwal, B Weisz, B Chayen, E Schiff… – Ultrasound in Obstetrics & …, 2015

Keywords: Monochorionic twins; selective reduction; bipolar cord coagulation; radiofrequency

ablation; selective intra-uterine growth restriction All rights reserved Abstract Objective: To

compare the outcome of radiofrequency ablation (RFA) and bipolar

 

Hypertensive crisis during hemostasis of adrenal bleeding using a soft‐coagulation device

T Kawai, M Suzuki, M Otsuka, S Nakazono, Y Tanaka… – International Journal of …, 2015

Fransson et al. reported hypertensive crisis during radiofrequency ablation of normal

adrenal tissue in dogs. The SA. Hemodynamic changes during laparoscopic

radiofrequency ablation of normal adrenal tissue in dogs. Vet. Surg.

 

[HTML] Contrast-Enhanced Subharmonic and Harmonic Ultrasound of Renal Masses Undergoing Percutaneous Cryoablation

JR Eisenbrey, CM Shaw, A Lyshchik, P Machado… – Academic Radiology, 2015

CT guidance during the session. Cryoablation is also significantly less painful than

heat-based techniques such as microwave and radiofrequency ablation, thereby

avoiding the use of general anesthesia in many patients (6).

 

Rare Endocrine Tumors of the Pancreas: Evidence of Management

JT Li, SY Peng, DF Hong – Pancreatic Cancer, Cystic Neoplasms and Endocrine …, 2015

Medical treatment such as a somatostatin analogue and/or other interventional modality

such as radiofrequency ablation or hepatic artery embolization can allow these patients

long survival times. Get PDF (2762K). More content like this.

 

New Treatment Modalities for Hepatocellular Cancer

K Mauer, R O’Kelley, N Podda, S Flanagan, S Gadani – Current Gastroenterology …, 2015

These include microwave ablation (MWA), which achieves higher temperatures more rapidly,

and irreversible electroporation (IRE higher in energy than RFA (ranging from 900 to 2400 MHz,

while radiofrequency is typically around 400 kHz) to thermally ablate the tumor

 

[HTML] Distribution of abnormal potentials in chronic myocardial infarction using a real time magnetic resonance guided electrophysiology system

SO Oduneye, M Pop, M Shurrab, L Biswas, V Ramanan… – Journal of Cardiovascular …, 2015

Further- more, linear radiofrequency ablation lesions designed to transect these channels of

slow conduction have been shown to be on average longer in length by several centimeters when

the isthmus has not been effectively identified and only voltage maps are known (eg

 

Evaluation of transforaminal endoscopic lumbar discectomy in the treatment of lumbar disc herniation

K Wang, X Hong, BY Zhou, JP Bao, XH Xie, F Wang… – International Orthopaedics, 2015

Last, elderly patients usually suffer from LDH for more years and have more severe vertebral

degeneration than younger pa- tients; thus, the clinical outcomes of elderly patients were not

good when the radiofrequency ablation for annuloplasty was performed.

 

[PDF] Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency Ablation for Lumbar Facet Syndrome

ZL McCormick, B Marshall, J Walker, R McCarthy… – Int J Anesthetic Anesthesiol, 2015

Abstract Objective: Radiofrequency ablation (RFA) of the medial branch nerves for facet-

mediated low back pain demonstrates clinical benefit for 6-12 months and possibly up to 2

years. This study investigated function, pain, and medication use outcomes of RFA for

 

Effect of Irrigant Characteristics on Lesion Formation after Radiofrequency Energy Delivery Using Ablation Catheters with Actively Cooled Tips

DT Nguyen, M Olson, L Zheng, W Barham, JD Moss… – Journal of Cardiovascular …, 2015

Background The delivery of radiofrequency (RF) energy through irrigated ablation catheters

may be affected by irrigant osmolarity and by catheter position. We sought to characterize

lesion formation characteristics using different irrigants in both open and closed irrigated

 

Efficacy and Safety of Radiofrequency Ablation for Treatment of Locally Recurrent Thyroid Cancers Smaller than 2 cm

J Kim, WS Yoo, YJ Park, DJ Park, TJ Yun, SH Choi… – Radiology, 2015

Purpose To evaluate the efficacy and safety of radiofrequency ablation (RFA) for localized

small recurrent thyroid cancers less than 2 cm by comparing them with those at repeat

surgery. Materials and Methods This retrospective study was institutional review board–

 

Long‐term local disease control in a recurrent soft‐tissue sarcoma of the thigh treated by radiofrequency ablation

MD Belfiore, P Maria, MD Ronza, M Francesco… – Journal of Surgical …, 2015

Locally recurrent soft-tissue sarcoma without distant metastases occurs in nearly 20% of

patients [1]. However, in these patients treatment options may be limited because of

previous limb-sparing surgery and radiation therapy, frequently resulting in a

 

Real Time Atrial Wall Imaging during Radiofrequency Ablation in a Porcine Model

M Granier, PF Winum, M Granier, P Liaud, G Cayla… – Heart Rhythm, 2015

Objective We used intravascular ultrasound (IVUS) to describe atrial wall changes during RF

ablation, and assess the extent of RF-induced lesions. Methods In nine piglets, RF and IVUS

catheters were coupled and introduced into the right atrium (RA). RF applications were

 

Efficacy of Computed Tomography Guided Radiofrequency Ablation for Osteoid Osteomas in 31 Patients

J Kim, JM Ahn, JW Lee, GY Lee, E Lee, JH Oh, HS Cho… – Journal of the Korean …, 2015

Purpose To present the clinical outcome of computed tomography (CT) guided

radiofrequency ablation (RFA) for osteoid osteoma. Materials and Methods Thirty-one

patients (M: F= 23: 8, mean age: 20 years, range: 4-54 years) who underwent RFA for

 

SPINAL DISK HERNIATION REPOSITIONING AND RADIOFREQUENCY ABLATION (RFA) DEVICE AND METHOD FOR TREATING VERTEBRAL DISC HERNIATION

H Wang, J Wang – US Patent 20,150,100,052, 2015

Abstract: Devices, components, apparatus, and/or methods for using and making a

combination spinal disk herniation repositioning and radiofrequency apparatus (RFA) or

device that uses one or more repositioning probes and one or more needles/electrodes,

 

[HTML] Radiofrequency ablation (RFA) for palliative treatment of painful non‐small cell lung cancer (NSCLC) rib metastasis: Experience in 12 patients

M Hu, X Zhi, J Zhang – Thoracic Cancer, 2015

Background Painful rib metastasis is common in non-small cell lung cancer (NSCLC). Pain

is often partially or totally refractory to analgesic medications or the side effects of medication

are unacceptable. We report the safety and efficacy of a new method: radiofrequency …

 

[PDF] Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European

KN Phoa, RE Pouw, IR Bisschops, O Pech, K Ragunath… – surgery, 2015

11 Jayan Mannath,4 CA Seldenrijk,12 Mike Visser,13 Toni Lerut,2 Stefan Seewald,14 Fiebo

J ten Kate,13 Christian EII,3 Horst Neuhaus,6 Jacques JGHM Bergman1 ABSTRACT Objective

Focal endoscopic resection (ER) followed by radiofrequency ablation (RFA) safely and

 

A National Analysis of the Complications, Cost, and Mortality of Percutaneous Lung Ablation

BT Welch, W Brinjikji, GD Schmit, MR Callstrom… – Journal of Vascular and …, 2015

Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology,

243 (2007), pp. 268–275. Primary non-small cell lung cancer: review of frequency, location, and

time of recurrence after radiofrequency ablation. Radiology, 254 (2010), pp. 301–307.

 

 Complex Regional Pain Syndrome (CRPS/RSD)

 

Substituted imidazolium compounds for treating disease

H Tabuteau – US Patent 9,006,279, 2015

In some embodiments, a subject compound may be administered to relieve complex regional

pain syndrome, such as complex regional pain syndrome type I (CRPS-I), complex regional

pain syndrome type II (CRPS-II), CRPS-NOS, or another type of CRPS.

 

CURRENT OPINION Improving the outcome of bacterial meningitis in newborn infants in Africa: reflections on recent progress

EM Molyneux, Q Dube, L Newberry – Curr Opin Infect Dis, 2015

C-REACTIVE PROTEIN Only 35–65% of serum CRPs are positive at the beginning of the illness

[14]. Serial CRPs 24–48h after the onset of symptoms are more helpful and if two tests, 24 h apart

are less than 10 mg/l, the nega- tive predictive value for sepsis is 99% [15].

