Researchers have discovered the recipe for painlessness

Researchers have discovered the recipe for painlessness

People born with a rare genetic mutation are unable to feel pain, but previous attempts to recreate this effect with drugs have had surprisingly little success. Using mice modified to carry the same mutation, UCL researchers funded by the MRC and Wellcome Trust have now discovered the recipe for painlessness.

‘Channels’ that allow messages to pass along nerve cell membranes are vital for electrical signalling in the nervous system. In 2006, it was shown that sodium channel Nav1.7 is particularly important for signalling in pain pathways and people born with non-functioning Nav1.7 do not feel pain. Drugs that block Nav1.7 have since been developed but they had disappointingly weak effects.

The new study, published in Nature Communications, reveals that mice and people who lack Nav1.7 also produce higher than normal levels of natural opioid peptides.

To examine if opioids were important for painlessness, the researchers gave naloxone, an opioid blocker, to mice lacking Nav1.7 and found that they became able to feel pain. They then gave naloxone to a 39-year-old woman with the rare mutation and she felt pain for the first time in her life.

“After a decade of rather disappointing drug trials, we now have confirmation that Nav1.7 really is a key element in human pain,” says senior author Professor John Wood (UCL Medicine). “The secret ingredient turned out to be good old-fashioned opioid peptides, and we have now filed a patent for combining low dose opioids with Nav1.7 blockers. This should replicate the painlessness experienced by people with rare mutations, and we have already successfully tested this approach in unmodified mice.”

Broad-spectrum sodium channel blockers are used as local anaesthetics, but they are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. By contrast, people born without working Nav1.7 still feel non-painful touch normally and the only known side-effect is the inability to smell.

Opioid painkillers such as morphine are highly effective at reducing pain, but long-term use can lead to dependence and tolerance. As the body becomes used to the drug it becomes less effective so higher doses are needed for the same effect, side effects become more severe, and eventually it stops working altogether.

“Used in combination with Nav1.7 blockers, the dose of opioid needed to prevent pain is very low,” explains Professor Wood. “People with non-functioning Nav1.7 produce low levels of opioids throughout their lives without developing tolerance or experiencing unpleasant side-effects. We hope to see our approach tested in human trials by 2017 and we can then start looking into drug combinations to help the millions of chronic pain patients around the world.”

The findings were made possible by the use of ‘transgenic’ mice, meaning they were modified to carry genetic material from another organism — in this case, the mutation that prevents humans from feeling pain. Precise physiological experiments showed that the nervous systems of the transgenic mice contained around twice the levels of naturally-produced opioids as unmodified mice from the same litter.

“Our results reaffirm the clinical relevance of transgenic mouse models for human diseases,” says Professor Wood. “Studying the mice showed us what was going on in the nervous system that led to painlessness and our findings were directly translatable to humans, as confirmed by the painless patient. Without the work in transgenic mice, none of this would have been possible and we still wouldn’t know how to replicate the effects to help people suffering from chronic pain.”


Story Source:

University College London. “Genetically modified mice reveal the secret to a painless life: Researchers have discovered the pharmaceutical recipe for painlessness.” ScienceDaily. ScienceDaily, 4 December 2015. <www.sciencedaily.com/releases/2015/12/151204090034.htm>


Journal Reference:

  1. Michael S. Minett, Vanessa Pereira, Shafaq Sikandar, Ayako Matsuyama, Stéphane Lolignier, Alexandros H. Kanellopoulos, Flavia Mancini, Gian D. Iannetti, Yury D. Bogdanov, Sonia Santana-Varela, Queensta Millet, Giorgios Baskozos, Raymond MacAllister, James J. Cox, Jing Zhao, John N. Wood. Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7Nature Communications, 2015; 6: 8967 DOI: 10.1038/ncomms9967

 

Worldwide Research Updates for Week of 8/13/2015

Worldwide Research Updates for Week of 8/13/2015

Weekly Breaking Research Updates

 

Scientific breakthroughs happen every day!  In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates.  The title of each article below is a link to the full study report.  If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.

