Weekly Breaking Research Updates
Scientific breakthroughs happen every day! In an effort to help our patients stay up to speed on the most cutting edge treatment options available for them, our scientists monitor current research and publish weekly research updates (below).
If you’d like to make an appointment with Dr. Hanna to discuss your treatment options, please contact us.
Ketamine
S Castiglioni, A Borsotti, I Senta, E Zuccato – Environmental Science & Technology, 2015
Wastewater analysis was applied in a four-year monitoring study to assess temporal and
spatial patterns of ketamine and mephedrone use in the general population in Italy.
Composite raw wastewater samples were collected from sewage treatment plants (STPs) …
The use of ketamine as an antidepressant: a systematic review and meta‐analysis
CM Coyle, KR Laws – Human Psychopharmacology: Clinical and …, 2015
Objective The current meta-analysis examines the effects of ketamine infusion on
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder
(BD). Methods Following a systematic review of the literature, data were extracted from 21 …
E Kiureghian, JM Kowalski – The American Journal of Emergency Medicine, 2015
Background Despite advances in outpatient treatment and an improved understanding of
the pathophysiology, asthma continues to be a significant source of morbidity and mortality
in the United States. While there is certainly a component of chronic inflammation, the …
M Haliloglu, M Ozdemir, N Uzture, PO Cenksoy… – The Journal of Maternal- …, 2015
Abstract Objective: In this study, the effect of perioperative uses of low dose ketamine on
post-operative wound pain and analgesic consumption in patients undergoing elective
Cesarean section was evaluated. Methods: In randomized, double blind clinical trial, 52 …
C Monsereenusorn, P Rujkijyanont, C Traivaree – JOURNAL OF THE MEDICAL …, 2015
Material and Method: A randomized, double-blinded, crossover trial was conducted with 55 children
undergoing painful procedures (intrathecal chemotherapy and/or bone marrow
aspiration/biopsy). Patients were randomly assigned in a double-blinded fashion to …
Dexmedetomidine, Ketamine, and Midazolam for Oral Rehabilitation: A Case Report
BWS Kim, RM Peskin – Anesthesia Progress, 2015
Abstract Intravenous sedation is frequently provided by anesthesiologists for phobic patients
undergoing elective dental treatment in outpatient settings. Propofol is one of the most
commonly used anesthetic agents that can result in apnea and respiratory depression, …
M Serinken, C Eken – The American Journal of Emergency Medicine, 2015
Objective Ketamine is a dissociative anesthetic agent that has an increased frequency of
usage in the last years particularly in emergency departments. In the present study, we
aimed to determine whether ketamine is related to myocardial injury in children …
Anesthesia and neuromonitoring
EN Menga, GJ Spessot, JA Bendo – Seminars in Spine Surgery, 2015
… Commonly used intravenous anesthetics include propofol, dexmedetomidine, etomidate,
barbiturates, ketamine, and benzodiazepines. … Using a canine model, Glassman et al. 13 reported
consistent and reproducible TcMEPs with ketamine and etomidate. …
Inflammatory Biomarkers as Differential Predictors of Antidepressant Response
K Hashimoto – International Journal of Molecular Sciences, 2015
… situation. This article discusses inflammatory molecules as predictive biomarkers
for antidepressant responses to several classes of antidepressants, including the
N-methyl-d-aspartate (NMDA) receptor antagonist ketamine. …
CC Liao, GE DiCarlo, OA Gharbawie, HX Qi, JH Kaas – Journal of Comparative …, 2015
… tranquilized with an intramuscular injection (IM) of ketamine hydrochloride (10-25 mg/ kg, IM)
and Page 4 of 55 John Wiley & Sons Journal of Comparative Neurology … In preparation for the
injection, each monkey was tranquilized with ketamine hydrochloride (10mg/kg, …
Radiofrequency Ablation (RFA)
Y Beşir, O Gökalp, U Yetkin, E Çelik, H İner, B Lafçı… – Türk Göğüs Kalp Damar …, 2015
ABSTRACT Background: This study aims to examine the effects of amiodarone versus
propafenone for maintenance of stable sinus rhythm after left atrial bipolar radiofrequency
ablation combined with a mitral valve procedure in patients with mitral valve disease and …
New Technologies and Approaches to Endoscopic Control of Gastrointestinal Bleeding
LL Fujii-Lau, LMWK Song, MJ Levy – Gastrointestinal Endoscopy Clinics of North …, 2015
… Radiofrequency Ablation. Technique. Focal radiofrequency ablation (RFA) catheters
(Barrx; Covidien, Mansfield, MA) have been used to treat GI bleeding in the setting of
gastric antral vascular ectasia (GAVE) (Fig. 3) and radiation proctitis. …
M Morlando, L Ferrara, F D’Antonio, A Lawin‐O’Brien… – BJOG: An International …, 2015
… Ultrasound-guided laser ablation or radiofrequency ablation of the pelvic vessels of one