 

Well‐Defined High Molecular Weight Polystyrene with High Rates and High Livingness Synthesized via Two‐Stage RAFT Emulsion Polymerization

K Yan, X Gao, Y Luo – Macromolecular Rapid Communications, 2015

in dead chains has long been pursued since it provides a powerful tool for synthesizing

well-defined nanostructured functional materials with precisely controlled chain microstructures

and complex architectures.[1] Controlled radical polymerizations (CRPs), which show some

 

Iatrogenic lesions of peripheral nerves

WN Löscher, J Wanschitz, S Iglseder, A Vass… – Acta Neurologica …, 2015

In addition to pain, patients may develop weakness or sensory, respectively, trophic disturbances.

Rarely, neuropathic pain without weakness occurs. In half of the cases, trophic disturbances

and a chronic regional pain syndrome (CRPS) develop [68, 70].

 

A survey on memristor modeling and security applications

MT Arafin, C Dunbar, G Qu, N McDonald, L Yan – Quality Electronic Design (ISQED), …, 2015

the discrepancy from the expected delay or the instable power-on states of the memory cells,

to generate chip-dependent PUF data that can be used as secret keys or as seeds of random

number generators, and/or to create challenge response pairs (CRPs) for authentication

 

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

JS Gewandter, RH Dworkin, DC Turk, JT Farrar… – PAIN, 2015

recovery (SNR); (4) chronic post-surgical pain (IG); (5) postherpetic neuralgia (RHD); (6) painful

diabetic peripheral neuropathy (DZ); (7) HIV and chemotherapy-associated peripheral

neuropathies (MJP); (8) complex regional pain syndrome (CRPS) type 1 (ALO); (9)

 

Surgical Management of Posttraumatic Midfoot Deformity and Arthritis.

JD Seybold, JC Coetzee – Techniques in Foot & Ankle Surgery, 2015

Kuo et al4 echoed these results, with neuritis, metatarsalgia, and malunion noted

as the most common complications in their series. One superficial infection, 1

asymptomatic nonunion, and 1 case of CRPS were also reported.

 

Using Augmented Reality in the Treatment of CRPS Patients

L Knudsen, HP Hansen, D Baskarada, N Nedergaard…

Background Mirror Visual Feedback (MVF) is an important part of therapeutic treatment of

Complex Regional Pain Syndrome (CRPS). Unfortunately mirror boxes (MB) are not

compatible with meaningful activities. Recently it was shown that Virtual Reality (VR) as

 

Development of a Clinical Framework for Mirror Therapy in Patients with Phantom Limb Pain: An Evidence‐based Practice Approach

A Rothgangel, S Braun, L Witte, A Beurskens… – Pain Practice, 2015

Only one protocol [41] specifically addressed patients with PLP. Two protocols [39, 42] were

applied in a mixed pain population and one protocol [40] mainly focused on patients with complex

regional pain syndrome (CRPS) but also provided some basic information on PLP.

 

Techniquesformonitoring, imaging, and pain relief

S Dhir, R Sharma, S Ganapathy – Trauma Anesthesia, 2015

 

Skin Hyperpigmentation in Complex Regional Pain Syndrome (CRPS)(P3. 315)

R Knobler – Neurology, 2015

OBJECTIVE: To characterize hyperpigmented skin changes which appear as a

manifestation in limbs affected by CRPS. BACKGROUND: CRPS is a neuropathic, often

treatment resistant, non-malignant pain syndrome. Early diagnosis is essential for a good

 

Chronic Regional Pain Syndrome: A Preliminary report on molecular mechanisms and structural correlates (S10. 005)

B Murinson, Z Ghersin, E Peled – Neurology, 2015

Abstract. OBJECTIVE: Complex Regional Pain Syndrome (CRPS) is a painful neurological

condition that is highly resistant to treatment. As the disease pathophysiology is not

definitively characterized, case studies may offer valuable insights.

 

[PDF] Towards an integrated probabilistic nowcasting system (En-INCA)

M Suklitsch, A Kann, B Bica – Advances in Science and Research, 2015

The two plots in the right column of Fig. 4 illustrate the Continuous Ranked Probability Score

(CRPS) and the per- centage of outliers. The CRPS compares a full distribution of ensemble

predictions with observations, both represented as cumula- tive distribution functions.

 

Role of magnetic resonance imaging in the diagnosis of the painful unicompartmental knee arthroplasty

CN Park, HA Zuiderbaan, A Chang, S Khamaisy… – The Knee, 2015

then the patient underwent MRI. Patients who presented with other obvious causes

of pain (eg lumbar spine stenosis, hip osteoarthritis, complex regional pain syndrome

(CRPS)) were excluded. The final study group consisted

 

New experimental hosts of Barley yellow dwarf virus among wild grasses with implications for grassland habitats

LL Ingwell, NA Bosque‐Pérez – Plant Pathology, 2015

virus reservoirs in the environment (Borer et al., 2007). Understanding the ability of BYDV to infect

grass species including those present in prairies and CRPs, and the suitability of these Page

5. Accepted Article This article is protected by copyright. All rights reserved.

 

[PDF] Evaluation of the CGIAR Research Program on Aquatic Agricultural Systems (AAS)

R Birner, R Bhujel, EM Rathgeber, J Sumberg… – 2015

Page 1. ! ! ! ! Fund%Council% ! 13th%Meeting%(FC13)—Bogor,%Indonesia%

April%28?29,%2015% % % ! ! WORKING(DOCUMENT( % % % % Evaluation!of!the!!

CGIAR!Research!Program!on!! Aquatic!Agricultural!Systems!(AAS)!! ! % Submitted!by:!!

 

[PDF] Evaluation of the CGIAR Research Program on Wheat

W Beversdorf, S Brouder, PP Sachdeva, R Sulaiman – 2015

Regarding research on sustainable intensification, the Team sees need for greater lateral learning

that spans across CRPs and crops and greater use of synthesis reviews and meta-analysis to

enhance the international public gods nature of the xii Page 17. cgiar.iea.org

 

[PDF] Evaluation of the CGIAR Research Program “Policies, Institutions and Markets”(PIM)

K Andersson, C Gerrard, W Meyers, F Nankhuni… – 2015

its funders and partners in making decisions with respect to the continuation, expansion, and

structuring of PIM during the extension phase of 2015–16; • to inform decisions on the program

in response to the call of the Fund Council for the second round of CRPs in 2016; • to

 

[HTML] Elucidating the Pathophysiology of Peripheral Neuropathies: A Conversation With Claudia Sommer

N Andrews – 2015

Uçeyler N, Zeller D, Kahn AK, Kewenig S, Kittel-Schneider S, Schmid A, Casanova-Molla J,

Reiners K, Sommer C. Brain. 2013 Jun; 136(Pt 6):1857-67. Anti-autonomic nervous system

antibodies in CRPS. Sommer C. Pain. 2011 Dec; 152(12):2675-6. Epub 2011 Jul 30.

 

Secondary Dystonia

P Kanovsky, D Dressler, K Menšíková – Dystonia and Dystonic Syndromes, 2015

Eur J Neurol. 2010;17:649–60.CrossRefPubMed. 38. Schott GD. Peripherally-triggered CRPS

and dystonia. Pain. 2007;130:203–7.CrossRefPubMed. 39. van Hilten JJ, Geraedts EJ, Marinus

J. Peripheral trauma and movement disorders. Parkinsonism Relat Disord.

 

[PDF] COMPLEX REGIONAL PAIN SYNDROME IN PEDIATRIC SPORTS: A CASE SERIES OF THREE YOUNG ATHLETES.

BAMDEP RICO

Patients: Three adolescent young female athletes who developed clinical findings compatible

with Complex Regional Pain Syndrome (CRPS) after lower extremity trauma. Conclusion: CRPS

is a challenging disease that may affect young active and athletic patients.

 

[PDF] Successful Treatment of a Nine—Year Case of Complex Regional Pain Syndrome Type-l (Reflex Sympathetic Dystrophy) Wlth

WAAF Patient

introduction Complat Pain Syndrome (CRPS) is a pain— ful and debilitating mopadtic

pain disorder. CRPS is classified into two types [1]. Both types appear to occur after

a traumatic event. With type-I. which is more common.