 

Ketamine

 

[HTML] Which Sedation is more Appropriate during Spinal Anesthesia: Propofol or Ketamine-Propofol Combination

H Güleç, ZB Tutal, M Şahap, M Babayiğit, H İnceöz… – Anaesth Pain & Intensive …, 2015

ABSTRACT Background and objective: Spinal anesthesia is a preferred method in daily

practice as it provides muscle relaxation and maintains spontaneous respiration during

surgical procedures. Opiods, midazolam, ketamine, propofol and dexmedetomidine are

 

[PDF] Evaluation of Use of Ketamine Hydrochloride for Induction of Anaesthesia in Rabbits with Experimentally Induced Unilateral Ureteral Obstruction

RI Udegbunam, KC Ogbanya, SO Udegbunam… – 2015

ABSTRACT This study investigated the anaesthetic characteristics of ketamine

hydrochloride in rabbits with Unilateral Ureteral Obstruction (UUO). Two groups of rabbits (B

and C) were anaesthetized with 30 mg kgG1 ketamine intravenously (IV) on days 7 and

 

Case 62: What Are the Safety Data for This Formulation?

JG Brock-Utne – Clinical Research, 2015

Discussion We were faced with this problem when we wanted to use ketamine intrathecally.

References 1. Brock-Utne JG, Mankowitz E, Kallichurum S, Downing JW. Effects of intrathecal

saline and ketamine with or without preservatives on the spinal nerve roots of monkeys.

 

[HTML] Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology

W Tong, M Maira, M Gagnon, HU Saragovi – PLOS ONE, 2015

For pharmacological inhibition, the Src kinase inhibitor PP2 (20 μM) (Enzo Life Science),

NMDA-R antagonist ketamine (Bioniche Animal Health) (20 μM) or the PKA inhibitor H-89 (Sigma)

(20 ng/ml) were added to the resting cells 30 minutes before the indicated treatments.

 

[PDF] Development of Certified Reference Materials of Drug Abuse (Heroin, Etc) for Elimination of Measurement Error in Forensic Drugs

F Su, X Dai, H Li – Pharm Anal Acta, 2015

For the first time, we developed 9 illicit drug CRMs, including methamphetamine, heroin,

ketamine and others. CRMs Column Mobile phase Acetonitrile:water Flow Rate (mL/min)

Injection volume(uL) DAD (nm) Ketamine hydrochloride a 40:60* 1.5 20 210

 

[HTML] AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates

M Jeyanathan, Z Shao, X Yu, R Harkness, R Jiang, J Li… – PLOS ONE, 2015

Animals were euthanized first by anesthesia with ketamine (im 10 mg/kg) and then by a lethal

dose injection of sodium pentobarbital (iv 100 mg/kg). Experimental animals and handling.

Animals were anesthetized with ketamine (10 mg/kg) before handling.

 

The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction.

ME Chua, J Mendoza, IV See, E Esmena, D Aguila… – Canadian Urological …, 2015

Under sedation with isoflurane inhalation, all rats were subsequently anesthetized with

intraperitoneal (IP) ketamine (100 mg/kg) plus xylazine (15 mg/kg) after being preopera- tively

hydrated by subcutaneous injection of 5 cc saline mixed with indigo carmine (5,5

 

P-193TRACHEAL RESECTION WITH PATIENT UNDER LOCAL ANAESTHESIA AND SEDATION

FP Caronia, D Loizzi, A Fiorelli – Interactive CardioVascular and Thoracic Surgery, 2015

During the procedure the patient remained awake in conscious sedation achieved by bolus

of ketamine and midazolam. During the entire procedure the patient remained awake in

conscious sedation achieved by bolus of ketamine and midazolam.

 

[HTML] Neural Resolution of Formant Frequencies in the Primary Auditory Cortex of Rats

C Honey, J Schnupp – PLOS ONE, 2015

Anesthesia was induced by intraperitoneal injection of ketamine (Ketaset; Fort Dodge Animal

Health, Overland Park, Kansas, USA) and medetomidine (Domitor, Pfizer, Walton Oaks, Surrey,

UK), and maintained with intraperitoneal infusions of ketamine, medetomidine and

 

Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR

GS Masson, AR Nair, PPS Soares, LC Michelini… – American Journal of …, 2015

Analysis of Cardiovascular Parameters and Baroreflex Function 135 At the end of the protocols,

rats were anaesthetized (ketamine, 80 mg.kg−1 plus 136 calculated as BrS = –(P2×P3)/4. 152

After the physiologic measurements, animals were anesthetized (ketamine, 80 153

 

Combination of intravenous S-ketamine and oral tranylcypromine in treatment-resistant depression: A case report

L Bartova, SE Vogl, M Stamenkovic… – European …, 2015

Abstract Ketamine, a rapid-acting antidepressant and anti-suicidal agent, is thought to

increase brain monoamine levels by enhancing monoamine release or inhibiting

presynaptic monoamine-reuptake. Here we present two female inpatients suffering from

 

Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.