of the monochorionic fetuses was used in all cases of reduction from three to two fetuses
for selective reduction of one of the two monochorionic fetuses. …
Interventional MR elastography for MRI‐guided percutaneous procedures
N Corbin, J Vappou, E Breton, Q Boehler, L Barbé… – Magnetic Resonance in …, 2015
… [27] showed that the Young’s modulus of the treated liver tumor in swine increases from 6 to 40
kPa approximately during a 5 min-long radiofrequency ablation by providing elastographic
information every 30 s. The monitoring of thermal ablations with MRE is limited by the …
[HTML] Editorials & Opinions
JP Tasto – Am J Orthop, 2015
… Published December 2014. Accessed March 6, 2015. « Back To: Editorials & Opinions. Did
you miss this content? Cutaneous Burn Caused by Radiofrequency Ablation Probe During
Shoulder Arthroscopy. More From The American Journal of Orthopedics …
Hysteroscopy and heavy menstrual bleeding (to cover TCRE and second generation endometrial ablation)
M Bongers – Best Practice & Research Clinical Obstetrics & …, 2015
… cryo-ablation (HerOption™, Cooper Surgical, Trumbull, CT) [14], and bipolar radiofrequency
(Novasure™, Hologic … The difference between the first and the second-generation endometrial
ablation are several. … Under direct vision the total endometrium can be resected or ablated. …
Atrioesophageal fistula and pneumocephalus after pulmonary vein isolation
BD Wilson, JH Morshedzadeh – European Heart Journal-Cardiovascular Imaging, 2015
… Catheter radiofrequency ablation of atrial fibrillation is an increasingly common procedure,
and atrioesophageal fistula is a rare and often fatal complication. High clinical suspicion,
rapid diagnosis, and surgical therapy may prevent death. …
Gastroparesis as a Complication of Atrial Fibrillation Ablation
T Aksu, S Golcuk, TE Guler, K Yalin, I Erden – The American Journal of Cardiology, 2015
… ventricular ejection fraction, M=male; N=normal; PIN=patient identification number; R=
radiofrequency. … more reasonable avoiding cryo-energy at lower temperatures while ablating
inferior PVs … The most possible mechanism of gastroparesis related with AF ablation is collateral …
H Greiss, A Berkowitsch, M Wojcik, S Zaltsberg… – Pacing and Clinical …, 2015
… 16 Impact of LA area on outcome In our previous studies performed on patients ablated with CB,
we found NLA area to be predictive for outcome, but absolute LA area was not predictive. … Raviele
A, Themistoclakis S, Rossillo A, Bonso A, Natale A. Radiofrequency ablation …
Y Saitoh, G Irfan, G Ciconte, G Mugnai, J Sieira… – Pacing and Clinical …, 2015
… Great attention must be paid when ablating with the large 28 mm CB2 due to the … large cryoballoon
for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and
non-randomised comparison with pulmonary venous isolation by radiofrequency ablation. …
Complex Regional Pain Syndrome (CRPS/RSD)
Hydromorphone for neuropathic pain in adults
D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015
… Types of participants Studies will include adults aged 18 years and above with one or more chronic
neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central
neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human …
Fentanyl for neuropathic pain in adults
S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015
… Types of participants Studies will include adults aged 18 years and above with one or more chronic
neuropathic pain condition including (but not lim- ited to): 1. cancer-related neuropathy; 2. central
neuropathic pain; 3. complex regional pain syndrome (CRPS) Type II; 4. human …
The role of glia in the spinal cord in neuropathic and inflammatory pain
EA Old, AK Clark, M Malcangio – Pain Control, 2015
… microglia pool. Nat Neurosci 14: pp. 1142-1149; Alexander, GM, Rijn, MA, Hilten,
JJ, Perreault, MJ, Schwartzman, RJ (2005) Changes in cerebrospinal fluid levels
of pro-inflammatory cytokines in CRPS. Pain 116: pp. 213-219; …
M Jajoo, K Kapoor, LK Garg, V Manchanda, SK Mittal – Journal of Clinical …, 2015
… [6] Screening tests such as total and differential leukocyte counts, band cells, absolute neutrophil
counts (ANCs), and rapid immunological techniques like C-reactive proteins (CRPs) assays may
help in the diagnosis of septicemia; however, they lack the capacity to detect …
[PDF] Psychological Aspects of Reflex Sympathetic Dystrophy (RSD) Complex Regional Pain Syndrome (CRPS)
H Hooshmand, EM Phillips, FL Vero Beach
Abstract. Reflex sympathetic dystrophy (RSD) or complex regional pain syndrome (CRPS) is
a complex form of neuropathic pain associated with hyperpathia; neurovascular instability;
neuroinflammation; and limbic system dysfunction. As the condition becomes chronic, the …
H Hooshmand, EM Phillips, FL Vero Beach
Complex Regional Pain Syndrome (CRPS)/Reflex Sympathetic Dystrophy (RSD) is a
disease that usually starts after a relatively minor trauma. In the early stages there is a