 

Pain Management

RK Naidu, TM Pham – Basic Clinical Anesthesia, 2015

 

[PDF] Nuclear Data Development Related to Th-U Fuel Cycle in India

S Ganesan

7. The IAEA Co-ordinated Research Projects (CRPs). International collaborations with CERN

n_TOF under BARC MOU, Korea, IAEA CRPs • Identification of faculty & support for formation

of useful local neutron data centres in Indian universities and institutes.

 

Appendix of Management Algorithms For Certain Clinical Conditions

M ABCs, C Intralipid – Basic Clinical Anesthesia

Page 660. 675 PK Sikka et al.(eds.), Basic Clinical Anesthesia, DOI 10.1007/978-

1-4939-1737-2,© Springer Science+ Business Media New York 2015 Appendix

of Management Algorithms For Certain Clinical Conditions A1.

 

Spinal Cord Stimulation for the Treatment of Neuropathic Pain Associated With Leprosy: A Case Report

NJ Brandmeir, MD Sather – Neuromodulation: Technology at the Neural Interface, 2015

Background. Leprosy is a major source of nerve damage and may lead to neuropathic pain as

well as complex regional pain syndrome (CRPS). Spinal cord stimulation is an effective treatment

for CRPS, but there are no reports of this treatment in a patient with leprosy.

 

Evaluating the skill of NMME seasonal precipitation ensemble predictions for 17 hydroclimatic regions in continental China

F Ma, A Ye, X Deng, Z Zhou, X Liu, Q Duan, J Xu… – International Journal of …, 2015

(7). where FracErr is the mean fractional error, which is not biassed by the number of bins. The

continuous ranked probability score (CRPS) applies to probabilistic forecasts that exhibit

predictive cumulative distribution functions. The CRPS is defined as. (8).

 

Reconfigurable physical unclonable function based on probabilistic switching of RRAM

A Chen – Electronics Letters, 2015

bit strings. These challenge–response pairs (CRPs) can be utilised as security

primitives. Ideally Most of these PUF designs are static with unalterable CRPs after

the fabrication of the underlying physical systems. The so-called

 

Burst Spinal Cord Stimulation in a Patient with Complex Regional Pain Syndrome: A 2‐year Follow‐Up

N Kriek, G Groeneweg, FJPM Huygen – Pain Practice, 2015

Spinal cord stimulation (SCS) is an effective therapy to treat most patients with complex

regional pain syndrome (CRPS); however, the effect is not always maintained over

time. We present a case report of a patient successfully

 

[PDF] Covariance models on the surface of a sphere: when does it matter?

J Jeong, M Jun – arXiv preprint arXiv:1504.01985, 2015

as well as the two popular scoring rules (Gneiting and Raftery, 2007), the mean absolute

error (MAE) and the continuous ranked probability score (CRPS). Figures 2(a)-(d) present

MAE and CRPS from the two models, the exponential models using

 

A novel modeling attack resistant PUF design based on non-linear voltage transfer characteristics

A Vijayakumar, S Kundu – Proceedings of the 2015 Design, Automation & Test in …, 2015

In addition, layout techniqu metallization and routing of interconnects can further increase the

resistance to such invasive PUF circuits can be widely classified as strong PUF based on their

physical implemen PUFs such as SRAM PUFs have limited ch pairs (CRPs).

 

Assimilation of stream discharge for flood forecasting: Updating a semidistributed model with an integrated data assimilation scheme

Y Li, D Ryu, AW Western, QJ Wang – Water Resources Research, 2015

Page 1. Assimilation of stream discharge for flood forecasting: Updating a

semi-distributed model with an integrated data assimilation scheme Yuan

Li1,2,3, Dongryeol Ryu1, Andrew W. Western1, QJ Wang2 1 Department of

 

Exploitation of complement regulatory proteins by Borrelia and Francisella

M Madar, E Bencurova, P Mlynarcik, AM Almeida… – Molecular BioSystems, 2015

university of veterinary medicine and pharmacy, Komenskeho – 73, Kosice, Slovakia Running

title: Exploitation of CRPs by Borrelia and Francisella binding to the host complement regulatory

proteins (CRPs) on their surface or expression of the CRP mimicking molecules.

 

Efficient attacks on robust ring oscillator PUF with enhanced challenge-response set

PH Nguyen, DP Sahoo, RS Chakraborty… – Proceedings of the 2015 …, 2015

The CRPs are generated by applying a log2 m–bit challenge, selecting (de- pending

on the applied challenge) a unique pair of ROs from the available set, and comparing

the oscillation frequencies of the two ROs in the pair.

 

A spatial hybrid approach for downscaling of extreme precipitation fields

A Bechler, M Vrac, L Bel – Journal of Geophysical Research: Atmospheres, 2015

ity Score (CRPS) and the 95% Quantile Score (QS95) [Gneiting and Raftery, 2007], the

multivariate energy score (ES), which generalizes the CRPS [Gneiting et al., 2008], is It appears

that concerning the marginal distribution (ie, CRPS, QS, KS and CVM

 

Fibromyalgia

 

Concomitance of fibromyalgia syndrome and cervical disc herniation

M Güler, T Aydın, E Akgöl, Ö Taşpınar – Journal of Physical Therapy Science, 2015

[Purpose] Fibromyalgia syndrome (FMS) and cervical disc herniation (CDH) are a common

diseases commonly encountered in physical therapy clinics. There are also patients who

have both of these diseases. In this study we aim to investigated whether FMS is a risk

 

[PDF] Evaluation of Depression in Women Affected by Fibromyalgia Syndrome

A Vespa, C Meloni, MV Giulietti, M Ottaviani… – J Depress Anxiety, 2015

Objective: In this paper, we explored the association between the clinical course of Fibromyalgia

Syndrome (FMS) and patient’s response to emotional stress in terms of depression.

Method: All participants (n=57 women with Fibromyalgia Sindrome (FMS); control group (

 

Scientific Controversy and its Relationship to the Media

K Perleberg – 2015

environmental, and health-related issues. Some examples of this phenomenon include

global climate change, the effects of hydraulic fracturing (fracking) on the environment,

and what fibromyalgia is exactly. While the media has

 

Osteomalacia, Severe Thoracic Deformities and Respiratory Failure in a Young Woman with Anorexia Nervosa

D Watanabe, M Hotta, A Ichihara – Internal Medicine, 2015

She worked indoors in part- time and had a body weight of 32 kg. In the summer of year X-3,

at 19 years of age, she complained of generalized pain, and her family physician suspected

fibromyalgia. However, the patient’s family physician diagnosed her with fibromyalgia.

 

[PDF] Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?

Y Khayyat, S Attar – Oman Medical Journal, 2015

It is no doubt a questionable fact whether vitamin D deficiency could be taken into account as

a causative factor relating to the pathogenic aetiology in the development of IBS as in the case

of vitamin deficiency induced fibromyalgia cases.14 The present study has shown

 

PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND AN ANALGESIC AGENT

S Gullapalli, PK Gupta, MN Gandhi, S Mandadi – US Patent 20,150,105,406, 2015

The method according to claim 19, wherein the neuropathic pain comprises peripheral neuropathy,

diabetic peripheral neuropathy (DPN), post herpetic neuralgia, spinal-cord injury pain, fibromyalgia,

multiple sclerosis pain, ischemic pain, chronic musculoskeletal pain

 

Evaluation of Pain in Humans

DB Ross – US Patent 20,150,105,688, 2015

There has been a clear link established between fibromyalgia and psychiatric disorders. Each

of these inputs is selective for different pathophysiologic phenomena. Palpation is often

applied for myofascial type pain syndromes (such as fibromyalgia).

 

[PDF] TENS for pain relief

T Can – 2015

As far as we can tell, the TENS machine can be used for all pain conditions, providing there

is no health reason preventing its use. However, it can be difficult if you have many pain

sites or more widespread pain, such as fibromyalgia syndrome.