JW Wang, V Kivovich, L Gordon – Pediatric Emergency Care, 2015

Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain

subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,

leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical

 

Ketamine Abuse Syndrome

JW Wang, V Kivovich, L Gordon – 2015

Objectives: Ketamine is a recreational drug widely abused in East Asia and also in certain

subpopulations of the United States. Many US clinicians are unaware of abuse symptoms,

leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical

 

Ondasetron Is More Likely Than Ketamine to Cause Ventricular Tachycardia

P Marzuillo, I Rabach, E Barbi – Pediatric Emergency Care, 2015

We read with interest the article published in the October 2014 issue of Pediatric Emergency

Care entitled “Ventricular tachycardia after ketamine sedation for fracture reduction.” Stukus

et al 1 described a 10-year-old female patient who experienced asymptomatic ventricular

 

The development of paper microfluidic devices for presumptive drug detection.

G Musile, L Wang, J Bottoms, F Tagliaro, B McCord – Analytical Methods, 2015

different lanes. A different colorimetric reaction occurs within each lane, permitting

the multiplexed detection of a variety of different compounds, including cocaine,

opiates, ketamine, and various phenethyl amines. Furthermore

 

[PDF] GLP-1 increases pre-ovulatory LH source and the number of mature follicles, as well as synchronizing the onset of puberty in female rats

V Outeiriño-Iglesias, M Romaní-Pérez… – Endocrinology, 2015

bregma. Cannulation was performed under ketamine/xylazine anesthesia (50

mg/kg and 5 mg/kg, respectively) and the correct placement of the cannula was

confirmed by postmortem injection of trypan- blue 0.5% (Sigma, St.

 

[HTML] Bispectral index-guided induction of anesthesia by ketofol infusion provides the same cardiovascular stability like that of etomidate infusion

HF Soliman – Ain-Shams Journal of Anaesthesiology, 2015

Get Permissions. Abstract, Introduction Various techniques have been tried to maintain

cardiovascular stability with anesthesia induction. This study compares the cardiovascular effects

of propofol-ketamine mixture versus etomidate during the induction of anesthesia.

 

[PDF] Anti-osteoporotic activity of ethanol extract of Terminalia arjuna (Roxb.) Wight & Arn. on ovariectomized rats

A Trivedi, HR Katti, MH Shalavadi, A Ramkishan… – Indian Journal of Natural …, 2015

Estrogen and Ketamine obtained from Neon Laboratories Ltd. Mumbai, India. After seven days

of acclimation, the rats were ovariectomized or Sham operated and then anesthetized with

Ketamine HCL (50 mg/kg, ip); the ovaries were removed bilaterally.

 

[HTML] Long-Term Extensive Ectopic Hair Growth on the Spinal Cord of Mice from Transplanted Whisker Follicles

W Cao, L Li, S Mii, Y Amoh, F Liu, RM Hoffman – PloS one, 2015

Animals were anesthetized by intramuscular injection of a 0.02 ml solution of 20 mg/kg

ketamine, 15.2 mg/kg xylazine, and 0.48 mg/kg acepromazine maleate. Non-transgenic nude

mice were anesthetized with a ketamine mixture (described above).

 

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin

KA Wunderlich, N Tanimoto, A Grosche, E Zrenner… – The FASEB Journal, 2015

Mice were dark- adapted (DA) overnight before the experiments and anesthetized with a

subcutaneous injection of a mixture of ketamine, xylazine, and physiologic saline. Ketamine

and xylazine were given at 66.7 and 11.7 mg/kg body weight, respectively.

 

Radiofrequency Ablation (RFA)

 

[PDF] Electrophysiological Bases of Torsion and Suction in the Continuous Cardiac Band Model

J Trainini, B Elencwajg, N López-Cabanillas… – Anat Physiol, 2015

early diastolic filling by the suction effect. We investigated the electrophysiological

basis of this mechanism, by electroanatomical left ventricular endoepicardial mapping

(EEM) in five patients, during radiofrequency ablation.

 

Uninterrupted Apixaban Safe and Effective in AF Ablation

EH Nichols – MD Conference Express, 2015

Summary. According to a multicenter, prospective registry study, uninterrupted apixaban used

in the periprocedural setting of radiofrequency catheter ablation in patients with atrial fibrillation

does not increase the risk of bleeding compared with uninterrupted warfarin.

 

Lateral Femoral Cutaneous Nerve Block

P Tumber, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Pain Pract. 2011;11(3):302–8.PubMedView Article; 15. Fowler IM, Tucker AA, Mendez RJ.