sympathetic component in the development of the disease, but with passage of time, quite …
[PDF] Complex Regional Pain Syndrome (CRPS) and Sympathectomy
H Hooshmand, EM Phillips
Abstract. Sympathectomy may provide temporary pain relief, but after a few weeks to months
it loses its effect. Sympathectomy and the application of Chemical Sympathectomy
(neurolytic agents eg, phenol, alcohol, etc.) should be limited to patients with life …
[PDF] REPETITIVE STRAIN INJURY (RSI) DIAGNOSIS AND TREATMENT
H Hooshmand, EM Phillips, FL Vero Beach
… Careful history taking, neurological evaluation, along with such tests as quantitative
sensory testing (QST) and infrared thermal imaging (ITI) is helpful to differentiate RSI
from other causes of complex regional pain syndrome (CRPS). …
MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015
… Glossary of terms. AHI apnea/hypopnea index. ArI arousal index. BDNF brain-derived neurotrophic
factor. CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic
widespread pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls. …
Fibromyalgia
M Gomez-Calvente, I Medina-Porqueres… – Rheumatology International, 2015
Abstract There are few high-quality instruments to evaluate the participation and social
functioning of fibromyalgia patients. The Fibromyalgia Participation Questionnaire (FPQ) is a
questionnaire that evaluates these aspects with high reliability and validity in its German …
AC Steere, SL Arvikar – Clinical Infectious Diseases, 2015
… This chronic syndrome, which sometimes meets criteria for fibromyalgia or chronic fatigue
syndrome, is not specific for Lyme disease [8]. Such symptoms may follow other infections or
physical or emotional trauma, or the inciting cause may not be apparent. …
Central sensitization in humans: assessment and pharmacology
L Arendt-Nielsen – Pain Control, 2015
… J Pain 4: pp. 372-380; Balasubramaniam, R, Leeuw, R, Zhu, H, Nickerson, RB, Okeson, JP,
Carlson, CR (2007) Prevalence of temporomandibular disorders in fibromyalgia and failed
back syndrome patients: a blinded prospective comparison study. …
Chronic pain and the adaptive significance of positive emotions.
AD Ong, AJ Zautra, MC Reid – 2015
… Indeed, such in- terventions may prove to be particularly important for patients with specific chronic
pain conditions, such as fibromyalgia, who show a core affective disturbance that is characterized
by an overall deficit in posi- tive emotion (Finan, Zautra, & Davis, 2009). …
A Burri, S Ogata, J Vehof, FMK Williams, B Box – 2015
… 3 1. Introduction Chronic widespread pain (CWP) is the cardinal symptom of fibromyalgia. … four
items pertaining to the “pain subscale” were drawn from the London Fibromyalgia Epidemiology
Symptom Screening questionnaire (LFESSQ).[34] The four items ask about pain …
Hydromorphone for neuropathic pain in adults
D Aldington, P Cole, R Knaggs, C Stannard, S Derry… – The Cochrane Library, 2015
… Pharmacological treatment of fibromyalgia. … Journal of Pain 2008;9(2): 105–21. [DOI:
10.1016/j.jpain.2007.09.005] Gaskell 2014 Gaskell H, Moore RA, Derry, S, Stannard
C. Oxycodone for neuropathic pain and fibromyalgia in adults. …
SR Huey – 2015
… REFERENCES Davis, MC, & Zautra, AJ (2013). An online mindfulness intervention targeting
socioemo- tional regulation in fibromyalgia: Results of a randomized controlled trial. … Daily affect
relations in fibromyalgia patients reveal positive affective disturbance. …
Fentanyl for neuropathic pain in adults
S Derry, R Knaggs, PJ Wiffen, C Stannard, D Aldington… – The Cochrane Library, 2015
… Pharmacological treatment of fibromyalgia. … Durogesic® DTrans. www.medicines.org.uk/EMC/
medicine/17088/ (accessed 16 December 2014). Gaskell 2014 Gaskell H, Moore RA, Derry, S,
Stannard C. Oxycodone for neuropathic pain and fibromyalgia in adults. …
MF Bjurstrom, MR Irwin – Sleep Medicine Reviews, 2015
… CNS central nervous system. CRPS complex regional pain syndrome,. CWP chronic widespread
pain. EEG electroencephalography. FM fibromyalgia. HC healthy controls. IL interleukin. MFP
myofascial pain. NREM non-rapid-eye-movement. NSM non-sleep migraine. OA …
AR Starkweather, A Heineman, S Storey, G Rubia… – Applied Nursing Research, 2015
… In order to evaluate and compare centralized mechanisms, the QST protocol of the German
Research Network on Neuropathic Pain was used in a group of 21 patient with fibromyalgia
(mean duration 13.4 years), 23 individuals with chronic back pain (mean duration 15.9 years …
One of Americans’ most common medical complaints is chronic pain. According to Institute of Medicine of The National Academies, over 100 million Americans suffer from chronic pain. Furthermore, it is one of the most common causes of disability in America — for example back pain is one of the leading causes of disability in Americans who are younger than the age of 45, and more than 26 million Americans have frequent back pain.