 

[PDF] Metformin and caloric restriction induce an AMPK-dependent 2 restoration of mitochondrial dysfunction in fibroblasts from 3 Fibromyalgia patients

M Battino, MD Cordero

50 Mitochondria are essential organelles present in virtually all eukary-51 otic cells. One of

the primary functions of mitochondria is ATP produc-52 tion via the oxidative

phosphorylation (OXPHOS) pathway. Moreover, 53 they play crucial roles in many other

 

[PDF] REVISTA BRASILEIRA DE REUMATOLOGIA

KF Salvato, JPM Santos, DAA Pires-Oliveira… – rev bras reumatol, 2015

The criteria for exclusion were individuals with full or partial prosthetics in any of the joints being

evaluated, with concomitant diagnosis of other osteoarticular/muscle dis- eases, such as

rheumatoid arthritis, fibromyalgia, systemic lupus erythematosus and other rheumatic

 

[PDF] Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unitary’hypothesis

S Pejovic, BH Natelson, M Basta… – BMC Neurology, 2015

Background Since chronic fatigue syndrome (CFS) and fibromyalgia (FM) often co-exist,

some believe they reflect the same process, somatization. Against that hypothesis are data

suggesting FM but not CFS was common in patients with sleep-disordered breathing (

 

Fibromyalgia Syndrome: Considerations for Dental Hygienists

A Walters, SL Tolle, GM McCombs – American Dental Hygienists Association, 2015

Purpose: Fibromyalgia syndrome (FMS) is a neurosensory disorder characterized by

widespread musculoskeletal pain. Typically persistent fatigue, depression, limb stiffness,

non-refreshing sleep and cognitive deficiencies are also experienced. Oral symptoms and

 

Physical Trauma and Infection as Precipitating Factors in Patients with Fibromyalgia.

J Jiao, A Vincent, SS Cha, CA Luedtke, CH Kim, TH Oh – American Journal of …, 2015

Objective: The objective of this study was to evaluate both precipitating factors in patients

with fibromyalgia and any differences in clinical presentation, symptom severity, and quality-

of-life between those with and without precipitating physical trauma or infection.

 

[PDF] The prevalence of severe fatigue in rheumatic diseases: an international study

CL Overman, MB Kool, JAP Da Silva, R Geenen… – Fatigue and functioning in …, 2015

Severe fatigue was least prevalent in patients with osteoarthritis (35%) and most

prevalent in patients with fibromyalgia (82%). In logistic regression analysis, severe

fatigue was predicted by having fibromyalgia, having multiple

 

Attention and Working Memory in Female Adolescents with Chronic Pain and Healthy Pain Free Female Adolescents: A Preliminary Pilot Study.

K Mifflin, J Chorney, B Dick – The Clinical Journal of Pain, 2015

in adults with chronic pain. In one study, adults with different types of chronic pain (fibromyalgia,

rheumatoid arthritis, and musculoskeletal pain) were found to perform found that patients with

chronic pain due to fibromyalgia had hypoactivation in overlapping areas commonly

 

Vulvar Vestibulodynia: Strategies to Meet the Challenge

A Bonham – Obstetrical & Gynecological Survey, 2015

Advertisement. Close Window. Close Window. Enter your Email address: Wolters Kluwer Health

may email you for journal alerts and information, but is committed to maintaining your privacy

and will not share your personal information without your express consent.

 

The head says yes but the heart says no: what is non-cardiac chest pain and how is it managed?

JB Chambers, EM Marks, MS Hunter – Heart, 2015

psychologist. It is likely that patients seen by a cardiologist with NCCP resemble those

referred to a rheumatologist with fibromyalgia and perhaps those seen first by a

gastroenterologist, but comparative data do not exist. Symptoms

 

[HTML] Internet-based interventions for pain management: A systematic review of randomised controlled trial (RCTs) conducted from 2010 to 2014

A El-Metwally – Journal of Public Health and Epidemiology, 2015

Description of participants. Most studies targeted patients with chronic pain syndrome including

low back pain, migraine, fibromyalgia and musculoskeletal pain (Table 1). Wide age range used

in these studies captures adults, elderly and children between 3 years and above.

 

Conditioned Pain Modulation in Patients with Acute and Chronic Low Back Pain.

S Mlekusch, AY Neziri, A Limacher, P Jüni… – The Clinical Journal of Pain, 2015

8. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and

heterotopic noxious conditioning stimulation (hncs) in fibromyalgia patients and healthy subjects.

Julien N, Goffaux P, Arsenault P,et al. Widespread pain in fibromyalgia is related to a

 

Manual Therapy, Therapeutic Patient Education, and Therapeutic Exercise, an Effective Multimodal Treatment of Nonspecific Chronic Neck Pain

H Beltran-Alacreu, I López-de-Uralde-Villanueva… – American Journal of …, 2015

associated with whiplash in- juries, medical red flag history (ie, tumor, fracture, metabolic diseases,

rheumatoid arthritis, and oste- oporosis), neck pain with cervical radiculopathy, neck pain

associated with externalized cervical disc herniation, fibromyalgia syndrome, previous

 

Pain Characteristics do not Distinguish Fibromyalgia Patients with Abnormal Skin Biopsy (P5. 069)

V Lawson, J Grewal, K Hackshaw, P Mongiovi – Neurology, 2015

OBJECTIVE: To determine whether pain characteristics can distinguish between

fibromyalgia patients who have abnormal skin biopsy and/or SNAP amplitudes.

BACKGROUND: Patients (n= 165) with fibromyalgia were assessed for differences in pain

 

Effects of functional training on pain, leg strength and balance in women with fibromyalgia

PÁ Latorre Román, MP Santos e Campos… – Modern Rheumatology, 2015

Abstract Aim: The aim of this study was to analyze the effect of 18-week functional training

(FT) program consisting in two sessions a week of in-water exercise and one of on-land

exercise on pain, strength and balance in women with Fibromyalgia. Methods: A total

 

[HTML] Elucidating the Pathophysiology of Peripheral Neuropathies: A Conversation With Claudia Sommer

N Andrews – 2015

She is active in the development of national and international guidelines on treatment

of peripheral neuropathies, on nerve and skin biopsies, and on treatment of

fibromyalgia and neuropathic and facial pain. Sommer spoke

 

Alterations in Brain Gray Matter Volume are Associated with Reduced Evoked-Pain Connectivity following Acute Pregabalin Administration (S10. 003)

T Puiu, A Kairys, L Pauer, T Schmidt-Wilcke, E Ichesco… – Neurology, 2015

Preclinical studies indicate that PGB may potentially down-regulate glutamate release in the

synapse. DESIGN/METHODS: Sixteen female fibromyalgia patients completed a randomized

double-blind two-period cross-over study of PGB versus placebo (PBO).

 

Clinical and molecular profiling of muscle pain in myotonic dystrophy type 2 (S10. 002)

V Palada, R Moshourab, S Kempa, M Boschmann… – Neurology, 2015

CONCLUSIONS: Our data show that DM2 related myalgias are primarily of muscular origin

but some patients also develop additional central pain. The results may also help to understand

other more common reasons for muscle pain such as fibromyalgia.

 

[HTML] Complementary and alternative medicine in chronic neurological pain

SK Mishra, B Trikamji, E Togneri – Indian Journal of Pain, 2015

[68] Biomagnetic therapy has also been used in treating chronic pain, particularly related to tissue

ischemia and fibromyalgia with low frequency and low intensity magnetic energy. Pioro-Boisset

M, Esdaile JM, Fitzcharles MA. Alternative medicine use in fibromyalgia syndrome.

 

[DOC] Nociception at the diabetic foot, an uncharted territory

EA Chantelau – World J Diabetes, 2015

Although this protocol had primarily been devised for examining hyperalgesia in non-nociceptive

pain syndromes like fibromyalgia, or neuropathic pains, and not for assessing hypoalgesia [18] ,

the author (Chantelau EA) believes that parts of it may well be applied for studying

 

[HTML] Need of Indian protocol in pain management

R Gurumurthi, G Das – Indian Journal of Pain, 2015

for responsible opioid prescribing in chronic noncancer pain and spine intervention procedures,

World Institute of Pain guidelines for interventional pain procedures, WHO ladder for cancer pain

management, American College of Rheumatology criteria for fibromyalgia and so

 

[PDF] The Effects of Coffee and Korean Red Ginseng with Body Wrap Steam Bathing on Stress Markers and Lipid Profiles

SY Park, SP Lee – Journal of Food and Nutrition Research, 2015

[4] Buskila, D., Abu-Shakra, M., Neumann, L., “Balneotherapy for fibromyalgia at the

Dead Sea,” Rheumatology International, 20, 105-108, 2001. [5] Neumann, L., Sukenik,

S., Bolotin, A., Abu-Shakra, M., Amir, M., Flusser, D., Buskila

 

An Innovative Nursing Approach to Caring for an Obstetric Patient With Rape Trauma Syndrome (RTS)

C Parker – Journal of Obstetric, Gynecologic, & Neonatal Nursing, 2015

Many survivors have a history of panic attacks, phobias, self-mutilation, personality disorders,

depression, anxiety, substance abuse, asthma, irritable bowel syndrome, chronic pain,

fibromyalgia, obesity, sleep disturbances, and migraines to name a few (Burian, 1995; Hobbins