Treatment of meralgia paresthetica with ultrasound-guided pulsed radiofrequency ablation of

the lateral femoral cutaneous nerve. Pain Pract. 2012;12(5):394–8.PubMedView Article.

 

Sacroiliac Joint

PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Am J Phys Med Rehabil. 2006;85:997–1006.PubMedView Article; 6. Roberts S, Burnham R,

Ravichandiran K, Agur A, Loh E. Cadaveric study of sacroiliac joint innervation: implications

for diagnostic blocks and radiofrequency ablation. Reg Anesth Pain Med.

 

Ilioinguinal, Iliohypogastric, and Genitofemoral Nerve Blocks

D Bugada, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

2014;2014:371703. doi:10. 1155/ 2014/ 371703.PubMed CentralPubMed; 47. Terkawi AS,

Romdhane K. Ultrasound-guided pulsed radiofrequency ablation of the genital branch of the

genitofemoral nerve for treatment of intractable orchalgia. Saudi J Anaesth.

 

[HTML] Neoplastic disease after liver transplantation: focus on de novo neoplasms

P Burra, KI Rodríguez-Castro – World J Gastroenterol, 2015

Prognosis seems dismal according to reported cases, despite tapering of

immunosuppression, transarterial chemoembolization, radiofrequency ablation, hepatic

resection, or retransplantation. Strategies for preventing this neoplasm

 

Pediatric Nuclear Medicine

PJ Koo, FD Grant – Nuclear Medicine and PET/CT Cases, 2015

 

European Heart Rhythm Society, EHRA EUROPACE-CARDIOSTIM2015

RP Giugliano, S Bansilal, MP Bonaca, M Cavender… – MD Conference Express, 2015

Two registry studies examined the use of non–vitamin K antagonist oral anticoagulant

use in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation

(RFA). The first determined that AF patients can safely

 

[HTML] Propensity Score Matching Analysis of Changes in Alpha-Fetoprotein Levels after Combined Radiotherapy and Transarterial Chemoembolization for Hepatocellular …

Y Jeong, SM Yoon, S Han, JH Shim, KM Kim, YS Lim… – PLOS ONE, 2015

Advertisement.

 

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

N Lee, D Yoo, D Ling, MH Cho, T Hyeon, J Cheon – Chemical Reviews, 2015

When a resonant radiofrequency is irradiated, the nucleus absorbs the energy and the

number of the spins with a higher-energy state increases. During the relaxation process,

the excited nuclei emit a weak radiofrequency that can be detected.

 

Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency

D Hyun, SK Cho, SW Shin, KB Park, HS Park… – CardioVascular and …, 2015

Purpose To report the results of combined therapy with transarterial chemoembolization

(TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC)

considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE

 

The procedure outcome of laparoscopic resection for’small’hepatocellular carcinoma is comparable to vlaparoscopic radiofrequency ablation

M Casaccia, G Santori, G Bottino, P Diviacco… – 2015

Background: The aim of this study was to compare the effectiveness of laparoscopic liver

resection (LLR) and laparoscopic radiofrequency ablation (LRFA) in the treatment of small

nodular hepatocellular carcinoma (HCC). Patients And Methods: We enrolled 50 cirrhotic

 

PTH-177 Radiofrequency ablation for complicated barrett’s oesophagus: experience of a tertiary centre in northern ireland at 5 years

P Hall, O Reed, I Mainie – Gut, 2015

Abstract Introduction The 2013 British Society of Gastroenterology (BSG) guideline supports

first line use of endoscopic therapy in patients with dysplastic Barrett’s oesophagus or

intramucosal carcinoma (IMC). 1 Endoscopic mucosal resection (EMR) and

 

Observations on Attenuation of Local Electrogram Amplitude and Circuit Impedance During Atrial Radiofrequency Ablation: An In vivo Investigation Using a Novel …

A Bhaskaran, W Chik, C Nalliah, J Pouliopoulos… – Journal of Cardiovascular …, 2015

Aims To define the temporal characteristics of atrial lesion growth (lesion surface area), local

electrogram amplitude attenuation and circuit impedance decrement during in vivo Radio

Frequency (RF) ablation with direct endocardial visualization (DEV).

 

[HTML] Intraductal Radiofrequency Ablation Followed by Locoregional Tumor Treatments for Treating Occluded Biliary Stents in Non-Resectable Malignant Biliary Obstruction …

XH Duan, YL Wang, XW Han, JZ Ren, TF Li, JH Zhang… – PloS one, 2015

Objectives To determine the safety and feasibility of intraductal radiofrequency ablation

(RFA) followed by locoregional tumor treatments in patients with non-resectable malignant

biliary obstruction and stent re-occlusion. Methods Fourteen patients with malignant biliary

 

Sorafenib combined with radiofrequency ablation in the treatment of a patient with renal cell carcinoma plus primary hepatocellular carcinoma

G Gang, Y Hongkai, Z Xu – 2015

The combination of renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) is

extremely rare, and the prognosis for patients with these two cancers is poor. In the past

decade, molecular targeted therapy and radiofrequency ablation (RFA) have emerged

 

RADIOFREQUENCY ABLATION FOR BENIGN THYROID NODULES-A LOOK TOWARDS THE FUTURE OF INTERVENTIONAL THYROIDOLOGY

MA Lupo – Endocrine Practice, 2015

Welcome to the new Endocrine Practice website. Click HERE to access your account and reset

your password if this is your first visit. The IP ranges for your institution have already been added

to your account. You may wish to review this information under the Institutional

 

[PDF] Clinical Effect of Percutaneous Radiofrequency Ablation for Residual Lung Metastases from Breast Cancer After Systemic Chemotherapy

Y Wang, X Lu, Y Wang, J Zhou – Journal of the College of Physicians and Surgeons …, 2015

Breast Cancer (BC) is the most common malignant tumor in women and it is the leading cause

of death in women.1 The earliest and most frequent site of BC metastasis is the lungs and

bones, and no more than 5 – 20% of cases have only liver metastases.2 Metastatic BC

 

Recanalization of obstructed metallic uncovered biliary stent using endobiliary radiofrequency ablation

N Musquer, E Ménager Tabourel, D Luet… – Gastrointestinal Endoscopy, 2015

We present the case of a 57-year-old woman with a history of hilar cholangiocarcinoma type

3A of the Bismuth classification. A right hepatectomy after right portal embolization was

planned. Finally, because peritoneal carcinomatosis was diagnosed during surgery, a

 

Ventricular premature depolarization ablation and reversal of nonischemic cardiomyopathy

RC Arroyo, S Maeda, BP Betensky, P Santangeli, D Lin… – Interventional Cardiology, 2015

4.4 cm. CM: Cardiomyopathy; LVDD: Left ventricular end-diastolic dimension; LVEF:

Left ventricular ejection fraction; RFA: Radiofrequency ablation; VPD: Ventricular

premature depolarization. Ventricular premature depolarization

 

Complex Regional Pain Syndrome (CRPS/RSD)

 

Lumbar Plexus and Femoral Nerve Block. Traditional and Ultrasound Guided Techniques

D Jankovic, J Kessler, AT Gray – Regional Nerve Blocks in Anesthesia and Pain …, 2015

5. Arterial occlusive disease and poor perfusion in the lower extremities. 6. Complex regional

pain syndrome (CRPS) types I and II. 7. Postamputation pain. 8. 3. Prophylaxis against complex

regional pain syndrome (CRPS). Contraindications. Specific. 1.

 

Superior Cervical Ganglion Block

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Therapeutic [ 3 ]. 1. Migraine [ 4 ], cluster headache, and headaches of cervical origin. 2. Complex

regional pain syndrome (CRPS) in the head region. 3. Perfusion disturbances and vasospastic

diseases. 4. Central poststroke syndrome (contralateral block!). 5. Facial pain. 6.

 

Brachial Plexus Blocks Above the Clavicle Traditional Techniques

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

10–20 mL local anesthetic – eg, 0.2–0.375 % ropivacaine or 0.25 % bupivacaine (0.25 %

levobupivacaine) in post-herpetic neuralgia, vascular diseases and injuries, complex

regional pain syndrome (CRPS) types I and II, post-amputation pain.

 

Stellate Ganglion Block

A Bhatia, PWH Peng – Regional Nerve Blocks in Anesthesia and Pain …, 2015

AACN Clin Issues. 2005;16:320–32.PubMedView Article; 25. Stanton-Hicks MD, Burton

AW, Bruehl SP, et al. An updated interdisciplinary clinical pathway for CRPS: report of

an expert panel. Pain Pract. 2002;2:1–16.PubMedView Article; 26.

 

[HTML] The efficacy of different doses of Midazolam added to Lidocaine for upper extremity Bier block on the sensory and motor block characteristics and postoperative pain

A Honarmand, M Safavi, K Nemati, P Oghab – Journal of Research in Pharmacy …, 2015

24. 25. Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): A

novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic

dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat.