 

Herpes Simplex Virus Type 1 Dorsal Root Ganglionitis in a 34 Year Old Male With Occipital Neuralgia Refractory to Medical and Radiofrequency Ablation Therapies: …

J Rathore, K Slavin, R Rathore, A Rakic, T Valyi-Nagy – Neurology, 2015

RESULTS: A 34 year old Caucasian homosexual male with past medical history of fibromyalgia,

post-traumatic stress disorder and bilateral occipital headaches that started 15 years ago after

a motor vehicle accident presented with a five week history of significantly worsened

 

Placebo-Controlled, Double-Blind, Randomized Pilot Study to Evaluate the Effects of Low-Dose Naltrexone on Quality of Life and Fatigue in Newly Diagnosed High- …

K Peters, M Affronti, S Woodring, E Lipp, P Healy… – Neurology, 2015

Naltrexone, an orally semisynthetic opiate antagonist, is FDA- approved for treatment of heroin/

alcohol addiction, but there have been observations that low dose naltrexone (LDN) can mitigate

fatigue and stress in fibromyalgia and multiple sclerosis patients.

 

Diagnosis at work–On sick leave in Sweden

L Eriksson – Social Theory & Health, 2015

The article explores how understandings of patients with symptom diagnoses, notably fibromyalgia,

are shaped by the introduction of a new medical decision-making support tool used to assess

patients’ ‘work capacity’, together with a revision of the Swedish social insurance.

 

[HTML] Pressure pain threshold and pain perception in temporomandibular disorder patients: is there any correlation?

J Stuginski-Barbosa, RS Silva, CO Cunha… – Revista Dor, 2015

in accordance with the RDC/TMD. Exclusion criteria included patients with systemic

disease like fibromyalgia or rheumatic conditions, odontogenic or neuropathic pain

and history of TMJ surgery. Patients on ongoing use of

 

Current Topical and Systemic Therapies for Itch

TA Leslie, MW Greaves, G Yosipovitch – Pharmacology of Itch, 2015

chronic kidney disease, cholestasis, myeloproliferative disorders and hyperthyroidism),

neuropathic (notalgia paresthetica, brachioradial pruritus and postherpetic neuralgia itch) and

psychogenic (obsessive-compulsive disorders, depression and fibromyalgia) (Yosipovitch and

 

Common Co-morbidities and Fibromyalgia

D Marcus, A Deodhar

The Infona portal uses cookies, ie strings of text saved by a browser on the user’s device.

The portal can access those files and use them to remember the user’s data, such as their

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[DOC] WHAT IS LYME DISEASE Named after the small town of Lyme, Connecticut, where the disease was first identified in 1975, Lyme disease is a bacterial illness …

T Der-Ohanian

In later stages, Lyme disease can become chronic and trigger serious conditions such as

rheumatoid arthritis, multiple sclerosis, AlzheimerÆs disease, chronic fatigue syndrome,

fibromyalgia, ParkinsonÆs disease, and a host of other illnesses.

 

[HTML] Chaga Mushroom Powder (1 lb)

ZNFSM Life

Wild, non-GMO Chaga Mushroom Powder- antioxidant & polysaccharide rich-

supports a healthy immune system. Fresh Chaga Powder.

 

The Dual-Dialectical Conceptualization in Psychotherapy

S Navon – American Journal of Psychotherapy, 2015

The American Journal of Family Therapy, 33, 103-116. Navon, S. (2005b). Listening to

illness/non-illness motifs: A case of fibromyalgia. Families Systems & Health, 23, 358-361. Navon, S. (2014). The illness/non-illness model: Hypnotherapy for Physically Ill Patients.

New study shines light on ketamine’s antidepressant effects

New study shines light on ketamine’s antidepressant effects

Ketamine, a long known anesthetic drug, has recently experienced resurgence in use due to the serendipitous discovery of new activities.  These new activities have afforded new treatment options for notoriously difficult to treat diseases such as depression and chronic pain.

Ketamine has been called the pharmacologist’s nightmare due to it’s numerous mechanisms of action, making it difficult to pinpoint exactly what makes the drug so effective for specific diseases.  A new study published in Biological Psychiatry found that ketamine induced large-scale persistent network reconfiguration in monkeys.  The scientists believe that this activity may be critical for ketamine’s anti-depressive effects.

These findings could rapidly advance the development of a ketamine-based drug for the treatment of depression.  Moreover, it opens the door for more physicians to use existing ketamine therapeutics off label to treat depression that is resistant to conventional antidepressants.

Dr. Hanna’s clinical team at the Florida Spine Institute has used intravenous ketamine therapy to treat many types of disorders, including depression.  To learn more about intravenous ketamine infusions, click here.  To find out if ketamine therapy is right for you, please make an appointment with Dr. Hanna.

For full article, visit: http://www.sciencedirect.com/science/article/pii/S0006322315001535

Latest Research Updates

Weekly Breaking Research Updates

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates (below).

If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

Ketamine 

 

Wastewater analysis to monitor spatial and temporal patterns of use of two synthetic recreational drugs, ketamine and mephedrone, in Italy

S Castiglioni, A Borsotti, I Senta, E Zuccato – Environmental Science & Technology, 2015

Wastewater analysis was applied in a four-year monitoring study to assess temporal and

spatial patterns of ketamine and mephedrone use in the general population in Italy.

Composite raw wastewater samples were collected from sewage treatment plants (STPs)

 

The use of ketamine as an antidepressant: a systematic review and meta‐analysis

CM Coyle, KR Laws – Human Psychopharmacology: Clinical and …, 2015

Objective The current meta-analysis examines the effects of ketamine infusion on

depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder

(BD). Methods Following a systematic review of the literature, data were extracted from 21

 

Intravenous Ketamine to Facilitate Non-Invasive Ventilation in a Patient with a Severe Asthma Exacerbation

E Kiureghian, JM Kowalski – The American Journal of Emergency Medicine, 2015

Background Despite advances in outpatient treatment and an improved understanding of

the pathophysiology, asthma continues to be a significant source of morbidity and mortality

in the United States. While there is certainly a component of chronic inflammation, the

 

Perioperative low-dose ketamine improves postoperative analgesia following Cesarean delivery with general anesthesia

M Haliloglu, M Ozdemir, N Uzture, PO Cenksoy… – The Journal of Maternal- …, 2015

Abstract Objective: In this study, the effect of perioperative uses of low dose ketamine on

post-operative wound pain and analgesic consumption in patients undergoing elective

Cesarean section was evaluated. Methods: In randomized, double blind clinical trial, 52

 

The Clinical Effect of Fentanyl in Comparison with Ketamine in Analgesic Effect for Oncology Procedures in Children: A Randomized, Double-Blinded, Crossover Trial

C Monsereenusorn, P Rujkijyanont, C Traivaree – JOURNAL OF THE MEDICAL …, 2015

Material and Method: A randomized, double-blinded, crossover trial was conducted with 55 children

undergoing painful procedures (intrathecal chemotherapy and/or bone marrow

aspiration/biopsy). Patients were randomly assigned in a double-blinded fashion to

 

Dexmedetomidine, Ketamine, and Midazolam for Oral Rehabilitation: A Case Report

BWS Kim, RM Peskin – Anesthesia Progress, 2015

Abstract Intravenous sedation is frequently provided by anesthesiologists for phobic patients

undergoing elective dental treatment in outpatient settings. Propofol is one of the most

commonly used anesthetic agents that can result in apnea and respiratory depression,

 

Ketamine May Be Related to Minor Troponin Elevations in Children Undergoing Minor Procedures in Emergency Department

M Serinken, C Eken – The American Journal of Emergency Medicine, 2015

Objective Ketamine is a dissociative anesthetic agent that has an increased frequency of

usage in the last years particularly in emergency departments. In the present study, we

aimed to determine whether ketamine is related to myocardial injury in children

 

Anesthesia and neuromonitoring

EN Menga, GJ Spessot, JA Bendo – Seminars in Spine Surgery, 2015

Commonly used intravenous anesthetics include propofol, dexmedetomidine, etomidate,

barbiturates, ketamine, and benzodiazepines. Using a canine model, Glassman et al. 13 reported

consistent and reproducible TcMEPs with ketamine and etomidate.