 

Complications of Peripheral Nerve Blocks

D Xu, A Hadzic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post–ischemia pain (CPIP): a novel

animal model of complex regional pain syndrome–type I (CRPS–I; reflex sympathetic dystrophy)

produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain.

 

Functional neurological symptoms

A Carson, J Stone – Landmark Papers in Neurology, 2015

 

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www.ifssh.info volume 5 issue 3 aUgUSt 2015 WHAT Does THe PRACTiCe oF HAND

THeRAPy looK liKe iN iFsHT memBeR CouNTRies? CoNseRvATive

 

Preparation of polydimethylaminoethyl methacrylate grafted attapulgite via ceric ion‐induced redox polymerization

H Xu, H Yang, S Xue, J Pan, Q Ni, F Gong – Journal of Applied Polymer Science, 2015

interests.[10-12] Surface-initiated graft polymerizations of various monomers onto inorganic

nanoparticles have been reported by using UV-induced polymerization,[13] conventional radical

polymerizations,[14] and controlled/living radical polymerizations (CRPs).[15, 16] CRPs

 

Total Elbow Arthroplasty for Distal Humerus Fractures

LS Harmer, J Sanchez-Sotelo – Hand Clinics, 2015

Mansat et al, 31 2013, 87, 80:7, Age: >65 Isolated #, —, A: 9 B: 8 C: 70, CM: 85 Lat: 1 Discovery:

1, 37.5 (6–106) (100%), 86 (45–100), 29–125/—, Hematoma: 5 CRPS: 2 Skin necrosis: 1 Neuro

injury: 7 Deep infection: 1 Stem #: 1 Stem loosening: 2 Elbow stiffness: 2 Peripros #: 1

 

Sacral roots stimulation in chronic pelvic pain

P Sokal, P Zieliński, M Harat – Neurologia i Neurochirurgia Polska, 2015

is not recommended because of long-term moderate effects and increased risk of major

complications [2]. The CPP with predominance of neuropathic pain can be the part of

failed-back-surgery syndrome (FBSS) or complex regional pain syndrome (CRPS) which are

 

[PDF] Probabilistic temperature forecasting based on an ensemble AR modification

A Möller, J Groß – arXiv preprint arXiv:1508.01397, 2015

Gneiting et al. (2005) propose to estimate the parameters by optimizing the continuous ranked

probability score (CRPS, Wilks, 2011) over the training data. EMOS AR-EMOS SLP MAE 2.042

2.036 1.969 CRPS 1.471 1.460 1.407 DSS 3.135 2.908 2.821

 

The value of SPECT/CT in carpal boss

U Bhure, U Hug, MW Huellner, H Grünig, A Zander… – European Journal of …, 2015

One patient was lost to follow-up after infiltration of CB. One patient had a complete response

to surgery initially but developed a CRPS (complex regional pain syndrome) some weeks after

surgery. Infiltration with complete response; surgery performed; CRPS during follow-up. 5.

 

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

G Littlejohn – Nature Reviews Rheumatology, 2015

fibromyalgia. Clinical features of CRPS. Neurogenic inflammation—comprising tissue

swelling, vasomotor changes and marked allodynia—also contributes substantially to

the clinical features of CRPS. 91. Neuropeptides in CRPS. Increased

 

[HTML] Memristive crypto primitive for building highly secure physical unclonable functions

Y Gao, DC Ranasinghe, SF Al-Sarawi, O Kavehei… – Scientific Reports, 2015

Our novel architecture demonstrates desirable characteristics of PUFs, including uniqueness,

reliability, and large number of challenge-response pairs (CRPs) and desirable characteristics

of strong PUFs. Number of CRPs. Figure 10: Number of CRPs.

 

Methods for Treating GI Syndrome and Graft versus Host Disease

JA Rotolo, RN Kolesnick – US Patent 20,150,216,971, 2015

Ceramide generated on the surface of endothelium coalesces to form ceramide-rich

platforms (CRPs) that transmit an apoptotic signal (Stancevic B., Kolesnick R.

Ceramide-rich platforms in transmembrane signaling. FEBS Lett.

 

Multivariate postprocessing techniques for probabilistic hydrological forecasting

S Hemri, D Lisniak, B Klein – Water Resources Research, 2015

river Lahn as these values lead to the best climatological forecasts in terms of the contin- uous

ranked probability score (CRPS, see equation (4)). The smaller the catchment, the of the EMOS

model are estimated by minimization of the CRPS over the training pe- riod.

 

Ambiguous anti‐fouling surfaces: Facile synthesis by light‐mediated radical polymerization

CW Pester, JE Poelma, B Narupai, SN Patel, GM Su… – Journal of Polymer Science …, 2015

the prevention of marine biofouling.[7, 8]. Controlled radical, surface-initiated

polymerizations (SI-CRPs) provide a robust and versatile strategy for the formation

of grafted polymer brushes. A variety of techniques have been

 

Fibromyalgia

 

Off-Label Trazodone Prescription: Evidence, Benefits and Risks

L Bossini, A Coluccia, I Casolaro, J Benbow… – Current Pharmaceutical …, 2015

depression, insomnia, anxiety (then Gen- eralized Anxiety Disorder, Post-Traumatic Stress

Disorder, Obses- sive-Compulsive Disorder and Panic Disorder), off-label uses (then bulimia,

benzodiazepine abuse, alcohol withdrawal, fibromyalgia, dementia, schizophrenia and

 

[PDF] Purification of A1PI from Human Plasma-an Improved Process to Achieve Therapeutic Grade Purity

NA Kumar, KL Rao, Z Chakraborthy, A Giri, KU Devi – J Chromatogr Sep Tech, 2015

due to congenital A1PI deficiency but as evident from the available literature, due to the multiple

biological activities of A1PI, it has been associated with other lung diseases (cystic fibrosis) and

many non-pulmonary diseases like vasculitis, fibromyalgia, asthma, pancreatitis

 

[PDF] Clinical features of musculoskeletal disorders due to hand-held devices

D Sharan – Proceedings 19th Triennial Congress of the IEA, 2015

Associated Disorder n % Myofascial pain syndrome of neck and upper back 48 69

Thoracic outlet syndrome 34 49 Fibromyalgia syndrome 07 10 Hypothyroidism 02 2.9

Extensor wrist tendinosis 04 5.7 De Quervain’s tenosynovitis 02 2.9

 

[PDF] Outcome of treatment of work related musculoskeletal disorders in on-site clinics in information technology companies)

DSMMR Ranganathan – Proceedings 19th Triennial Congress of the IEA, 2015

Common diagnosis made were Myofascial Pain Syndrome (49.20%), Fibromyalgia (8.5%),

Thoracic Outlet Syndrome (25.02%), Cubital Tunnel Syndrome (0.16%), Chronic Regional

Pain Syndrome (0.20%), and Wrist Tendinities (3.70%).

 

COMPLEX PHYSIOTHERAPEUTIC PROGRAM FOR IMPACT ON INDIVIDUALS WITH CHRONIC PAIN IN THE BACK AND LOW BACK.

YV Pashkunova – Activities in Physical Education & Sport, 2015

mechanical back pain associated with the work done are charac teristic for men.

Polymyalgia rheumatic, fibromyalgia, osteoporosis and diseases of parathyroid glands

are characteristic for women (Borenstein, 1998). Generally

 

[HTML] Animal-Assisted Therapy for People with Chronic Pain

MOT Kristen Counts

In 2013, a follow-up study was done with fibromyalgia patients (3) . Fibromyalgia is a disorder

characterized by widespread muscle pain that is accompanied by fatigue, sleep, memory, and

mood issues. Of course, the exercise further decreased my fibromyalgia symptoms.

 

[PDF] The barrier of hidden disabilities

Ε Βαβουράκη, Γ Παναγιάρης, Κ Σφλώμος – 2015

hyperactivity disorder(AD/HD), asthma and allergies, bipolar disorder, psychiatric disorders,

depression, anxiety, cancer, cardiac or respiratory conditions, chronic fatigue syndrome, colour

blindness, cystic fibrosis, diabetes, epilepsy, seizure disorders, fibromyalgia, HIV/AIDS

 

Superior Cervical Ganglion Block

D Jankovic – Regional Nerve Blocks in Anesthesia and Pain …, 2015

number of patients. These observations principally concern patients with

pain-associated depression in chronic pain conditions (various types of headache,

migraines, facial pain, post-nucleotomy pain, fibromyalgia, etc.). In the

 

[HTML] Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot

S Wang, J Zhou, X Wei, P Li, K Li, O Wang, F Wei… – Rheumatology: Current …, 2015

Arthritis Res Ther 10: R117. Schmechel DE, Edwards CL (2012) Fibromyalgia, mood disorders,

and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology

33: 1454-1472. Goldring MB, Goldring SR (2007) Osteoarthritis.