 

Inflammatory Biomarkers as Differential Predictors of Antidepressant Response

K Hashimoto – International Journal of Molecular Sciences, 2015

situation. This article discusses inflammatory molecules as predictive biomarkers

for antidepressant responses to several classes of antidepressants, including the

N-methyl-d-aspartate (NMDA) receptor antagonist ketamine.

 

Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury

CC Liao, GE DiCarlo, OA Gharbawie, HX Qi, JH Kaas – Journal of Comparative …, 2015

tranquilized with an intramuscular injection (IM) of ketamine hydrochloride (10-25 mg/ kg, IM)

and Page 4 of 55 John Wiley & Sons Journal of Comparative Neurology In preparation for the

injection, each monkey was tranquilized with ketamine hydrochloride (10mg/kg,

 

Radiofrequency Ablation (RFA)

 

[PDF] Comparison of amiodarone and propafenone for maintenance of stable sinus rhythm after bipolar radiofrequency ablation combined with a mitral valve procedure in …

Y Beşir, O Gökalp, U Yetkin, E Çelik, H İner, B Lafçı… – Türk Göğüs Kalp Damar …, 2015

ABSTRACT Background: This study aims to examine the effects of amiodarone versus

propafenone for maintenance of stable sinus rhythm after left atrial bipolar radiofrequency

ablation combined with a mitral valve procedure in patients with mitral valve disease and

 

New Technologies and Approaches to Endoscopic Control of Gastrointestinal Bleeding

LL Fujii-Lau, LMWK Song, MJ Levy – Gastrointestinal Endoscopy Clinics of North …, 2015

Radiofrequency Ablation. Technique. Focal radiofrequency ablation (RFA) catheters

(Barrx; Covidien, Mansfield, MA) have been used to treat GI bleeding in the setting of

gastric antral vascular ectasia (GAVE) (Fig. 3) and radiation proctitis.

 

Dichorionic triplet pregnancies: risk of miscarriage and severe preterm delivery with fetal reduction versus expectant management. Outcomes of a cohort study and …

M Morlando, L Ferrara, F D’Antonio, A Lawin‐O’Brien… – BJOG: An International …, 2015

Ultrasound-guided laser ablation or radiofrequency ablation of the pelvic vessels of one

of the monochorionic fetuses was used in all cases of reduction from three to two fetuses

for selective reduction of one of the two monochorionic fetuses.

 

Interventional MR elastography for MRI‐guided percutaneous procedures

N Corbin, J Vappou, E Breton, Q Boehler, L Barbé… – Magnetic Resonance in …, 2015

[27] showed that the Young’s modulus of the treated liver tumor in swine increases from 6 to 40

kPa approximately during a 5 min-long radiofrequency ablation by providing elastographic

information every 30 s. The monitoring of thermal ablations with MRE is limited by the

 

[HTML] Editorials & Opinions

JP Tasto – Am J Orthop, 2015

Published December 2014. Accessed March 6, 2015. « Back To: Editorials & Opinions. Did

you miss this content? Cutaneous Burn Caused by Radiofrequency Ablation Probe During

Shoulder Arthroscopy. More From The American Journal of Orthopedics

 

Hysteroscopy and heavy menstrual bleeding (to cover TCRE and second generation endometrial ablation)

M Bongers – Best Practice & Research Clinical Obstetrics & …, 2015

cryo-ablation (HerOption™, Cooper Surgical, Trumbull, CT) [14], and bipolar radiofrequency

(Novasure™, Hologic The difference between the first and the second-generation endometrial

ablation are several. Under direct vision the total endometrium can be resected or ablated.

 

Atrioesophageal fistula and pneumocephalus after pulmonary vein isolation

BD Wilson, JH Morshedzadeh – European Heart Journal-Cardiovascular Imaging, 2015

Catheter radiofrequency ablation of atrial fibrillation is an increasingly common procedure,

and atrioesophageal fistula is a rare and often fatal complication. High clinical suspicion,

rapid diagnosis, and surgical therapy may prevent death.

 

Gastroparesis as a Complication of Atrial Fibrillation Ablation

T Aksu, S Golcuk, TE Guler, K Yalin, I Erden – The American Journal of Cardiology, 2015

ventricular ejection fraction, M=male; N=normal; PIN=patient identification number; R=

radiofrequency. more reasonable avoiding cryo-energy at lower temperatures while ablating

inferior PVs The most possible mechanism of gastroparesis related with AF ablation is collateral

 

The impact of left atrial surface area and the second generation cryoballoon on clinical outcome of atrial fibrillation cryoablation

H Greiss, A Berkowitsch, M Wojcik, S Zaltsberg… – Pacing and Clinical …, 2015

16 Impact of LA area on outcome In our previous studies performed on patients ablated with CB,

we found NLA area to be predictive for outcome, but absolute LA area was not predictive. Raviele

A, Themistoclakis S, Rossillo A, Bonso A, Natale A. Radiofrequency ablation

 

Persistence of Phrenic Nerve Palsy Following 28 mm Cryoballoon Ablation: A Four Year Single Center Experience

Y Saitoh, G Irfan, G Ciconte, G Mugnai, J Sieira… – Pacing and Clinical …, 2015

Great attention must be paid when ablating with the large 28 mm CB2 due to the large cryoballoon

for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and

non-randomised comparison with pulmonary venous isolation by radiofrequency ablation.

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

Hydromorphone for neuropathic pain in adults

D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015

Types of participants Studies will include adults aged 18 years and above with one or more chronic

neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central

neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human

 

Fentanyl for neuropathic pain in adults

S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015

Types of participants Studies will include adults aged 18 years and above with one or more chronic

neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central

neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human

 

The role of glia in the spinal cord in neuropathic and inflammatory pain

EA Old, AK Clark, M Malcangio – Pain Control, 2015

microglia pool. Nat Neurosci 14: pp. 1142-1149; Alexander, GM, Rijn, MA, Hilten,

JJ, Perreault, MJ, Schwartzman, RJ (2005) Changes in cerebrospinal fluid levels

of pro-inflammatory cytokines in CRPS. Pain 116: pp. 213-219;

 

[HTML] To study the incidence and risk factors of early onset neonatal sepsis in an out born neonatal intensive care unit of India

M Jajoo, K Kapoor, LK Garg, V Manchanda, SK Mittal – Journal of Clinical …, 2015

[6] Screening tests such as total and differential leukocyte counts, band cells, absolute neutrophil

counts (ANCs), and rapid immunological techniques like C-reactive proteins (CRPs) assays may

help in the diagnosis of septicemia; however, they lack the capacity to detect

 

[PDF] Psychological Aspects of Reflex Sympathetic Dystrophy (RSD) Complex Regional Pain Syndrome (CRPS)

H Hooshmand, EM Phillips, FL Vero Beach

Abstract. Reflex sympathetic dystrophy (RSD) or complex regional pain syndrome (CRPS) is

a complex form of neuropathic pain associated with hyperpathia; neurovascular instability;

neuroinflammation; and limbic system dysfunction. As the condition becomes chronic, the

 

[PDF] COMPLEX REGIONAL PAIN SYNDROME (CRPS) REFLEX SYMPATHETIC DYSTROPHY (RSD) DIAGNOSIS AND MANAGEMENT PROTOCOL

H Hooshmand, EM Phillips, FL Vero Beach

Complex Regional Pain Syndrome (CRPS)/Reflex Sympathetic Dystrophy (RSD) is a

disease that usually starts after a relatively minor trauma. In the early stages there is a

sympathetic component in the development of the disease, but with passage of time, quite

 

[PDF] Complex Regional Pain Syndrome (CRPS) and Sympathectomy

H Hooshmand, EM Phillips

Abstract. Sympathectomy may provide temporary pain relief, but after a few weeks to months

it loses its effect. Sympathectomy and the application of Chemical Sympathectomy

(neurolytic agents eg, phenol, alcohol, etc.) should be limited to patients with life

 

[PDF] REPETITIVE STRAIN INJURY (RSI) DIAGNOSIS AND TREATMENT

H Hooshmand, EM Phillips, FL Vero Beach

Careful history taking, neurological evaluation, along with such tests as quantitative

sensory testing (QST) and infrared thermal imaging (ITI) is helpful to differentiate RSI

from other causes of complex regional pain syndrome (CRPS).

 

Polysomnographic Characteristics in Nonmalignant Chronic Pain Populations: A Review of Controlled Studies

MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015

Glossary of terms. AHI apnea/hypopnea index. ArI arousal index. BDNF brain-derived neurotrophic

factor. CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic

widespread pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls.