 

[PDF] Examining the relationship between childhood victimization, health risk behaviors, and adult physical health outcomes among women on probation and parole.

TR Renn – 2015

Chartier, Walker & Naimark (2009) Female & Male Obesity OR=1.61 Rohde et al. (2008)

Female Adjusted for age and race Obesity OR=1.84 Alexander et al (1998) Fibromyalgia

Heitkemper et al (2001) Irritable bowel syndrome Rich-Edwards, et al.

 

Thalamic Mechanisms Underlying Alpha-Delta Sleep with Implications for Fibromyalgia

S Vijayan, EB Klerman, GK Adler, N Kopell – Journal of Neurophysiology, 2015

Abstract Alpha-delta sleep is the abnormal intrusion of alpha activity (8-13 Hz oscillations)

into the delta activity (1-4 Hz oscillations) that defines slow wave sleep. Alpha-delta sleep is

especially prevalent in fibromyalgia patients and there is evidence suggesting that the

 

SP0131 Fibromyalgia: What is New

LJ Crofford – Annals of the Rheumatic Diseases, 2015

Abstract Further clarification of the impact of FM classification criteria has emerged with a

higher prevalence and greater proportion of men identified with the modified 2010 criteria.

This together with ongoing epidemiologic studies has confirmed the relationships

 

Pelvic Floor and Urinary Distress in Women with Fibromyalgia

KD Jones, C Maxwell, SD Mist, V King, MA Denman… – Pain Management Nursing, 2015

Abstract Fibromyalgia (FM) patients were recently found to have more symptom burden from

bothersome pelvic pain syndromes that women seeking care for pelvic floor disease at a

urogynecology clinic. We sought to further characterize pelvic floor symptoms in a larger

 

[PDF] Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

DJ Engen, SJ McAllister, MO Whipple, SS Cha, LJ Dion… – J Integr Med, 2015

ABSTRACT BACKGROUND: Fibromyalgia is a syndrome characterized by chronic pain,

fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies

have reported decreased intracellular magnesium levels in patients with fibromyalgia and

 

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

G Littlejohn – Nature Reviews Rheumatology, 2015

Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical

phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in

each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both

 

Validation of fibromyalgia survey questionnaire and polysymptomatic distress scale in a Persian population

A Bidari, B Ghavidel-Parsa, AA Maafi, A Montazeri… – Rheumatology International, 2015

Abstract The aim of this study was to assess validity of the fibromyalgia survey questionnaire

(FSQ) and polysymptomatic distress scale (PSD) in an Iranian population. We also sought to

classify the severity levels of fibromyalgia (FM) symptoms according to the PSD scale.

 

Health anxiety and depression in patients with fibromyalgia syndrome

M Uçar, Ü Sarp, Ö Karaaslan, AI Gül, N Tanik, HO Arik – Journal of International …, 2015

Methods Patients with FMS and healthy control subjects were recruited. All participants

completed the Health Anxiety Inventory Short Form (HAI-SF) and Beck Depression Inventory

(BDI). Pain was assessed in patients with FMS using the Fibromyalgia Impact

 

Subgroups of fibromyalgia patients using the 1990 American College of Rheumatology criteria and the modified 2010 preliminary diagnostic criteria: the al-Ándalus …

V Segura-Jiménez, A Soriano-Maldonado… – Clinical and experimental …, 2015

OBJECTIVES: We aimed to investigate the symptom profiles in subsets of fibromyalgia

patients according to the subgroups created from the satisfaction of the 1990 American

College of Rheumatology (ACR) diagnostic criteria (1990c) and/or the modified 2010 ACR

 

Effects of music on pain in patients with fibromyalgia

GB Alparslan, B Babadağ, A Özkaraman, P Yıldız… – Clinical Rheumatology, 2015

Abstract Fibromyalgia syndrome (FMS) is a chronic syndrome characterized by diffuse

musculoskeletal system pain and painful tender points in certain areas of the body. The aim

of the investigation was to determine the effects of music on pain in fibromyalgia patients.

 

[HTML] Oral Burning With Dysphagia and Weight Loss

TM Seccia, G Rossitto, LA Calò, GP Rossi – Medicine, 2015

Accepted June 22, 2015. Collapse Box Abstract. Abstract: Fibromyalgia is a disorder characterized

by an abnormal pain regulation. We report on the case of a patient with fibromyalgia, who

presented with dysphagia, odynophagia, and glossodynia as prevalent symptoms.

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