 

Fibromyalgia

 

Validation and cross-cultural adaptation of the ‘Fibromyalgia Participation Questionnaire’to the Spanish population: study protocol

M Gomez-Calvente, I Medina-Porqueres… – Rheumatology International, 2015

Abstract There are few high-quality instruments to evaluate the participation and social

functioning of fibromyalgia patients. The Fibromyalgia Participation Questionnaire (FPQ) is a

questionnaire that evaluates these aspects with high reliability and validity in its German

 

What Constitutes Appropriate Treatment of Post-Lyme Disease Symptoms and Other Pain and Fatigue Syndromes?

AC Steere, SL Arvikar – Clinical Infectious Diseases, 2015

This chronic syndrome, which sometimes meets criteria for fibromyalgia or chronic fatigue

syndrome, is not specific for Lyme disease [8]. Such symptoms may follow other infections or

physical or emotional trauma, or the inciting cause may not be apparent.

 

Central sensitization in humans: assessment and pharmacology

L Arendt-Nielsen – Pain Control, 2015

J Pain 4: pp. 372-380; Balasubramaniam, R, Leeuw, R, Zhu, H, Nickerson, RB, Okeson, JP,

Carlson, CR (2007) Prevalence of temporomandibular disorders in fibromyalgia and failed

back syndrome patients: a blinded prospective comparison study.

 

Chronic pain and the adaptive significance of positive emotions.

AD Ong, AJ Zautra, MC Reid – 2015

Indeed, such in- terventions may prove to be particularly important for patients with specific chronic

pain conditions, such as fibromyalgia, who show a core affective disturbance that is characterized

by an overall deficit in posi- tive emotion (Finan, Zautra, & Davis, 2009).

 

Chronic widespread pain: clinical comorbidities and psychological correlates Running title: Genetics of CWP

A Burri, S Ogata, J Vehof, FMK Williams, B Box – 2015

3 1. Introduction Chronic widespread pain (CWP) is the cardinal symptom of fibromyalgia. four

items pertaining to the “pain subscale” were drawn from the London Fibromyalgia Epidemiology

Symptom Screening questionnaire (LFESSQ).[34] The four items ask about pain

 

Hydromorphone for neuropathic pain in adults

D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015

Pharmacological treatment of fibromyalgia. Journal of Pain 2008;9(2): 105–21. [DOI:

10.1016/j.jpain.2007.09.005] Gaskell 2014 Gaskell H, Moore RA, Derry, S, Stannard

C. Oxycodone for neuropathic pain and fibromyalgia in adults.

 

Tarasoff’s catch-22.

SR Huey – 2015

REFERENCES Davis, MC, & Zautra, AJ (2013). An online mindfulness intervention targeting

socioemo- tional regulation in fibromyalgia: Results of a randomized controlled trial. Daily affect

relations in fibromyalgia patients reveal positive affective disturbance.

 

Fentanyl for neuropathic pain in adults

S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015

Pharmacological treatment of fibromyalgia. Durogesic® DTrans. www.medicines.org.uk/EMC/

medicine/17088/ (accessed 16 December 2014). Gaskell 2014 Gaskell H, Moore RA, Derry, S,

Stannard C. Oxycodone for neuropathic pain and fibromyalgia in adults.

 

Polysomnographic Characteristics in Nonmalignant Chronic Pain Populations: A Review of Controlled Studies

MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015

CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic widespread

pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls. IL interleukin. MFP

myofascial pain. NREM non-rapid-eye-movement. NSM non-sleep migraine. OA

 

Methods to Measure Peripheral and Central Pain Sensitization Using Quantitative Sensory Testing: A Focus on Individuals with Low Back Pain

AR Starkweather, A Heineman, S Storey, G Rubia… – Applied Nursing Research, 2015

In order to evaluate and compare centralized mechanisms, the QST protocol of the German

Research Network on Neuropathic Pain was used in a group of 21 patient with fibromyalgia

(mean duration 13.4 years), 23 individuals with chronic back pain (mean duration 15.9 years

Clinical study shows safety and efficacy of ketamine in pediatric patients with chronic pain

Clinical study shows safety and efficacy of ketamine in pediatric patients with chronic pain

Ketamine has long been used as an anesthetic in both adults and children for more than 50 years.  Although it is still used for anesthesia and also off-label for the treatment of many pain and psychiatric disorders, concerns of possibly deleterious neurocognitive effects have lingered.  This is due to sparse reports of children that have experienced neurocognitive delays following multiple surgeries using a ketamine and other anesthetics.  Since these occurrences were not associated with any primary endpoints in a clinical study setting, the cognitive delays could not be attributed to ketamine but it did raise the question.

A recent clinical study was conducted by researchers at the University of Rochester (Rochester, New York) and published in the Journal of Palliative Care & Medicine.  These investigators designed a clinical trial to monitor neurocognitive function and pain levels in pediatric patients with chronic pain.  Patients enrolled in the trial completed 2 weeks of daily oral ketamine exposure.  Neurocognitive assessments were conducted at baseline and at weeks 2 and 14.  Further, pain levels were assessed using the Numerical Rating Scale.

The researchers found no deleterious effects on neurocognitive function in the children at any time point during the study or for 3 months following completion of the study.  In fact, they found that executive function scores improved in children following oral administration of ketamine.  These findings support the safe use of ketamine in pediatric patients with chronic pain that is refractory to more conventional medications, such as opioid medicines.

Dr. Hanna’s clinical team at the Florida Spine Institute has used intravenous ketamine therapy to treat pediatric cases of chronic regional pain syndrome with great success.  To learn more about intravenous ketamine infusions, click here.  To find out if ketamine therapy is right for you, please make an appointment by contacting Dr. Hanna.

For full article, visit the Journal of Palliative Care & Medicine.

Citation: Bredlau AL, Harel BT, McDermott MP, Dworkin RH, Korones DN, et al. (2015) Neurocognitive Changes after Sustained Ketamine Administration in Children with Chronic Pain. J Palliat Care Med 5: 215. doi:10.4172/2165-7386.1000215

Helpful steps for Migraine Relief

Helpful steps for Migraine Relief

Simple lifestyle changes and natural approaches can often make a difference when you’re seeking migraine relief. Here are 8 self-care techniques that may help…

What do you do once you feel the throbbing pain and other symptoms that accompany migraine headaches?

Whether you run for a dark room or to the medicine cabinet, you might consider one more approach: self-care therapies. They can ease pain and reduce the frequency of migraine attacks.

Migraines are vascular headaches, meaning they’re triggered by the temporary narrowing of blood vessels in your head. This reduces the flow of blood-transporting oxygen to your brain, producing many unpleasant symptoms. They can include severe pain, light and noise sensitivity, auras, nausea and vomiting. Often, the pain is felt on just one side of the head, according to the National Institute of Neurological Diseases and Stroke (NINDS).

Many migraine patients use self-care techniques along with medication to relieve migraine symptoms. In fact, about half of patients reported using at least one non-pharmaceutical therapy to self-treat their migraines, according to a 2013 study published in Headache: The Journal of Head and Face Pain.

Here are 8 self-care techniques that experts say may help.

1. Keep a migraine diary.
You might think that migraines are unpredictable. But 70% of migraine sufferers experience early warning symptoms that may be identified with a headache diary, according to a 2009 Georgia State University study.

“Keep a really good diary or journal,” advises Sheena Aurora, M.D., clinical professor of Neurology and Neurological Sciences at the Stanford University School of Medicine in California.

“This is where you can log your medication use, how often you’re having headaches, your diet and any other triggers or patterns that you see,” she says.

Share this information with your doctor at each appointment.

2. Work out regularly.
Moderate exercise may reduce frequency, intensity and length of migraine attacks, according to a 2011 study in Cephalalgia, a peer-reviewed medical journal.

“Take a walk in a casual, yoga-like fashion for 30 minutes a day – or even a 15-minute outdoor walk on your lunch break – to [give] your body the benefits of modest exercise and your brain space and relief,” suggests Richard P. Kraig, M.D., Ph.D., director of the migraine headache clinic at the University of Chicago Medicine.

This process will help release stress, improve concentration and reduce excitability or tension, Dr. Kraig says.

“We’ve found that exercise, plus environmental enrichment [spending time in pleasant or interesting surroundings], makes the brain stronger against migraines,” he says.


3. Snuggle up with your partner.
Many people avoid sexual activity during migraine attacks. But engaging in it may actually lead to partial or complete relief, German researchers found in 2013.

That’s because physical intimacy produces a rush of feel-good hormones called endorphins, your body’s own natural painkillers.

“Although the science on this is limited, it’s intriguing that it might work for some individuals,” Dr. Aurora says. “I’ve actually heard about this approach being used by patients.”

4. Consider supplements.
Migraines are sometimes caused by vitamin or mineral deficiencies or imbalances, and many patients who take riboflavin or magnesium supplements find relief with minimal side effects, according to a 2012 study published in the journal Biological Trace Elements Research.

Ask your doctor before taking any supplements.

Taking 50 mg of riboflavin daily is enough to treat mild migraines; 500 mg of magnesium has been shown to reduce migraine frequency and severity, Dr. Aurora says.

“I tell those with regular migraines to start taking a supplement and keep a log to see if certain symptoms subside,” she adds.

5. Clean up your sleep act.
If you often wake up with a headache, this is a sign that your sleep patterns may be the culprit.

In fact, the onset of nearly half of all migraines occurs between 4 and 9 a.m., according to the American Headache Society Committee on Headache Education, a nonprofit educational resource for health professionals.

Being sleep deprived, over-sleeping or suffering from sleep disturbances, such as obstructive sleep apnea or restless leg syndrome, may trigger a migraine, according to the American Migraine Foundation.

In turn, headache sufferers are also at higher risk of developing a sleep disorder.

Establish regular sleep hours to lower your chances of experiencing sleep-related migraines.

“Stability with sleep is crucial with migraines,” says Dr. Aurora. “Going to bed and getting up at the same time each day is generally more important than the total number of hours you’re sleeping at night.”

6. Practice mindfulness meditation or yoga.
One of the biggest migraine triggers is stress, but it’s often the hardest one to manage. Luckily, a variety of stress-reduction techniques can help.

Adults found relief from migraine symptoms when they participated in 8 weeks of a mindfulness-based stress reduction program, according to a 2014 study conducted at Wake Forest Baptist Medical Center in Winston-Salem, N.C. After using meditation and yoga principles, subjects reported fewer migraine attacks, less pain, reduced stress, anxiety and disability, and a better quality of life.

People with migraines “are often anxious people,” Dr. Kraig says. “Since migraines and anxiety are [associated medical conditions], finding a way to relax, like yoga, will help calm the winding up of the string of stressors that can trigger migraine attacks.”

7. Get a massage.
Massage can be an effective complementary therapy for treating migraines, especially those brought on by stress or sleep issues.

“Massage works mostly as a de-stressor,” explains Dr. Aurora. “As women get older, we hold more pressure in our necks, and that seems to be a hot-spot trigger for migraines.”

The neck-brain stem connection stores tension and pressure that can be released with physical manipulation from a massage.

You don’t need a daily massage, but the healing touch might be just enough to keep symptoms at bay when you feel the warning signs of a migraine attack. Just make sure you choose a licensed massage therapist.

8. Learn biofeedback.
Biofeedback, a pain management intervention, may work to lessen the stress and muscle tension that can trigger migraine, according to a 2010 study reported in Cleveland Clinic Journal of Medicine.

Although there are home programs available, biofeedback is traditionally done with a psychologist who uses a computer monitor device that illustrates what happens when your brain responds to stress. The aim is to help patients learn to control specific body functions, including breathing rate, muscle tension and heart rate.

“It’s very valuable to learn biofeedback and muscle relaxation with a practitioner first and be taught the techniques properly,” says Dr. Aurora. “Then, they can be effective self-care tools that you may use on your own.”

Leg Cramps: Causes and What to Do

Leg Cramps: Causes and What to Do

Leg Cramps: Causes and What to Do

There is nothing quite like having leg cramps. I can be sleeping soundly one minute and be wide awake and writhing in pain the next. It feels like someone has tied barbed wire around my calf muscle and then put a wrench on both ends. But what are some possible causes?

There have been times when it’s easy to assume my leg cramps simply come from too much exercise. Roughly 10 years ago, I was an avid gym patron. Each morning, I got up at 5 a.m. and headed out. I had a pretty stringent routine.

First, I did my cardio exercises. I ran between 3.1 and 5 miles on the treadmill every morning. I started out at a modest 8 miles per hour, but as I went along, I increased my speed. By the end of my run, I was at a sprint.

Then I did strength training on both the weight machines and free weights. One morning, I would work on my upper body. On the following day, I would work on everything from the waist down.

One day, I noticed a growing pain in my hip. Before long, it was pretty clear to me I had injured a flexor muscle due to overuse. But at night ? when I had cramps in the back of my calf, too ? I assumed it also was due to my exercise routine.

I stopped using the treadmill for a while and used the ellipticals instead. This helped my hip to heal. However, I still continued to get leg cramps off and on.

In my experience, muscle injury due to overuse can certainly cause leg cramps. But one should not just assume that’s what it is.

The Mayo Clinic says that during periods of heavier exercise than normal you can become dehydrated, which can cause leg cramps as well. Simply replenishing your body’s water supply can alleviate leg cramps that result from dehydration.

But dehydration also can result from inadequate fluid intake even during normal daily activity.

Other Leg Cramps Causes

I’ve mentioned a few leg cramps causes. These were the causes I originally knew about. But there are many more.

According to the Mayo Clinic the depletion of calcium in your body is one of them. But Mayo also states that too little potassium and magnesium can play a role in leg cramps as well. And the depletion of these minerals in the body can be caused by several factors.

For example, the Mayo Clinic says people who take diuretics and blood pressure medications may find their levels of calcium, potassium and magnesium are still not up to par. These medications have a tendency to deplete mineral levels, in spite of efforts to eat foods rich in these minerals.

Leg cramps causes can come from much more serious issues as well. Harvard Medical School says about 30,000 people in America currently suffer with amyotrophic lateral sclerosis (otherwise known as ALS, or Lou Gehrig’s disease). About 5,600 people are newly diagnosed every year. Muscle cramps in the legs can be one of the symptoms.

The National Institute of Neurological Disorders and Stroke states that muscle pain, stiffness and cramping in the legs and toes are also symptoms of Parkinson’s disease.

Studies through the National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) show that leg cramps can be the beginning signs of serious kidney malfunction. When kidneys don’t function properly, wastes aren’t being filtered from the blood in a sufficient manner. The resulting condition is called uremia.

Sometimes leg cramps causes are simply unknown. Although my leg cramps are terribly painful, at least they don’t happen on a frequent basis.

I’ve never consulted a doctor about my own leg cramps. So far, the ones I’ve experienced seem to be of this variety: infrequent, with no other symptoms that accompany them.

But if leg cramps should become frequent and persistent, you should not hesitate to see your doctor. There may be a serious underlying cause.

Remedies for Leg Cramps

There are many remedies for alleviating leg cramps causes, but you should do your homework and choose wisely.

One of the most common remedies doctors used to treat leg cramps was quinine, a chemical with medical uses. However, according to Johns Hopkins Health Alerts, quinine can have some serious side effects. It should only be used for its primary purpose: to treat malaria.

Johns Hopkins says that doctors are exploring the use of muscle relaxers, numbing agents and calcium channel blockers as other treatments for leg cramps causes. Johns Hopkins also says diazepam and naftidrofuryl (an antiseizure medication) may be effective, but patients are encouraged to try B-complex vitamins.

As I said earlier, I don’t know what causes my leg cramps. I haven’t consulted a doctor because they happen so rarely. So far, I have found relief with some very simple methods.

Most of my leg cramps tend to happen at night. Simply getting out of bed and walking around for a minute or two has made them go away.

I’ve also used eucalyptus-based salves or rubs. Between the massaging motion and the warmth that radiates to my muscle, the pain usually subsides within a few minutes.

But if my pain still persists, I find relief by applying a heating pad. However, other people I’ve talked to have preferred to use ice packs to soothe their leg cramps.

Some athletes I know swear by stretching exercises. One exercise I hear about often is placing your hands on each side of your foot with your fingers cupping the bottom right around the ball joint, just below the toes. Pull the foot gently toward the shin.

The Mayo Clinic suggests doing light activity for five to 10 minutes before stretching. For calf muscles, you can also try the downward dog pose exercise.

Keep yourself hydrated. Again, be sure to see your doctor if leg cramps become frequent and persistent or if you have any other concerns about their causes.

Source: Lifescripts

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